throbber
DR STUART ALLEN JONES
` _________________________________________________________
`Reader - Pharmaceutics, Pharmacy Dept.,
`CURRENT
`2019 – present
`POST(S)
`King’s College London, UK
`
`PREVIOUS
`APPOINTMENTS
`
`EDUCATION
`
`RESEARCH
`FUNDING
`
`Senior Lecturer – Pharmaceutics, Pharmacy
`Dept. King’s College London
`Consultant Pharmacist, Directorate of
`Rational Use of Medicines, Ministry of Health,
`Oman (12 month secondment)
`Company Founder, Porto Life Sciences,
`Oxford, UK (part-time post).
`Lecturer - Pharmaceutics, Pharmacy Dept.,
`King’s College London, UK
`Pharmaceutical Consultant, King’s College
`London
`Pharmaceutical Consultant, MedPharm Ltd,
`Guildford, UK
`Head of Research and Development,
`MedPharm Ltd, UK
`Formulation Scientist
`Pfizer Pharmaceuticals, UK
`
`PhD Drug Delivery
`Pharmacy Dept., King’s College London, UK
`Masters Degree in Academic Practice
`King’s Learning Institute, King’s College
`London, UK
`Masters Degree in Pharmacy
`University of Nottingham, UK
`Diploma Academic Practice
`King’s Learning Institute, UK
`
`Post-Doc Grant ‘Engineering a topical
`hypobaric patch: A needle-free solution for
`biopharmaceutical drug administration into
`the skin’
`(EPSRC) S. A. Jones
`Research Assistant Grant. Phosphorylated
`vitamins and oral health
`(GSK Ltd) S. A. Jones and G. Carpenter
`Post-Doc Grant’ Vasodilator nitric oxide
`donors’
`(Syndermix Ltd.) S. A. Jones, S. Brain
`Hypobaric cytokine profiling a noninvasive
`means to characterise skin health during
`aging
`RoseTrees Trust
`Multifunctional self-assembling ion-pair
`complexes
`(EPSRC, Johnson and Johnson Ltd, UK) S. A.
`Jones
`The influence of barometric pressure
`changes upon membrane physiology and
`
`2010 - 2019
`
`2015 – 2016
`
`2008 – 2012
`
`2005 –2010
`
`2009 - present
`
`2005 – 2009
`
`2004 –2005
`
`2001- 2002
`
`2002 –2005
`
`2013 – 2015
`
`1997 –2001
`
`2011 –2013
`
`2019-2022
`£568,560
`
`2019-2020
`£28,000
`
`2018-2019
`£65,000
`
`2017-2020
`£60,000
`
`2013-2017
`£112,630
`
`2013- 2017
`£90,000
`
`Opiant Exhibit 2200
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00694
`Page 1
`
`

`

`xenobiotic penetration
`(BBSRC, UK) S. A. Jones
`In vitro biopharmaceutical evaluation of
`novel respiratory medicines for airway
`disease
`(MRC, GlaxoSmithKline Ltd, UK) S. A. Jones,
`B. Forbes, C. Page
`The formation and delivery of novel drug-
`ion-pair combinations to the airways of the
`lung
`(EPSRC, MedPharm Ltd, UK) S. A. Jones, C.
`Page
`In Vivo Safety and Particokinetics of Inhaled
`Nanomedicines
`(MRC, UK) S. A. Jones, B. Forbes, L. Daily, D.
`Spina. C. Page
`Mucus penetrating nanoparticles – a novel
`targeting strategy for the treatment of
`respiratory disease
`(BBSRC, UK) S. A. Jones
`Novel cosmetically acceptable methods of
`keratin manipulation to facilitate hair
`removal
`(EPSRC and DTI, UK) S. A. Jones
`A fundamental investigation of the barrier
`properties of the human nail
`(BBSRC, UK) S. A. Jones, M. B. Brown, M.
`Traynor, S. Murdan
`Development of a novel self-assembling
`thermoregulation device to enhance
`transdermal drug delivery’
`(EPSRC and MedPharm) S. A. Jones
`A novel intransal microencapsulated
`nanoparticle formulation
`(BBSRC SBRI and MedPharm Ltd) S. A.
`Jones, M. B. Brown,
`The development of a novel self-assembling
`patchless-patch (Medspray) for topical drug
`delivery
`(SEEDA) S. A. Jones M. B. Brown.
`Engineering of novel nanofoams
`(BBSRC Dorothy Hodgkin award)
`S. A. Jones
`‘Novel topical formulations for ungula drug
`delivery’
`(BBSRC SBRI with MedPharm)
`Iontophoresis induced collagen production
`(Transport Pharmaceuticals) S. A. Jones, M. B.
`Brown.
`Novel topical formulations for ungula drug
`delivery
`(MedPharm Ltd studentship) S. A. Jones, M. B.
`Brown.
`
`2011- 2015
`£90,000
`
`2009-2013
`£90,000
`
`2010-2013
`£660, 000
`
`2009-2013
`£70,000
`
`2010- 2012
`£121,600
`
`2010-2012
`£280,000
`
`2006-2010
`£70,000
`
`2006-2008
`£203,000
`
`2005-2009
`£230,000
`
`2005-2009
`£75,000
`
`£215,000
`2005-2007
`
`2005-2009
`£110,000
`
`2005-2008
`£67,000
`
`Opiant Exhibit 2200
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00694
`Page 2
`
`

