CURRICULUM VITAE
`
`Pierre LEBRETON, PhD
`Dir, R&D Fillers, Prod Dev Fillers Pr
`
`1. Relevant information
`
`Postal address: 16, rue Guillaume Fichet 74000 Annecy (France)
`Email: Lebreton_Pierre@Allergan.com
`Phone : +33 (0)4 50 10 71 70
`Languages: French, English
`50 years old.
`
`Professional Address
`• Allergan Industrie
`Route de Promery, Zone Artisanale de Pré Mairy
`Pringy 74370 Annecy
`France
`
`2. Academic achievements
`
`1994-1998 Ph.D. in Chemistry & Physico-Chemistry of Polymers,
`University of Montpellier - France
`Title: « Synthesis, Characterization and Associative Properties of
`Perfluoroalkyl Polyacrylamide” with Honor of the Jury
`1993 - 1994 Master of Science in Polymer Material
`National Chemistry School of Montpellier - France
`1989-1991: Post Graduated in Chemistry & Engineering Science
`National Chemistry School of Mulhouse - France
`
`3. Skills
`
`Management Skills
`
`• Occupied Positions:
`2017-
` Exec. Director (R&D)
`2011- 2017
` Director (R&D)
`2007- 2011
` Sr Manager (R&D)
`2005-2007
` Manager (R&D)
` Project Leader (R&D) 2002-2005
` Engineer (R&D)
`2001-2002
` Engineer (Research) 1993-2001
`
`Company : Allergan
`Company : Allergan
`Company : Allergan
`Company : Corneal
`Company : Corneal
`Company : Corneal
`Company : Atofina
`
`•
`
`Team size : 30 people (Managers, Engineers, Pharmacist, Toxicologist,
`Technicians)
`• Cross-functional Management: Marketing (filler strategic team), Clinical,
`Operations, Quality, Logistic, Medical Team & Regulatory Affairs
`Pierre Lebreton - Page 1 of 4
`
`ALL 2081
`PROLLENIUM V. ALLERGAN
`IPR2019-01505 et al.
`
`

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`• Member of the board of director of the center of excellence for Juvéderm
`• Annual Budget: > 5 M€ - Annual Investment: up to 10M€
`• Methodology: Operational Excellence – Design of Experiment (DOE), Design
`For Six Sigma (DFSS), Systematic Inventive Thinking (SIT), Project Management
`Tools, Risk Analysis ISO 14971; Lean Six Sigma; benchmarks; situational
`management, coaching;
`
`Technical Expertise
`
`Formulation
`Free Radical Polymerization / Grafting & Cross linking / Aqueous Formulation
`/ Polycondensation/ Organic Synthesis/ HA raw material
`
`Characterization
`Spectroscopic Analysis / Rheological Characterization / Analytical
`Characterization / Validation per ISO / USP / Pharmacopeia and IQ/OQ/PQ
`methodology / Competitor Product Analysis
`
`Process & Engineering
`Purification Validation of Raw material and finished Product
`Process Validation per ISO9001: 2000 and 21CFR820
`Validation Master Plan
`
`Field of expertise
` Formulations: 25+ years of R&D in formulation area for various
`application such as: Medical Esthetic, Ophthalmic,
`Rheumatology, industrial foams & polymers additives for oil
`recovery systems.
` Medical Devices (injectables) : Dermal Filler, Cataract Surgery ,
`Arthritis treatment, Urology
` Design File (ISO13485, 21CFR820) including Validation
`Reports and Risk Analysis per ISO14971,
` Marketing Support and product positioning,
` Regulatory and Operation Support,
` Manufacturing Transfer from R&D to Launch.
` Clinical Evaluation Report (reviewer)
` Biocompatibility studies (ISO 10993)
`Filler performance and competitor testing
`
` Materials : Hyaluronic Acid (15 years of R&D activities on HA
`based medical devices), Hydro-soluble Polymers (10 additional
`years of research activities on polysaccharides,
`poly(acrylamide), polyethylene oxide, polyvinyl alcohol,
`polyacrylates, poly(butadienes), & cellulosic material used as
`additives in aqueous formulations for any kind of industrial
`purposes other than medical esthetic).
