AQUESTIVE EXHIBIT 1076 Page 0001
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`AQUESTIVE EXHIBIT 1076 Page 0001
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`

`

`CeRRLeI
`
`THE
`
`MERCK INDEX
`
`AN ENCYCLOPEDIA OF
`
`CHEMICALS, DRUGS, AND BIOLOGICALS
`
`TWELFTH EDITION
`
`Susan Budavari, Editor
`Maryadele J. O'Neil, Senior Associate Editor
`Ann Smith, Associate Editor
`Patricia E. Heckelman, Assistant Editor
`Joanne F. Kinneary, Assistant Editor
`
`Published by
`Merck Research Laboratories
`Division of
`
`MERCK & CO., Inc.
`
`Whitehouse Station, NJ
`
`1996
`
`AQUESTIVE EXHIBIT 1076 Page 0002
`
`AQUESTIVE EXHIBIT 1076 Page 0002
`
`

`

`
`
`MERCK & CO., INC.
`WhitehouseStation, N.J.
`US.A.
`
`1st Edition—1889
`2nd Edition—1896
`3rd Edition—1907
`4th Edition—1930
`5th Edition—1940
`6th Edition—1952
`7th Edition—1960
`8th Edition—1968
`Oth Edition—1976
`10th Edition—1983
`11th Edition—1989
`
`Library of Congress Catalog
`Card Number 89-60001
`ISBN Number 091 1910-12-3
`
`First Printing—March 1996
`Second Printing—April 1997
`
`Witht
`
`century «
`ciplinary
`lished in
`cation ov
`the text
`biochem
`tion of iu
`of discip
`mind, bu
`lence in.
`This e
`which m
`ticals, ov
`and anot
`tional 1,(
`almost 1
`hundred«
`A num
`lished in
`chemical
`chemical
`scriptors
`readershij
`1983 in th
`of Chemi
`panded. §
`some of1
`and immt
`In reco
`reference
`major onl
`whichis t
`Compa:
`unparallel
`ronment,
`refer to Tl
`by Merck
`the traditi:
`
`Copyright © 1996 by MERCK & CO., INC.
`All rights reserved. Copyright under the Universal Copyright Convention
`and the International Copyright Convention.
`Copyrightreserved under the Pan-American Copyright Convention.
`Printed in the U.S.A.
`
`AQUESTIVE EXHIBIT 1076 Page 0003
`AQUESTIVE EXHIBIT 1076 Page 0003
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`

