`
`AQUESTIVE EXHIBIT 1076 Page 0001
`. QUESTIVE EXHIBIT 1076 Page 0001
`
`

`

`F
`
`THE
`
`MERCK INDEX
`
`AN ENCYCLOPEDIA OF
`
`CHEMICALS, DRUGS, AND BIOLOGICALS
`
`TWELFTH EDITION
`
`Susan Budavari, Editor
`Maryadele J. O’Neil, Senior Associate Editor
`Ann Smith, Associate Editor
`Patn'cia E. Heckelman, Assistant Editor
`Joanne F. Kinneary, Assistant Editor
`
`Published by
`Merck Research Laboratories
`
`Division of
`
`MERCK & CO.5 INC.
`
`Whitehouse Station, NJ
`
`1996
`
`. QUESTIVE EXHIBIT 1076 Page 0002
`
`AQUESTIVE EXHIBIT 1076 Page 0002
`
`

`

`
`
`MERCK & C0., INC.
`Whitehouse Station, NJ.
`U.S.A.
`
`lst Edition—1889
`2nd Edition—1896
`2:151:223323
`5m Edition—1940
`6th Edition—1952
`7m Edition—1960
`8th Edition—1968
`9th Edition—1976
`1% Efllfi°n‘l983
`mom—1989
`
`Library of Congress Catalog
`Card Number 89-60001
`ISBN Number 0911910-12-3
`First Printing—March 1996
`Second Printing—April 1997
`
`With l
`
`century 1
`
`ciplinary
`lished in
`cation 0\
`the text
`biochem
`tion of i1
`
`of discip
`mind, bl]
`lence in .
`This 6
`
`Wthh 111‘
`ticals, ov
`andanot
`tional 1,(
`almost 1
`
`hundred 1
`A nurn
`lished in
`chemical
`
`Chemical
`SCI‘iptOI‘S
`readershi]
`1983 in 3
`of Chemj
`panded. 5
`some of I
`and imm1
`In reco
`reference
`
`major on]
`which is l
`
`Compa
`unparallel
`ronment,
`refer to T1
`
`by Merck
`the traditic
`
`Copyright © 1996 by MERCK & C0., INC.
`All rights reserved. Copyright under the Universal Copyright Convention
`and the International Copyright Convention.
`Copyright reserved under the Pan-American Copyright Convention.
`Printed in the U.S.A.
`
`AQUESTIVE EXHIBIT 1076 Page 0003
`AQUESTIVE EXHIBIT 1076 Page 0003
`
`
`

`

`———7——————
`
`Abbreviations and Selected Definitions
`
`al similarl-
`
`1ged alpha-
`mber order.
`,
`_
`denvatives.
`-
`unspeCIfied
`.
`C. IHCIUSIOn
`sement but
`’
`RAPEUTIC
`h
`) Paragrap S
`'
`al prOPefileS
`armation 0n
`=d t consult
`v
`0
`'
`information
`.
`’
`16 respecthC
`
`intly updated
`.
`h
`actlonsi 630
`m index.
`.
`a glossary, IS
`N
`_
`5-
`ion contalned
`her cannOt be
`tences arising
`.
`:ordingly, I'Cf-
`(1
`0f errors an
`‘
`'de m the n
`
`ext
`
`A
`A
`AAT
`Sb:
`abs config
`abstr
`Abu
`Ac
`acc
`ACE
`Acetyl CoA
`Ac20
`COEt
`QCOH
`ACP
`AQS,
`ACT
`AcylSCOA
`ADCC
`
`add(n)
`Ade
`ADH
`ADP
`ABC
`
`Ag
`AI
`AIDS
`
`Ala
`alc, alcoh
`ALG
`alk
`[at]?
`
`ALS
`
`aM
`
`amorph
`AMP
`
`cAMP
`amps
`amt(s)
`ANF
`
`anhydr
`anti
`Ann.
`APhA
`
`approx
`APT
`aq
`Ar
`A-R.
`ARC.
`Archzv Exp.
`Pathol.
`Pharmakol.
`ATCO-
`Arg
`Asa
`Asn
`ASP
`ass0°01)
`
`
`
`Please consult the Glossary (Misc. Tables Section) for additional definitions.
`adenine; adenosine; absorbance
`A.S.T.M.
`American Society for Testing
`(extinction)
`Materials
`_
`Angstrom units
`as-, asym-
`asymmetrical, unsymmetrical
`oti-ztgltitrypsin
`XTC
`aAtomic
`T
`C 1
`C
`anti od
`merican ype
`u ture
`C
`ollection
`absolutg; absorption
`atm, atmos
`atmosphere(s), atmospheric
`absolute configuration
`at. no.
`atomic number
`abstract
`ATP
`adenosine triphosphate
`ot—aminobutyric acid
`ATPase
`adenosine triphosphatase
`acetyl CH3CO—
`at. wt.
`atomic weight
`according
`BAN
`British Approved Name
`angiotensin converting enzyme
`B cell
`bone marrow or bursa of Fabricius
`acetyl coenzyme A
`derived cell
`acetic anhydride
`BCG
`Bacillus Calmette-Guerin
`a1
`ethyl acetate
`Bé
`Baumé (a specific gravity sc e)
`acetic acid
`Beilstein
`Beilstein’s Handbuch der
`acyl carrier
`rotein
`Organischen Chemie
`American C emical Society
`Belgian patent
`adrenocorticotropic hormone
`Chemische Ben'chte (Berichte der
`acyl coenzyme A
`Deutschen Chemischen
`antibody-dependent cellular
`Gesellschaft)
`cytotoxicity
`bovine gamma globulin
`adding, addition
`biological
`adenine
`British Intelligence Objectives
`alcohol dehydrogenase
`Subcommittee
`adenosine diphosphate
`tert—butoxycarbonyl
`(United States) Atomic Energy
`biochemical oxygen demand
`Commission
`boiling
`antigen, silver
`basepair; boiling point; boils at;
`anaphylotoxin inhibitor
`boiling at Example: bp7o 48°
`acquired immunodeficiency
`means boils at 48°C if the pressure
`syndrome
`is 70 mm Hg
`alanine
`British Pharmacopeia
`alcohol(ic); ethanol; ethyl alcohol
`British Pharmaceutical Codex
`anti~1ymphocyte globulin
`British patent
`alkali(ne)
`biological response modifier
`specific optical rotation at 25° C for
`bovine serum albumin
`D (sodium) line; absence of
`British thermal units
`brackets indicates optical rotation
`butyl
`of a liquid in a 1 decimeter cell,
`lgenzoyl CélélsCO—
`neat
`enzaldehy e
`anti—lymphocyte serum, amyotrophic
`benzoic acid
`lateral sclerosis
`concentration by volume (g/100ml)
`molar absorptivity (concn in
`after optical rotations only
`g—moles/l)
`cytosine; cytidine; complement
`amorphous
`Centigrade degrees; Celsius
`adenosine 5’-monophosphate
`degrees
`(adenylic acid)
`heat capacity (constant pressure)
`cyclic AMP
`(circa) about
`ampules
`Chemical Abstracts
`amount(s)
`calorie(s)
`anti-nuclear factor; atrial natriuretic
`calculate, calculated
`factor
`Canadian patent
`anhydrous
`carbobenzoxy
`stereodescriptor, see Glossary
`complete blood count
`Justus Liebig’s Annalen der Chemie
`cubic centimeter(s) (milliliter)
`American Pharmaceutical
`cholecystokinin
`Association
`circular dichroism
`approximate(ly)
`cytidine di hosphate
`alum precipitated toxoid
`carcinoem ryonic antigen
`aqueous
`(confer) compare
`aryl
`com lete Freund’s adjuvant (same as
`analytical reagent
`F A)
`AIDS related com lex
`complement fixation test
`Naunyn Schmiede ergs Archiv fu'r
`coronary heart disease
`Experimentalle Pathologie und
`congestive heart failure
`Pharmakologie
`chemical
`aromatic acyl radical
`Journal of the Chemical Society,
`arginine
`Chemical Communications.
`B—carboxyaspartic acid
`curie
`asparagine
`Colour Index (British)
`aspartic acid
`stereodescriptor, see Glossary
`association; associated
`centimeter(s)
`
`Belg. pat.
`Ber.
`
`BGG
`biol
`B.I.O.S.
`
`BOC
`3.0.1).
`boil.
`bp
`
`B.P.
`B.P. C.
`Brit. pat.
`BRM
`BSA
`Btu
`Bu
`Bz
`BzH
`BzOH
`c
`
`C
`°C
`
`Cp
`ca.
`C.A.
`cal
`calc(d)
`Can. pat
`Cbz
`cbc
`cc
`CCK
`CD
`CDP
`CEA
`cf.
`CFA
`
`CFI‘
`CHD
`CHF
`chem
`Chem. Commun.
`Ci
`01.
`cis—
`cm
`
`xiii
`
`‘ QUESTIVE EXHIBIT 1076 Page 0004
`
`AQUESTIVE EXHIBIT 1076 Page 0004
`
`

