BIOCHEMICAL AND
`OUNDS
`
`1988
`PRICE UST
`
`1111111prcjl 111161.113151,11111111
`and DIAGNOSTIC
`CLINICAL REAGENTS
`
`TO PLACE AN ORDER
`
`TOLL FREE
`
`Chimes hover sect
`horn Anywhere in the WoiW
`1 A M to 1 PM Monday Ow, Fruity
`II AM to I PM Saturday Swat* dad flabieyi
`
` 1 800.325-3010
`
`
`
`1 800 3255052
`314-771.5757
`
`TELEPHONE
`
`USAICanada
`Outside the LISA 'Caned.
` . 314 771 5750
`call COLLECT
`Skold roe hem fin emAilme gift maim sinks or off al the deo oombon two Ca
`coma anyhow osv•imisit ealselos Wilionis and Mermielh 114131•110
`FAX
`USA
`Outside USA
`TWX or TELEX
`
`
`910 761 0593 or 434475
`Answarback • SIG OK COLLECT.
`SIGMACHEM
`Cable Address
`CUSTOMERITECHNICAL SERVICE
`
`Telephone numbers on convenient tear out card inside front cover
`Numbers also listed nn page 11
`
`SIGMA
`
`CHEMICAL COMPANY
`P.O. BOX 14508. ST. LOUIS, MO 33178 USA
`
`Neurelis - EX. 2006
`Aquestive Therapeutics, Inv. v. Neurelis, Inc. - IPR2019-00451
`
`

`

`1t
`
`TABLE OF CONTENTS
`
`DOES
`
`.
`
`3-4
`.5
` 6
`7
`.8-9
`
`. . .11
`17
`82-1508
`
` 327
`
`
`
`
`
`626
`
`638
`.656
`
`T
`A
`B
`E
`0
`
`F C
`
`
`
`1148
`i c
` .,441
`'
`1179
`POLYAMINO ACIDS
` 1214
`...,
`PROTEIN A
`1219
`PROTEIN SEQUENCING REAGENTS
` 1233
`RADIOCHEMICALS
`1291
`SPIN LABELS AND SPIN TRAPS
`
`TISSUE CULTURE MEDIA AND REAGENTS 1334
`1454
`TRICHLOROACETIC ACID ESTERS
`1471
`TRIZMA
`1495
`VENOMS
`
`EQUIPMENT
`BOOKS
`COMPUTER SOFTWARE
`
` 1509-1616
`1513
`1565
`
`STANDARDS AND CONTROLS
`INDIVIDUAL REAGENTS AND SETS . .1617-1650
`
`THIN LAYER CHROMATOGRAPHY
`REAGENTS
`SIGMA SPRAY REAGENTS FOR
`PAPER AND TLC
`ADSORBENTS FOR TLC
`
`1651-1658
`
`1652-1654
`1657-1658
`
`RESEARCH KITS AND REAGENTS . . . . . . . .1659
`Adenosine 5'-Triphosphate (ATP)
`. . . . . . .1660
`Bioluminescent Assay Kit
` 1660
`Bioluminescence Demonstration
`1662
`Cytochemistry Panel
` 1663
`Dietary Fiber, Total
`1664
`Dietary Fiber, Total, Assay Control Kit
`1665
`Esterases (Histochemical) . . . . . . .
`1668
`E-TOXATE®
`
`1669
`Factor XIII Deficient Plasma
`Gal-1-P Uridyl Transferase (Ultraviolet) . 1670
`1671
`Lymphocyte Enzymes
`1674
`B-Lymphocyte Test
`1675
`Monoclonal Antibodies
`1676
`NBT Reduction
` 1677
`Phosphatase, Acid (Histochemical)
` 1679
`Phosphatase, Alkaline
`Protein, Total (Micro Method)
`1680
`1682
`Pyrophosphate Assay
`Spectrophotometer Calibration at
`340 nm
`TdT Immunoperoxidase
`
`1682
`1683
`
`1685
`
`DIAGNOSTIC KITS AND REAGENTS .
`For: Chemistry
`Coagulation
`Electrophoresis
`Hematology
`Screening Test for Enzyme Deficiencies
`Indirect Immunofluorescence Tests
`(Kits are listed in alphabetic order)
`
`REAGENTS FOR AUTOANALYZER
`
`
`
`1825
`
`ALPHABETIC AND NUMERICAL LIST
`OF MANUAL ANALYTICAL AND
`DIAGNOSTIC PROCEDURES
`
`NEW ITEMS
`
`1835
`
`1843
`1
`
`'
`CIISTO)AER INFORMATION
`Ordering Controlled Substances
`. . . . .
`Transportation Charges
`Return Policies
`How to use this Price List
`Label Information.
`Ordering Information/
`Customer Service . . . . . . . . . . .
`:HEIIICAL CATEGORY LISTS
`ILPIABETIC LIST OF COMPOUNDS . .
`'ROUCT GROUPS:
`101
`ACS REAGENTS
`ADENOSINE TRIPHOSPHATE ASSAY KIT . 124
`130
`AFFINITY CHROMATOGRAPHY MEDIA
`177
`AGAROSE
`199
`AMINO ACID ANALYSIS REAGENTS
`272
`BIOACTIVE PEPTIDES
`313
`BIOLOGICAL BUFFERS
`316
`BIOLOGICAL DETERGENTS
`BIOLOGICAL STAINS
`322
`
`BLOOD COAGULATION •FACTORS
`AND REAGENTS
`
`CARBON43 LABELED COMPOUNDS
`AND OTHER STABLE ISOTOPES. . . . . . .369
`CHROMOSORBS
`421
`COENZYME. A AND DERIVATIVES
`431
`COLLAGEN
`436
`
`COLLAGENASE
`437
`COMPLEMENT PRODUCTS
` . .439
`CONTROLLED SUBSTANCES
`
`. 443
`CYTOCH ROME C
`467
`DEUTERATED COMPOUNDS
`487
`FERMENTATION NUTRIENTS
` 582
`GLUCOSE-6-PHOSPHATE
`DEHYDROGENASE
`GLUTATHIONE DERIVATIVES AND
`ENZYMES
`GOLD COLLOID CONJUGATES
`.H1GH PRESSURE LIQUID CHROMATO-
`; GRAF'HY SORBENTS
`
`670
` .715
`IMMUNOCHEMICALS
`ION EXCHANGERS, GEL FILTRATION AND
`CHROMATOGRAPHIC MEDIA
`ISOELECTRIC FOCUSING REAGENTS
`LASER DYES
`LECTINS
`LIPIDS
`LIPO PO L YSACCHARI D ES
`LIPOPROTEINS AND RELATED
`PRODUCTS
`MOLECULAR BIOLOGY PRODUCTS
`MOLECULAR WEIGHT MARKERS
`FOR PROTEINS
`NICOTINAMIDE COENZYMES
`OLIGONUCLEOTIDE SYNTHESIS
`REAGENTS
`
`
`ORGANOMETALLIC REAGENTS
`FOR SYNTHESIS
`PERIODATE OXIDIZED NUCLEOSIDES
`AND NUCLEOTIDES
`
`PHEROMONES
`DunCOLJATnec n, VAI tnir
`C#
`
`3788150
`5-
`135:08-
`7C
`9
`: fr t ." 54
`1-44-cr-S- 5-5
`cq •
`
`
`
`
`
`
`
`
`
`816
`828
`849
`856
`895
`914
`
`920
`977
`
`1016
`1049
`
`1081
`
`1097
`
`1116
` 1133
`1139
`
`C
`F
`
`C
`
`i
`
`Neurelis - EX. 2006
`Aquestive Therapeutics, Inv. v. Neurelis, Inc. - IPR2019-00451
`
`

