throbber
Backs: Nu: 2311166854 3 823:
`
`(PATENT)
`
`3N THE 31133311333333 S’E‘AT IS PATENT AND TRADEMARK 03333113313
`
`3::r3aw13wtimot {BALL\GE333R,Cy::11ua,(ml Examina: MLKNLS,Z&CEC:Ԥ~' .1,
`
`Apgfic 3332):: E30,: 14£853,168
`
`(11:31.:pAfiL3rJit: 87633
`
`3113:: Scptcmbc: 15 2013
`
`{20111311113316.0231 No: 3675
`
`33:77::
`
`{IL—1.1:"3-33 (311.)MLP13183'1'333NS AND 313317330338 FOR THE PREV .15IN'3.'3()N AM.)
`
`ERASE INHLBITOR
`
`REA] MEN10FD}901C191RS ASSOC‘:ALE3) 113’11733 CL 1
`L3331:ICIENCY
`
`V3.3: 1:17.335 WEB FILING w W’33:31:32 USPTQGOV
`
`Commissioner 30: Patents
`33.0. Bax. 1235:)
`
`Alexandria, VA 223 '13~ 1 4
`
`r‘
`:1
`
`(J2
`
`DEX" L3:11AM:3N {BF UR 13:3 'CHAEI M ERANK3NDER 37C 3*R
`
`Dee-12‘ Comnfissicncr:
`
`1, Michaei, M. F:‘€n:k,1:€rerby
`
`decia’re as fblLows:
`
`.3 am a 50:32.133301‘33: the papa-1‘ 333313, 23: 211., “8:31:301331360 us infusim: 031323132331: C1
`
`inhibimt1:: swinC ’C'{m 36:21.] m'msmwmj 136: 32 323238, pubLishcd 313.116. 2010 (“333113;”)
`
`(312363135313 3:3”refer::ed 30 as 112mg“
`
`11
`
`The: studies described in this paper were degigufid and. conducted in my labmamry
`
`3C: Campfire 1313.531::.2J“V:1:2; $553.55 3116: 13:13:33.0 main: 133/233. and 31mm:-: :23'n:::1:::3:—m:m::e, and :0
`
`452C» 1310 5:13:21}; :.:,3"3:::1:1a:: {.71 1531313331017 a.€3:).1.13133i€t€<3
`
`5::buflaremsi: VEISUSM311113:030.le 33am:
`
`3.
`
`C'INRY71‘3V3:331:1:11:23. 311C): punt:‘dTJEY‘:21:30:: 033::1man piasnmxderiwd
`
`C1 31111313310: was used as. the 301mm 01"{31 11113313310: med in 31:55:: Studies.
`
`Page 1 0f 2
`
`CSL EXHIBIT 1016
`
`Page 1 of 2
`
`CSL EXHIBIT 1016
`
`