`

`RESEARCH
`PUBLICATIONS
`
`H-index (19
`Scopus)
`
`Harper, R. A., Petersen, L., Saleh, M.M., Proctor, G. B., Carpenter, G.
`H., Gambogi, R., Hider, R., Jones, S.A. Targeting macrophages and
`their recruitment in the oral cavity using swellable (+) alpha
`tocopheryl phosphate nanostructures, Nanomedicine:
`Nanotechnology, Biology and Medicine. (2019) 21: 102010
`
`Chen, H. Mansfield, E.D.H., Woods, A., Khutoryanskiy, V.V.,
`Forbes, B., Jones, S.A. Mucus penetrating properties of soft,
`distensible lipid nanocapsules European Journal of Pharmaceutics
`and Biopharmaceutics. (2019) 139, pp 76-84.
`
`Harper, R.A., Saleh, M.M., Carpenter, G., Abbate, V., Proctor, G.,
`Harvey, R.D., Gambogi, R.J., Geonnotti, A., Hider, R., Jones, S.A.
`Diminishing biofilm resistance to antimicrobial nanomaterials through
`electrolyte screening of electrostatic interactions Colloids and
`Surfaces B: Biointerfaces. (2019) 173 (1), pp 392-399.
`
`Benaouda, F., Jones, S.A., Chana, J., Dal Corno, B.M., Barlow, D.J.,
`Hider, R.C., Page, C.P., Forbes, B. Ion-Pairing with Spermine Targets
`Theophylline to the Lungs via the Polyamine Transport System
`(2018) Molecular Pharmaceutics, 15 (3), pp. 861-870.
`
`Harper, R.A., Saleh, M.M., Carpenter, G., Abbate, V., Proctor, G.,
`Harvey, R.D., Gambogi, R.J., Geonnotti, A., Hider, R., Jones, S.A.
`Soft, adhesive (+) alpha tocopherol phosphate planar bilayers that
`control oral biofilm growth through a substantive antimicrobial effect
`(2018) Nanomedicine: Nanotechnology, Biology, and Medicine, .
`Article in Press.
`
`Cai, X.J., Mesquida, P., Jones, S.A. Investigating the ability of
`nanoparticle-loaded hydroxypropyl methylcellulose and xanthan gum
`gels to enhance drug penetration into the skin (2016) International
`Journal of Pharmaceutics, 513 (1-2), pp. 302-308.
`
`Patel, A., Keir, S.D., Brown, M.B., Hider, R., Jones, S.A., Page, C.P.
`Using Salt Counterions to Modify β2-Agonist Behaviour in Vivo
`(2016) Molecular Pharmaceutics, 13 (10), pp. 3439-3448.
`
`Chen, H., Woods, A., Forbes, B., Jones, S. Controlled drug release
`from lung-targeted nanocarriers via chemically mediated shell
`permeabilization (2016) International Journal of Pharmaceutics, 511
`(2), pp. 1033-1041.
`
`Patel, A., Woods, A., Riffo-Vasquez, Y., Babin-Morgan, A., Jones, M.-
`C., Jones, S., Sunassee, K., Clark, S., De Rosales, R.T.M., Page, C.,
`Spina, D., Forbes, B., Dailey, L.A. Lung inflammation does not affect
`the clearance kinetics of lipid nanocapsules following pulmonary
`administration 2016) Journal of Controlled Release, 235, pp. 24-33.
`
`Inacio, R., Barlow, D., Kong, X., Keeble, J., Jones, S.A.
`Investigating how the attributes of self-associated drug complexes
`influence the passive transport of molecules through biological
`membranes (2016) European Journal of Pharmaceutics and
`Biopharmaceutics, 102, pp. 214-222.
`
`Opiant Exhibit 2200
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00694
`Page 3
`
`