`

`0
`
`rackets indicates optical rotation
`
`Bu
`
`butyl
`
`ca.
`
`al similari-
`
`iged alpha-
`mberorder.
`=
`os
`derivatives.
`unspecified
`
`BOC
`oe
`oil.
`bp
`
`Abbreviations and Selected Definitions
`Please consult the Glossary (Misc. Tables Section) for additional definitions.
`adenine; adenosine; absorbance
`A.S.T.M.
`American Society for Testing
`A
`2 (extinction)
`Materials
`.
`ngstrom units
`as-, asym-
`asymmetrical, unsymmetrical
`A
`o-antitrypsin
`atomic
`at.
`‘AAT
`antibody
`ATCC
`American Type Culture Collection
`Ab
`absolute; absorption
`atm, atmos
`atmosphere(s), atmospheric
`abs
`aot configuration
`at. no.
`atomic number
`abs config
`abstract .
`ATP
`adenosine triphosphate
`abstr
`;
`a-aminobutyric acid
`ATPase
`adenosine triphosphatase
`‘Abu
`e. Inclusion
`acetyl CH;CO—
`at. wt.
`atomic weight
`Ac
`sement, but
`according
`BAN
`British Approved Name
`acc
`angiotensin converting enzyme
`B cell
`bone marrow or bursa of Fabricius
`ACE
`RAPEUTIC
`acetyl coenzyme A
`derived cell
`Acetyl CoA
`)
`paragraphs
`acetic anhydride
`BCG
`Bacillus Calmette-Guerin
`Ac,O
`p
`:
`ethyl acetate
`Baumé(a specific gravity scale)
`Bé
`AcOEt
`al properties
`oe acid
`2
`Beilstein
`Raliiein’s Bendeh der
`AcOH
`srmation Gf
`acyl carrier protein
`rganischen Chemie
`A
`American Chemical Society
`Belg.pat.
`Helen patent
`ACS.
`ad to consult
`airenadoeiifotropte hormone
`Ber.
`Cee eee (Berichte der
`ute -
`saat
`acyl coenzyme
`eutschen Chemischen
`Acy!SCo.
`_info
`antibody-dependentcellular
`Gesellschaft)
`ADCC
`ie respective
`cytotoxicity
`BGG
`bovine gammaglobulin
`p'
`adding, addition
`biological
`biol
`add(n)
`adenine
`BLOS.
`British Intelligence Objectives
`Ade
`algehel dehydrogenase
`Subcommittee
`ADH
`antly updated
`adenosine diphosphate
`tert-butoxycarbonyl
`ADP
`:
`ates States) Atomic Energy
`biochemical ae demand
`AEC
`ae each
`ommission
`oilin:
`in index.
`antigen, silver
`hasepait boiling point; boils at;
`Ag
`1
`-
`anaphylotoxin inhibitor
`boiling atExample: bp7o 48°
`AI
`a glossary,
`AIDS eee
`ee bats at 48°C ifthe pressure
`‘.
`. is70mm
`
`ion contained
`Ala
`alanine |
`British_
`B.P.
`h
`alc, alcoh
`alcohol(ic); ethanol; ethyl alcohol
`British Pharmaceutical Codex
`nat be
`B.P.C.
`er can
`a
`aie globulin
`Brit. pat.
`British patent
`nces arisin
`alkali(ne)
`_
`;
`BRM
`biological response modifier
`
`
`
`
`ie specific opticalrotation at 25°C for|BSA: e [ale bogie enumalbanian
`
`cordingly, rei-
`pee absence of
`Btu
`British thermal units
`o ie and
`ofa liquid in a 1 decimetercell,
`Bz
`heey C.H;CO—
`de in
`the nex
`neat
`BzH
`benzaldehyde
`
`ALS anti-lymphocyteserum, amyotrophic|BzOH benzoic arid
`
`lateral sclerosis
`;
`c
`concentration by volume (g/100ml)
`amy,
`molar absorptivity (concn in
`after optical rotations only
`g-moles/l)
`GC
`cytosine; cytidine; complement
`amorph
`amorphous
`Centigrade degrees; Celsius
`°C
`adenosine5’-monophosphate
`degrees
`AMP
`cAMP
`\epeeacid)
`Cc,
`ee ee (constant pressure)
`cyclic
`circa) about
`aus)
`aaeenl ,
`oe
`ieneAbstracts
`calorie(s
`c
`amount(s
`ANF
`anti-nuclear factor; atrial natriuretic
`calc(d)
`calculate, calculated
`factor
`Can.pat
`Canadian patent
`anhydr
`anhydrous
`Cbz
`carbobenzoxy
`stereodescriptor, see Glossary
`cbe
`complete blood count
`anti
`ou,
`coe aed’s Annalen der Chemie
`cc
`cubic centimeter(s) (milliliter)
`merican
`Pharmaceutical
`CCK
`cholecystokinin
`Association
`cD
`Greatilae dichroism
`approx
`approximate(ly)
`;
`CDP
`cytidine diphosphate
`alum precipitated toxoid
`CEA
`carcinoembryonic antigen
`APT
`al
`aqueous
`of.
`(confer) compare
`.
`A
`.
`CFA
`complete Freund’s adjuvant (same as
`-R.
`analytical reagent
`FCA)
`ARC
`AIDSrelated complex
`CFT
`complementfixation test
`Archiv Exp.
`Naunyn Schmiedebergs Archivfiir
`coronary heart disease
`CHD
`rear
`Experimentelle Pathologie und
`CHF
`congestive heart failure
`harmakol.
`Pharmakologie
`chem
`chemical
`re is
`aromatic acyl radical
`Chem. Commun.
`Journal ofthe Chemical Society,
`arginine .
`;
`Chemical Communications.
`Ac
`nN a
`B-carboxyaspartic acid
`Ci
`curie
`ia
`asparagine
`CI.
`Colour Index (British)
`a Sp
`aspartic acid
`cis-
`stereodescriptor, see Glossary
`ssoc(d)
`association; associated
`cm
`centimeter(s)
`
`xiii
`
`AQUESTIVE EXHIBIT 1076 Page 0004
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`