`

`
`
`(Deutsches Reichs—Patentherman
`patent
`double stranded
`dithiothreitol
`dynes
`entgegen, stereodescriptor, see
`Glossary
`the absorbance of a solution
`containing one gram per 100 m1
`contained in a cell having an
`absorption path of one cm
`molar extinction coefficient (concn in
`g-moles/l)
`excitatory amino acid
`erythrocyte coated by antibody and
`complement
`experimental allergic
`encephalomyelifis
`electron capture
`cosinophil chemotactic factor of
`anaphylaxis
`electrocardiogram
`Enzyme Commission Number
`edition
`'
`effective dose
`edit0r(s)
`ethylenediaminetetraacetic acid
`electroencephalo ram
`(exempli gratia) or example
`epidermal growth factor
`the same (authors), plural of idem
`European Inventory of Existing
`Chemical Substances
`.
`electrocardiogram
`enzyme-linked immunosorbent assay
`electromotive force
`ethylenediarnine (in formulas)
`stereochemical descriptor, see
`Glossary
`Environmental Protection Agency
`erythropoietin; European Patent
`Office
`molar extinction coefficient (concn in
`g-moles/l); dielectric constant
`equation
`equilibrium
`equivalent
`especially
`electrostatic units of electrical charge
`ethyl C2H5—
`viscosity
`(et alii) and others
`et cetera
`-
`ether
`ethyl alcohol
`European patent application
`electron volt
`evacuated
`evaporation
`stereochemical descriptor, see
`Glossary
`experimentalfly)
`extract, extracted
`externally
`Fahrenheit degrees; also Fourneau
`fructose l—phosphate
`fructose 6—phosphate
`fatty acid
`fast atom bombardment
`fiavin adenine dinucleotide (reduced
`form)
`Freund’s complete adjuvant (same as
`CFA)
`ferredoxin
`Food and Drug Administration
`(U.S.A.)
`Food, Drug and Cosmetic (U.S.A).
`
`FDNB
`FDP
`ff
`FFA
`FFC
`FIA
`
`FIAT
`
`FMN (FMNHZ)
`
`Fmoc
`Fonschr. Chem.
`Org. Naturst.
`
`fp
`FP
`FPLC
`Fr. pat.
`Frdl.
`
`
`
`ummmnhnnMr-hb-hNMFhFhF'S510
`
`....~.H-M
`
`Gly
`Glycerol-3-P
`Gmelin ’s
`
`GMP
`
`cGMP
`GM-CSF
`
`gOV’t
`GP
`GRE, GHRF
`GSSG
`GTP
`GU
`
`D.R_.P,
`
`DTT
`dyn
`(E)-
`1%
`Elem
`
`EM
`
`EAA
`EAC
`
`EAE
`
`EC
`ECF-A
`
`ECG
`EC. No.
`ed.
`ED
`Ed(s).
`EDTA
`EEG
`e.g.
`EGF
`eidem
`EINECS
`
`EKG
`ELISA
`emf
`en
`endo—
`
`EPA
`EPO
`
`e (epsilon)
`
`eq
`equilib
`equiv
`esp
`esu
`Et
`n (eta)
`et al.
`etc .
`EtZO
`EtOH
`Eur. pat. Appl.
`ev
`evac
`evapn
`exo-
`
`expt(ly)
`ext(d)
`extern
`°F
`F— l —P
`F-6—P
`FA
`FAB
`FAD (FADHZ)
`FCA
`
`Fd
`F.D.A.
`
`FD&C
`
`0-(carboxymethyl) cellulose
`cell—mediated immunity
`cell-mediated lymphocytotoxicity
`cytidine 5’-monophosphate (cytidylic
`acid)
`central nervous system
`coenzyme A
`collective volume
`compound
`composition
`concanavalin A
`concentrated
`concentration
`configuration
`constituent
`continued
`containing
`coenzyme Q (ubiquinone)
`corrected .
`corresponding, corresponds
`centipoise
`chemically pure
`compound
`critical pressure
`critical temperature
`crystalline, crystals
`crystallization
`colony stimulating factor; cerebral
`spinal fluid
`Cosmetic, Toiletry and Fragrance
`Assoc.
`cytidine triphosphate
`cysteine
`cytosine
`density; specific gravity (d19 specific
`gravity at 19° referred to water at
`40
`dextro(rotatory), the Opposite of l
`dextro (in configurational sense
`only), the opposite of L
`daltons
`0—(diethylarninoethyl)cellulose
`decompose(s), decomposition
`decomposition
`degree
`deliquescent
`indicates the locant of the double
`bond
`derivative
`determination
`diisopropyl fiuorophosphate or
`diisopropyl phosphofluoridate
`dihydroalanine
`dehydrobutyrine,
`B-methyldehydroalanine
`difference
`dilute, diluted, dilution
`distillation
`racemic
`optically inactive by external
`compensation as contrasted with
`meso—
`decimeter(s)
`dimethylacetamide
`disease modifying antirheumatic drug
`dimethylforrnamide
`dimethylsulfoxide
`deoxyribonucleic acid
`complementary DNA
`mitochondrial DNA
`deoxyribonuclease
`2,4—dinitro-1—fluorobenzene
`2,4-dinitro henyl or 2,4—
`dinitrop enol
`dihydrox phenylalanine
`degree 0 polymerization (number of
`monomeric units in the polymer)
`
`CM—cellulose
`CMI
`CML
`CMP
`
`CNS
`CoA or CoASH
`coll. vol.
`compd
`compn
`Con A
`conc(d)
`concn
`config
`constit
`contd
`contg
`CoQ
`cor(r)
`corresp
`0P
`QR
`cpd
`crit press
`crit temp
`cryst
`crystn
`CSF
`
`CTFA
`
`CTP
`
`yt
`
`d d
`
`-
`D-
`
`Da
`DEAE cellulose
`dec, decomp
`decompn
`deg
`deliquesc
`A (delta)
`
`deriv
`determn
`DFP, DIFP, DIPF
`
`Dha
`Dhb
`
`diff
`dil(d), (n)
`distln
`dl-
`DL—
`
`drn
`DMA
`DMARD
`DMF
`DMSO
`DNA
`cDNA
`mtDNA
`DNAase
`DNFB
`DNP
`
`Dopa
`dp, DP
`
`
`
`AQUESTIVE EXHIBIT 1076 Page 0005
`AQUESTIVE EXHIBIT 1076
`Page 0005
`
`
`xiv
`
`

