`Sent:
`To:
`
`Starbuck, Cindy [/0=MERCK/OU=NORTHAMERICA/CN=RECIPIENTS/CN=STARBUCK]
`11/22/2002 7:48:17 PM
`Santos, Ivan [iyan_santos@merck.com]; Wenslow, Robert M. [robert_wenslow@merck.com]; Ferlita, Russell Rosario
`[russell_ferlita@merck.com]; Armstrong, Joe D [joe_armstrong@merck.com]; Hansen, Karl
`[karl_hansen@merck.com]; Ward, Michael D MRL/RY [michael_ward@merck.com]; lampietro, Daniel
`[daniel_iampietro@merck.com]; VanCleaf, Stephen J. [stephen_yancleaf@merck.com]; Jurgenson, Christopher
`[christopher jurgenson@merck.com]; Zhang, Dina [dina_zhang@merck.com]; Billington, Sharon
`[sharon_billington@merck.com]
`Fisher, Elizabeth S [elizabeth_fisher@merck.com]; Wieczorek, Albert A [al_wieczorek@merck.com]; Kaba, Mahmoud
`[mahmoud_kaba@merck.com]; Dienemann, Erik A [erik_dienemann@merck.com]; Larson, Karen A
`[karen_larson@merck.com]; Tabora, Jose E [jose_tabora@merck.com]; Tom, Jean W [jean_tom@merck.com]
`L-224,715 drying
`Subject:
`Attachments: L715 Compiled_112202.doc
`
`CC:
`
`This week has been a great week for L-715:
`•definitive proof of concept was achieved in the Phase IB study (this is restricted and confidential information)
`•Cannpaign I was completed, producing a grand total of 95 kg of L-715 after 10 months of constant piloting (pending
`release assays)
`.Crystallization/drying improvements led to delivery of large (50 um) particles to Pharnn R&D for further development of
`the direct compression formulation
`
`Lots of people not included on this mailing list need to be thanked for the success of the campaign as a whole.
`Regarding crystallization/drying improvements between PPB#1-2 and PPB#2/3-2 I would like to make a few
`acknowledgments. First, thanks to Beth Fisher and Al Wieczorek who were instrumental in the design and execution of
`the UOPS drying studies. Thanks are also due to the SSO facilities staff (particularly Dan, Mike and Steve Van Cleat) for
`d usting the cobwebs off of DR-90G. Without the Sumnnix in working order in the SSO we wouldn't have been able to
`support Pharm R&D in their development of the optimal formulation for Phase IIB. Thanks are also due to our Physical
`Measurements colleagues who analyzed numerous PSD, TG and XRD samples this week and last.
`
`I have enclosed our weekly for further discussion of this week's drying studies and PP performance.
`
`L715
`Compiled_11220...
`
`-Cindy
`
`Merck Exhibit 2139
`Mylan Pharmaceuticals Inc. v. Merck Sharp & Dohme Corp.
`IPR2020-00040
`
`
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