`

`McAuley, W.J., Jones, S.A., Traynor, M.J., Guesné, S., Murdan, S.,
`Brown, M.B. An investigation of how fungal infection influences drug
`penetration through onychomycosis patient's nail plates (2016)
`European Journal of Pharmaceutics and Biopharmaceutics, 102, pp.
`178-184.
`
`Cai, X.J., Patel, T., Woods, A., Mesquida, P., Jones, S.A.
`Investigating the influence of drug aggregation on the percutaneous
`penetration rate of tetracaine when applying low doses of the agent
`topically to the skin (2016) International Journal of Pharmaceutics,
`502 (1-2), pp. 10-17.
`
`Cai, X.J., Woods, A., Mesquida, P., Jones, S.A. Assessing the
`Potential for Drug-Nanoparticle Surface Interactions to Improve Drug
`Penetration into the Skin (2016) Molecular Pharmaceutics, 13 (4), pp.
`1375-1384.
`
`Inacio, R., Poland, S., Cai, X.J., Cleary, S.J., Ameer-Beg, S., Keeble,
`J., Jones, S.A. The application of local hypobaric pressure - A novel
`means to enhance macromolecule entry into the skin (2016) Journal
`of Controlled Release, 226, pp. 66-76.
`
`Fiala, S., Roman, M., Inacio, R., Mashal, S., Brown, M.B., Jones, S.A.
`New insights into eutectic cream skin penetration enhancement
`(2016) International Journal of Pharmaceutics, 499 (1-2), pp. 403-
`411.
`
`Benaouda, F., Jones, S.A., Martin, G.P., Brown, M.B.
`Localized Epidermal Drug Delivery Induced by Supramolecular
`Solvent Structuring (2016) Molecular Pharmaceutics, 13 (1), pp. 65-
`72.
`
`Dailey, L.A., Hernández-Prieto, R., Casas-Ferreira, A.M., Jones, M.-
`C., Riffo-Vasquez, Y., Rodríguez-Gonzalo, E., Spina, D., Jones, S.A.,
`Smith, N.W., Forbes, B., Page, C., Legido-Quigley, C. Adenosine
`monophosphate is elevated in the bronchoalveolar lavage fluid of
`mice with acute respiratory toxicity induced by nanoparticles with high
`surface hydrophobicity (2015) Nanotoxicology, 9 (1), pp. 106-115.
`
`Jones, S.A., Fiala, S., Brown, M.B. Eutectic systems for penetration
`enhancement (2015) Percutaneous Penetration Enhancers Chemical
`Methods in Penetration Enhancement: Drug Manipulation Strategies
`and Vehicle Effects, pp. 163-173.
`
`Chana, J., Forbes, B., Jones, S.A. Triggered-release nanocapsules
`for drug delivery to the lungs (2015) Nanomedicine: Nanotechnology,
`Biology, and Medicine, 11 (1), pp. 89-97.
`
`Baraldi, A., Jones, S.A., Guesné, S., Traynor, M.J., McAuley, W.J.,
`Brown, M.B., Murdan, S. Human Nail Plate Modifications Induced by
`Onychomycosis: Implications for Topical Therapy (2015)
`Pharmaceutical Research, 32 (5), pp. 1626-1633.
`
`Jones, M.-C., Jones, S.A., Riffo-Vasquez, Y., Spina, D., Hoffman, E.,
`Morgan, A., Patel, A., Page, C., Forbes, B., Dailey, L.A.
`
`Opiant Exhibit 2200
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00694
`Page 4
`
`

`

`Quantitative assessment of nanoparticle surface hydrophobicity and
`its influence on pulmonary biocompatibility (2014) Journal of
`Controlled Release, 183 (1), pp. 94-104.
`
`Teixeira, R.S., Veiga, F.J.B., Oliveira, R.S., Jones, S.A., Silva,
`S.M.C., Carvalho, R.A., Valente, A.J.M. Effect of Cyclodextrins and
`pH on the permeation of tetracaine: Supramolecular assemblies and
`release behaviour (2014) International Journal of Pharmaceutics, 466
`(1-2), pp. 349-358.
`
`Baraldi, A., Khengar, R.H., Murdan, S., Traynor, M.J., Jones, S.A.,
`Brown, M.B. The effect of disulphide bond disruption on the barrier
`integrity of the human nail (2014) Issues in Toxicology, pp. 101-112.
`
`Zhao, Y., Alas'Ad, M.A., Jones, S.A. Modifying theophylline
`microparticle surfaces via the sequential deposition of poly(vinyl
`alcohol-co-vinyl acetate) copolymers (2014) International Journal of
`Pharmaceutics, 463 (1), pp. 27-30.
`
`Benaouda, F., Bachoo, Z., Brown, M.B., Martin, G.P., Jones, S.A.
`In situ self assembly of soft diclofenac loaded microparticles in
`superstructured fluids (2013) Soft Matter, 9 (42), pp. 10165-10173.
`
`Reid, M.L., Benaouda, F., Khengar, R., Jones, S.A., Brown, M.B.
`Topical corticosteroid delivery into human skin using
`hydrofluoroalkane metered dose aerosol sprays (2013) International
`Journal of Pharmaceutics, 452 (1-2), pp. 157-165.
`
`Benaouda, F., Brown, M.B., Shah, B., Martin, G.P., Jones, S.A.
`The influence of self-assembling supramolecular structures on the
`passive membrane transport of ion-paired molecules (2012)
`International Journal of Pharmaceutics, 439 (1-2), pp. 334-341.
`
`Benaouda, F., Brown, M.B., Martin, G.P., Jones, S.A.
`Triggered in situ drug supersaturation and hydrophilic matrix self-
`assembly (2012) Pharmaceutical Research, 29 (12), pp. 3434-3442.
`
`Benaouda, F., Brown, M.B., Ganguly, S., Jones, S.A., Martin, G.P.
`Discriminating the molecular identity and function of discrete
`supramolecular structures in topical pharmaceutical formulations
`(2012) Molecular Pharmaceutics, 9 (9), pp. 2505-2512.
`
`Wood, D.G., Brown, M.B., Jones, S.A. Understanding heat facilitated
`drug transport across human epidermis (2012) European Journal of
`Pharmaceutics and Biopharmaceutics, 81 (3), pp. 642-649.
`
`Zhao, Y., Brown, M.B., Khengar, R.H., Traynor, M.J., Barata, P.,
`Jones, S.A. Pharmacokinetic evaluation of intranasally administered
`vinyl polymer-coated lorazepam microparticles in rabbits
`(2012) AAPS Journal, 14 (2), pp. 218-224.
`
`Grainger, C.I., Saunders, M., Buttini, F., Telford, R., Merolla, L.L.,
`Martin, G.P., Jones, S.A., Forbes, B. Critical characteristics for
`corticosteroid solution metered dose inhaler bioequivalence
`(2012) Molecular Pharmaceutics, 9 (3), pp. 563-569.
`
`Opiant Exhibit 2200
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00694
`Page 5
`
`