`

`A FEW WORDS ABOUT OUR PRODUCTS
`
`• USE OF OUR PRODUCTS
`SIGMA RESEARCH REAGENTS ARE FURNISHED FOR LABORATORY USE ONLY.
`This means our products:
`,.. may be used in laboratory research and experiments,
`may NOT be used as DRUGS,
`... may NOT he used as COSMETICS,
`... may NOT be used as AGRICULTURAL or PESTICIDAL PRODUCTS,
`... may NOT be used as FOOD ADDITIVES, and
`... may NOT be used as HOUSEHOLD CHEMICALS.
`SIGMA DIAGNOSTIC REAGENTS ARE FURNISHED FOR IN VITRO DIAGNOSTIC USE.
`We are required to use "Due Diligence" when processing orders to ensure that our
`reagents are not purchased for drug or other use. In order to avoid delays, we recom-
`mend that orders carry the statement: "FOR LABORATORY USE ONLY. NOT FOR DRUG,
`HOUSEHOLD OR OTHER USES."
`We are unable to ship our reagents to individuals not affiliated with institutions or
`firms. Please place your order through the institution or firm with which you are affiliated.
`Food & Drug Use: Inquiries for our products for food and/or drug use are invited and
`will be considered on an individual basis under Food and Drug Administration regula-
`tions. For additional information, ask for the Sigma F & D Division.
`Commercial Use: We will consider requests for commercial use of our products. For
`additional information, ask for the Commercial Division.
`All Orders From High Schools must be: Submitted in writing and on an official school
`purchase order, with a minimum of two authorizing signatures.
`
`• TOXICITY AND HAZARDS
`Some reagents are marked with hazardous warnings; others are not. The absence of
`a warning must not be interpreted as an indication of safety. We must emphasize that
`information is not available on the possible hazards of many compounds.
`Through our experience and/or extensive literature references, we have classified
`certain items as "EXTREMELY HAZARDOUS!" If you are unfamiliar with the hazards of
`these items, please request Safety Data Sheets from our Customer Service Department
`before ordering.
`CAUTION: Failure to classify a product as "EXTREMELY HAZARDOUS!" does not
`imply lack of toxicity and hazards. Each product offered by Sigma is intended for use
`by qualified professionals who will safely handle and dispose of the products they receive.
`
`• WARRANTIES
`Sigma warrants that its products perform as described in Sigma literature. Should
`any fail for reason other than through misuse, at Sigma's option, Sigma will replace it
`free of charge or refund the purchase price.
`This warranty is exclusive and Sigma makes no other warranty, expressed or implied,
`including any implied warranty of merchantability or fitness for any particular purpose.
`Sigma shall not be liable for any incidental, consequential or contingent damages.
`For more information about the terms and conditions of sale, you should review our
`invoices and packing slips. Any customer who does not already have one of our invoices
`or packing slips may obtain a copy of our terms and conditions by writing or calling our
`Customer Service Department.
`
`2
`
`Neurelis - EX. 2006
`Aquestive Therapeutics, Inv. v. Neurelis, Inc. - IPR2019-00451
`
`

