AFFIDAVIT
`
`I, Ronald Figueroa, under oath, hereby depose and state as follows:
`
`1.
`
`I am the Resource Sharing Manager at the Libraries at Syracuse University
`
`("SU Library"). The SU Library consists of three main libraries on campus:
`
`the Bird Library, the Carnegie Library and the King & King Architecture
`
`Library.
`
`2.
`
`All books and periodicals at SU Library are routinely cataloged and viewable
`
`by the public through a user-interface searchable catalog. The SU Library's
`
`collection is also available through member-cooperative databases, including
`
`the Online Computer Library Catalog ("OCLC"), which uses a web-based
`
`interface to allow catalog searching of member libraries, including the SU
`
`Library.
`
`3.
`
`On Thursday, May 16, 2019, we received a request to retrieve the 1988 version
`
`of the Sigma Catalog, including pages 316-321, table of contents and copyright
`
`information, which is cataloged under the title "Biochemical and organic
`
`compounds for research and diagnostic clinical reagents." The requested 1988
`
`Sigma Catalog was held at an offsite location, and was retrieved by our staff on
`
`the following day, Friday, May 17, 2019. A copy of what our library provided
`
`is seen in Exhibit A, which is attached.
`
`Neurelis - EX. 2026
`Aquestive Therapeutics, Inv. v. Neurelis, Inc. - IPR2019-00451
`
`

`

`4.
`
`I hereby declare that all statements made herein of my own knowledge are true
`
`and correct. I further declare that all of my statements are made with the
`
`knowledge that willful false statements and the like so made are punishable by
`
`fine or imprisonment, or both, under Section 1001 of Title 18 of the United
`
`States Code.
`
`Dated: /r/i/-2 /r//r7
`
`B
`
`m
`
`roa
`onald Fi
`Resource Sharing Manager
`The Libraries at Syracuse University
`
`-2-
`
`Neurelis - EX. 2026
`Aquestive Therapeutics, Inv. v. Neurelis, Inc. - IPR2019-00451
`
`

`

`STATE OF NEW YORK
`
`)
`
`COUNTY OF ONONDAGA )
`
`SS:
`
`On this 21st day of November, 2019, before me personally came Ronald Figueroa to me
`
`known and known to me to be the person described in and who executed the foregoing instrument
`
`and he acknowledged to me that he executed the same.
`
`Notary Public
`
`ALISON J. WATERS
`Notary Public - State of New York
`No. 01%0,6247:333
`Qualified in Onondaga County 2,
`My Commission Expires t)8/29/..
`'
`
`-3-
`
`Neurelis - EX. 2026
`Aquestive Therapeutics, Inv. v. Neurelis, Inc. - IPR2019-00451
`
`

`

`
`
`
`
`
`
`
`
`
`
`
`
`
`
`EXHIBIT
`A
`
`Neurelis - EX. 2026
`Aquestive Therapeutics, Inv. v. Neurelis, Inc. - IPR2019-00451
`
`

`

`•HM
`BIOCHEMICAL AND
`OUNDS
`
`1988 •
`PRICE UST
`
`fc.
`
`,
`
`\0
`
`| ;
`^ a n d D I A G N O S T I C
`' CLINICAL REAGENTS li.
`TO PLACE AN ORDER TOLL FREE 1 {j|
`$ AM. M t P¥ Utm+y SmnUy mi Htk*f &
`
`^
`
`Chargst
`(torn Anywhan in lha WwU
`/ AM m 7 PM Monday It** frtif
`
`S 8
`
`h\
`II
`
`TELEPHONE
`USA/Canada
`Outside the USA/Canada
`call COLLECT
`tkaaU fn IMM mi pnttm fMa«
`0»» m HnM
`CMUCT
`FAX
`USA
`Outside USA .
`TWX or TELEX
`
`1 8003253010
`
`3M 7715750
`
`Mratn m my * t%»
`md Mil«i||] }M 111 MM
`
`18003255052
`...3W 7715757
`
`Cable Address
`
`L
`
`—
`
`1
`
`910761 0593 or 434475
`AimMctMch SIC OK COUECT "
`SIGMACHEM
`CUSTOMER/TECHNICAL SERVICE
`T«4«phon« numbers on convenient tear out card inside front cover
`Numbers also listed on page 11.
`
`iii
`D
`SIGMA I
`
`J
`
`CHEMICAL COMPANY
`P O BOX t4SM. ST. LOUIS. MOUtrtUSA
`
`• •
`
`Neurelis - EX. 2026-A
`IPR2019-00451
`
`