`

`Fiala, S., Brown, M.B., Jones, S.A. Dynamic in-situ eutectic formation
`for topical drug delivery (2011) Journal of Pharmacy and
`Pharmacology, 63 (11), pp. 1428-1436.
`
`Traynor, M.J., Zhao, Y., Brown, M.B., Jones, S.A. Vinyl polymer-
`coated lorazepam particles for drug delivery to the airways (2011)
`International Journal of Pharmaceutics, 410 (1-2), pp. 9-16.
`
`Staff, K., Brown, M.B., Chilcott, R.P., Hider, R.C., Jones, S.A., Kong,
`X.L. Ga(III) complexes-The effect of metal coordination on potential
`systemic absorption after topical exposure (2011) Toxicology Letters,
`202 (3), pp. 155-160.
`
`Wood, D.G., Brown, M.B., Jones, S.A., Murnane, D. Characterization
`of latent heat-releasing phase change materials for dermal therapies
`(2011) Journal of Physical Chemistry C, 115 (16), pp. 8369-8375.
`
`Wood, D.G., Brown, M.B., Jones, S.A. Controlling barrier penetration
`via exothermic iron oxidation (2011) International Journal of
`Pharmaceutics, 404 (1-2), pp. 42-48.
`
`Jones, S.A. Suspension versus solution metered dose inhalers:
`Different products, different particles? (2011) Journal of Drug Delivery
`Science and Technology, 21 (4), pp. 319-322.
`
`Jones, S.A., Kalia, M. Inhaled formulation development: Back to
`basics? (2010) Pharmaceutical Manufacturing and Packing Sourcer,
`(WINTER), pp. 52-56.
`
`Moddaresi, M., Brown, M.B., Zhao, Y., Tamburic, S., Jones, S.A.
`The role of vehicle-nanoparticle interactions in topical drug delivery
`(2010) International Journal of Pharmaceutics, 400 (1-2), pp. 176-
`182.
`
`Khengar, R.H., Brown, M.B., Turner, R.B., Traynor, M.J., Holt, K.B.,
`Jones, S.A. Free radical facilitated damage of ungual keratin
`(2010) Free Radical Biology and Medicine, 49 (5), pp. 865-871.
`
`Staff, K., Brown, M.B., Hider, R.C., Kong, X.L., Friden, P., Jones, S.A.
`Recovering Ga(III) from coordination complexes using pyridine 2,6-
`dicarboxylic acid chelation ion chromatography
`(2010) Biomedical Chromatography, 24 (9), pp. 1015-1022.
`
`Fiala, S., Jones, S.A., Brown, M.B. A fundamental investigation into
`the effects of eutectic formation on transmembrane transport
`(2010) International Journal of Pharmaceutics, 393 (1-2), pp. 68-73.
`
`Zhao, Y., Brown, M.B., Jones, S.A. Pharmaceutical foams: are they
`the answer to the dilemma of topical nanoparticles? (2010)
`Nanomedicine: Nanotechnology, Biology, and Medicine, 6 (2), pp.
`227-236.
`
`Zhao, Y., Brown, M.B., Jones, S.A. The effects of particle properties
`on nanoparticle drug retention and release in dynamic minoxidil
`
`Opiant Exhibit 2200
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00694
`Page 6
`
`