`

`.
`
`n German
`-
`2‘
`'ZChs Pate t)_
`ed
`r, see
`'
`eodescripto
`e Of a solution
`one gram per 100 ml
`n a cell having an
`path Of one cm
`ion coefficient (concn in
`ino acid
`)ated by antibody and
`1t
`allergic
`nyelitis
`ire
`emotactic factor of
`3
`:ram
`fmjssion Number
`3
`inetetraacetic acid
`ialogram
`la) for example
`)wth factor
`:hors), plural of idem
`'entory of Existing
`Substances
`gram
`:d immunosorbent assay
`3 force
`ine (in formulas)
`al descriptor, see
`a1 Protection Agency
`[1; European Patent
`:ion coefficient (concn in
`- dielectric constant
`'
`
`units of electrical Charge
`
`_
`
`3thers
`
`tent application
`
`:al descriptor, see
`(1y)
`reted
`egrees; also Fourneau
`iosphate
`iosphate
`mbardment
`1e dinucleotide (reduced
`nplete adjuvant (same as
`
`ug Administration
`and Cosmetic (U.S.A).
`
`FDNB
`FDP
`ff
`FFA
`FFC
`FIA
`FIAT
`FMN (FMNHZ)
`
`Fmoc
`Fortschr. Chem.
`Org. Naturst.
`
`fp
`FP
`FPLC
`Fr.
`at.
`Frd.
`
`Fru
`FSH
`FT
`g
`G
`G-I—P
`G-3—P
`G—6-P
`GA A
`gal
`Gal
`GalNAc
`v (gamma)
`GC
`GDH
`GDP
`gem-
`geol
`Ger. pat
`GH
`GI
`g/l
`Gla
`Glc
`GLC
`Gch
`GlcN
`GlcNAc
`GlcUA
`Gln
`Glu
`GluA
`Gly
`Glycerol—3-P
`Gmelin’s
`
`GMP
`cGMP
`GM-CSF
`gov’t
`GP
`GRF, GHRF
`GSH
`GSSG
`GTP
`GU
`Gua
`
`
`
`l-fluoro-2,4—dinitrobenzene
`fructose 1,6—diphosphate
`following
`free fatty acid
`d
`free from chlorinle
`Freund’s incomp etc a juvant (same
`as ICFA)
`Field Information Agency, Technical
`(us. reports)
`.
`flavm mononucleotide (reduced
`form); same as riboflaVin
`phosphate
`9-fluorenylmethoxycarbonyl
`Fortschritte der Chemie Organischer
`Naturstofie (Progress in the
`Chemistry of Organic Natural
`Products)
`freezing point
`flavoprotein
`fast protein liquid chromatography
`French patent
`P. Friedlander Fortsehritte der Teer-
`farbenfabrikation, a collection of
`patents
`fructose
`follicle-stimulating hormone
`Fourier transform
`grani(s)
`.
`guanine; guanosme
`glucose l-phosphate
`glyceraldehyde 3-phosphate
`glucose 6-phosphate
`y-aminobutyric ac1d
`gallon(s)
`.
`galactose
`Niacetyl-D-galactosamine
`Imcrogram(S)
`gas chromatography
`glutamate dehydrogenase
`guanosine diphosphate
`geminal, stereodescriptor see
`Glossary
`geological
`German patent
`growth hormone
`gastrointestinal
`grams per liter
`y-carboxyglutamic acid
`glucose
`gas—liquid chromatography
`gluconic acid
`glucosamine
`N—acetyl—D-glucosamine
`glucuronic acid
`glutamine
`glutamic acid
`glucuronic acid
`glycine
`glycerol 3-phosphate
`Gmelin’s Handbuch der
`Anorganischen Chemie, a
`comprehensive German
`encyclopedia of inorganic
`chemistry
`guanosine 5’—monophosphate
`(guanylic acid)
`cyclic GMP
`granulocyte macrophage colony
`stimulating factor
`government
`glycoprotein
`growth hormone releasing factor
`glutathione (reduced)
`glutathione~(oxidized)
`guanosine triphosphate
`genitourinary
`guanine
`
`xv
`
`
`
`GVH
`habit.
`Har
`Hb
`HbCO
`Hb02
`HCG
`Hcy
`HDL
`HeLa
`
`HGG
`HGH
`His
`HIV
`Hiv
`HLA
`HMG—CoA
`Houben
`Houben Weyl
`
`HPLC
`hr
`HSA
`Hse
`HSV
`HT
`HTLV
`Hyl
`Hyp
`i—
`
`I
`Ia
`IACR
`IARC
`IARC Monographs
`
`ibid.
`I.C.C.
`ICFA
`ICSH
`IDDM
`idem
`IDP
`i.e.
`IEF
`IF, IFN
`i.g.
`Ig
`I.G. Farben
`
`IGF—I
`IL
`Ile
`i.m.
`IMP
`incl
`incompat
`INN
`
`aft—versus—host
`lgnribitat
`homoarginine
`hemoglobin
`carbon monoxide hemoglobin;
`carboxyhemo lobin
`oxyhemoglobing
`human chorionic gonadotropin
`homocysteine
`_
`high dens1ty lipoproteins
`cells of the first continuously
`cultured (human cervical)
`carcinoma strain
`human gamma globulin
`human growth hormone
`histidine
`human immunodeficiency virus
`OL-hydroxyisovaline
`human leukocyte antigen
`3—hydroxy-3-methylglutaryl
`coenzyme A
`a German collection of medicinal
`patents
`Houben— Weyl Methoden der
`Organischen Chemie, a German
`collection of preparative methods
`. in organic chemistry
`high performance (pressure, power)
`liquid chromatography
`hour
`human serum albumin
`homoserine
`_
`herpes Simplex virus
`hydroxytryptamine (serotonin)
`human T lymphotropic virus see also
`I-HV
`_
`hydroxylysuie
`hydroxyproline
`optically inactive by internal
`compensation as i-inositol; archaic
`for meso-
`inosine
`I—region antigen
`International Association of Cancer
`Registries
`International Agency for Research on
`Cancer
`IARC Monographs on the Evaluation
`of Carcinogenic Risk of Chemicals
`to Man
`(ibidem) at the same place
`Interstate Commerce Commission
`incomplete Freund’s adjuvant (same
`as FIA)
`interstitial cell—stimulating hormone
`(same as LH)
`insulin dependent diabetes mellitis
`the same (author); plural: eldem, the
`same (authors)
`inosine diphosphate
`(id est) that is
`Isoelectric focusing
`interferon
`intragastric
`immunoglobulin
`Interessengemeinschafi der
`Farbenindustrie, Aktiengesellschafi—
`the German dye trust
`insulin-like growth factor 1
`interleukin
`isoleucine
`intramuscular
`inosine 5'-monophosphate (inosinic
`acid)
`including
`incompatibility
`International Nonproprietary Name
`
`. QUESTIVE EXHIBIT 1076 Page 0006
`
`AQUESTIVE EXHIBIT 1076 Page 0006
`
`

