One reactive moiety, one inactive
`
`
`One reactive moiety, one inactive
`
`Two inactive moieties
`Two inactive moieties
`
`*".
`HA*
`HA*1
`HA*
`HA*
`�
`
`HA
`HA
`
`Aqueous solution
`Aqueous solution
`Crosslinking agent with
`and /or organic
`and/or organic
`
`Crosslinking agent with
`solvent
`two reactive moieties
`solvent
`two reactive moieties
`
`One HA modification, one inactive
`
`One HA modification, one inactive
`
`One HA modification, one reactive moiety
`
`
`One HA modification, one reactive moiety
`
`HA*
`HA*
`�
`
`HA*
`
`'
`/HA*
`
`One crosslink = two HA modifications
`
`One crosslink = two HA modifications
`
`HA* is HA attached as either
`
`HA* is HA attached as either
`HA -CHZO- or
`HA-CH20-or
`HA- C(0)O-
`HA-C(O)O-
`
`Prollenfunr v. Ailergan
`
`IPR2019-01505, eral.
`DeVore ]epo. Ex. 49
`
`ALL 2149
`PROLLENIUM V. ALLERGAN
`IPR2019-01505 et al.
`
`
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