`

`foams (2010) International Journal of Pharmaceutics, 383 (1-2), pp.
`277-284.
`
`Moddaresi, M., Brown, M.B., Tamburic, S., Jones, S.A. Tocopheryl
`acetate disposition in porcine and human skin when administered
`using lipid nanocarriers (2010) Journal of Pharmacy and
`Pharmacology, 62 (6), pp. 762-769.
`
`Zhao, Y., Jones, S.A., Brown, M.B. Dynamic foams in topical drug
`delivery (2010) Journal of Pharmacy and Pharmacology, 62 (6), pp.
`678-684.
`
`Zhao, Y., Brown, M.B., Jones, S.A. The topical delivery of benzoyl
`peroxide using elegant dynamic hydrofluoroalkane foams (2010)
`Journal of Pharmaceutical Sciences, 99 (3), pp. 1384-1398.
`
`Traynor, M.J., Turner, R.B., Evans, C.R.G., Khengar, R.H., Jones,
`S.A., Brown, M.B. Effect of a novel penetration enhancer on the
`ungual permeation of two antifungal agents (2010) Journal of
`Pharmacy and Pharmacology, 62 (6), pp. 730-737.
`
`Gul, M.O., Jones, S.A., Dailey, L.A., Nacer, H., Ma, Y., Sadouki, F.,
`Hider, R., Araman, A., Forbes, B. A poly(vinyl alcohol) nanoparticle
`platform for kinetic studies of inhaled particles (2009) Inhalation
`Toxicology, 21 (7), pp. 631-640.
`
`Patel, A., Jones, S.A., Ferro, A., Patel, N. Pharmaceutical salts: A
`formulation trick or a clinical conundrum? (2009) British Journal of
`Cardiology, 16 (6), pp. 281-286.
`
`Zhao, Y., Moddaresi, M., Jones, S.A., Brown, M.B. A dynamic topical
`hydrofluoroalkane foam to induce nanoparticle modification and drug
`release in situ (2009) European Journal of Pharmaceutics and
`Biopharmaceutics, 72 (3), pp. 521-528.
`
`Zhao, Y., Brown, M.B., Jones, S.A. Engineering novel topical foams
`using hydrofluroalkane emulsions stabilised with pluronic surfactants
`(2009) European Journal of Pharmaceutical Sciences, 37 (3-4), pp.
`370-377.
`
`Moddaresi, M., Tamburic, S., Williams, S., Jones, S.A., Zhao, Y.,
`Brown, M.B. Effects of lipid nanocarriers on the performance of
`topical vehicles in vivo (2009) Journal of Cosmetic Dermatology, 8
`(2), pp. 136-143.
`
`Madlova, M., Jones, S.A., Zwerschke, I., Ma, Y., Hider, R.C., Forbes,
`B. Poly(vinyl alcohol) nanoparticle stability in biological media and
`uptake in respiratory epithelial cell layers in vitro (2009) European
`Journal of Pharmaceutics and Biopharmaceutics, 72 (2), pp. 438-443.
`
`Reid, M.L., Jones, S.A., Brown, M.B. Transient drug supersaturation
`kinetics of beclomethasone dipropionate in rapidly drying films
`(2009) International Journal of Pharmaceutics, 371 (1-2), pp. 114-
`119.
`
`Opiant Exhibit 2200
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00694
`Page 7
`
`

`

`Brown, M.B., Khengar, R.H., Turner, R.B., Forbes, B., Traynor, M.J.,
`Evans, C.R.G., Jones, S.A. Overcoming the nail barrier: A systematic
`investigation of ungual chemical penetration enhancement
`(2009) International Journal of Pharmaceutics, 370 (1-2), pp. 61-67.
`
`Jones, S.A., Reid, M.L., Brown, M.B.
`Determining degree of saturation after application of transiently
`supersaturated metered dose aerosols for topical delivery of
`corticosteroids (2009) Journal of Pharmaceutical Sciences, 98 (2), pp.
`543-554.
`
`Fiala, S., Brown, M.B., Jones, S.A. An investigation into the influence
`of binary drug solutions upon diffusion and partition processes in
`model membranes (2008) Journal of Pharmacy and Pharmacology,
`60 (12), pp. 1615-1623.
`
`Chana, J., Forbes, B., Jones, S.A. The synthesis of high molecular
`weight partially hydrolysed poly(vinyl alcohol) grades suitable for
`nanoparticle fabrication (2008) Journal of Nanoscience and
`Nanotechnology, 8 (11), pp. 5739-5747.
`
`Reid, M.L., Brown, M.B., Jones, S.A. Manipulation of corticosteroid
`release from a transiently supersaturated topical metered dose
`aerosol using a residual miscible co-solvent
`(2008) Pharmaceutical Research, 25 (11), pp. 2573-2580.
`
`Reid, M.L., Brown, M.B., Moss, G.P., Jones, S.A.
`An investigation into solvent-membrane interactions when assessing
`drug release from organic vehicles using regenerated cellulose
`membranes (2008) Journal of Pharmacy and Pharmacology, 60 (9),
`pp. 1139-1147.
`
`Jones, S.A., Mesgarpour, S., Chana, J., Forbes, B. Preparation and
`characterisation of polymeric nanoparticles using low molecular
`weight poly(vinyl alcohol) (2008) Journal of Biomedical
`Nanotechnology, 4 (3), pp. 319-325.
`
`Buttini, F., Soltani, A., Colombo, P., Marriott, C., Jones, S.A.
`Multilayer PVA adsorption onto hydrophobic drug substrates to
`engineer drug-rich microparticles (2008) European Journal of
`Pharmaceutical Sciences, 33 (1), pp. 20-28.
`
`Buttini, F., Colombo, P., Wenger, M.P.E., Mesquida, P., Marriott, C.,
`Jones, S.A. Back to basics: The development of a simple,
`homogenous, two-component dry-powder inhaler formulation for the
`delivery of budesonide using miscible vinyl polymers
`(2008) Journal of Pharmaceutical Sciences, 97 (3), pp. 1257-1267.
`
`Khengar, R.H., Jones, S.A., Turner, R.B., Forbes, B., Brown, M.B.
`Nail swelling as a pre-formulation screen for the selection and
`optimisation of ungual penetration enhancers (2007) Pharmaceutical
`Research, 24 (12), pp. 2207-2212.
`
`Brown, M.B., Jones, S.A., He, W., Martin, G.P.
`Hyaluronan: Investigations into the mode of action of hyaluronan in
`
`Opiant Exhibit 2200
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00694
`Page 8
`
`