`

`: Galiagher, 811' 1111'.
`111 1'8
`15111111. N0:
`1"1."855 1138
`131100“
`: 13‘8“le! 15., 21115
`Page.
`: 2111‘".1.
`
`13111131110318 1300110111111: 201166854 1311
`
`4.
`
`.‘4
`‘
`‘ .J‘
`.
`>—
`1.:
`‘
`;
`.
`_
`‘
`.7119
`T
`L!
`LENKYLE was 0 0001011 00001111111; 1.0 1118 111511118 1.10115 p1'1.W11.10-;
`
`-.
`111 1.118
`
`prescri11i1‘1g 111111.1'1'111111011.
`
`141081'11'8131'1g1y. 081011 5110 U V1511 was E‘GCOH513111th 1.16111515 11.11.. 01 $101i1s
`
`1.8010110 61131118VC 8 11113.11 C1-11\-'1100118811118111"? 011U0 11111111.. T110 321me 100 1121311.. 01811012111011
`
`as {11110111011010} 1'11 03011111'131'1111L 1111111 some 18001Wi11g’1118 111.11g 311138111800111551‘}? 1.11111 5011)
`
`11111317611013.9131.
`
`.5
`
`171.18 pigs were (103011111. 51.11.11’kg. 191811.10 1111351011ng 111 \SC‘ULE1mm 16*23 kg, 1111‘:
`
`101111 (1010 111111111111»18100 13110011 171-:11118.11“; 11101150 U 01' 10115111.
`
`131001.11'11111g1m 1.118 101111110 of
`
`1011 Ufml. preparation 0111118118181811111100 1mm 8 1.01 11.111.51.111
`
`('1'.
`
`The 10111115011011 5:; 81101111151101.1011 1.111110 11.111 11.1111111310 3111811011 was 1101101111081 0181'
`
`:1 31')011111.118 111j601111‘1-11111161‘1‘1 {N‘dfil‘ 10 5111111111310 1111121‘1451‘1113 {1111111111311'011011 10 1111018113.
`
`'1’.
`
`T110 311110111211'18
`
`El
`15 38111311111311‘1‘11‘1111101'.11101.111111'1111. 13881351121111.111111103118.1‘1'1'1111'1'1‘101'1113'
`
`31.111011111000113 infusc3011- (101-11'01'01'1 by 00111111110113 pump 01/0111311-1'1'11.11.110 {1013:111:1. This was
`
`1100011311131 8100101118 large 1101111110 017131'81101'1111011 11111031113182100 :0 1110 pigs.
`
`8.1115151100101115 11100101181810 {1151113401811110W1€dd576 L118 1110 and 21.11 81:816.“!101’113 11100.0 01'}
`
`10101111311011 and 1301105118 1.38.183180 t0 110 1.1118; 21.111;1'11111101: 1.110.510 5111181110015 ware 11121118 1111311111110.
`
`,2,
`.4.)
`1111011310 g0 11113.: 1311111111 1721138 51111011181113 1.11111 111-:- 111'05.0 made are 01111131181310 by fine 01'
`
`1.1110113011010111. 01: 10111., 11118101 80811011 10111 01' T1110. 18011110 1.101.100 8111103 C1300 and 11101511011
`
`"11111111111 11113631611181.1113 may 18113111(1130 1011 validity 015118 301050.111 0.111311001101101 any patent
`
`..1..
`
`“1“,“
`
`("A
`
`"
`
`
`
`1V11C1-1E113'1 1511'1 {511111, M. D
`
`issue-:110'011'111'188 1118-18011.
`
`0.1111
`
`91‘"!
`‘5'
`1"
`1"
`,2. .1 13 1 86' 121:;
`
`Page 2 of 2
`
`Page 2 of 2
`
`

This document is available on Docket Alarm but you must sign up to view it.


Or .

Accessing this document will incur an additional charge of $.

After purchase, you can access this document again without charge.

Accept $ Charge
throbber

Still Working On It

This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.

Give it another minute or two to complete, and then try the refresh button.

throbber

A few More Minutes ... Still Working

It can take up to 5 minutes for us to download a document if the court servers are running slowly.

Thank you for your continued patience.

This document could not be displayed.

We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.

Your account does not support viewing this document.

You need a Paid Account to view this document. Click here to change your account type.

Your account does not support viewing this document.

Set your membership status to view this document.

With a Docket Alarm membership, you'll get a whole lot more, including:

  • Up-to-date information for this case.
  • Email alerts whenever there is an update.
  • Full text search for other cases.
  • Get email alerts whenever a new case matches your search.

Become a Member

One Moment Please

The filing “” is large (MB) and is being downloaded.

Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.

Your document is on its way!

If you do not receive the document in five minutes, contact support at support@docketalarm.com.

Sealed Document

We are unable to display this document, it may be under a court ordered seal.

If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.


Access Government Site

We are redirecting you
to a mobile optimized page.





Document Unreadable or Corrupt

Refresh this Document
Go to the Docket

We are unable to display this document.

Refresh this Document
Go to the Docket