`
`
`monomeric units in the polymer) D.R.P.
`
`ds
`
`dyn
`(E)-
`1%
`Eicm
`
`O-(carboxymethyl) cellulose
`cell-mediated immunity
`cell-mediated lymphocytotoxicity
`cytidine 5'-monophosphate (cytidylic
`‘acid)
`central nervous system
`coenzyme A
`collective volume
`compound
`composition
`concanavalin A
`concentrated
`concentration
`configuration
`constituent
`continued
`containing
`coenzyme Q (ubiquinone)
`corrected |
`corresponding, corresponds
`centipoise
`chemically pure
`compound
`critical pressure
`critical temperature
`crystalline, crystals
`crystallization
`colony stimulating factor; cerebral
`spinal fluid
`Cosmetic, Toiletry and Fragrance
`Assoc.
`cytidine triphosphate
`cysteine
`cytosine
`density; specific gravity (di? specific
`gravity at 19° referred to water at
`dextro(rotatory), the opposite of 1
`dextro (in configurational sense
`only), the opposite of L
`daltons
`O-(diethylaminoethyl)cellulose
`decompose(s), decomposition
`decomposition
`degree
`deliquescent
`indicates the locant of the double
`bond
`derivative
`determination
`diisopropyl fluorophosphateor
`diisopropyl phosphofluoridate
`dihydroalanine
`dehydrobutyrine,
`§-methyldehydroalanine
`difference
`dilute, diluted, dilution
`distillation
`racemic
`optically inactive by external
`compensation as contrasted with
`meso-
`decimeter(s)
`dimethylacetamide
`disease modifying antirheumatic drug
`dimethylformamide
`dimethylsulfoxide
`deoxyribonucleic acid
`complementary DNA
`mitochondrial DNA
`deoxyribonuclease
`2,4-dinitro-1-fluorobenzene
`oAtipirepeny or 2,4-
`dinitrophenol
`dihydroxyphenylalanine
`degree of polymerization (number of
`
`CM-cellulose
`CMI
`CML
`CMP
`
`CNS
`CoA or CoASH
`coll. vol.
`compd
`compn
`Con A
`conc(d)
`concn
`config
`constit
`contd
`contg
`CoQ
`cor(r)
`corresp
`cp
`CP.
`cpd
`crit press
`crit temp
`cryst
`crystn
`CSF
`
`CTFA
`
`CTP
`
`yt
`
`d d
`
`-
`D-
`
`Da
`DEAEcellulose
`dec, decomp
`decompn
`deg
`deliquesc
`A (delta)
`
`deriv
`determn
`DFP, DIFP, DIPF
`
`Dha
`Dhb
`
`diff
`dil(d), (n)
`distin
`dl-
`DL-
`
`dm
`DMA
`DMARD
`DMF
`DMSO
`DNA
`cDNA
`mtDNA
`DNAase
`DNFB
`DNP
`
`Dopa
`dp, DP
`
`(Deutsches Reichs-Patent)-German
`patent
`double stranded
`dithiothreitol
`dynes
`entgegen, stereodescriptor, see
`Glossary
`the absorbanceof a solution
`containing one gram per 100 ml
`contained in a cell having an
`absorption path of one cm
`molar extinction coefficient (concn in
`g-moles/l)
`excitatory amino acid
`erythrocyte coated by antibody and
`complement
`experimental allergic
`encephalomyelitis
`electron capture
`eosinophil chemotactic factor of
`anaphylaxis
`electrocardiogram
`Enzyme Commission Number
`edition
`effective dose
`editor(s)
`ethylenediaminetetraacetic acid
`electroencephalogram
`(exempli gratia) for example
`epidermal growth factor
`the same (authors), plural of idem
`European Inventory of Existing
`Chemical Substances
`i
`electrocardiogram
`enzyme-linked immunosorbentassay
`electromotive force
`ethylenediamine (in formulas)
`stereochemical descriptor, see
`Glossary
`Environmental Protection Agency
`erythropoietin; European Patent
`Office
`molar extinction coefficient (concn in
`g-moles/1); dielectric constant
`equation
`equilibrium
`equivalent
`especially
`electrostatic units of electrical charge
`ethyl C,H;—
`viscosity
`(et alii) and others
`et cetera
`ether
`ethyl alcohol
`European patent application
`electron volt
`evacuated
`evaporation
`stereochemical descriptor, see
`Glossary
`experimental(ly)
`extract, extracted
`externally
`Fahrenheit degrees; also Fourneau
`fructose 1-phosphate
`fructose 6-phosphate
`fatty acid
`fast atom bombardment
`flavin adenine dinucleotide (reduced
`form)
`Freund’s complete adjuvant (same as
`CFA)
`ferredoxin
`Food and Drug Administration
`(U.S.A.)
`Food, Drug and Cosmetic (U.S.A).
`
`=pSO
`
`DeeBRPenfefrhedeSderMedehbehPoh
`
`ieeectsSSSSeecee
`
`FIAT
`
`FMN (FMNH))
`
`Fmoc
`Fortschr. Chem.
`Org. Naturst.
`
`fp
`FP
`FPLC
`Fr.pat.
`Frdi.
`
`GI
`g/l
`Gla
`Gle
`GLC
`GIcA
`GleN
`GlcNAc
`GICUA
`Gln
`Glu
`GluA
`Gly
`Glycerol-3-P
`Gmelin’s
`
`GMP
`
`cGMP
`GM-CSF
`
`gov't
`G
`
`(epsilon)
`
`eq
`equilib
`equiv
`esp
`esu
`Et
`1 (eta)
`et al.
`etc.
`Et,O
`EtOH
`Eur. pat. Appl.
`ev
`evac
`evapn
`exo-
`
`expt(ly)
`ext(d)
`extern
`°F
`F-1-P
`F-6-P
`FA
`FAB
`FAD (FADH)
`FCA
`
`Fd
`F.D.A.
`
`FD&C
`
`AQUESTIVE EXHIBIT 1076 Page 0005
`AQUESTIVE EXHIBIT 1076
`Page 0005
`
`
`xiv
`
`€
`