`

`UNITED STATES CUSTOMERS ORDERING CONTROLLED SUBSTANCES
`legulations issued by the United States Department of Justice, Drug Enforcement Administration (DEA) require us to obtain certain
`moments before we can ship any Controlled Substance.
`:uomers ordering products on this page for the first time must send a photocopy of their federal registration, required for
`yxlling Controlled Substances, attached to the purchase order. As your federal registration is renewed by the DEA, a photocopy
`houtd be mailed to us for updating our records. This will reduce the time needed to process your order for shipment.
`isingle $3500 See is added to multiple classes and/or items placed on one order
`.is necessary that you furnish us with the following documents when ordering Controlled Substances listed on this page in either
`the two following categories
`Your written purchase order must show:
`a) your DEA registration number,
`b) the "ship to' name and address exactly as it appears on your DEA registration certificate,
`c) your acceptance of a $3500 administrative fee Because of the special handling and processing, we have been
`forced to increase the administrative fee. This fee should be added to each
`purchase order
`d) Be sure we have a current copy of your Federal Registration Form 223 on file.
`A completed DEA-222 form is required for orders of Classes I & II items. We are not permitted to fill orders on
`altered or incomplete order forms.
`or complete product listings see our new sectIon of CONTROLLED SUBSTANCES.
`
`2
`
`BEA Sive
`lass Prated
`No
`Na
`
`Name
`
`11 a
`II
`ll
`
`A 0408 Alenaprodiee HCI
`A 5255 Amobarbital
`A 0533
`i-Amphetamine Pee Base
`A 5880
`.Amphetamine Sulfate
`A 1263
`cr. Amphetamine Sulfate
`B 4147 Benzoyiecgonme Hydrate
`8 8021 Benzoylecgonine-di
`8 0503 Butotenine Monooxalate
`C 1515 Cannabidiol
`C 6888 Cannabinot
`C 5776 Cocaine HCI
`C 5901 Codeine
`D 0524 Dextropropaxyphene SKI
`4636
`titi-Drethyttryotarnme
`6129 N N-3imelhyltryptamine
`B 6029 Diphenoxylate MCI
`E 5137 &gnome NCI
`E 3761 Ecgomne-d, NCI
`
`CLASSES 18 Il
`Sigma
`Product
`No
`
`Name
`
`DEA
`Class
`No
`
`F 3886
`I
`I H 4516
`1
`H 5136
`I 7003
`I M 3142
`1 1 5143
`M 8375
`M 8500
`M 6515
`I M 0267
`I M 8254
`I M 8750
`1 M 2771
`M 9146
`M 3637
`M 6267
`
`PA 2892
`M 6886
`
`Fentanyl Citrate
`Hydrocodone Bitartrate
`Hydrumorphone HCI
`lbogaine MCI
`Meperidine HCI
`Leyorphanol Tartrate
`Mescaline Hemisultate
`Mescaline HCI
`Mescaline Sulfate
`Methadone HCI
`m•Melhamphetamine HCI
`(+)Methamphetamine HCI
`ot-Methamphetamme-d, HCI
`Methaqualone Free Base
`Methaqualone HCI
`(+) 3,4 Methylenedtoxy-
`amphetamine HCi
`Methylphenidate HCI
`Morphine-3-0-o-Clucuromde
`
`Sigma
`DEA
`Class Product
`No
`No
`
`Name
`
`If
`it
`II
`II
`11
`II
`11
`
`II
`
`II
`
`N 7640
`N 1513
`0 1253
`0 1378
`P 3636
`P 3761
`P 3029
`P 4540
`P 3522
`S 1503
`S 1378
`T 2386
`T 2511
`T 2019
`T 2641
`
`Norcodeme NCI
`Noroxymorphone
`Opium Powder
`0 p ex ny tcoobilaconrbei t HCI
`
