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`Page 1 of 3
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`Exam (Samples)|Problem Sets|
`PHA 5127
`Basic Principles of Dose Optimization
`
`On-Line Pharmacokinetic Simulations
`Computer Programming
`by Ned Phillips
`
`One Compartment Model
`
`• IV bolus
`
`Single Dose
`
`Physiological Model
`
`Metabolism
`
`• Oral Single Dose Absorption
`
`• Multiple IV Bolus Injection
`
`• Multiple Dosing with Absorption
`
`• Single Dose Zero Order Infusion
`
`• Multiple Dose Zero Order Infusion
`
`Two Compartment Model
`
`• IV bolus
`
`PK/PD
`
`• IV bolus
`
`Single Dose
`
`Excel Pharmacokinetic Simulations
`Developed by Hartmut Derendorf and Guenther Hochhaus
`
`http://copnt13.cop.ufl.edu/pat/pha5127/simulatn.htm
`
`4/10/2020
`
`Opiant Exhibit 2218
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00685, IPR2019-00688, IPR2019-00694
`Page 1
`
`
`
`PHA 5127 Simulations
`
`Page 2 of 3
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`Excel Files To Download
`
`NOTE: If you have the excel program:
`The following excel files can be downloaded to your own computer by clicking on the name and
`following the choice to save to disk.
`Then you can use your own excel program to run these files.
`
`I. 1 compartment body model
`• IV bolus
`
`◦ IV bolus single dose
`
`◦ IV bolus physiological model (hepatic)
`
`◦ IV bolus metabolism
`
`◦ IV bolus physiological model (GFR)
`
`◦ IV bolus physiological model (urine flow)
`
`◦ IV renal acid
`
`◦ IV renal base
`
`• Oral single dose with absorption
`
`• Infusion single dose
`
`• Multiple IV bolus injection
`
`• Multiple dosing with absorption
`
`• Multiple dose zero order infusion
`II. 2 compartment body model
`IV bolus
`
`http://copnt13.cop.ufl.edu/pat/pha5127/simulatn.htm
`
`4/10/2020
`
`Opiant Exhibit 2218
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00685, IPR2019-00688, IPR2019-00694
`Page 2
`
`
`
`PHA 5127 Simulations
`
`Page 3 of 3
`
`PK/PD
`• IV bolus
`
`Please contact me if you notice any errors. Thank you. Guenther Hochhaus
`
`Here is an additional site for further information (Creighton University)
`
` Return to Table of Contents
`
`Last modified July 1, 2011
`
`http://copnt13.cop.ufl.edu/pat/pha5127/simulatn.htm
`
`4/10/2020
`
`Opiant Exhibit 2218
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00685, IPR2019-00688, IPR2019-00694
`Page 3
`
`
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