`

`graft-versus-host
`habitat
`homoarginine
`hemoglobin
`carbon monoxide hemoglobin;
`carboxyhemoglobin
`oxyhemoglobin
`humanchorionic gonadotropin
`homocysteine
`high density lipoproteins
`cells ofthe first continuously
`cultured (human cervical)
`carcinomastrain
`human gammaglobulin
`human growth hormone
`histidine
`human immunodeficiencyvirus
`ot-hydroxyisovaline
`human leukocyte antigen
`3-hydroxy-3-methylglutary]
`coenzyme A
`a German collection of medicinal
`patents
`Houben-Weyl Methoden der
`Organischen Chemie, a German
`collection of preparative methods
`in organic chemistry
`high performance(pressure, power)
`liquid chromatography
`hour
`human serum albumin
`homoserine
`.
`herpes simplex virus
`hydroxytryptamine (serotonin)
`cee T lymphotropicvirus see also
`hydroxylysine
`hydroxyproline
`optically inactive by internal
`compensation asi-inositol; archaic
`for meso-
`inosine
`Lregion antigen
`International Association of Cancer
`Registries
`International Agency for Research on
`Cancer
`IARC Monographs on the Evaluation
`of Carcinogenic Risk of Chemicals
`to Man
`(ibidem) at the same place
`Interstate Commerce Commission
`incomplete Freund’s adjuvant (same
`as FIA)
`interstitial cell-stimulating hormone
`(same as LH)
`insulin dependent diabetes mellitis
`the same (author); plural: eidem, the
`same(authors)
`inosine diphosphate
`(id est) thatis
`Isoelectric focusing
`interferon
`intragastric
`immunoglobulin
`Interessengemeinschaft der
`Farbenindustrie, Aktiengesellschaft-
`the German dye trust
`insulin-like growth factor |
`interleukin
`isoleucine
`intramuscular
`inosine 5'-monophosphate (inosinic
`acid)
`including
`incompatibility
`International Nonproprietary Name
`
`
`
`GVH
`habit.
`Har
`Hb
`HbCO
`
`HbO,
`HCG
`Hey
`HDL
`HeLa
`
`HGG
`HGH
`His
`HIV
`Hiv
`HLA
`HMG-CoA
`
`Houben
`
`Houben Weyl
`
`HPLC
`
`hr
`HSA
`Hse
`HSV
`HT
`HTLV
`
`Hyl
`HypL-
`
`IT
`
`a
`IACR
`
`IARC
`
`IARC Monographs
`
`ibid.
`LEG:
`ICFA
`
`ICSH
`
`IDDM
`idem
`
`IDP
`Le.
`JEF
`IF, IFN
`ig.
`Ig
`1G. Farben
`
`IGF-1
`IL
`Tle
`im.
`IMP
`
`incl
`incompat
`INN
`
`1-fluoro-2,4-dinitrobenzene
`fructose 1,6-diphosphate
`following
`free fatty acid
`free from chlorine
`Freund’s incomplete adjuvant (same
`as ICFA)
`Field Information Agency, Technical
`(U.S. reports)
`flavin mononucleotide (reduced
`form); same as riboflavin
`phosphate
`9-fluorenyimethoxycarbonyl