`Pentobarbital Sodium
`Phencyclidine HCI
`Phencyclidine-4 HCI
`Phenylacetone
`Secobarbdal
`Secobarbital Sodium
`1-Tetrahydrocannabinol
`6-Tetrahydrocannabinol
`Thebaine Alkaloid Powder
`Tropacocaine HCI
`
`Sigma
`bus Product
`to
`No
`la
`
`7662
`
`III
`dl
`fV
`IV
`111
`11'
`0
`III
`01
`w
`IV
`N
`N
`
`7537
`7141
`0375
`0500
`8263
`4144
`8380
`6638
`6763
`8383
`2517
`0531
`1277
`
`CLASSES III & IV
`SIRma
`DEA
`Class Product
`No
`No
`
`Name
`
`DEA
`Sigma
`Class Product
`No
`No
`
`Name
`
`Name
`
`AllYkrdope.ntenyl Barbituric
`Arid
`Alphenal
`Aprobarbital
`8arbeial
`Barbital Sodium
`Bearpnetarsine HCI
`Bromanam
`Bulabarbital
`Butalbnal
`Butethal
`cniorai Hydrate
`Chlordiazepoxido HCi
`ChlordlaloPOride-d.
`Clonazepam
`
`ry
`IV
`tv
`III
`N
`ni
`N
`IV
`Iv
`iv
`IV
`III
`III
`IV
`IV
`III
`IV
`
`C 1407
`O 7282
`O 1278
`D 5761
`D 0899
`▪ 0406
`D 0273
`E 3258
`F 8507
`F 9261
`F 3883
`G 6633
`H 1005
`L 1764
`L 7518
`L 5376
`M 0521
`
`Clorazepate Dipotassium
`Desmethyldiazepam
`Desmethyldiazepam-d,
`5,5-DiaitylbarbituriC Acid
`Diazepam
`Diazepam-d,
`Diethylpropion HCI
`Ethinamate
`Fenfluramine HCI
`Flundrazepam
`Flurazepam Dihydrochloride
`nr-Glutethimide
`Hexobarbital
`(t) Lorazepam
`Lormetazepam
`o-Lysergic Acid
`Medazepam
`
`IV
`IV
`111
`III
`IV
`IV
`IV
`IV
`IV
`IV
`Ill
`Iv
`IV
`IV
`IV
`Ill
`Ill
`III
`
`N
`N
`
`3887
`2392
`2142
`3135
`3889
`1880
`5520
`6260
`6527
`6652
`5645
`1636
`3654
`8275
`8653
`0894
`1019
`6023
`
`Mephobarbital
`Meprobamate
`Methyprylon
`Nalorphine HCI
`Nitrazepam
`Dozolam
`Paraldehyde
`Pemoline
`Pentazocine Free Base
`Pentazoone HCI
`Phendimetrazine Bitartrate
`Phenobarbital
`Prazepam
`Temazepam
`Phentermine !ICI
`Thiamylal Sodium
`Thiopental
`(*) Thiopental Sodium
`
`P
`P
`P
`P
`P
`P
`P
`T
`P
`T
`T T
`OTHER DEA CONTROLLED SUBSTANCES
`(Not classified, but reporting required by the DEA )
`8a16 4-Amino-2.2,6.6•Tetramethyl
`cis-2,4-Piperdine
`1-Methylpipendine
`P 3156
`M 3519
`DicarboxyliC Acid
`2-Met hylpi pe rid one
`Ptioendine
`M 2394
`css-2,5-Piperdine
`3-Methylpipendine
`7633 2-Ethylpiperidine
`M 0270
`2383 1-Ethylpiperidine
`Dicarboxylic Acid
`4-Methylpiperidine
`M 4019
`cis-2,6-Piperdine
`3013 /42-HydroxyethyDpipendine
`3-Phenylacetylamino-
`P 1789
`Dicarboxylic Acid
`2763 3-1-1ydroxymethyl-l-methyl-
`2,6-piperidinedione
`Piperidine-4-sulphonic Acid
`Pipericline
`pipendine
`2,2,6,6-Tetramethyl
`1629 3-Hydroxy-N-methyl-
`cis-2,3-Piperdine
`Pipendine
`Dicarboxylic Acid
`pipendine
`then ordering any of these items, please provide your written purchase order, your acceptance of the $3500 administrative
`the Intended ultimate use, and the signature of the end user
`Older to avoid any delay in receiving material, we suggest double-checking your order and documents for accuracy and
`Veteness before mailing them to us for processing
`thone and telegraph orders not accepted
`
`P 5881
`P 8782
`
`P 9657
`
`P 2031
`
`P 9159
`T 9264
`
`3
`
`Neurelis - EX. 2006
`Aquestive Therapeutics, Inv. v. Neurelis, Inc. - IPR2019-00451
`
`