` Organic additives (lidocaine, mannitol, vitamin C)& other API
`
`Pierre Lebreton - Page 2 of 4
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`4. Achievements
`
`Development of 23 formulations of Hyaluronic Acid Based Products (CE
`Mark) including accessories:
` Juvéderm Brand (Dermal Filler) including Juvéderm with lidocaine
` Surgiderm Brand (Dermal Filler)
` Juvéderm Voluma (Volumizing ; Dermal Filler) including Juvéderm
`Voluma with lidocaine
` Juvéderm Hydrate (Rejuvenation)
` Juvéderm Volite (next gen skin quality product)
` Juvéderm Volux (volume creation)
` Juvartil (Arthrisis)
` Neovisc (Cataract Surgery and eye drop)
` Juvederm Vycross technology (Volift & Volbella)
` Accessories: Syringe, Needle, Canulas
`
`
`
`5. Publications
`
`CORE PATENTS (7)
`
`Dermal Filler: 5 ; Viscoelastic formulation for cataract Surgery : 1; Aqueous foams : 1
`
` 1
`
` MX2011001321 (A) HYALURONIC ACID-BASED GELS INCLUDING ANESTHETIC AGENTS
`Inventors: Lebreton Pierre Applicant : Allergan
`Publication : 25 March 2011 – Priority : 04 August 2008
`
` 2
`
` US20111892 DERMAL FILLERS COMPRISING SILK FIBROIN HYDROGELS AND USE THEREOF
`Inventors : LEBRETON PIERRE F [FR]; PIERRE SEBASTIEN [FR]; COLLETTE ADAM L [US]; HORAN
`REBECCA L [US]; CHEN JINGSONG [US]; ALTMAN GREGORY H [US] +
`Applicant ; Allergan
`Publication : 04 August 2011- Priority : 20 April 2009
`
` 3
`
` WO2011086458 (A1) STABLE HYDROGEL COMPOSITION INCLUDING ADDITIVES
`Inventors:Gousse Cecile, Lebreton Pierre, Prost Nicolas,
`Publication : 21 July 2011-08-29 Priority : 13 january 2010
`
` 4
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` WO2010/015901/HYLAURONIC ACID BASED GELS INCLUDING LIDOCAINE
`Inventor : P. LEBRETON Compagny : Allergan
`Publication date = 2010-02-11
`
`5- EP1817065 /”VISCOELASTIC SOLUTIONS CONTAINING SODIUM HYALURONATE AND
`HYDROXYPROPYLMETHYLCELLULOSE, PREPARATION AND USES”
`Inventors : P.LEBRETON
`Company = CORNEAL
`Publication Date = 2007-08-15
`
`6- WO2004092222 “CROSS-LINKING OF LOW AND HIGH MOLECULAR WEIGHT
`POLYSACCHARIDES PREPARATION OF INJECTABLE MONOPHASE HYDROGELS AND
`POLYSACCHARIDES AND HYDROGELS THUS OBTAINED”
`Date de publication: 2004-10-28
`Inventors : P.LEBRETON
`Company = CORNEAL
`
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`7- FR2746322 « EMULSEURS ANTI-INCENDIE POLYVALENTS COMPRENANT UN
`POLYSACCHARIDE ET UN POLYMERE FLUORE TRIBLOC »
`Date de publication : 1997-10-30
`Inventors : GARCIA GILBERT (FR); COLLETTE CHRISTIAN (FR); LEBRETON PIERRE (FR); BOUTEVIN
`BERNARD (FR) Company = ATOCHEM ELF SA (FR)
`
`
`SCIENTIFIC PUBLICATIONS (6)
`
`1- P. LEBRETON, B. AMEDURI, B. BOUTEVIN, J.M. CORPART, D. COT, “Radical telomerization
`of 1,3-butadiene with perfluoroalkyl iodides in the presence of potassium carbonate” J.
`Polym. Sci. Part A, Polym. Chem., 2002, 40, 3743-3756.
`2- P. LEBRETON, B. AMEDURI, B. BOUTEVIN, J.M. CORPART, “Use of original omega-
`perfluorinated dithioesters for the synthesis of well-controlled polymers by reversible
`addition-fragmentation chain transfer (RAFT)”, Macromol. Chem. Phys., 2002, 203, 522-537
`3 P. LEBRETON, B. AMEDURI, B. BOUTEVIN, J.M. CORPART, D. JUHUE, “Radical telomerization
`of 1,3-butadiene with perfluoroalkyl iodides. Macromol. Chem. Phys., 2000, 201, 1016.
`4- P. LEBRETON, B. BOUTEVIN, “Primary radical termination and unimolecular termination in
`the heterogeneous polymerization of acrylamide initiated by a fluorinated azo-derivative
`initiator : a kinetic study.”, J. Appl. Polym. Sci., 2000, 38, 1834-1843
`5- P. LEBRETON, P. GRAMAIN, “A facile synthesis of hydrophobically end-capped
`poly(oxymethylene-co-polyethylene oxide) by controlled step condensation.Designed
`Monomers and Polymers”, 1999, 2, 3, 209-216.
`6- P. LEBRETON, B. BOUTEVIN, P. GRAMAIN, J.M. CORPART, “Synthesis, characterization and
`associative properties of triblock and diblock perfluorinated poly(acrylamide)s.
`Polym. Bull., 1999, 43, 59.
`
`CONFERENCES
`
`Communications and/or participation in International Congresses:
`International Conference on Hyaluronan Glycoscience
`•
`2003 (Cleveland US), 2007 (Charleston US), 2010 (Kyoto Japan)
`IMCAS International Master Course on Skin Aging, Paris
` 2003, 2005, 2007, 2009, 2012, 2014 (speaker), 2018 (speaker), 2019(speaker)
`• AMWC, Monaco, 2012, 2014 (round table), 2018
`• EMAA European Master in Aesthetics and Anti Ageing, Paris, 2010
`• French Society of Ophtalmology SFO, Paris, 2002.
`• American Society for Metabolic and bariatric Surgery, Orlando US, 2011
`• Convention on Pharmaceutical Ingredient CPhI, Milan (2007), Madrid (2009)
`The Aesthetic Academy. Los Angeles, Juin, 2011
`•
`• DU injectables, Dr Kestemont, Nice, Mai 2012, Mai 2013, Mai 2014 (speaker)
`• DU injectables Dr Asher, Janvier 2014 (speaker)
`• Conférence Médecine Régénératives , tissu Adipeux, cellules souches, Dr Mojallal, Dr
`Brown, Dr Delvecchio, Hôpital La croix Rousse, Lyon, Juin 2012
`International Congress on Aesthetic and Anti-Ageeing Medecin, Warsaw, October
`2016 (round table)
`• Congress 28 Oct 2017 Lviv "ALCHEMY AND CHEMISTRY IN AESTHETIC MEDICINE", speaker
`• DEFEE congress, 2 dec 2017, Lille, speaker
`• Sales force meeting, Paris, 16 january 2017, speaker
`• Volite launch in Belgrade (speacker on science), Nov 3rd, 2018
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