`

`i r _ps Ernmfi
`
`'J. ^ •'
`
`3-4
`. .. . 5
`6
`7
`8-9
`
`Ordering Controlled Substances
`Transportation Charges
`Return Policies
`How to use this Price List
`Label Information
`Ordering Information/
`11
`Customer Service
`CHEHICAL CATEGORY LISTS ....
`17
`HPIABETIC LIST OF COMPOUNDS . . 82-1508
`'RODUCT GROUPS;
`ACS REAGENTS .
`101
`ADENOSINE TRIPHOSPHATE ASSAY KIT . 124
`AFFINITY CHROWATOGRAPHY MEDIA .... 130
`AGAROSE
`177
`AMINO ACID ANALYSIS REAGENTS
`199
`BIOACTIVE PEPTIDES
`272
`BIOLOGICAL BUFFERS
`313
`BIOLOGICAL DETERGENTS
`316
`BIOLOGICAL STAINS
`322
`BLOOD COAGULATION FACTORS
`AND REAGENTS
`CARBON-13 LABELED COMPOUNDS
`AND OTHER STABLE ISOTOPES
`CHROMOSORBS
`COENim A AND DERIVATIVES
`COLLAGEN
`COLLAGENASE
`COMPLEMENT PRODUCTS
`CONTROLLED SUBSTANCES
`CYTOCHROME C
`DEUTERATED COMPOUNDS
`FERMENTATION NUTRIENTS
`GLUCOSE-6-PHOSPHATE
`DEHYDROGENASE
`GLUTATHIONE DERIVATIVES AND
`ENZYMES
`GOLD COLLOID CONJUGATES
`.HIGH PRESSURE LIQUID CHROMATO-
`; GRAPHY SORBENTS
`IMMUNOCHEMICALS
`ION EXCHANGERS, GEL FILTRATION AND
`CHROMATOGRAPHIC MEDIA
`ISOELECTRIC FOCUSING REAGENTS .
`LASER DYES
`LECTINS
`LIPIDS
`LIPOPOLYSACCHARIDES
`LIPOPROTEINS AND RELATED
`PRODUCTS
`MOVECULAR BIOLOGY PRODUCTS
`MOLECULAR WEIGHT MARKERS
`FORVROTEINS
`NICOTINRMIDE COENZYMES ....
`OLIGONUCLEOTIDE SYNTHESIS
`REAGENTS
`ORGANOMETALUC REAGENTS
`FOR SYNTHESIS
`PER10DATE OXIDIZED NUCLEOSIDES
`AND NUCLEOTIDES
`PHEROMONES
`DUnCOUftT* C C A l l / r t M M C
`C » 3 7 8 8 1 5 9 0
`f M&dc
`7C
`S * WrS-TTS
`t
`T f c p i p q n
`
`327
`
`369
`421
`431
`436
`437
`439
`443
`467
`487
`. 582
`
`626
`
`638
`656
`
`670
`715
`
`816
`828
`849
`856
`895
`914
`
`. . . . 9 2 0
`977
`
`1016
`1049
`
`1081
`
`1097
`
`1116
`1133
`1139
`
`FC :
`7C-
`cc » cyr
`
`1148
`1179
`POLYAM1NO ACIDS
`1214
`PROTEIN A
`1219
`PROTEIN SEQUENCING REAGENTS
`RADIOCHEMICALS
`1233
`SPIN LABELS AND SPIN TRAPS
`1291
`TISSUE CULTURE MEDIA AND REAGENTS 1334
`TRICHLOROACETIC ACID ESTERS
`1454
`TRI2MA
`1471
`VENOMS
`1495
`
`EQUIPMENT
`BOOKS
`COMPUTER SOFTWARE
`
`1509-1616
`1513
`1565
`
`STANDARDS AND CONTROLS
`INDIVIDUAL REAGENTS AND SETS .. 1617-1650
`
`THIN LAYER CHROMATOGRAPHY
`REAGENTS
`SIGMA SPRAY REAGENTS FOR
`PAPER AND TLC
`ADSORBENTS FOR TLC
`
`T
`A
`1651-1658
`B
`1652-1654 I
`E
`1657-1658
`RESEARCH KITS AND REAGENTS
`o
`Adenosine S'-Triphosphate (ATP)
`Bioluminescent Assay Kit....
`1660 g-
`1860 r
`Bioluminescence Demonstration
`1662
`Cytochemistry Panel
`1663 c
`Dietary Fiber, Total
`Dietary Fiber, Total, Assay Control Kit... 1664
`1665 Q
`Esterases (Histochemical)
`1668 N
`E-TOXATE®
`1669
`Factor XIII Deficient Plasma
`Gal-l-P Uridyl Transferase (Ultraviolet) .. 1670 T
`1671 E
`Lymphocyte Enzymes
`B-Lymphocyte Test
`1675 N
`1674 M
`Monoclonal Antibodies
`1676 T
`NBT Reduction
`1677 i.
`Phosphatase, Acid (HistochemicaO
`1679 O
`Phosphatase, Alkaline
`Protein, Total (Micro Method) ...
`1680
`Pyrophosphate Assay
`1682
`Spectrophotometer Calibration at
`340 nm
`TdT Immunoperoxidase
`
`1659
`
`1682
`1683
`
`1685
`
`DIAGNOSTIC KITS AND REAGENTS
`For; Chemistry
`Coagulation
`Electrophoresis
`Hematology
`Screening Test for Enzyme Deficiencies
`Indirect Immunofluorescence Tests
`(Kits are listed in alphabetic order)
`
`REAGENTS FOR AUTOANALYZER
`
`ALPHABETIC AND NUMERICAL LIST
`OF MANUAL ANALYTICAL AND
`DIAGNOSTIC PROCEDURES
`
`NEW ITEMS
`
`1825
`
`1835
`
`1843
`1
`
`Neurelis - EX. 2026-A
`IPR2019-00451
`
`