`

`
`
`N.N.R.
`
`no.
`nor—
`
`N R DC
`
`NSAID(s)
`
`NSC
`NTP
`
`PAGE
`passim
`pat.
`PB report
`
`PCA
`PCT
`PEP
`PET
`etr, petrol
`FC
`3PG
`PG
`PGA
`PGP
`pH
`
`PHA
`Phe
`Physio]
`pK
`
`PKU
`PMN
`PPi
`
`COI
`
`rac
`
`microgram
`millicun'e
`
`100
`
`moecuarroa on
`malate dehydrogenase
`methyl CH3—
`acetone
`methyl alcohol
`Mellor’s Comprehensive Treatise on
`Inorganic and Theoretical
`Chemistry
`milli-equivalent (0.001 of an
`equivalent)
`methionine
`N—formylmethionine
`methemoglobin
`millielectron volts
`manufacturing
`manufacture
`milligram
`major histocompatibility complex
`microcun'e
`microgram
`rnicrocrystalline
`migration inhibition factor
`minimum; minute(s)
`Mullen'an inhibiting substance
`miscible
`mixture
`milliliter (cubic centimeter)
`minimum lethal dose
`mixed lymphocyte reaction
`millimeter
`millirnicron(s), nm
`molecular weight
`Monatshefte fiir Chemie
`milliosmolar
`melting point; melts, melting at,
`when followed by a figure
`denoting temperature
`relative molecular mass
`magnetic resonance imaging
`meso- (internally compensated)
`mass spectrometry
`melanocyte-stimulating hormone
`(melanotropin)
`index of refraction (r119 for 20° and
`sodium light); normal, as n—propyl
`normal (equivalents per liter, as
`applied to concentration); nitrogen
`(as in N—methylpyridine)
`N—acetylneuraminic acid
`nicotinamide adenine dinucleotide
`(reduced form)
`nicotinamide adenine dinucleotide
`phosphate (reduced form)
`nonaspu'in nonsteroidal anti-
`inflammatory drugs
`National Bureau of Standards
`National Collection of Type Cultures
`nucleoside 5’-phosphate
`Netherlands patent application
`National Formulary
`nanogram (10'9 grams)
`nerve growth factor
`Non-insulin dependent diabetes
`mellitis
`National Institute for Occupational
`Safety and Health
`nanometer
`nicotinamide mononucleotide
`(reduced form)
`nucleoside 5’-monophosphate
`nuclear magnetic resonance
`New and Nonofi‘icial Drugs
`(Lippincott, 1959-1964)
`
`mcg
`mCi
`
`MD
`
`MDH
`
`MCZCO—
`MeOH
`Mellor’s
`
`mEq
`Met
`fMet
`MetHb
`meV
`mfg, manuf
`mfr
`mg
`MHC
`mCi
`mg
`microcryst
`MIF
`min
`MIS
`misc
`mixt
`ml
`MLD
`MLR
`mm
`mu
`mol wt
`Monatsh.
`mOsm
`mp
`
`Mr
`MRI
`ms-
`MS
`MSH
`
`n N N
`
`Acneu
`NAD+ (NADH)
`
`NADP+ (NADPH)
`NANSAIDS
`
`NBS
`NCTC
`NDP
`Neth. pat. App].
`N.F.
`“g
`NGF
`NIDDM
`
`NIOSH
`
`nm
`NMN+ (NMNH)
`NMP
`NMR
`N.N.D.
`
`inorganic
`insoluble
`internal
`International
`intrapen'toneal
`infrared
`immune response genes
`Internal Organization for
`Standardization
`isolation
`inosine triphosphate; idiopathic
`thrombocytopenic purpura
`international unit
`Intemational Union of Chemistry
`International Union of Pure and
`Applied Chemistry
`intravenous
`Japanese patent (unexamined)
`Japanese patent
`dissociation constant; equilibrium
`constant
`degrees Kelvin
`kilobase
`kilocalories(s)
`killer cell
`kilograrn(s)
`ot-ketoglutarate
`keyhole limpet hemocyanin
`kidney plasminogen activator
`liter
`levo(rotatory), the opposite of d
`levo (in configurational sense only),
`the opposite of D
`lactose
`lymphocyte—activating determinant
`wavelength
`laser microprobe mass analysis
`long acting thyroid stimulator
`pound(s)
`lethal concentration; liquid
`chromatography
`median lethal concentration, the
`concn of a chemical that is
`estimated to be fatal to 50% of the
`organisms tested
`lymphocyte choriomeningitis
`lethal dose
`median lethal dose, the quantity of a
`chemical that is estimated to be
`fatal to 50% of the organisms
`tested
`lactate dehydrogenase
`low density lipoproteins
`leucine
`luteinizing hormone (same as ICSH)
`natural logarithm
`(loco citato) in the place cited
`logarithm (common)
`limit of impurities
`lipopolysaccharide
`lysine
`meter; given after mass number
`signifies metastable isomer
`meta chemical locant for ring
`substituents
`molar (concentration)
`monoclonal antibody
`maximum allowable concentration
`macrophage activating factor
`monoamine oxidase
`monoamine oxidase inhibitor
`mass spectrometry
`max1mum, max1ma
`myoglobin
`oxymyoglobin
`Manufacturing Chemists Association
`(U.S.A.)
`
`
`
`xvi
`
`inorg
`insol
`intern
`. Intl
`i.p.1R
`Ir genes
`ISO
`
`isoln
`ITP
`
`_
`I.U.
`l.U.C.
`I.U.P.A.C.
`
`i.v.
`Japan. Kokai
`Japan. pat.
`
`K °
`
`K
`Kb
`kcal
`K cell
`kg
`orKG
`KLl-l
`
`LCM
`LD
`LDso
`
`LDH
`LDL
`Leu
`LH
`1n
`loc. cit.
`log
`l.o.i.
`LPS
`
`Mab, mAb
`MAC
`MAF
`MAO
`MAOI
`mass spec
`max
`Mb
`MbOz
`M.C.A.
`
`AQUESTIVE EXHIBIT 1076 Page 0007
`AQUESTIVE EXHIBIT 1076
`Page 0007
`
`
`
`