`Fortschritte der Chemie Organischer
`Naturstoffe (Progress in the
`Chemistry of Organic Natural
`Products)
`freezing point
`flavoprotein
`fast protein liquid chromatography
`French patent
`P. Friedlander Fortschritte der Teer-
`farbenfabrikation, a collection of
`patents
`fructose
`follicle-stimulating hormone
`Fourier transform
`gram(s)
`guanine; guanosine
`glucose 1-phosphate
`glyceraldehyde 3-phosphate
`glucose 6-phosphate
`‘y-aminobutyric acid
`gallon(s)
`galactose
`N-acetyl-p-galactosamine
`microgram(s)
`gas chromatography
`glutamate dehydrogenase
`guanosine diphosphate
`geminal, stereodescriptor see
`Glossary
`geological
`Germanpatent
`growth hormone
`gastrointestinal
`grams perliter
`y-carboxyglutamic acid
`glucose
`gas-liquid chromatography
`gluconic acid
`glucosamine
`N-acetyl-D-glucosamine
`glucuronic acid
`glutamine
`glutamic acid
`glucuronic acid
`glycine
`glycerol 3-phosphate
`Gmelin’s Handbuch der
`Anorganischen Chemie, a
`comprehensive German
`encyclopedia of inorganic
`chemistry
`guanosine 5'-monophosphate
`(guanylic acid)
`cyclic GMP
`granulocyte macrophage colony
`stimulating factor
`government
`glycoprotein
`growth hormonereleasingfactor
`glutathione (reduced)
`glutathione (oxidized)
`guanosinetriphosphate
`genitourinary
`guanine
`
`FMN (FMNH,)
`
`Fmoc
`Fortschr. Chem.
`Org. Naturst.
`
`GLC
`GIcA
`GIcN
`GlcNAc
`GIcUA
`Gin
`Glu
`GluA
`Gly
`Glycero]-3-P
`Gmelin’s
`
`GMP
`
`cGMP
`GM-CSF
`
`gov't
`
`GRF, GHRF
`GSH
`GSSG
`GTP
`GU
`Gua
`
`2ichs-Patent)-German
`ed
`
`‘eodescriptor, see
`e of a solution
`one gram per 100 ml
`nacell having an
`:
`path of one cm
`ion coefficient (concn in
`ino acid
`yated by antibody and
`it
`allergic
`ayelitis
`re
`emotactic factor of
`
`s z
`
`and Cosmetic (U.S.A).
`
`ram
`umission Number
`
`2 i
`
`netetraacetic acid
`ralogram
`ia) for example
`wth factor
`hors), plural ofidem
`‘entory of Existing
`substances
`gram
`:d immunosorbent assay
`> force
`ine (in formulas)
`al descriptor, see
`
`al Protection Agency
`a; European Patent
`
`ion coefficient (concn in
`, dielectric constant
`
`units of electrical charge
`
`others
`
`tent application
`
`-al descriptor, see
`
`(ly)
`icted
`
`egrees; also Fourneau
`1osphate
`losphate
`mbardment
`1e dinucleotide (reduced
`
`nplete adjuvant (same as
`
`ug Administration
`
`XV
`
`
`
`AQUESTIVE EXHIBIT 1076 Page 0006
`AQUESTIVE EXHIBIT 1076 Page 0006
`
`