`

`.A *
`A FEW WORDS ABOUT OUR PRODUCTS
`
`• USE OF OUR PRODUCTS
`SIGMA RESEARCH REAGENTS ARE FURNISHED FOR LABORATORY USE ONLY.
`This means our products:
`... may be used in laboratory research and experiments,
`... may NOT be used as DRUGS,
`... may NOT be used as COSMETICS,
`... may NOT be used as AGRICULTURAL or PESTICIDAL PRODUCTS,
`... may NOT be used as FOOD ADDITIVES, and
`... may NOT be used as HOUSEHOLD CHEMICALS.
`SIGMA DIAGNOSTIC REAGENTS ARE FURNISHED FOR IN VITRO DIAGNOSTIC USE.
`We are required to use "Due Diligence" when processing orders to ensure that our
`reagents are not purchased for drug or other use. In order to avoid delays, we recom­
`mend that orders carry the statement: "FOR LABORATORY USE ONLY. NOT FOR DRUG
`HOUSEHOLD OR OTHER USES."
`
`We are unable to ship our reagents to individuals not affiliated with institutions or
`firms. Please place your order through the institution or firm with which you are affiliated.
`Food & Drug Use: Inquiries for our products for food and/or drug use are invited and
`will be considered on an individual basis under Food and Drug Administration regula­
`tions. For additional Information, ask for the Sigma F & D Division.
`Commercial Use: We will consider requests for commercial use of our products. For
`additional information, ask for the Commercial Division.
`All Orders From High Schools must be: Submitted in writing and on an official school
`purchase order, with a minimum of two authorizing signatures.
`
`• TOXICITY AND HAZARDS
`Some reagents are marked with hazardous warnings; others are not. The absence of
`a warning must not be interpreted as an indication of safety. We must emphasize that
`information is not available on the possible hazards of many compounds.
`Through our experience and/or extensive literature references, we have classified
`certain items as "EXTREMELY HAZARDOUS!" If you are unfamiliar with the hazards of
`these items, please request Safety Data Sheets from our Customer Service Department
`before ordering.
`CAUTION: Failure to classify a product as "EXTREMELY HAZARDOUS!" does not
`imply lack of toxicity and hazards. Each product offered by Sigma is intended for use
`by qualified professionals who will safely handle and dispose of the products they receive.
`
`• WARRANTIES
`Sigma warrants that its products perform as described in Sigma literature. Should
`any fail for reason other than through misuse, at Sigma's option, Sigma will replace it
`free of charge or refund the purchase price.
`This warranty is exclusive and Sigma makes no other warranty, expressed or implied,
`including any implied warranty of merchantability or fitness for any particular purpose.
`Sigma shall not be liable for any incidental, consequential or contingent damages.
`For more information about the terms and conditions of sale, you should review our
`invoices and packing slips. Any customer who does not already have one of our invoices
`or packing slips may obtain a copy of our terms and conditions by writing or calling our
`Customer Service Department.
`
`2
`
`Neurelis - EX. 2026-A
`IPR2019-00451
`
`