`

`topical drug delivery (2006) ACS Symposium Series, 934, pp. 141-
`153.
`
`Jones, S.A., Martin, G.P., Brown, M.B. Stabilisation of
`deoxyribonuclease in hydrofluoroalkanes using miscible vinyl
`polymers (2006) Journal of Controlled Release, 115 (1), pp. 1-8.
`
`Brown, M.B., Martin, G.P., Jones, S.A., Akomeah, F.K.
`Dermal and transdermal drug delivery systems: Current and future
`prospects (2006) Drug Delivery: Journal of Delivery and Targeting of
`Therapeutic Agents, 13 (3), pp. 175-187.
`
`Jones, S.A., Martin, G.P., Brown, M.B. Manipulation of
`beclomethasone-hydrofluoroalkane interactions using biocompatible
`macromolecules (2006) Journal of Pharmaceutical Sciences, 95 (5),
`pp. 1060-1074.
`
`Jones, S.A., Martin, G.P., Royall, P.G., Brown, M.B. Biocompatible
`polymer blends: Effects of physical processing on the molecular
`interaction of poly(vinyl alcohol) and poly(vinyl pyrrolidone)
`(2005) Journal of Applied Polymer Science, 98 (5), pp. 2290-2299.
`
`Liao, Y.-H., Brown, M.B., Jones, S.A., Nazir, T., Martin, G.P. The
`effects of polyvinyl alcohol on the in vitro stability and delivery of
`spray-dried protein particles from surfactant-free HFA 134a-based
`pressurised metered dose inhalers (2005) International Journal of
`Pharmaceutics, 304 (1-2), pp. 29-39.
`
`Liao, Y.-H., Jones, S.A., Forbes, B., Martin, G.P., Brown, M.B.
`Hyaluronan: Pharmaceutical characterization and drug delivery
`(2005) Drug Delivery: Journal of Delivery and Targeting of
`Therapeutic Agents, 12 (6), pp. 327-342.
`Jones, S.A., Martin, G.P., Brown, M.B. High-pressure aerosol
`suspensions - A novel laser diffraction particle sizing system for
`hydrofluoroalkane pressurised metered dose inhalers
`(2005) International Journal of Pharmaceutics, 302 (1-2), pp. 154-
`165.
`
`Brown, M.B., Jones, S.A. Hyaluronic acid: A unique topical vehicle for
`the localized delivery of drugs to the skin
`(2005) Journal of the European Academy of Dermatology and
`Venereology, 19 (3), pp. 308-318.
`
`Jones, S.A., Martin, G.P., Brown, M.B.
`Determination of polyvinylpyrrolidone using high-performance liquid
`chromatography (2004) Journal of Pharmaceutical and Biomedical
`Analysis, 35 (3), pp. 621-624.
`
`Jones, S.A., Brown, M., Martin, G.P. Determination of Polyvinyl
`Alcohol Using Gel Filtration Liquid Chromatography
`(2004) Chromatographia, 59 (1-2), pp. 43-46.
`
`Jones, S. Assessing the effectiveness of one-stop dispensing
`(2002) Hospital Pharmacist, 9 (8), pp. 237-239.
`
`Opiant Exhibit 2200
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00694
`Page 9
`
`

`

`PATENTS
`
`‘Metered dose inhalation preparations’ Y-H Liao, S. A. Jones M. B.
`Brown and G. P. Martin. (UK0226274.9). WO2004043442 (2004).
`‘Metered dose inhalation preparations of therapeutic drugs’ S. A.
`Jones, M. B. Brown and G. P. Martin.
`(UK0328630.9).
`WO2005055985 (2005).
`‘Metered dose inhalation preparations for peptides and proteins’
`S. A. Jones, M. B. Brown and G. P. Martin. (UK0328629.1).
`WO2005056037. (2006).
`‘Topical ungula formulations’ M. B. Brown, S. A. Jones, R.
`Khengar, R. Turner. WO2006131721 (2006).
`‘Topical formulations’. S. A. Jones, M. B. Brown, M. Reid.
`(UK0518769.5) WO2007031753. (2007).
`‘Topical formulations’. S. A. Jones, M. B. Brown, Y. Zhao. UK
`Patent Appl. No (0715646.6). (2007).
`Iontophoretic Delivery of
`‘Pharmaceutical Formulations for
`Gallium’. P.M. Friden, H. Kim, K. Staff, M. B. Brown and S.A. Jones.
`US patent application 4035.3007 US (2010).
` ‘Topical heat generating formulations’. S. A. Jones, M. B. Brown,
`D. Wood. UK No (1005639.8). (2010).
`
`RESEARCH
`STUDENTS
`
`6 Post-doctoral students supervised (1 current)
`30 PhD students (24 successfully completed 6 on-going; 23 passed
`within 4 years)
`42 Masters students (all passed)
`
`1. ‘Development of novel dry-powder inhaler formulations’ PhD
`Completed 2007. Second supervisor. Collaboration with the
`University of Parma
`2. ‘Investigation into the use of novel nanocarriers’ PhD Completed
`2005. Second supervisor. Collaboration with the University of Istanbul
`3. ‘Development of novel topical metered dose aerosol sprays’ PhD
`Completed 2009. First supervisor. Self-funded student from USA
`4. ‘Engineering novel hydrofluoroalkane nanofoams’ PhD Completed
`2009. First supervisor. Dorothy Hodgkin award
`5. ‘Novel topical ungula formulations’ PhD. Completed 2009. Second
`supervisor. MedPharm Funded
`6. ‘Harnessing nanotechnology for nasal drug delivery’ PhD
`Completed 2009. First supervisor. Self-funded student from Algeria
`7. ‘Novel eutectic compositions for topical drug delivery’ PhD
`Completed 2010. First supervisor. Self-funded student from Algeria
`8. ‘Delivery of inorganic agents into the skin’ PhD. Completed 2010.
`First supervisor. Funded by MedPharm Ltd
`9. ‘Novel cosmetic formulations derived from natural sources’ PhD.
`Completed 2010. Second supervisor. Collaboration with University of
`the Arts London
`10. ‘Development of a novel self-assembling thermoregulation device’
`PhD. Completed 2010. First supervisor. Funded by MedPharm Ltd
`11. ‘Novel supersaturated systems for transdermal drug delivery’ PhD
`Completed 2010. First supervisor. Self-funded student from Algeria
`12. ‘Zinc as an antimicrobial agent’ PhD Completed 2010. Second
`supervisor. Funded by GSK.
`13. ‘The development of a novel powder formulation for topical drug
`delivery’ PhD Completed 2010. Second supervisor. Funded by
`MedPharm Ltd at University of Hertfordshire
`14. ‘Poly-vinyl nanoparticles for the administration of antimicrobials to
`
`Opiant Exhibit 2200
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00694
`Page 10
`
`