`

`
`
`N.N.R.
`
`no.
`nor-
`
`NRDC
`
`NSAID(s)
`
`NSC
`NTP
`
`o-
`
`PAGE
`passim
`pat.
`PB report
`
`PCA
`PCT
`PEP
`PET
`Pr petrol
`FC
`3PG
`PG
`PGA
`PGP
`pH
`
`PHA
`Phe
`physiol
`pK
`
`PKU
`PMN
`PPj
`Ppm
`me
`BQ
`Pr
`Prepd
`Prepn
`press,
`‘°
`PRPP
`v(psi)
`H
`
`Q4
`
`-G.v.
`Q.v.
`-
`
`rr
`
`microgram
`millicurie
`
`100
`
`molecular rotation
`malate dehydrogenase
`methyl CH,—
`acetone
`methyl alcohol
`Mellor’s Comprehensive Treatise on
`Inorganic and Theoretical
`Chemistry
`milli-equivalent (0.001 of an
`equivalent)
`methionine
`N-formylmethionine
`methemoglobin
`millielectron volts
`manufacturing
`manufacture
`milligram
`major histocompatibility complex
`microcurie
`microgram
`microcrystalline
`migration inhibition factor
`minimum; minute(s)
`Mullerian inhibiting substance
`miscible
`mixture
`milliliter (cubic centimeter)
`minimum lethal dose
`mixed lymphocyte reaction
`millimeter
`millimicron(s), nm
`molecular weight
`Monatshefte fiir Chemie
`milliosmolar
`melting point; melts, melting at,
`when followed bya figure
`denoting temperature
`relative molecular mass
`magnetic resonance imaging
`meso- (internally compensated)
`mass spectrometry
`melanocyte-stimulating hormone
`(melanotropin)
`index ofrefraction (n29 for 20° and
`sodium light); normal, as n-propyl
`normal (equivalents perliter, as
`applied to concentration); nitrogen
`(as in N-methylpyridine)
`N-acetylneuraminic acid
`nicotinamide adenine dinucleotide
`(reduced form)
`nicotinamide adeninedinucleotide
`phosphate (reduced form)
`nonaspirin nonsteroidal anti-
`inflammatory drugs
`National Bureau of Standards
`National Collection of Type Cultures
`nucleoside 5’-phosphate
`Netherlands patentapplication
`National Formulary
`nanogram (107? grams)
`nerve growth factor
`Non-insulin dependent diabetes
`mellitis
`National Institute for Occupational
`Safety and Health
`nanometer
`nicotinamide mononucleotide
`(reduced form)
`nucleoside 5’-monophosphate
`nuclear magnetic resonance
`New and Nonofficial Drugs
`(Lippincott, 1959-1964)
`
`NMR NN.D.
`
`NAcneu
`NAD* (NADH)
`
`NADP* (NADPH)
`NANSAIDS
`
`NBS
`NCTC
`NDP
`Neth. pat. Appl.
`N.F.
`ng
`NGF
`NIDDM
`
`NIOSH
`
`nm
`NMN* (NMNH)
`NMP
`
`mcg
`mCi
`
`MD
`
`MDH
`Me
`Me.CO—
`MeOH
`Mellor’s
`
`mEq
`Met
`fMet
`MetHb
`meV
`mfg, manuf
`mfr
`mg
`MHC
`mCi
`mg
`microcryst
`MIF
`min
`MIS
`misc
`mixt
`mi
`MLD
`MLR
`mm
`my
`mol wt
`Monatsh.
`mOsm
`mp
`
`inorganic
`insoluble
`internal
`International
`intraperitoneal
`infrared
`immuneresponse genes
`Internal Organization for
`Standardization
`isolation
`inosine triphosphate; idiopathic
`thrombocytopenic purpura
`international unit
`International Union of Chemistry
`International Union of Pure and
`Applied Chemistry
`intravenous
`Japanese patent (unexamined)
`Japanese patent
`dissociation constant; equilibrium
`constant
`degrees Kelvin
`kilobase
`kilocalories(s)
`killer cell
`kilogram(s)
`a-ketoglutarate
`keyhole limpet hemocyanin
`kidney plasminogen activator
`liter
`levo(rotatory), the opposite of d
`levo (in configurational sense only),
`the opposite of D
`lactose
`lymphocyte-activating determinant
`wavelength
`laser microprobe mass analysis
`long acting thyroid stimulator
`pound(s)
`lethal concentration;liquid
`chromatography
`median lethal concentration, the
`concn of a chemical thatis
`estimated to be fatal to 50% ofthe
`organisms tested
`lymphocyte choriomeningitis
`lethal dose
`median lethal dose, the quantity of a
`chemical that is estimated to be
`fatal to 50% of the organisms
`tested
`lactate dehydrogenase
`low density lipoproteins
`leucine
`luteinizing hormone (same as ICSH)
`natural logarithm
`(loco citato) in the place cited
`logarithm (common)
`limit of impurities
`lipopolysaccharide
`lysine
`meter; given after mass number
`signifies metastable isomer
`meta chemical locantfor ring
`substituents
`molar (concentration)
`monoclonal antibody
`maximum allowable concentration
`macrophageactivating factor
`monoamine oxidase
`monoamine oxidase inhibitor
`mass spectrometry
`maximum, maxima
`myoglobin
`oxymyoglobin
`Manufacturing Chemists Association
`(U.S.A.)
`
`inorg
`insol
`intern
`ntl
`Lp.
`IR
`Ir genes
`ISO
`
`isoln
`ITP
`
`LU.|
`LUC.
`LU.P.A.C,
`
`Lv.
`Japan. Kokai
`Japan.pat.
`
`K *
`
`K
`Kb
`kcal
`K cell
`kg
`akG
`KLH
`KPA
`
`1LL
`
`-
`
`Lac
`LAD
`» (lambda)
`LAMMA
`LATS
`Ib
`LC
`
`LCsq
`
`LCM
`LD
`LDso
`
`LDH
`LDL
`Leu
`LH
`In
`loc. cit.
`log
`l.o.i.
`LPS
`Lysm
`
`m-
`
`M M
`
`ab, mAb
`MAC
`MAF
`MAO
`MAOI
`mass spec
`max
`Mb
`MbO,
`MCA.
`
`AQUESTIVE EXHIBIT 1076 Page 0007
`AQUESTIVE EXHIBIT 1076
`Page 0007
`
`
`
`
`xvi
`
`