`

`UNITED STATES CUSTOMERS ORDERING CONTROLLED SUBSTANCES
`
`tMv1ata<7S issued by (he United Slates Oepanment of Justice, Drug Enforcemery Admmisiration IDEA) require us to obtain certain
`uccmerts be'o's we can ship any Controlled Substance.
`'.uscnets ordeiirg pnjducts on this page for the first tine must send a photocopy ol their federal registration, required lor
`iWlmg ConlroUerfSuDstances. attached to the purchase order. As your federal recystiatioo is renewed by the DEA. a photocopy
`Aoutd be mailed 10 us tor updating our records. Thrs wiil reduce the time needed to process your order for shipment,
`isingie $3500 tee is 8dded to multiple classes and/or items placed on one order
`•isnecesstfylhalywlumish us with the following documents when ordering Controlled Substances listed on this page
`in either
`I the two toiWog categories
`"feuf wrriren purchase order must show:
`f
`a) your OEA registration
`
`mber. nu
`b)
`the "ship to' name a
`nd
`address exactly as it appears on your DEA registration certificate,
`c) your acceptance ol a
`$3500 administrative fee Because ol the special handling and processing, we have been
`torcwl to increase the
`administrative fee. This lee should be added (o each
`order
`sure we have a current copy of your Federal Registration Form 223 on file.
`d)
`2 Acompleied DEA-222 form is required for orders of Classes ISM items. We are not permitted to liH orders on
`altered or incomplete order forms,
`or complete product listings see our new section of CONTROLLED SUBSTANCES.
`
`KA Ura
`Jill PrMofl
`No
`*o
`
`Nme
`
`" * O(0t AWjpiotfire HCl
`• * 525S AwobarMjl
`I * 0533
`
`neummt free Base t-Amp
`II
`A 5KQ
`a-Ang
`sVtimirt Sulfate
`U * i?63
`x AnphetiiMM Sulfate
`ft B 4M7
`
`Bec.'c^cto nine Hydrate
`Sf-i:r 'cso
`It B B0?l
`unfrd,
`I B 0503
`Bufeteoinf Mi
`onooulate
`I t 7515
`CanniindiQi
`I C 6838
`Camabmoi
`It
`C 5775
`Cocame HCl
`II C 5901
`Ccaemt
`
`II D 0524 Dexlrop'opaxyphen i iM
`I D 4636 N N-DieHiyltf/oljmmc
`' 0 6I?9 N N-OimelhylUyptjm
`,rir
`II D 6029 Diphenoiylste HCl
`II
`f 5137 Eciomne HCl
`[cgome-t), HCl
`II E 3761
`
`CLASSES I & II
`Of A Sifma
`Cl«5» Product
`No
`No
`
`Name
`
`Sigma
`DEA
`Class ProtfMt
`No
`No
`
`Name
`
`F 3886
`Fentanyl Citrate
`H 4516
`Hydrocodone Brtart'ale
`Hydromorphone HQ
`H 5136
`ibogameHCt
`I 7003
`M 314? Mepe'id nc HCi
`t 5143
`levorphanot Tartrate
`M 8375 Mescaline Hemtsulfale
`M 8500 Mescaline HCl
`M 6515 Mescaline Sulfate
`M 0767 Methadone HCl
`M 8?54 m-MeHiamprtetainine HCl
`M 8750
`( + lMelliamptietainine HCl
`M 2771 oi Melhainphetamine-^i HCl
`M 9146 Methaguatone Free Base
`M 3637 Methaquaione HCl
`M 6267
`(+) 3.4 Methylenedioiy-
`amphetamme HCl
`M 2892 Methylpnenidate HCl
`M 6886 Morphine-3-e-o-GlucuronidB
`
`II
`II
`
`II
`II
`H
`II
`II
`It
`II
`II
`I
`I
`II
`II
`
`N 7640 Norcodeine HCl
`N 1513 Noroxymorphone
`0 1253 Opium Powder
`0 1378 Oxycodone HQ
`P 3636 Pentobarbital