`

`SALE OF CONTROLLED SUBSTANCES TO CUSTOMERS OUTSIDE USA
`The United States Department of Justice, Drug Enforcement Administration (DEA) regulates exporting of Con-
`trolled Substances from the United States The products listed in the classes below are available for export. However,
`other Controlled Substances listed in this catalog may become eligible for exporting in the future Please contact
`us if you have a requirement for a Controlled Substance not shown
`Sigma routinely ships these items via Air Freight or Surface Freight, F.O. B. Sigma The shipping cost will be ad-
`ded to your invoice.
`An administrative fee of $4500 is charged on each order to help defray our expenses in obtaining the necessary
`export documents Multiple orders received at the same time for the same product or a combination of items
`from the same group listed below will be subject to only one administrative fee.
`You must furnish us with the following documents when ordering from the two following groups of Controlled
`Substances:
`1. A signed, original Import License or import Permit issued by your government agency which cor-
`responds to the US. Department of Justice, Drug Enforcement Administration. The Import Permit
`may be in the form of a letter from your drug agency advising us that you are authorized to import
`these items.
`2. A signed statement from you stating that these substances will be used exclusively for scientific pur-
`poses and will not be exported
`For complete product listings see our new section of Controlled Substances.
`Classes f & II
`DEA
`Class
`No.
`
`DEA
`Class
`No
`
`Sigma
`Product
`No.
`
`Name
`
`0408 Alphaprodine Hydrochloride
`A
`5255 Amobarbital
`A
`5880 o-Amphetamine Sulfate
`A
`1263 of-Amphetamine Sulfate
`A
`t-Amphetamine Free Base
`0533
`A
`4147 Benzoylecgonme Hydrate
`B
`8021 Benzoylecgonine-d,
`B
`5776 Cocaine HCI
`C
`5901 Codeine
`C
`0 0524 Dextropropoxyphene HCI
`D 6029 Diphenoxylate HCI
`3886 Fentanyl Citrate
`F
`4516 Hydrocodone Bitartrate
`H
`H 5136 Hydromorphone HC1
`5143 Levorphanol tartrate
`L
`M 3142 Meperidine HCI
`
`DEA
`Class
`No.
`Ili
`
`III
`III
`IV
`IV
`II
`II
`II
`V
`V
`V
`11
`V
`
`A
`
`Name
`
`Sigma
`Product
`No.
`7662 Allycyclopentenyl Barbituric
`Acid
`7537 Alphenal
`A
`7144 Aprobarbital
`A
`0375 Barbital
`B
`13
`0500 Barbital Sodium
`B 8263 Benzphetamine NCI
`B 8380 Bulabarbital
`6638 Butalbital
`B
`C
`8383 Chloral Hydrate
`C
`1277 Clonazepam
`D
`7282 Desmethyldiazeparn
`5761 5,5-Diallylbarbituric Acid
`D
`0 0273 Diethylpropion HCI
`
`Classes III & IV
`DEA
`Class
`No.
`
`IV
`IV
`III
`I11
`V
`IV
`IV
`III
`IV
`V
`IV
`III
`IV
`V
`III
`11
`Ill
`
`Name
`
`Sigma
`Product
`No.
`M 0267 Methadone HCI
`M 8254 ot-Methamphetamine HCI
`M 8750 (+)Methamphetam ne HCI
`M 6267 {+)3,4 Melhyleiedioxy-
`amphetamine HCI
`M 2892 Methylphenidate HCI
`7640 Norcodeme HCI
`N
`1513 Noroxymorphone
`N
`0 1253 Opium Powder
`0 1378 Oxycodone HCI
`3636 Pentobarbital
`P
`3761 Pentobarbital Sodium
`P
`3522 Phenylacetone
`P
`1503 Secobarbitat
`S
`1378 Secobarbital Sodium
`S
`2019 Thebaine Alkaloid Powder
`T
`
`F
`
`G
`H
`I
`
`Sigma
`Product
`Name
`No.
`3258 Ethrnamate
`3883 Flurazepam Dihydrochloncle
`6633 ot-Giutethimide
`1005 Hexobarbital
`7518 Lormetazepam
`3887 Mephobarbital
`M 2392 Meprobamate
`M 2142 Methyprylon
`3889 Nitrazepam
`N
`0 1880 Oxazolam
`5520 Paraldehyde
`P
`5645 Phendimetrazine Bitartrate
`P
`1636 Phenobarbital
`P
`8653 Prientermine HCI
`P
`0894 Thiarnylal Sodium
`T
`1019 Thiopental
`T
`T
`6023 (±)Thiopental Sodium
`
`A
`
`H
`
`Other DEA Controlled Substa aces
`(Not classified, but reporting required by the DEA )
`8896 4-Amino-2,2,6,6-Tetramethyl
`P
`7789 3-Phenylacetylamino-
`Pipe/dine
`2,6-piperidinedione
`7633 2-Ethylpipendine
`5881 Piperidine
`E
`8782 cis-2,3-Piperdine
`2383 1-Ethylpiperidine
`E
`H
`3013 1-(2-Hydroxyethyl)piperrdine
`Dicarboxyhc Acid
`H 2763 3-Hydroxymethy1-1-methyl-
`3156 cis-2.4-Piperdine
`piperidine
`Dicarboxylic Acid
`1629 3-Hydroxy-N-methyl-
`9657 cis-2.5-Prperdine
`pipendine
`Dicarboxylic Acid
`M 3519 1-Methy lope
`ne
`2031 cis-2,6-Piperdine
`M 2394 2-Methylpiperidine
`Dicarboxylic Acid
`M 0270 3-Methylpipenchne
`9159 Piperidine-4-su!phonic Acid
`M 4019 4-Methylpiperidine
`9264 2,2,6.6-Tetramethyl
`Piperidine
`
`P
`P
`
`P
`
`P
`
`P
`T
`
`When ordering any of these items, please provide your written purchase order, your acceptance of the
`$45.00 admin►strative fee, the intended ultimate use, and the signature of the end user.
`In order to avoid any delay in receiving material, we suggest double-checking your order and documents
`for accuracy and completeness before mailing them to us for processing
`
`4
`
`Neurelis - EX. 2006
`Aquestive Therapeutics, Inv. v. Neurelis, Inc. - IPR2019-00451
`
`