`

`the lung’ PhD Completed 2012. First supervisor. Self-funded student
`from Algeria
`15. ‘The absorption of ion-pairs across the respiratory epithelia’ PhD
`Completed 2013. First supervisor. Funded by Medpharm Ltd KTN
`Case award
`16. ‘Mucus penetrating nanoparticles – a novel targeting strategy for
`the treatment of respiratory disease’ PhD Completed 2014. First
`supervisor. Funded by a BBSRC DTA
`17. ‘Ion-pair inclusion complexes’
`PhD Completed 2014. First
`supervisor. Collaboration with the University of Porto
`18. ‘The influence of barometric pressure changes upon membrane
`physiology and xenobiotic penetration’ PhD Completed 2015. First
`supervisor. Funded by BBSRC CASE award
`19. ‘Self-assembling nanocrystals for topical drug delivery’ PhD
`Completed 2016. First supervisor. Self-funded student from
`Singapore
`20. ‘Nanoparticle transport through mucus’ PhD Completed 2017.
`First supervisor. Self-funding student from China
`21. ‘Multifunctional self-assembling ion-pair complexes’ PhD
`Completed 2017. First supervisor. Funded by a ESPRC CASE award
`with Johnson & Johnson
`22. ‘In vitro biopharmaceutical evaluation of novel respiratory
`medicines for airway disease’ PhD Completed 2017. First supervisor.
`Funded by MRC CASE award with GSK
`23. ‘Cyclodextrin stabilized ion-pair complexes’ PhD Completed 2018.
`First supervisor. Funded by a grant from the Malaysian Government
`24. ‘Alpha-tocopherol nanomaterials for UV protection’ PhD
`Completed 2018. First supervisor. Funded by the Jordanian
`Government
`25. ‘Hypobaric pressure facilitated drug delivery into the skin’. PhD
`Completed 2019. First supervisor. Self-funded student from Iran
`26. ‘Cyclodextrin antimicrobial complexes’ PhD completed 2018.
`Second supervisor. Self-funded student from Greece
`27. ‘Pentamadine ion-pair complexes’ PhD Current. Second
`supervisor. Self-funded student from China
`28. ‘Targeting mTOR using phosphorylated vitamin D’ PhD Current
`First supervisor. Self-funded student from Japan
`29. ‘Hydrogen sulphide as a novel antifungal’ PhD Current. First
`supervisor. Self-funded student from Jordan
`30. ‘Hydrogen sulphide to reduce food spoilage’ PhD Current. First
`supervisor. BBSRC CASE award with Natures Way Foods
`
`1. Formulation V. Berlin Germany (2007) ‘Enhancing topical drug
`delivery using a novel self-assembling supersaturated patch’.
`2. Drug Delivery to the Lungs 18. Edinburgh UK (2007) ‘Novel poly
`(vinyl alcohol-vinyl acetate) nanoparticulate systems containing
`rifampicin’.
`3. University of Bath. UK (2008) ‘The use of non-polar solvents to
`enhance topical drug delivery’.
`4. University of Parma, Italy (2008) ‘Novel topical formulations’.
`5. University of Hertfordshire (2008) ‘Non-polar solvents – ideal
`vehicles for topical drug delivery?’.
`6. 11th International Inhalation Symposium: Benefits and Risks of
`Inhaled Engineered Nanoparticles in Hannover, Germany (2008)
`‘PVA nanoparticles as tools for delivery and diagositics’.
`
`INVITED TALKS
`
`Opiant Exhibit 2200
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00694
`Page 11
`
`