`P 3761 Pentobarbital Sodium
`P 3029 Ptfencyclidme HCl
`P 4540 Phencyclidme-rf, HCl
`P 3522 Phenylacetone
`S 1503 Secobarbital
`S 1378 Secobarbital Sodium
`T 2386 I Tetrahydrocannabinol
`T 2511 6-Teltahydrocannabinol
`T 2019 Thebame Alkaloid Powder
`T 2641 Tropacocaine HCl
`
`Sum i
`(A
`tBi Product
`W
`No
`
`Nmi
`
`*Ai
`
`III A 7662 ASytcycWpentenyl Barbituric
`'CO
`•r ,i
`
`W A 7537 , Alp I
`<l A 7144 apr
`A or a
`•V B 0375 8a-
`IV B 05M BafMai So3n,Bi
`111
`8 8263 Swi/pnstamne HCl
`I* B 4)44 Br»iiia:»p3m
`" B 8350 BuUba-Oiljl
`HI 6 6538 BulalMal
`III B 6763 BuWhai
`V C 8383 CBtoal Hydrate
`IV
`C 2517 ChtorflijwpowJe HCl
`l* C 0531 ChkifStaippoHae-d,
`* C
`'277 Clonajejm
`
`CLASSES III & IV
`Sigma
`DEA
`Class Product
`No
`No
`
`Name
`
`Sigma
`DEA
`Class Product
`No
`No
`
`Name
`
`IV C 1402 Clorazepaie Dipotassium
`IV D 7282 Desmethyldiarepam
`(V D 1278 Oesmeihyldia;epam-<i,
`D 5761 5,3-Diallylbarbiluric Acid
`D 08^9 Diazepam
`D 0406 Diazepam-^,
`D 0273 Diethylpropion HCl
`E 3258 Ethinamate
`F 8507 Fenlluramine HCl
`F 9261 Elunitrazepam
`F 3883 Flurazepam Dihydrochloride
`G 6633 Di-Glutethimide
`H 1005 Hexobarbital
`L 1764 (±) Lorazeoam
`:epam
`L 7518 Lormetaz
`
`L 5376 o-Lysergi c Acid
`M 0521 Medazepam
`
`IV
`IV
`IV
`IV
`IV
`IV
`IV
`111
`III
`IV
`tv
`III
`IV
`
`IV
`IV
`
`IV
`IV
`IV
`IV
`IV
`IV
`III
`IV
`IV
`IV
`IV
`IM
`III
`III
`
`M 3887 Mephobarbital
`M 2392 Meprobamate
`M 2142 Methyprylon
`N 3135 Nalorphine HCl
`H 3839 Nitrazepam
`0 >880 Oozolam
`P 5520 Paraldehyde
`P 6250 Pemoline
`P 6527 Pentazocine Free Base
`P 6652 Penla/oeine HCl
`P 5645 Phendirnetrazme Bitartrate
`P 1636 Phenobarbital
`P 3654 Prareoam
`T 8275 Temazepam
`P 8653 Phentermme HCl
`T 0894 Thiamylal Sodium
`
`T 1019 Thio penlal
`
`T 6023 (t> Thiopental Sodium
`
`OTHER DEA CONTROLLED SUBSTANCES
`(Not classified, but reporting required by the DEA )
`1-Methylpipendine
`M 3519
`8^6 <-Amino-2,2,6,6-Tetramethyl
`P 3156 cis-2.4-Piperdrne
`2-Melhylpiperidine
`M 2394
`Dicarboxylic Acid
`7HJ 2 EthPy'SeZne
`3-Methyipiperidine
`M 0270
`P 9657 cis-2,5-Piperdine
`4-Vethylpiperidine
`M 4019
`Oicarboxylic Acid
`l-Hlhylpiperidine
`3-Phenylacetylamino-
`M'J /•(2-Hydroxyelhyl)pipendine
`P 7789
`P 2031 cis-2,6-Piperdine
`
`Dicarboxylic Acid
`<'63 34<ydro*ymethyl-l-melhyl-
`i-pi
`me
`9159 Pipcridmi
`e-4-sulphonic
`nd
`9264 2,2.6.6-T
`3-Piperdine
`etramethyl
`Dicarboxylic
`Acid
`Pipendme
`
`P
`T
`
`Acid
`
`1629 S-Hydwty^melhyl-
`pipetidme
`
`2,6-piperidinedio ne
`
`P 5881
`P 8782 cis-
`
`Mdenng any of these items, please provide you
`r written purchase order, your acceptance ol the $35.00 administrative
`1 the mended ultimate use, and the signature of the
`end user
`order io avoid any delay m receiving material, we suggest double-checking your order and documents for accuracy and
`Weteness before mailing them to us for processing
`•Oona and telegraph orders not accepted
`
`3
`
`Neurelis - EX. 2026-A
`IPR2019-00451
`
`