`

`alkyl, univalent hydrocarbon radical
`(or hydrogen)
`rectus (right), stereodescriptor see
`Glossary
`radioallergosorbent test
`red blood cell; red blood count
`aliphatic acyl radical
`recrystallize, recrystallization
`reference
`“roentgen equivalent physical”
`means a dose of ionizing radiation
`capable of producing energy
`absorption of 93 ergs per gram of
`tissue
`respectively
`(in paper chromatography) ratio of
`movement of the band to the front
`of the solvent
`radioimmunoassay
`D—ribose
`radioimmunosorbent test
`ribonucleic acid
`heterogeneous nuclear RNA
`messenger RNA
`nuclear RNA
`ribosomal RNA
`small nuclear RNA
`transfer (soluble) RNA
`ribonuclease
`Registry of Toxic Effects of Chemical
`Substances
`symmetrical
`denoting attachment to sulfur as in
`S—rnethylcysteine
`sinister (left), stereodescriptor see
`Glossary
`Society of Automotive Engineers
`S—adenosylmethionine
`saponification
`sarcosine
`saturated
`subcutaneous
`sodium dodecyl sulfate
`second(s)
`secondary
`separation
`serine
`International System of Units
`systemic lupus erythematosus
`serotonin-noradrenaline reuptake
`inhibitor
`soluble; solubility
`solidifies, solidification
`solution
`species; specific
`spectroscopy
`single photon emission computed
`tomography
`specific gravity
`species (plural)
`square
`(sequentia) and following
`sheep red blood cells
`slow reacting substance of
`anaphylaxis
`single stranded
`subacute sclerosing panencephalitis
`selective serotonin reuptake inhibitor
`standard temperature and pressure
`sublimes
`supplement
`symmetrical
`stereochemical descriptor see
`Glossary
`thymine; thymidine
`half—life
`tablet(s)
`
`R
`
`(R)—
`'
`RAST
`rbc
`RCO-
`recryst(n)
`ref
`rep [REP]
`
`resp
`R; or RF
`
`RIA
`Rib
`RIST
`RNA
`hnRNA
`mRNA
`nRNA
`rRNA
`snRNA
`tRNA
`RNase
`RTECS
`
`3—
`S
`(S)-
`
`
`
`S.A.E.
`SAM
`sapon(if)
`Sar
`satd
`s.c.
`SDS
`sec
`sec—
`sepn
`Ser
`SI
`SLE
`SNRI
`
`sol; soly
`solidif
`soln
`sp.
`spec
`SPECT
`
`sp gr
`spp.
`sq
`sqq
`SRBC
`SRS-A
`
`ss
`SSPE
`SSRI
`S.T.P.
`subl
`suppl
`sym-
`syn—
`T
`tm
`tabl
`
`New and Nortofi‘icial Remedies
`(Lippincott, 1933-1958)
`number
`chemical nomenclature descriptor,
`see Glossary
`National Research Development
`Corporation
`nonsteroidal anti—inflammatory
`drugs
`National Service Center
`nucleoside 5’—1Iiphosphate; National
`Toxicology Program (U.S.)
`ortho chemical locant for ring
`substituents
`denoting attachment to oxygen, as in
`0- acetylhydroxylamine
`ovalburnin
`oxaloacetate
`optical density
`(opere citato) in the work cited
`organic
`Occu ational Safety and Health Act
`osmo ar
`ounce(s)
`concentration by weight (after optical
`rotations only)
`page(s)
`para chemical locant for ring
`substituents
`inorganic phosphate
`pascal
`p-aminobenzoic acid
`platelet-activating factor
`polyacrylarnide gel electrophoresis
`here and there, scattered
`patent
`Publication Board Report (United
`States Department of Commerce,
`Scientific and Industrial Reports)
`passive cutaneous anaphylaxis
`Patent Co—operation Treaty
`phosphoenolpyruvate
`positron emission tomography
`petroleum
`plaque—forming cell
`-phosphoglycerate
`prostaglandin
`pteroylglutamic acid (folic acid)
`3—phosphoglyceroyl phosphate
`ac1d-base scale; log of reciprocal of
`hydrogen ion concentration
`phytohemagglutin
`phenylalanine
`physiological
`0g of the reciprocal of the
`dissociation constant, l/log K
`phenylketonuria
`polymorphonuclear leukocyte
`inorganic pyrophosphate
`parts per million
`precipitate, precipitating
`precipitated
`plastoquinone
`propyl (normal)
`prepared
`preparation
`pressure
`proline
`5—phosphoribosyl l—pyrophosphate
`pseudo
`point
`parathyroid hormone
