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`Page 1 of 2
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`How does the nose work?
`The nasal mucosa
`
`The nasal cavities are lined by the nasal mucous membrane, or mucosa. The surface, or
`epithelium, contains the cells which produce mucus and the ciliated cells, covered with fine hairs
`called vibrating cilia (see illustration, below). Underneath the epithelium is a dense network of
`capillary blood vessels.
`
`The nasal mucosa is essential to correct operation of the entire respiratory system. The nose
`heats and humidifies more than 12,000 liters of air every day.
`
`The nose works as it does thanks to various defensive mechanisms: its epithelium and dense
`network of capillaries, its mucus, the vibrating cilia which move the mucus, the cells of the
`immune system and many substances capable of combating bacteria and viruses and harmful
`substances.
`
`The nose is the respiratory system’s first line of defense.
`
`The mucosa is the nose’s first line of defense
`
`https://www.fitonasal2act.com/how-does-the-nose-work/the-nasal-mucosa/
`
`11/5/2019
`
`Neurelis - EX. 2021
`Aquestive Therapeutics, Inv. v. Neurelis, Inc. - IPR2019-00451
`
`
`
`The nasal mucosa - Fitonasal 2Act
`
`Page 2 of 2
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`The mucus traps harmful substances (viruses, bacteria, dust, pollens, etc.) on the surface
`of the mucosa and the vibratory cilia move the mucus toward the pharynx to eliminate it.
`
`https://www.fitonasal2act.com/how-does-the-nose-work/the-nasal-mucosa/
`
`11/5/2019
`
`Neurelis - EX. 2021
`Aquestive Therapeutics, Inv. v. Neurelis, Inc. - IPR2019-00451
`
`
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