`

`SALE OF CONTROLLED SUBSTANCES TO CUSTOMERS OUTSIDE USA
`
`The United Stales Department of Justice, Drug Enforcement Administration (DEA) regulates exporting of Con­
`trolled Substances from the United States The products listed in Ihe classes below are available for export. However,
`other Controlled Substances listed in this catalog may become eligible for exporting in the future Please contact
`us if you have a requirement for a Controlled Substance not shown
`Sigma routinely ships these items via Air Freight or Surface Freight, F.O.B. Sigma The shipping cost will be ad­
`ded to your invoice.
`An administrative fee of $4500 is charged on each order to hetp defray our expenses in obtaining Ihe necessary
`export documents Multiple orders received at the same time for the same product or a combination of items
`from the same group listed below will be subject to only one administrative fee.
`You must furnish us with the following documents when ordering from the two following groups of Controlled
`Substances:
`1. A signed, original Import License or Import Permit issued by your government agency which cor­
`responds to the US. Department of Justice. Drug Enforcement Administration. The Import Permit
`may be in the form of a letter from your drug agency advising us that you are authorized to import
`these items.
`2. A signed statement from you stating that these substances will be used exclusively for scientific pur­
`poses and will not be exported
`For complete product listings see our new section of Controtled Substances.
`
`DEA
`Class
`No
`
`Sigma
`Product
`No.
`
`Name
`
`Classes t & il
`DEA
`Class
`No.
`
`Sigma
`Product
`No.
`
`Name
`
`0408 Alphaprodine Hydrochloride
`A
`5255 Amobarbital
`A
`5880 o-Amphelamine Sulfate
`A
`1263 oi-Amptietamine Sulfate
`A
`0533 L-Amphefamine Free Base
`A
`4147 Bemoyiecgonme Hydrate
`B
`Benzoylecgo
`B 8021
`nms-tf.
`5776 Cocame HCI
`C
`C
`5901 Codeine
`D
`
`0524 Dextropropoxypl hene HCl
`D
`6029 Diprtenoxylate HCI
`F
`3886
`fentanyl Citrate
`H 4516 Hydrocodone
`Bitartrate
`lone HCI
`H 5136 Hydromorphc
`L
`5143
`Leworphanol tartrate
`M 3142
`Meperidine HCI
`
`M 0267 Methadone HCI
`M 8254
`iu.-Methamphet3iiime HCI
`M 8750 (+)Metnamphelamine HCl
`M 6267 (+)3.4 Methyienedioxy-
`amphetamine HCI
`M 2892 Methylptiemdate HCI
`N
`7610 Norcodeme HCI
`N
`1513 Noroxymorphone
`0 1253 Opium Powder
`0 1378 Oxycodone HCI
`P
`3636 Penlobarbrtal
`P 3761 Pentobarbital Sodium
`P
`3522 Phenylacetone
`S
`1503 Secobarbital
`Secobarbital Sodium
`S
`1378
`Thebaine AJkaloid Powder
`T
`2019
`
`DEA
`Class
`No.
`
`Sigma
`Product
`No.
`
`Name
`
`Classes III & IV
`DEA
`Class
`No.
`
`Sigma
`Product
`No.
`
`Name
`
`A
`
`7662
`
`Allycyclopenteny! Barbituric
`Acid
`7537 Alpfienal
`A
`7144 Aprobarbital
`A
`B 0375 Barbital
`B
`0500 Barbital Sodium
`B 8263 Benzphetamme HCI
`B 8380 Butabarbital
`B 6638 Butalbital
`C
`8383 Chloral Hydrate
`C
`1277 Clonazepam
`D 7282 Desmelhyldiazepam
`D 5761 5.5-DiaMylbarbituric Acid
`0 0273 Diethylpropion HCI
`
`Ethmamate
`3258
`E
`Flurazepam Dihydrochlonde
`3883
`f
`w.-Giulethimide
`6633
`G
`Hexobarbital
`H 1005
`I 7518 Lormetazepam
`M 3887 Mephobarbrtal
`M 2392 Meprobamate
`M 2142 Methyprylon
`N
`3889 Nitrazepam
`0 1880 Oxazolam
`P
`5520 Paraldehyde
`P
`5645 Phendimetrazme Bitartrate
`P
`1636 Phenobarbrtal
`P
`8653 Phenteimme HCI
`Thiamylal Sodium
`T
`0894
`1019 Thiopental
`T
`T
`6023 <±)Thiopent3l Sodium
`
`III
`III
`IV
`IV
`III
`III
`Ml
`IV
`IV
`IV
`III
`IV
`
`N
`
`A
`
`H
`
`Other DEA Controlled Substances
`(Not classified, but reporting required by the OEA )
`8896 4-Amirio-2.2.6,6-Tetraraethyl
`P
`7789 3-Phenylacetylamino-
`Piperidine
`2,6-piperidmedione
`7633 2-Eltiylpiperidine
`E
`Piperidine
`2383
`l-Ethylpipendme
`E
`cis-2.3-Piperdine
`3013
`H
`H2-Hydroxyetfiyl)piperidine
`Dicarboxyhc Acid
`H 2763
`3-Hydroxymethyl-l-methyl-
`3156 cis-2.4-Piperdine
`pipendme
`Dicarboxylic Acid
`1629 3-Hydroxy-N-melhyl-
`9S57 cis-2.5-Piperdine
`pip
`endme
`Dicarboxylic Acid
`M 3519 1 Metm
`ylpipendme
`2031 cis-2,6-Piperdine
`M 2394 2-Metliylpiperidine
`Dicarboxylic Acid
`M 0270 S-Methylpipendine
`9159 Piperidine-4-sulphomc Acid
`M 4019 4 Methylpipendme
`9264 2,2,6.6-Tetrartielhyl
`Piperidine
`
`588 J
`8782
`
`P
`P
`
`P
`
`P
`
`P
`
`P
`T
`
`When ordering any of these items, please provide your written purchase order, your acceptance of the
`$45.00 administrative fee, the intended ultimate use. and the signature of the
`end user.
`In order to avoid any delay in receiving material, we suggest double-checking your order and documents
`lor accuracy and completeness before mailing them to us for processing
`
`4
`
`Neurelis - EX. 2026-A
`IPR2019-00451
`
`

