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`Proven symptom reduction for your HAE attacks
`In clinical trials, patients treated with KALBITOR showed significant
`improvement in hereditary angloedema (HAE) attack symptoms at 4 hours.
`
`LEARN MORE ABOUT KALBITOR › (/how-ka bitor-works)
`
`https://www kalbitor.com/
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`CSL EXHIBIT 1075
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`
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`KALBITOR® (ecallantide) | Official KALBITOR® Site
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`Please see Full Prescribing Information
`(http://www.shirecontent.com/PI/PDFs/Kalbitor USA ENG.pdf), including
`Boxed Warning and Medication Guide (http://www.shirecontent.com/?
`product=Kalbitor&country=USA&language=ENG&contenttype=medguide).
`
`
`
`
`
`Patient Ambassador Events
`Attend a live event and hear from someone with HAE. You can learn about his or her path to diagnosis and
`how they manage life with HAE.
`
`FIND AN EVENT NEAR YOU ›
`
`(/events)
`
`OnePath Product Support Services
`OnePath is here to support you throughout your treatment journey with KALBITOR.
`
`®
`
`LEARN MORE ›
`
`(/onepath)
`
`Sign Up & Stay in Touch
`
`https://www.kalbitor.com/
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`KALBITOR® (ecallantide) | Official KALBITOR® Site
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`Register to receive more information from Shire about HAE.
`
`SIGN UP TODAY ›
`
`(/join)
`
`Important Safety Information
`What is the most important information I should know about KALBITOR?
`Serious allergic reactions may happen in some people who receive KALBITOR. These allergic reactions can
`be life-threatening and usually happen within 1 hour after receiving KALBITOR.
`
`• KALBITOR should be given to you by a doctor or nurse in a healthcare setting where
`serious allergic reactions and hereditary angioedema (HAE) can be treated.
`
`• Symptoms of a serious allergic reaction to KALBITOR can be similar to the symptoms
`of HAE, the condition that you are being treated for. Your doctor or nurse should
`watch you for any signs of a serious allergic reaction after treatment with KALBITOR.
`
`• Tell your doctor or nurse right away if you have any of these symptoms of a serious
`allergic reaction during or after treatment with KALBITOR:
`◦ wheezing, shortness of breath, cough, chest tightness, or trouble breathing
`◦ dizziness, fainting, fast or weak heartbeat, or feeling nervous
`◦ reddening of the face, itching, hives, or feeling warm
`◦ swelling of the throat or tongue, throat tightness, hoarse voice, or trouble
`swallowing
`◦ runny nose, nasal congestion, or sneezing
`Who should not receive KALBITOR?
`Do not receive KALBITOR if you are allergic to KALBITOR. Before receiving KALBITOR, tell your doctor if
`you have ever had an allergic reaction to KALBITOR.
`
`What else should I tell my doctor before I receive KALBITOR?
`Tell your doctor if you are pregnant, plan to become pregnant, breast-feeding, or plan to breast-feed. It is
`not known if KALBITOR will harm your unborn baby or pass into your breast milk.
`
`What are the possible side effects?
`Common side effects of KALBITOR include headache, nausea, diarrhea, fever, injection site reactions, such
`as redness, rash, swelling, itching, or bruising, and stuffy nose. You are encouraged to report negative side
`effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch (http://www.fda.gov/medwatch),
`or call 1-800-FDA-1088.
`
`Talk to your doctor for more information about your medical condition or treatment.
`
`https://www.kalbitor.com/
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`
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`KALBITOR® (ecallantide) | Official KALBITOR® Site
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`Page 4 of 4
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`Please see the Full Prescribing Information
`(http://www.shirecontent.com/PI/PDFs/Kalbitor_USA_ENG.pdf), including Boxed Warning and
`Medication Guide (http://www.shirecontent.com/?
`product=Kalbitor&country=USA&language=ENG&contenttype=medguide).
`
`(https://www.shire.com)
`
`Hereditary Angioedema
`
`TM or ® items and the associated logos are trademarks or registered trademarks of Shire or its affiliates.
`
`© 2017 Shire US Inc., Lexington, MA 02421 1-800-828-2088
`All rights reserved. SHIRE and the Shire Logo are trademarks or registered trademarks of Shire
`Pharmaceutical Holdings Ireland Limited or its affiliates.
`S28528 06/17
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`https://www.kalbitor.com/
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