`INDIVIOR’S INTR!N!S!L
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` NALOXONE
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` Steve Hebert
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` Global Therapy Leader
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`Opiant Exhibit 2173
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00688
`Page 1
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`Opiant Exhibit 2173
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00688
`Page 2
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` Our Passion Drives Our Success
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` Stock listing:
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`LON: INDV.L
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` Headquarters: Richmond, Virginia, United States
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` Employees: 700+
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` Regions:
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` ͩΡΰξ; !Ι͂ΰ̴̦ͺ EϙΰΡέ͂ ͨ̾̾Γ͂ E̦δξ & !͌ΰ̴̦ ;EͨE!͟Ϳͺ
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` Australasia; and Greater China
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` Portfolio:
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` SUBOXONE® (buprenorphine/naloxone) Sublingual Film (CIII)
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` SUBOXONE® (buprenorphine/naloxone) Sublingual Tablets (CIII)
` SUBUTEX® (buprenorphine HCl) Sublingual Tablets (CIII)
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` Suboxone
` Patients >5 Million
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` Treated:
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` SUBOXONE® Film
` Orange-colored, rectangular film
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` with white printed logo
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` SUBOXONE® Tablets
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` Orange-colored, hexagonal tablet
` available in a 30-count bottle
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` SUBUTEX® Tablets
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` White tablets
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`Opiant Exhibit 2173
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00688
`Page 3
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` A Growing Epidemic
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`260 M opioid prescriptions for 50 M Americans
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`25 K overdose deaths in US in 2013
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`69 K fatal overdoses worldwide
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` Naloxone is effective in reversing opioid overdose, but…
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` Not readily available
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` outside of hospitals and EMS settings
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` Source: National Institute of Health, Centers for Disease Control and Prevention and World Health Organization
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`Opiant Exhibit 2173
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00688
`Page 4
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` What if there was an alternative available that could be accessed by non-
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` healthcare professionals, anywhere at anytime?
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` Key Product Attributes
` • Device / Drug Combo
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` • Needle free
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` • Ready to use
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` Accessible to
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` everyone
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` • Compact / Portable
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`NDA Submitted May 2015
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`Opiant Exhibit 2173
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00688
`Page 5
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` INDIVIOR MISSION: All patients around the world will have access to high quality
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` treatment services for the chronic relapsing conditions of addiction
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` INDIVIOR
` Goal:
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`Work with communities to
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` cut annual opioid overdose
` deaths by 50%
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`PRODUCT
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` Vision:
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`Everyone understands the
`risks of overdose and
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` embraces their community
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` responsibility and personal
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` role in potentially saving a life
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` from opioid overdose
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`Opiant Exhibit 2173
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00688
`Page 6
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` The path to eliminating opioid overdose deaths
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` ER/Harm Reduction
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` Co-Rx
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` Community/OTC
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` OD
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` Risk Management
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` Prevention
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` Poor
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` Awareness
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` Stigma
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` Knowledge gaps
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` NALOXONE ACCESS LEGISLATION
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` Lack of leadership/
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` champion
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`Opiant Exhibit 2173
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00688
`Page 7
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` Where are the overdoses in the US?
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`Opiant Exhibit 2173
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00688
`Page 8
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` County Segmentation
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`US has ~3 K counties but 251 Counties account for 2/3 of all overdoses1
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` Suburban / Middle Class
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` Rural / Poor
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` • Examples: Bell County, KY, Rio Arriba, NM and
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` Cabell, WV
` • Overdose largely driven by prescription Rx
` • High Medicaid population
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` • Examples: Worcester, MA, Montgomery, PA and
` New Haven, CT
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` • Overdose largely driven by opioids but heroin on
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` the rise
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` • Examples: Seattle, Albuquerque and Las Vegas
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` • Mix of Heroin and Opioid Rx
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`• Often younger victims
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` Urban / Middle Class
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` 1: CDC Opioid Overdose Data by County
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` • Examples: Baltimore, Cleveland and Detroit
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`• Heroin responsible for a large proportion of
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` overdoses
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` • Overdose in public bathrooms, abandoned
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` houses, etc.
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` Urban / Poor
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`Opiant Exhibit 2173
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00688
`Page 9
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` Indivior will work with communities to reduce opioid overdose
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` death rates by
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`Working with the top 250 counties for opioid overdose (rate + absolute number)
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` Train and mobilize ~500 community champions
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`Community champions train at least 500 local advocates
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`250K trained advocates across 250 communities
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` 1: Training 100 – 250 people per 100 K population in high overdose communities in Massachusetts resulted in a significant reduction in opioid
` overdose deaths. Walley et al. BMJ 2013; 346: f174
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`Opiant Exhibit 2173
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00688
`Page 10
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` Together, we CAN reduce opioid overdose death
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` rates by 50%
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`Opiant Exhibit 2173
`Nalox-1 Pharmaceuticals, LLC v. Opiant Pharmaceuticals, Inc.
`IPR2019-00688
`Page 11
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