`coenzyme Q (ubiquinone)
`(quae vide) which see, plural
`(Quad vide) which see
`‘ roentgen” unit of radiation
`racemic
`
`N.N.R.
`
`[10.
`nor—
`
`NRDC
`
`NSAID(s)
`
`NSC
`
`Pi
`Pa
`PABA
`PAF
`PAGE
`passim
`pat.
`PB report
`
`PCA
`PCT
`PEP
`PET
`petr, petrol
`PFC
`3PG
`PG
`PGA
`PGP
`pH
`PHA
`Phe
`physiol
`pK
`PKU
`PMN
`PPi
`PPm
`ppt(g)
`pptd
`PQ
`Pr
`prepd
`prepn
`press.
`Pro
`PRPP
`ll! (psi)
`tP
`PTH
`
`Qq
`
`. q. v.
`q. v.
`.
`
`rr
`
`99m
`100
`se
`
`zsive Treatise on
`eoretical
`
`)01 of an
`
`bility complex
`
`1 factor
`;)
`g substance
`
`Itimeter)
`se
`reaction
`
`iemie
`
`ts, melting at,
`)y a figure
`“ature
`mass
`re imaging
`:ompensated)
`
`Vating hormone
`
`1 (r1218 for 20° and
`tormal, as n-propyl
`ts per liter, as
`entration); nitrogen
`pyridine)
`ic acid
`tine dinucleotide
`
`line dinucleotide
`iced form)
`roidal anti—
`rugs
`)f Standards
`on of Type Cultures
`>sphate
`1t application
`"3’
`grams)
`tor
`ndent diabetes
`
`: for Occupational
`31th
`
`nonucleotide
`
`) )
`
`nophosphate
`1 resonance
`'cial Drugs
`)59— 1964)
`
`xvii
`
`
`
`AQUESTIVE EXHIBIT 1076 Page 0008
`. QUESTIVE EXHIBIT 1076 Page 0008
`
`

`

`
`
`United States Dispensatory
`United States Department of
`Agriculture
`United States Pharmacopel'a
`United States patent
`uridine triphosphate
`ultraviolet
`volt(s)
`vicinal (adjacent)
`valine
`variety
`(videlicet) that is to say; namely
`very low density lipoproteins
`volume
`versus
`percent “volume in volume”
`expresses the number of milliliters
`of an active constituent in 100
`milliliters of solution
`white blood cell; white blood count
`World Health Organization
`weeks
`weight
`percent “weight in volume”
`expresses the number of grams of
`an active constituent in 100
`milliliters of solution, and is used
`regardless of whether water or
`another liquid is the solvent
`percent “weight in weight”
`expresses the number of grams of
`an active constituent in 100 grams
`of solution or mixture
`xanthosine monophosphate
`Year(S)
`carbobenzoxy
`zusammen stereodescriptor see
`Glossary
`Hoppe—Seyler’s Zeitschriftfi'ir
`Physiologische Chemie
`approximately
`approximately equal
`greater than
`less than
`
`tuberculosis
`trichloroacetic acid; tricarboxylic
`acid
`thymus derived cell
`thoracic duct lymphocyte
`thymidine diphosphate
`0-(tn'ethylaminoethyl)-cellulose
`technical
`temperature
`tertiary
`thyrotropic hormone
`tetrahydrofuran
`tetrahydrofolic acid
`threonine
`thymine
`thin—layer chromatography
`thymidine 5 ’—monophosphate
`tobacco mosaic virus
`tumor necrosis factor
`triniuophenyl
`tissue plasminogen activator
`thiamine pyrophosphate
`stereodescriptor see Glossary
`tris(hydroxymethyl)aminomethane;
`2—amino-Z—hydroxymethylpropane-
`1,3-diol
`tryptophan
`thyroid-stimulating hormone
`tumor-specific transplantation
`antigens
`thymidine triphosphate
`tyrosine
`uracil or uridine
`uridine diphosphate
`uridine diphosphogalactose
`uridine disphosphoglucose
`United Kingdom
`uridine 5’—monophosphate (uridylic
`acid)
`uncorrected
`unsymmetrical, asymmetrical
`uracil
`United States Atomic Energy
`Commission
`United States Adopted Names
`
`
`
`U.S.D.
`U.S.D.A.
`
`U.S.P.
`U.S. pat.
`UTP
`uv
`v
`v-
`Val
`var
`viz.
`VLDL
`vol
`vs
`v/v
`
`wbc
`WHO
`wks
`wt
`w/v
`
`w/w
`
`XMP
`yr(s)
`Z
`(Z)-
`
`Z Physio].
`
`w
`2
`>
`<
`
`TB, tb
`TCA
`
`T cell
`TDL
`TDP
`TEAE cellulose
`tech
`temp
`tert—
`TH
`THF
`THFA
`Thr
`Thy
`TLC
`TMP
`TMV
`TNF
`TNP
`TPA
`TPP, ThPP
`trans-
`Tris
`
`Trp
`TSH
`TSTA
`
`'ITP, dTTP
`Tyr
`DP
`UDP—gal
`UDP—glc
`U.K.
`UMP
`
`UU
`
`uncor(r)
`uns-, unsym—
`Ura
`U.S.A.E.C.
`
`USAN
`
`xviii
`
`AQUESTIVE EXHIBIT 1076 Page 0009
`AQUESTIVE EXHIBIT 1076 Page 0009
`L
`
`