`

`SHIPPING INFORMATION
`For over 35 years, Sigma has been paying almost all transportation charges. During the last few years, we have
`nd an explosion of regulations and an increased awareness of hazards. We have been able to maintain our original
`plicyofno minimum charge and to pay shipping costs, There are certain situations where our preferred method
`ol stiipment (which we consider to be safe, secure and economical) is not acceptable to our transportation agents,
`loriingustoalterour policy of paying transportation costs Items which may fall into these situations are identified
`js'OBSIGMA incur catalog. The only other case where we ask you to pay transportation costs is if you request
`islo ship via air those items which are normally shipped via surface.
`On a continuous basis. Sigma is doing everything possible to get relief from this deterrent to our "normal"
`policy of paying (he shipping costs. We are working with local, national and international groups to get exemptions
`for shipments of small quantities of hazardous chemicals In our opinion, there is very little rationale for refusing
`sttpments of very small quantities of hazardous substances properly packaged in safe containers.
`
`DOMESTIC SHIPMENTS
`One example where someone has listened to us: the U.S. Department of Transportation (D O.T.) and U.S. Postal
`Service have granted exemptions from certain shipping requirements for transporting small packages of hazardous
`iratenalsin the United States. Whenever possible we will take advantage of this exemption.
`If we cannot take advantage of the U.S D.O.T. guideline for your domestic shipment, to avoid charging expen­
`se transportaffon costs we can ship by our "normal" methods using Poison Packs ($8.50 will be charged) or
`Wooden Boxes ($10.00 will be charged), We will combine all compatible items in a single container whenever possi­
`ble lot shipping in Poison Packs or Wooden Boxes.
`
`INTERNATIONAL SHIPMENTS
`Even though we feel we have the finest and fastest means of distributing chemicals world-wide, hazardous items
`still cause shipping problems and create additional costs. One method we use to minimize your shipping costs for
`tordous
`Items is consolidated air freight and subsequent distribution to you via local methods. Unfortunately,
`customs or other regulations prevent us from doing this in all countries.
`We will continue (o do everything possible to minimize your shipping costs, but YOU ALSO CAN HELP US to
`continue lo lower the cosls ol shipping your orders.
`• Ask your local airline(s) and postal authorities to adopt the U.S. DOT. guidelines.
`• Consolidate your orders of hazardous items so that airfreight cosls can be spread over as many products
`as possible; air carriers, Iruckl/nes and shipping companies have minimum charges.
`• Authorize accumulation of hazardous chemicals. We will ship when we have sufficient material to exceed the
`minimum charge.
`• Consolidate orders from several departments of your instilulion; we can bill each separately as you instruct
`• Advise the best route for hazardous hems which must be shipped by air cargo only (no passenger) planes,
`as some countries no longer have air cargo services.
`• Sfateon yourorder that you are aware of possible additional FOB freight charges. This will allow us to process
`your order promptly.
`• Ask your favorite dealer to stock these items for you.
`If you are aware of any other means of getting hazardous shipments to you, please advise us.
`The foregoing information is correct as we understand the current regulations. However, there are numerous
`stMrtional restrictions based upon toxicity, carcinogenicity and possible other factors that may affect our handling
`of this problem m Ihe future
`
`STORAGE - DRY ICE
`
`Recommended Storage is indicated below each product number in the product listing, as follows'
`53 = ULTRACOLD
`ECT = DEEP FREEZE
`ECT = FREEZER
`IM = FREEZER
`fo^ = REFRIGERATOR
`(S) = ROOM TEMPERATURE
`Items requiring storage at other than ambient temperature, but not requiring ice lor shipment, will be shipped
`order condif/ons that will ensure the quality of the product
`For shipments within the continental USA (excluding Alaska) of items requiring Ice, package prices also include
`ice,container and freight. For shipment outside the USA see approximate Dry ice shipping costs below.
`dipping weight of Dry Ice and container is about 35 lbs We try to estimate Dry Ice needed; but we cannot
`predicume lost in Customs offices or en route. The customer is responsible for prompt Customs clearance. If you
`cannot ensure prompt Customs clearance, be sure to order additional dry ice, and always specily which airport
`you prefer
`
`The estimated airfreight F.O.B. costs to typical destinations are:
`$ 54 00
`Africa.,
`. ..$224.00
`Canada-
`$ 75.00
`Mexico
`Alaska
`.138.00
`Europe.
`104.00
`New Zealand
`.204.00
`Hawaii.,
`Asia.
`, ..79.00
`175 00
`South America ...168 00
`India....
`Australia.
`244.00
`..192.00
`Hazardous items cannot generally be included with your ice (dry or wet) airfreight shipments. If your order con­
`sists of both an ice and hazardous shipment, please acknowledge that you expect two airfreight shipments; one
`for the ice shipment and one for the hazardous shipment.
`
`5
`
`Neurelis - EX. 2026-A
`IPR2019-00451
`
`