`

`tabl
`
`R (
`
`RCO-
`recryst(n)
`re
`rep [REP]
`
`resp
`Ry Or Reg
`
`(S)-
`
`S.A.E.
`SAM
`sapon(if)
`Sar
`satd
`S.C.
`SDS
`sec
`sec-
`sepn
`Ser
`SI
`SLE
`SNRI
`
`sol; soly
`solidif
`soln
`sp.
`spec
`SPECT
`
`sp gt
`Spp.
`sq
`sqq
`SRBC
`SRS-A
`
`$s
`SSPE
`SSRI
`S.TP.
`subl
`suppl
`sym-
`syn-
`
`T t
`
`in
`
`
`
`N.N.R.
`
`NRDC
`
`NSAID(s)
`
`NSC
`NTP
`
`PABA
`PAF
`PAGE
`passim
`pat.
`PB report
`
`PCA
`PCT
`PEP
`PET
`petr, petrol
`PEC
`3PG
`PG
`PGA
`PGP
`
`se
`
`isive Treatise on
`eoretical
`
`101 of an
`
`bility complex
`
`1 factor
`
`3 g
`
`substance
`
`itimeter)
`se
`reaction
`
`r1emie
`
`ts, melting at,
`oy a figure
`‘ature
`mass
`e imaging
`sompensated)
`
`ating hormone
`
`1 (n38 for 20° and
`iormal, as n-propyl
`ts perliter, as
`entration); nitrogen
`pyridine)
`ic acid
`line dinucleotide
`
`iine dinucleotide
`iced form)
`roidal anti-
`rugs
`of Standards
`on of Type Cultures
`»sphate
`it application
`ary
`grams)
`tor
`ndent diabetes
`
`: for Occupational
`alth
`
`nonucleotide
`
`) m
`
`ophosphate
`: resonance
`‘cial Drugs
`359-1964)
`
`alkyl, univalent hydrocarbon radical
`New and Nonofficial Remedies
`(or hydrogen)
`(Lippincott, 1933-1958)
`rectus (right), stereodescriptorsee
`R)-
`number
`no.
`Glossary
`nor-
`chemical nomenclature descriptor,
`“JpX_molwt
`radioallergosorbent test
`RAST
`see Glossary
`100
`red blood cell; red blood count
`National Research Development
`aliphatic acyl radical
`recrystallize, recrystallization
`Corporation
`reference
`nonsteroidal anti-inflammatory
`“roentgen equivalent physical”’
`drugs
`means a doseof ionizing radiation
`National Service Center
`nucleoside 5’-triphosphate; National
`capable of producing energy
`Toxicology Program (U.S.)
`absorption of 93 ergs per gram of
`tissue
`ortho chemical locant for ring
`substituents
`respectively
`denoting attachment to oxygen,as in
`(in paper chromatography)ratio of
`O- acetylhydroxylamine
`movement of the bandto the front
`ovalbumin
`of the solvent
`oxaloacetate
`radioimmunoassay
`p-ribose
`optical density
`(opere citato) in the work cited
`radioimmunosorbenttest
`organic
`ribonucleic acid
`Occupational Safety and Health Act
`heterogeneous nuclear RNA
`osmolar
`messenger
`ounce(s)
`nuclear RNA
`concentration by weight (after optical
`ribosomal RNA
`rotations only)
`small nuclear RNA
`transfer (soluble) RNA
`page(s).
`para chemical locant for ring
`ribonuclease
`Registry of Toxic Effects of Chemical
`substituents
`Substances
`inorganic phosphate
`pascal
`symmetrical
`denoting attachmentto sulfur as in
`p-aminobenzoic acid
`platelet-activating factor
`S-methylcysteine
`polyacrylamide gel electrophoresis
`sinister (left), stereodescriptor see
`here and there, scattered
`Glossary
`Society of Automotive Engineers
`patent
`Publication Board Report (United
`S-adenosylmethionine
`States Department of Commerce,
`saponification
`Scientific and Industrial Reports)
`sarcosine
`passive cutaneous anaphylaxis
`saturated
`Patent Co-operation Treaty
`subcutaneous
`phosphoenolpyruvate
`sodium dodecy! sulfate
`positron emission tomography
`second(s)
`secondary
`petroleum
`laque-formingcell
`separation
`serine
`-phosphoglycerate
`International System of Units
`prostaglandin
`pteroylglutamic acid (folic acid)
`systemic lupus erythematosus
`3-phosphoglyceroyl phosphate
`serotonin-noradrenaline reuptake
`acid-base scale; log of reciprocal of
`inhibitor
`hydrogen ion concentration
`soluble; solubility
`phytohemagglutin
`solidifies, solidification
`solution
`phenylalanine
`hysiological
`species; specific
`og ofthe reciprocal of the
`spectroscopy
`dissociation constant, I/log K
`single photon emission computed
`phenylketonuria
`tomography
`polymorphonuclear leukocyte
`specific gravity
`inorganic pyrophosphate
`species (plural)
`parts per million
`square
`precipitate, precipitating
`(sequentia) and following
`precipitated
`sheep red blood cells
`slow reacting substance of
`plastoquinone
`propyl (normal)
`anaphylaxis
`prepared
`single stranded
`subacute sclerosing panencephalitis
`preparation
`selective serotonin reuptake inhibitor
`pressure
`standard temperature and pressure
`proline
`5-phosphoribosyl 1-pyrophosphate
`sublimes
`pseudo
`supplement
`point
`symmetrical
`parathyroid hormone
`stereochemical descriptor see
`coenzyme Q (ubiquinone)
`Glossary
`(quae vide) which see, plural
`thymine; thymidine
`(quod vide) which see
`half-life
`*roentgen’’ unit of radiation
`tablet(s)
`racemic
`
`xvii
`
`
`
`AQUESTIVE EXHIBIT 1076 Page 0008
`AQUESTIVE EXHIBIT 1076 Page 0008
`
`