`

`SHIPPING INFORMATION
`For over 35 years, Sigma has been paying almost all transportation charges. During the last few years, we have
`ad an explosion of regulations and an increased awareness of hazards. We have been able to maintain our original
`risky of no minimum charge and to pay shipping costs. There are certain situations where our preferred method
`of shipment (which we consider to be safe, secure and economical) is not acceptable to our transportation agents,
`forting us to alter our policy of paying transportation costs Items which may fall into these situations are identified
`WU SIGMA in our catalog. The only other case where we ask you to pay transportation costs is if you request
`unto ship via air those items which are normally shipped via surface.
`On a continuous basis, Sigma is doing everything possible to get relief from this deterrent to our "normal"
`plicy of paying the shipping costs. We are working with local, national and international groups to get exemptions
`tor shipments of small quantities of hazardous chemicals In our opinion, there is very little rationale for refusing
`slipments of very small quantities of hazardous substances properly packaged in safe containers.
`DOMESTIC SHIPMENTS
`One example where someone has listened to us: the U.S. Department of Transportation (D 0.T.) and U.S. Postal
`Service have granted exemptions from certain shipping requirements for transporting small packages of hazardous
`materials in the United States. Whenever possible we will take advantage of this exemption.
`ff we cannot take advantage of the U.S D.O.T. guideline for your domestic shipment, to avoid charging expen-
`se transportation costs we can ship by our "normal" methods using Poison Packs ($8.50 will be charged) or
`Wooden Boxes ($10.00 will be charged). We wilt combine alt compatible items in a single container whenever possi-
`ble for shipping in Poison Packs or Wooden Boxes.
`INTERNATIONAL SHIPMENTS
`Even though we feel we have the finest and fastest means of distributing chemicals world-wide, hazardous items
`slit cause shipping problems and create additional costs. One method we use to minimize your shipping costs for
`hazardous items is consolidated air freight and subsequent distribution to you via local methods. Unfortunately,
`customs or other regulations prevent us from doing this in all countries.
`We will continue to do everything possible to minimize your shipping costs, but YOU ALSO CAN HELP US to
`continue to lower the costs 01 shipping your orders.
`• Ask your local airline(s) and postal authorities to adopt the U.S. D 0 T. guidelines.
`• Consolidate your orders of hazardous items so that airfreight costs can be spread over as many products
`as possible; air carriers, trucklines and shipping companies have minimum charges.
`• Authorize accumulation of hazardous chemicals. We will ship when we have sufficient material to exceed the
`minimum charge.
`• Consolidate orders from several departments of your institution; we can bill each separately as you instruct
`• Advise the best route for hazardous items which must be shipped by air cargo only (no passenger) planes,
`as some countries no longer have air cargo services.
`• State on your order that you are aware of possible additional FOB freight charges. This will allow us to process
`your order promptly.
`• Ask your favorite dealer to stock these items for you.
`If you are aware of any other means of getting hazardous shipments to you, please advise us.
`The foregoing information is correct as we understand the current regulations. However, there are numerous
`additional restrictions based upon toxicity, carcinogenicity and possible other factors that may affect our handling
`of this problem in the future
`
`STORAGE - DRY ICE
`Recommended Storage is indicated below each product number in the product listing, as follows*
`azo*dl
`= DEEP FREEZE
`I-20(rcl = FREEZER
`C7) = ULTRACOLD
`lo-s*c1
`= REFRIGERATOR
`E21 = FREEZER
`EJ = ROOM TEMPERATURE
`Items requiring storage at other than ambient temperature, but not requiring ice for shipment, will be shipped
`urder conditions that will ensure the quality of the product
`For shipments within the continental USA (excluding Alaska) of items requiring ice, package prices also include
`ice,container and freight. For shipment outside the USA see approximate Dry ice shipping costs below.
`Slapping weight of Dry Ice and container is about 35 lbs We try to estimate Dry Ice needed; but we cannot
`predicuime lost in Customs offices or en route. The customer is responsible for prompt Customs clearance. If you
`cannot ensure prompt Customs clearance, be sure to order additional dry ice, and always specify which airport
`you prefer
`
`
`
`The estimated airfreight F.O.B. costs to typical destinations are:
`$ 54 00
`Africa
`.$224.00
`Canada
` $ 75.00
`Mexico
`138.00
`Europe.
`Alaska
`104.00
`New Zealand
` .204.00
`Hawaii ..... .... ,.. ... ..79.00
`175 00
`South America .. .168 00
`Asia
`India.... ...... ... .. ...192.00
` 244.00
`Australia
`Hazardous items cannot generally be included with your ice (dry or wet) airfreight shipments. if your order con-
`sists of both an ice and hazardous shipment, please acknowledge that you expect two airfreight shipments; one
`for the ice shipment and one for the hazardous shipment.
`
`5
`
`Neurelis - EX. 2006
`Aquestive Therapeutics, Inv. v. Neurelis, Inc. - IPR2019-00451
`
`