`

`RETURN PRIVILEGES & POLICIES
`
`Sigma is certainly unique with regard to policies of cooperation, whereby we will do almost ani
`thing to help you with your problems, but one matter in which we are rather stubborn is the accep
`tance of returns. Policies have been developed through the years which we feel are extremely fai
`and cover almost every conceivable situation. To avoid future misunderstandings, we have outline
`these policies here;
`
`Any reagent offered by Sigma is unconditionally guaranteed to be "satisfactory" to you. An
`reagent that does not perform as it should when you use it may be replaced without charge an
`postage paid anywhere in the world. We do not care how old the reagent is or if it was damage-
`in your own laboratory by improper storage condihons. If you have any problem using one of ou
`reagents and feel that a personal conversation would be helpful, please telephone the Custome
`Service Department collect. We want you to tell us when you find something wrong and we as
`for an opportunity to replace the materials. However, government directives that require expiratio1
`dating before deterioration occurs, make it impossible for us to replace such items after the expire
`tion date has been reached. Preferably, we hope you will advise us of your problem before makin.
`the return. Please telephone (collect) the Customer Service Department for return shipping instruc
`tions and a Returned Materials Number to identify an authorized return. Unidentified returns ma
`be discarded; unauthorized returns will not be accepted.
`
`Any reagent which we ship to you because of an error on our part is, of course, immediatel
`returnable for replacement. Should this happen, not only the replacement but our sincere apolc
`gies for the inconvenience we have caused you wilt go with the shipment. Sometimes purchas
`orders are received which are not clear, A stock number is given together with an item descriptiO'
`and they do not jibe. Such orders must be carefully scrutinized and compared with the customer'
`history in order to make a decision—to ship or not to ship—without delaying your work. If we writ-
`to you for clarification, you may be irritated with the delay. If we ship without writing to you first
`we are similarly risking your ire. Then when the inevitable return is made, we prefer to discard thi
`reagents and charge it off to experience. Sometimes this is quite expensive to us. but you an
`entirely within your rights in sending it back. Here again, if time is of the essence, you may tele
`phone us collect to bawl us out and ask that the correct item be shipped without further delaj
`
`Items that you receive because of your error are not returnable for credit. We certainly war
`to be cooperative and pleasant in every way, but to accept returns because you are overstockei
`or have discontinued use of the reagent, or any of many other reasons would result in a tremen
`dous loss to us unless we were to pass the expense on to other customers in some fashion. Althougl
`practically all other dealers will accept the return or a sealed package and resell it to someom
`else, we feel this could seriously jeopardize the work of the next customer. Once an item has beet
`out of our control, we do not think it is fair to ask another customer to accept it. We acknowledg»
`that in most cases the reagents are still entirely up to standard in every way and no harm woul(
`be done. However, in a small percentage of cases, purity or activity of the reagent is seriousl;
`affected by the extra trip, or by improper storage at the other end, or even by contamination, 1
`is impossible for us to detect all of these possibilities and we could not resell that item witl
`complete confidence, Fortunately, the vast majority of our customers are aware of Sigma's meticulou:
`attention to detail and understand that this policy is one of many that give them confidence ir
`Sigma. Instead of resenting this policy, many letters come to us expressing appreciation for it
`Occasionally, we encounter a particularly stubborn individual typified by the expression. "My mine
`is made up; don't confuse me with facts!" who refuses to listen to reason and is only concernec
`with the refund. Of course, this person would be the first to refuse a shipment of a reagent if tolc
`in advance that it was returned merchandise. When such an individual is encountered, wt
`personally want to talk to the customer and do everything possible to work out an agreeable solu
`tion to the problem. We sincerely want our customers to feel that "It's a pleasure doing business
`with Sigma. You must be satisfied or there is no cost."
`
`Please Inspect your packages upon receipt and inform us Immediately of any damage. Shoulc
`a product be found damaged, please retain the original shipping carton, shipping documents anc
`any documents that might indicate that the shipment was received in a damaged condition.
`
`THANK YOU FOR TAKING TIME TO READ ABOUT THE SIGMA POLICY.
`WE ARE SURE THAT IT HAS HELPED US TO HELP YOU.
`
`6
`
`\
`
`Neurelis - EX. 2026-A
`IPR2019-00451
`
`

`

`HOW TO USE THIS PRICE LIST
`
`Tie products in this price list are divided into various sections:
`RESEARCH AND ANALYTICAL KITS
`DIAGNOSTIC KITS AND REAGENTS
`REAGENTS FOR AUTOANALY2ERS
`
`ALPHABETICAL LIST OF COMPOUNDS
`EQUIPMENT, BOOKS AND SUPPLIES
`STANDARDS AND CONTROLS
`CHROMATOGRAPHY SUPPLIES
`
`I
`
`'ns alphabetical section contains specialty groups such as Affinity Chromatography. Bioactive Peptides,
`"ssue Culture. A complete list of these special groups may be found in the Table of Contents on page
`These sections are indicated by a black border around the edge of the page and special headings
`il the lop of the page. Note that these sections interrupt the alphabetical list of compounds where they
`tppear. Immediately following the section, the alphabetical list picks up where it left off.
`
`telow are 5 listings which are typical formats for our product listings.
`
`1.
`
`J
`
`19.
`
`1
`
`18.
`
`PRODUCT
`NUMBER
`L'Q-LYSO PHOSPHATIDYLCHOLINE
`* (1-0-Lysolecithin)
`
`17.
`
`»
`
`1
`
`16.
`
`.••Type III: Approx 99W •1
`L 5004 From Bovine Liver
`Fo^ci White powder.
`Prepared by the action of
`phosphohpase A on bovine hvet
`i-o-phosphatidylcholme (P 7753).
`
`Contains primarily palmitic and stearic acids } 15.
`
`5 mg 10 75
`25 mg 33.20
`100 mg 106.05
`
`HODOn /
`jMBtR/
`10 50
`250 units
`,• HYPOXANTHJNE-GUANINE
`1.000 units 34 10
`13389 PHOSPHORIBOSYL
`TRANSFERASE
`•;oc
`CO (HCPRT. Transohophonbosidase.
`IMP pyrophosphate phosphonbosyltransferase.
`EC 2 4 2 8)
`5. /From Bakers Yeast
`f Lyophilued powder conlaming approx 80%
`J proton (Biuret) and 5H MgCI, , balance primarily
`' Tnj buffer salts
`7 Adi/ly 300-600 units per mg protein
`/l/nit Delmition One unit will catalyse the
`//lormation of 1 nmole of mosme
`/ y monophosphate (IMP) per mm from
`/ hypoxanlhme and phosphonbosyl pyrophosphate
`9
`aJpH 74al 3/,,C
`May be useful in the enzymafic determination of
`phosphonbosyt pyrophosphate (PRPP)
`lO(-»Re( Salerno. C. et al. Expenentia. 35. 1016
`(1979)
`
`8
`
`••Type V: Approx. 99W
`L 1381 / From Bovine Brain
`Prepared by the action ol
`/ phosphohpase A on bov.ne btam
`t4.
`i-a-phosphalif