`

`
`
`3042
`
`Diazepam
`
`similar hydrocarbons. More stable in alkaline fOI’mula
`then when at neutral or acid pH. LDso in male, fema]
`(mg/kg): 250, 285 orally (Gaines).
`Caution: Cholinesterase inhibitor: Clinical Toxicolog,
`Commercial Products, R. E. Gosselin et al. Eds. (willing!
`& Wilkins, Baltimore, 5th ed., 1984) Section II, p 294
`s
`USE:
`Insecticide.
`mew CAT (VET): Ectoparasiticide.
`
`lionsI
`6 rats
`
`[2,5-Bis(1—aziridinyl)-3,6~dioxo.14
`3044. Diaziquone.
`cyclohexadiene—1,4—diyl]biscarbamic acid diethyl ester,- 2’5:
`bis(1-aziridinyl)-3,6-dioxo-1,4—cyclohexadiene—1,4—dicarba,;n-c
`acid diethyl ester; 2,5-diaziridinyl-3,6-bis(ethoxycarb0nyl_
`amino)-l,4-benzoquinone; aziridinylbenzoquinone; AZQ-
`CI-904; NSC-182986.
`c,,H,oN,o,; mol wt 364.36. 6
`52.74%, H 5.53%, N 15.38%, 0 26.35%. Quinone-comaiu.
`ing lipophilic alkylating agent. Prepn as intermediate in
`dyestuffs:
`S. Petersen et al., US. pat. 2,913,453 (1959 to
`Schenley Ind.) Synthesis and antitumor activity: A. H.
`Khan, .1. S. Driscoll, J. Med. Chem. 19, 313 (1976); 1,3.
`Driscoll et al., US. pat. 4,146,622 (1979 to US. Gov't). 1,,
`
`vivo antitumor studies:
`
`J. S. Driscollret al., J. Pharm. Sci
`
`Intracerebral penetration and tissue dis.
`68, 185 (1979).
`tribution in humans: N. Savaraj et al., J. Neuro-Oncol 1,15
`(1983). LC determn: B. A. Allen et aL. J. Chromatog. 222,
`146 (1981). Pharmacokinetics: S. Zimm et aL, Cancer Res
`44, 1698 (1984). Clinical studies in treatment of CNS neo-
`plasms: R. T. Eagan et al., J. Neuro-Oncol. 5, 309 (1987); E.
`Tapazoglou et al., Am. J. Clin. Oncol. 11, 474 (1988). Re-
`view: J. F. Bender et al., Invest. New Drugs 1, 71-84 (1983).
`o
`
`n
`
`o
`H,
`3V\n/
`0
`N
`V
`
`A
`O
`A
`
`N
`H
`
`0
`
`o/“cna
`
`i
`:
`
`I
`
`
`
`I
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`7—Chloro-1,3-dihydro-1-methyl-5—
`3042. Diazepam.
`phenyl-ZH—I,4-benzodiazepin-2-ane; 7-chloro-1-methyl-5-
`phenyl-3H-1,4~benzodiazepin-2(1H)—one; methyl diazepin-
`one; diacepin; LA-III; Ro-5—2807; Wy-3467; NSC-77518;
`Apaurin; Atensine; Atilen; Bialzepam; Calmpose;
`(Deregu-
`lart; Dialar; Diazemuls; Dipam; Eridan; Eurosan; Evacalm;
`Faustan; Gewacalm; Horizon; Lamra’; Lembrol; Levium;
`Mandrozep; Neurolytril; Noan; Novazam; Paceum; Paci-
`tran; Paxate; Paxel (obsolete); Pro-Pam; Q-Pam; Relanium;
`Sedapam; Seduxen; Servizepam; Setonil; Solis; Stesolid;
`Tranquase; Tranquo-Puren; Tranquo-Tablinen; Unisedil;
`Valaxona; Valiquid; Valium; Valrelease; Vival; Vivol. C15-
`HuClNzO; mol wt 284.74. C 67.49%, H 4.60%, Cl 12.45%,
`N 9.84%, O 5.62%.
`Prepn:
`Sternbach, Reeder, J. Org.
`Chem. 26, 4936 (1961); Reeder, Stembach, U.S. pat. 3,371,-
`085 (1968 to Hoffmann-La Roche); prepd but not claimed:
`eidem, U.S. pats. 3,109,843 and 3,136,815 (1963, 1964 to
`Hoffmann-La Roche); M. Gates, J. Org. Chem. 45, 1675
`(1980); M. Ishikura et al.,
`ibid. 47, 2456 (1982). Purifica-
`tion: Chase, U.S. pat. 3,102,116 (1963 to Hoffrnann-La
`Roche). Pharmacology: Hudson, Wolpert, Arch. Int. Phar-
`macodyn. Ther. 186, 388 (1970). Metabolism: Randall et
`al., Curr. Ther. Res. Clin. Exp. 7, 590 (1965); Van der
`Kleijn, Ann. N. Y. Acad. Sci. 179, 115 (1971). Toxicity: E. I.
`Goldenthal, Toxicol. Appl. PharmacoL 18, 185 (1971). Bind-
`ing study in rat brain: R. F. Squires, C. Braestrup, Nature
`266, 732 (1977). Comprehensive description: A. Mac-
`Donald et al., Anal. Profiles Drug Subs. 1, 79-99 (1972).
`Clinical pharmacokinetics: M. Mandelli et al., CIin. Phar-
`macokinet. 3, 72 (1978).
`
`Plates from acetone + petr ether, mp 125-126°. pKI 3.4.
`Sol in chloroform, DMF, benzene, acetone, alc; slightly sol
`in water. LDso orally in rats: 710 mg/kg (Goldenthal).
`Note: This is a controlled substance (depressant) listed in
`1995 .
`the U).S. Code of Federal Regulations, Title 21 Part 1308.14