`

`RETURN PRIVILEGES & POLICIES
`
`Sigma is certainly unique with regard to policies of cooperation, whereby we will do almost any
`thing to help you with your problems, but one matter in which we are rather stubborn is the accer
`tance of returns. Policies have been developed through the years which we feel are extremely fai
`and cover almost every conceivable situation. To avoid future misunderstandings, we have outline
`these policies here:
`
`Any reagent offered by Sigma is unconditionally guaranteed to be "satisfactory" to you. An
`reagent that does not perform as it should when you use it may be replaced without charge an.
`postage paid anywhere in the world. We do not care how old the reagent is or if it was damage,
`in ',,our own laboratory by improper storage conditions. If you have any problem using one of ou
`reagents and feel that a personal conversation would be helpful, please telephone the Custome
`Service Department collect. We want you to tell us when you find something wrong and we as
`for an opportunity to replace the materials. However, government directives that require expiratio
`dating before deterioration occurs, make it impossible for us to replace such items after the expire
`tion date has been reached. Preferably, we hope you will advise us of your problem before makin,
`the return. Please telephone (collect) the Customer Service Department for return shipping instruc
`Lions and a Returned Materials Number to identify an authorized return. Unidentified returns ma
`be discarded; unauthorized returns will not be accepted.
`
`Any reagent which we ship to you because of an error on our part is, of course, immediatel
`returnable for replacement. Should this happen, not only the replacement but our sincere apolc
`gies for the inconvenience we have caused you will go with the shipment. Sometimes purchas
`orders are received which are not clear. A stock number is given together with an item descriptio
`and they do not jibe. Such orders must be carefully scrutinized and compared with the customer'
`history in order to make a decision—to ship or not to ship—without delaying your work. If we writ.
`to you for clarification, you may be irritated with the delay. If we ship without writing to you first
`we are similarly risking your ire. Then when the inevitable return is made, we prefer to discard thi
`reagents and charge it off to experience. Sometimes this is quite expensive to us, but you ar,
`entirely within your rights in sending it back. Here again, if time is of the essence, you may tele
`phone us collect to bawl us out and ask that the correct item be shipped without further dela
`
`Items that you receive because of your error are not returnable for credit. We certainly war
`to be cooperative and pleasant in every way, but to accept returns because you are overstocke'
`or have discontinued use of the reagent, or any of many other reasons would result in a tremen
`dous loss to us unless we were to pass the expense on to other customers in some fashion. Althougl
`practically all other dealers will accept the return or a sealed package and resell it to someone
`else, we feel this could seriously jeopardize the work of the next customer. Once an torn has beer
`out of our control, we do not think it is fair to ask another customer to accept it. We acknowledge
`that in most cases the reagents are still entirely up to standard in every way and no harm wouk
`be done. However, in a small percentage of cases, purity or activity of the reagent is serious!,
`affected by the extra trip, or by improper storage at the other end, or even by contamination. I
`is impossible for us to detect all of these possibilities and we could not resell that item wit!
`complete confidence. Fortunately, the vast majority of our customers are aware of Sigma's meticulous
`attention to detail and understand that this policy is one of many that give them confidence it
`Sigma. Instead of resenting this policy, many letters come to us expressing appreciation for it
`Occasionally, we encounter a particularly stubborn individual typified by the expression, "My mint
`is made up; don't confuse me with facts!" who refuses to listen to reason and is only concernec
`with the refund. Of course, this person would be the first to refuse a shipment of a reagent if tolc
`in advance that it was returned merchandise. When such an individual is encountered, wt
`personally want to talk to the customer and do everything possible to work out an agreeable solu
`tion to the problem. We sincerely want our customers to feel that "It's a pleasure doing business
`with Sigma. You must be satisfied or there is no cost."
`
`Please Inspect your packages upon receipt and inform us Immediately of any damage. Shoulc
`a product be found damaged, please retain the original shipping carton, shipping documents anc
`any documents that might indicate that the shipment was received in a damaged condition.
`
`THANK YOU FOR TAKING TIME TO READ ABOUT THE SIGMA POLICY.
`WE ARE SURE THAT IT HAS HELPED US TO HELP YOU.
`
`6
`
`Neurelis - EX. 2006
`Aquestive Therapeutics, Inv. v. Neurelis, Inc. - IPR2019-00451
`
`