`

`7. Drug Delivery to the Lungs 19. Edinburgh UK (2008) ‘The transport
`of nanoparticle across respiratory cell lines’.
`8. Novos Medicamentos Manipulados E Novos Sistemas
`Therapeuticos. Universidade Fernando Pessoa, Portugal (2009)
`‘Novel nasal drug delivery systems’.
`9. Inhalation Drug Development ‘Excipient selection for inhaled
`formulations’. London 22nd September (2009).
`10. 12th Biennial Perspectives in Percutaneous Penetration (PPP)
`conference. ‘Dynamic Foams for topical drug delivery’ La Grande
`Motte, France, 7–10 April (2010).
`11. UKPharmSci 2010 Plenary Lecture ‘Dynamic Aerosols: Chemical
`Solutions For Drug Delivery’ Nottingham (2010)
`12. Measurement Challenges in Analysis of Topical products. ‘Topical
`pharmaceutical salts’. A JPAG symposium. Royal Pharmaceutical
`Society, London (2011).
`13. PharmSciFair III. Pharmaceutical Sciences for the Future of
`Medicines. ‘Inhaled biopharmaceutics’ Prague, Czech Republic,
`(2011).
`14. 13th Biennial Perspectives in Percutaneous Penetration (PPP)
`conference. ‘Past, Present and future applications of topical ungual
`formulations’ La Grande Motte, France, April (2012).
`15. Biotechnology Forum, University of Oran, Algeria.
`‘Biopharmaceutical products’. (2014) in French.
`16. Formulation Perspective Conference, Munich, Germany (2015).
`‘Drug Delivery Technologies that utilise nanomaterials to enhance the
`bioavailability of topical products’
`17. Skin@Bath. Bath. UK. (2017). ‘Using nanomaterials to modify
`drug deposition profiles in the skin’
`18. 13th Meeting in Pharmaceutics, Biopharmaceutics and
`Pharmaceutical Technology. Granada, Spain. (2018) ‘Topical
`hypobaric pressure: a novel means to enhance the delivery of
`nanosized drug aggregates into the skin.’
`19. 16th Biennial Perspectives in Percutaneous Penetration (PPP)
`conference. (2018). ‘Enhancing delivery into the skin via the follicular
`route using topical hypobaric pressure’. La Grande Motte, France.
`20. University of Oxford. (2019). ‘Adverse drug reactions of topical
`and systemic medicinal products on the human skin’
`21. Skin@Bath. Bath. UK. (2019). Conference session chair – Using
`the skin for biomarker extraction
`22. University of Jordan. (2019). ‘The skin, a highly versatile organ for
`the diagnosis and treatment of human disease’
`23. 17th Biennial Perspectives in Percutaneous Penetration (PPP)
`conference. (2020). ‘Extracting macromolecules out of the skin using
`hypobaric pressure’. La Grande Motte, France.
`
`Masters in Pharmacy
`Physical Pharmaceutics (Year 1) - Laboratory class leader; Lectures:
`Colloids & Gels; Colligative properties; Electrolytes.
`Formulation Analysis (Year 2) – Lectures: Dissolution
`Medicines Discovery and Development (Year 3) – Lectures:
`Experimental Design
`Gastrointestinal and Skin (Year 3) Lectures: Drug Delivery to the skin
`
`Masters in Pharmaceutical Science
`Lectures: Dissolution, Topical Drug delivery, Crystallisation, Particle
`
`TEACHING
`
`Opiant Exhibit 2200
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00694
`Page 12
`
`

`

`ADMIN
`
`PEER REVIEW
`
`engineering
`
`Masters in Drug Development Science / Clinical Pharmacology
`Lectures: Clinical Pharmaceutics; Drug Formulation; Inhaled and
`Nasal Drug Delivery; Solution Formulations
`Current teaching load = 117 contact hours per year
`
`Director of the MSc in Pharmaceutical Technology 2005-2009
`Director of Pharmaceutical Science Postgraduate Studies (3 MSc
`programs in the Department of Pharmacy) 2007-2009
`Chair of t

This document is available on Docket Alarm but you must sign up to view it.


Or .

Accessing this document will incur an additional charge of $.

After purchase, you can access this document again without charge.

Accept $ Charge
throbber

Still Working On It

This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.

Give it another minute or two to complete, and then try the refresh button.

throbber

A few More Minutes ... Still Working

It can take up to 5 minutes for us to download a document if the court servers are running slowly.

Thank you for your continued patience.

This document could not be displayed.

We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.

Your account does not support viewing this document.

You need a Paid Account to view this document. Click here to change your account type.

Your account does not support viewing this document.

Set your membership status to view this document.

With a Docket Alarm membership, you'll get a whole lot more, including:

  • Up-to-date information for this case.
  • Email alerts whenever there is an update.
  • Full text search for other cases.
  • Get email alerts whenever a new case matches your search.

Become a Member

One Moment Please

The filing “” is large (MB) and is being downloaded.

Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.

Your document is on its way!

If you do not receive the document in five minutes, contact support at support@docketalarm.com.

Sealed Document

We are unable to display this document, it may be under a court ordered seal.

If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.


Access Government Site

We are redirecting you
to a mobile optimized page.





Document Unreadable or Corrupt

Refresh this Document
Go to the Docket

We are unable to display this document.

Refresh this Document
Go to the Docket