`THERAP CAT: Anxiolytic; muscle relaxant (skeletal).
`3043. Diazinon. Phosphorothioic acid 0,0-diethyl 0-
`[6-methyl-2-(1-methylethyl)-4-pyrimidinyl] ester,- thiophos-
`phoric acid 2-isopropyl-4-methyl-6-pyrimidyl diethyl ester;
`0,0-diethy1 0-2-isopropyl~4—methyl-6-pyrimidyl thiophos-
`phate; diethyl 2-isopropyl-4-methyl-6-pyrimidyl thiono-
`phosphate; dimpylate; G-24480; Antigal; Basudin; Diazol;
`D-z-n; Garden Tox; HelfaCat; HelfaDog; Neocidol; Parasi-
`tex; Sarolex; Spectracide; Taberdog; Tabergat. CHI-121N203-
`PS; mol wt 304.35. C 47.36%, H 6.95%, N 9.20%, O
`15.77%, P 10.18%, S 10.54%. Prepn: Gysin, Margot, U.S.
`pat. 2,754,243 (1956 to Geigy).
`Insecticidal properties:
`Gasser, Z Naturforsch 8b, 225 (1953). Toxicity data: T. B.
`Gaines, Toxicol. App]. Pharmacol. 14, 515 (1969).
`
`H3C
`
`O
`
`0
`HSCVOQP/
`ll
`S
`
`CH3
`
`CH3
`
`N
`\
`I / N
`CH3
`
`Liquid. Faint ester-like odor. d? 1.116-1.118. bPomz 83-
`84”.
`n}? 1.4978-1.4981. Vapor pressure at 20°: 1.4X10";
`at 40°:
`1.1X10—3 (~5 times vapor pressure of parathion).
`Volatility at 20": 2.4 mg/m3; at 40°: 17.6 mg/m’. Decom—
`poses above 120°. Soly in water at 20": 0.004%. Miscible
`with alcohol, ether, petr ether, cyclohexane, benzene, and
`
`
`
`
`Page 508
`
`Consult the Name Index before using this section.
`
`AQUESTIVE EXHIBIT 1076 Page 0010
`AQUESTIVE EXHIBIT 1076 Page 0010
`A
`
`Whetsel et al., J. Am.
`:5; et al.. Acta Cryst. 17, 76'.
`mN +
`
`30,
`
`White or slightly red crysta.
`by heat, a blow, or on rubbing
`Slightly sol in cold water, alcol
`alkalies, HCl.
`USE: As reagent for phenol, i
`aldehydes, and albumin; also
`dyes.
`3048. Diazomethane. Az
`42.04. C 28.57%, H 4.80%,
`Prepd from chloroform and
`potassium hydroxide: Stand
`(1912); McManus et aL, J. Org.
`KOH and nitrosomethylurea:
`Chim. France 1963, 41. These
`methane. The following pro
`diazomethane. From N-niti
`methyl ketone in ether and i:
`sodium isopropoxide or from
`reaction with sodium cyclohexi
`Syn. 25, 28 (1945). By KO
`methylurea in ether: Arndt,
`(1943), or of nitrosomethyluret
`Ber. 27, 1888 (1894); 28, 855
`Ber. 61, 1845 (1928).
`In the 1
`be Prepd most simply by the
`mercially available N-methyl-
`C117 McKay, J. Am. Chem. Soc
`‘6; Can. J. Res. 28, 683 (195C
`t emuny (Reinhold, New Yo:
`(53am intermediate: p-tol)
`O Ia7ald” Aldrich Chemical
`"3,- Syn. e011. vol. IV, 250 (15
`diouery toxxc yellow gas. Explc
`am; Dotson, a well-ventilated
`5011:, “1"”- mp —145°; bp
`Sent may explode violently, es
`100.” 0r aseous diazomethane
`and glasgnstFOUgh glass surfac
`may 0°C
`lrrers wrth glass 51
`ex 1
`. “T, Should not be used
`sop 0510115 With diazometh
`if Ins d” Only slo 1
`am.
`alcohols
`w y at low to
`actix,e deco or Water are pres«
`mation of imp" “Eh the evolu
`Calcium chino-l White flakes of
`This Pheno 0nde or boiling s
`.
`1azomet
`0
`'
`menon appears to o
`cation; bane 0“ Solid subsi
`l”merit
`sh
`Ial sym tom
`ness 0f breath; Ihead
`zEmma; fatig‘EmOnary edmaz
`e.
`See NIOSE
`"Zar
`D
`. NIOSH 90.1
`Sensnizer.
`See Pt
`I 2A, G. D. c
`
`Phenols, e
`e reviews by
`$1.2: Angew. Chen
`"1 Newer Me
`eagemx V(Ne2w York, 1948)
`'
`(John Wiley, b
`
`Orange needles from ethanol, mp 230° (doc); also repomd
`as yellowish-brown crystals from ethanol decomposing at
`temperatures above 250“ (Petersen).
`uv max (methanol):
`340 nm (log 5 4.17). Soly in water: 0.5 mg/ml. LDsn“1
`mice (mg/m1): 30.9 i.v. (Bender).
`THERAP CAT: Antineoplastic.
`3045. Diazoacetic Ester. Ethyl diazoacetate; 8111?;
`diazoethanoate. C‘H‘NZOZ; mol wt 114.10. C 42.11%:H
`5.30%. N 24.55%, 0 28.04%.
`-N=N+=cnc00Cz“;
`Prepd by the action of sodium nitrite on glycine eth)’l 3:8)
`hydrochloride: Oirtius J. Prakt. Chem.
`[2] 33, 396 (1ij
`Silberrad, J. Chem. Soc. 81, 600 (1902); Womack, Nes
`Org. Syn. 24, 56 (1944).
`.
`Dir
`Yellow oil. P