`

`HOW TO USE THIS PRICE LIST
`
`the products in this price list are divided into various sections:
`RESEARCH AND ANALYTICAL KITS
`ALPHABETICAL LIST OF COMPOUNDS
`DIAGNOSTIC KITS AND REAGENTS
`EQUIPMENT, BOOKS AND SUPPLIES
`REAGENTS FOR AUTOANALYZERS
`STANDARDS AND CONTROLS
`CHROMATOGRAPHY SUPPLIES
`'he alphabetical section contains specialty groups such as Affinity Chromatography, Bioactive Peptides,
`'issue Culture. A complete list of these special groups may be found in the Table of Contents on page
`. These sections are indicated by a black border around the edge of the page and special headings
`it the top of the page. Note that these sections interrupt the alphabetical list of compounds where they
`ippear. Immediately following the section, the alphabetical list picks up where it left off.
`lelow are 5 listings which are typical formats for our product listings.
`
`2.
`
`1.
`
`19.
`
`18.
`
`J 1250 units 10 50
`
`1,000 units 34 10
`
`7
`
`9
`
`(UMBER.
`Ap HYPDXANTH1NE-GUANINE
`13389 PHOSPHORIBOSYL
`.; c c
`TRANSFERASE
`cop (HCPRT. Transphophoribosidase,
`4
`IMP pyrophosphate phosphoribosyltransferase,
`I
`EC 2 4 2 8)
`From Bakers Yeast
`Lyophilized powder containing approx. 80%
`protein (Biuret) and 5% MgCl2, balance primarily
`Iris buffer salts
`Activity 300.600 units per mg protein
`Unit Definition One unit will catalyze the
`formation of I nmole of inosine
`Y-monophosphate (IMP) per min from
`hypoxanthine and phosphonbosyl pyrophosphate
`a! pH 7 4 at 37°C
`May be useful in the enzymatic determination of
`phosphonbosyI pyrophosphate (PRPP)
`-• Ref : Salerno, C , et al , Experientia, 35, 1016
`(1979)
`CHLOROMETHYLD1METHYL-
`:0523 CHLOROSILANE (p s)
`
`PRODUCT
`NUMBER
`L-a-LYSOPHOSPHATIDYLCHOLINE
`(L-a-Lysolecithin)
`
`17.
`
`A- Type 111: Approx 99%.*
`L 5004 From Bovine Liver
`White powder.
`=
`Prepared by the action of
`phospholipase A on bovine liver
`L-a-phosphatidylcholine (P 7763).
`Contains primarily paimitic and stearic acids
`
`5 mg 10 75
`25 mg 33.20
`100 mg 106.05
`
`115.
`
`Ao- Type V: Approx. 99%
`L 1381 From Bovine Brain
`Prepared by the action of
`LcIc
`phosphoiipase A on bovine brain
`L-a-phosphatidylcholine (P 6638)
`Contains primarily palmitic, stearic and oleic
`acids.
`
`14.
`
`8 85
`5 mg
`25 mg 28 05
`100 mg 76 65
`
`Inquir
` 7
`
`13.
`
`11. (pfs) - Prepared for Sigma, not prepared in
`our own laboratories. Located immediately
`after the product name when appropriate.
`12. FOB Sigma - see page 5 for complete
`explanation. Located in this position when
`applicable.
`13. Inquire - For current status please call for
`availability.
`14. Type - convenient classification to
`distinguish various preparations.
`15. Other descriptive information
`16. Products with various salt forms, purities,
`sources, or preparations are listed with
`common information above the related
`group of compounds. In the example, the
`name and synonym for 1.-a-Lysophospha-
`tidylcholine is common to both Type 111 and
`Type V (differ in source only).
`17. Purity
`18. Synonym
`19. Package Size(s) and Price(s)
`
`e;00,-,
`
`de
`
`7
`
`18 85
`25g
`60 95
`100 g
`FOB Sigma
`
`4-0-0-0-GALACTOPYRANDSYL-
`G 8269 o-GALACTOPYRANOSE
`(a-o-GaI41-41-o-Gal)
`
`11.
`
`12.
`
`1. Product Name
`2. Air symbol - Product is shipped by air
`or best method. Method of shipment is
`dependent upon country of destination,
`nature of product, and available modes
`of transportation. See page 5 for
`additional information.
`3. Product Number
`4 Storage Temperature
`Recommended storage is indicated as
`follows:
`f-o•c
`-•• ULTRACOLD
`= FREEZER
`co-s•cl
`DEEP FREEZE
`= REFRIGERATOR
`af
`= FREEZER
`= ROOM TEMPERATURE
`5 New products for this price list
`6. Enzyme Commission number
`7 Source
`B- Activity specification
`9 Unit definition for activity
`0- Technical reference - related to
`preparation, application or explanation
`of product.
`
`Neurelis - EX. 2006
`Aquestive Therapeutics, Inv. v. Neurelis, Inc. - IPR2019-00451
`
`

`

`SI