`
`OH
`
`O
`
`P
`
`O
`
`OH
`
`+
`NH3
`
`O
`
`F
`
`F
`
`F
`
`N
`
`N
`
`N
`
`N
`
`F
`
`F
`
`F
`
`
`
`CONFIDENTIAL
`
`Merck Exhibit 2138, Page 1
`Mylan Pharmaceuticals Inc. v. Merck Sharp & Dohme Corp.
`IPR2020-00040
`
`
`
`Low B.P. acid polymorph library (129542)
`
`10mg/well, 800uL solvents in mother plate
`From filter plate:
`100uL to precipitation plate with 300uL anti-solvent
`200uL for cubic cooling from 65 to10ºC for 8 hours in crystallizer
`200uL to evaporation plate
`
`
`
`CONFIDENTIAL
`
`Merck Exhibit 2138, Page 2
`Mylan Pharmaceuticals Inc. v. Merck Sharp & Dohme Corp.
`IPR2020-00040
`
`
`
`High B.P. acid polymorph library (129543)
`
`10mg/well, 800uL solvents in mother plate
`From filter plate:
`100uL to precipitation plate with 300uL anti-solvent
`200uL for cubic cooling from 95 to10ºC for 8 hours in crystallizer
`200uL to evaporation plate
`
`
`
`CONFIDENTIAL
`
`Merck Exhibit 2138, Page 3
`Mylan Pharmaceuticals Inc. v. Merck Sharp & Dohme Corp.
`IPR2020-00040
`
`
`
`129542 birefringence (2.5x & automatic exposure)
`
`
`
`CONFIDENTIAL
`
`Merck Exhibit 2138, Page 4
`Mylan Pharmaceuticals Inc. v. Merck Sharp & Dohme Corp.
`IPR2020-00040
`
`
`
`129543 birefringence (2.5x & automatic exposure)
`
`
`
`CONFIDENTIAL
`
`Merck Exhibit 2138, Page 5
`Mylan Pharmaceuticals Inc. v. Merck Sharp & Dohme Corp.
`IPR2020-00040
`
`
`
`L224715 H3PO4 birefringence
`
`Form A: 129543 ppt E2
`
`Group 1: 129543 cool E7
`
`Group 2: 129542 evp G11
`
`Group 3: 129542 ppt H12
`
`Group 4: 129542 cool A2
`
`Group 5: 129543 cool B11
`
`
`
`CONFIDENTIAL
`
`Merck Exhibit 2138, Page 6
`Mylan Pharmaceuticals Inc. v. Merck Sharp & Dohme Corp.
`IPR2020-00040
`
`
`
`1 2 3 4 5
`
`A
`
`CONFIDENTIAL
`
`L224715 H3PO4 Raman spectra
`
`
`
`Merck Exhibit 2138, Page 7
`Mylan Pharmaceuticals Inc. v. Merck Sharp & Dohme Corp.
`IPR2020-00040
`
`
`
`L224715 H3PO4 XRD pattern
`
`A
`
`5
`
`1
`
`CONFIDENTIAL
`
`
`
`Merck Exhibit 2138, Page 8
`Mylan Pharmaceuticals Inc. v. Merck Sharp & Dohme Corp.
`IPR2020-00040
`
`
`
`129542 assignment
`
`
`
`CONFIDENTIAL
`
`Merck Exhibit 2138, Page 9
`Mylan Pharmaceuticals Inc. v. Merck Sharp & Dohme Corp.
`IPR2020-00040
`
`
`
`129543 assignment
`
`
`
`CONFIDENTIAL
`
`Merck Exhibit 2138, Page 10
`Mylan Pharmaceuticals Inc. v. Merck Sharp & Dohme Corp.
`IPR2020-00040
`
`