`

`
`
`
`
`tuberculosis
`trichloroacetic acid; tricarboxylic
`acid
`thymus derived cell
`thoracic duct lymphocyte
`thymidine diphosphate
`O-(triethylaminoethy])-cellulose
`technical
`temperature
`tertiary
`thyrotropic hormone
`tetrahydrofuran
`tetrahydrofolic acid
`threonine
`thymine
`thin-layer chromatography
`thymidine 5’-monophosphate
`tobacco mosaic virus
`tumornecrosis factor
`trinitrophenyl
`tissue plasminogen activator
`thiamine pyrophosphate
`stereodescriptor see Glossary
`tris(hydroxymethyl)aminomethane;
`2-amino-2-hydroxymethylpropane-
`1,3-diol
`tryptophan
`thyroid-stimulating hormone
`tumor-specific transplantation
`antigens
`thymidine triphosphate
`tyrosine
`uracil or uridine
`uridine diphosphate
`uridine diphosphogalactose
`uridine disphosphoglucose
`United Kingdom
`uridine 5’-monophosphate (uridylic
`acid)
`uncorrected
`unsymmetrical, asymmetrical
`uracil
`United States Atomic Energy
`Commission
`United States Adopted Names
`
`TB, tb
`TCA
`
`T cell
`TDL
`TDP
`TEAEcellulose
`tech
`temp
`tert-
`TH
`THF
`THFA
`Thr
`Thy
`TLC
`TMP
`TMV
`TNF
`TNP
`TPA
`TPP, ThPP
`trans-
`Tris
`
`Trp
`TSH
`TSTA
`
`TTP, dTTP
`Tyr
`DP
`UDP-gal
`UDP-gic
`U.K.
`UMP
`
`UU
`
`uncor(r)
`uns-, unsym-
`Ura
`U.S.A.E.C.
`
`USAN
`
`U.S.D.
`U.S.D.A.
`
`U.S.P.
`US.pat.
`UTP
`uv
`Vv
`y-
`Val
`var
`viz.
`VLDL
`vol
`vs
`viv
`
`wbc
`WHO
`wks
`wt
`wiv
`
`w/w
`
`XMP
`yr(s)
`Z
`(Z)-
`
`Z. Physiol.
`
`sc
`=
`>
`<
`
`United States Dispensatory
`United States Department of
`Agriculture
`United States Pharmacopeia
`United States patent
`uridine triphosphate
`ultraviolet
`volt(s)
`vicinal (adjacent)
`valine
`variety
`(videlicet) that is to say; namely
`very low density lipoproteins
`volume
`versus
`percent ‘‘volume in volume’’
`expresses the numberof milliliters
`of an active constituent in 100
`milliliters of solution
`white blood cell; white blood count
`World Health Organization
`weeks
`weight
`percent ‘‘weight in volume’”’
`expresses the number of grams of
`an active constituent in 100
`milliliters of solution, and is used
`regardless of whether water or
`anotherliquid is the solvent
`percent ‘‘weight in weight’’
`expresses the number of grams of
`an active constituent in 100 grams
`of solution or mixture
`xanthosine monophosphate
`year(s)
`carbobenzoxy
`zusammen stereodescriptor see
`Glossary
`Hoppe-Seyler’s Zeitschriftfiir
`Physiologische Chemie
`approximately
`approximately equal
`greater than
`less than
`
`xviii
`
`AQUESTIVE EXHIBIT 1076 Page 0009
`AQUESTIVE EXHIBIT 1076 Page 0009
`a»
`
`

`

`
`
`3042
`
`Diazepam
`
`similar hydrocarbons. Morestable in alkaline formulatig
`then whenat neutral or acid pH. LDsgp in male, femaje Bi
`(mg/kg): 250, 285 orally (Gaines).
`as
`Caution: Cholinesterase inhibitor: Clinical Toxicology
`Commercial Products, R. E. Gosselin et al, Eds. (Witliant
`& Wilkins, Baltimore, 5th ed., 1984) Section II, p 294.
`USE:
`Insecticide.
`THERAP CAT (VET): Ectoparasiticide.
`
`Whetsel et al, J. Am.
`pote!
`pose & al, Acta Cryst. 17, 765
`N
`Me
`
`i
`
`¥
`S03
`
`
`
`
`
`7-Chloro-1,3-dihydro-1-methyl-5S-
`3042, Diazepam.
`phenyl-2H-1,4-benzodiazepin-2-one; 7-chloro-1-methyl-5-
`phenyl-3H-1,4-benzodiazepin-2(1H)-one; methyl diazepin-
`one; diacepin; LA-III; Ro-5-2807; Wy-3467; NSC-77518;
`Apaurin; Atensine; Atilen; Bialzepam; Calmpose; Ceregu-
`lart; Dialar; Diazemuls; Dipam; Eridan; Eurosan; Evacalm;
`Faustan; Gewacalm; Horizon; Lamra; Lembrol; Levium;
`Mandrozep; Neurolytril; Noan; Novazam; Paceum; Paci-
`tran; Paxate; Paxel (obsolete); Pro-Pam; Q-Pam; Relanium;
`Sedapam; Seduxen; Servizepam; Setonil; Solis; Stesolid;
`Tranquase; Tranquo-Puren; Tranquo-Tablinen; Unisedil;
`Valaxona; Valiquid; Valium; Valrelease; Vival; Vivol. Cy.-
`H,jCIN,O; mol wt 284.74. C 67.49%, H 4.60%, Cl 12.45%,
`N 9.84%, O 5.62%.
`Prepn:
`Sternbach, Reeder, J. Org.
`Chem. 26, 4936 (1961); Reeder, Sternbach, U.S. pat. 3,371,-
`085 (1968 to Hoffmann-La Roche); prepd but not claimed:
`eidem, U.S. pats. 3,109,843 and 3,136,815 (1963, 1964 to
`Hoffmann-La Roche); M. Gates, J. Org. Chem. 45, 1675
`(1980); M. Ishikura et al, ibid. 47, 2456 (1982). Purifica-
`tion: Chase, U.S. pat. 3,102,116 (1963 to Hoffmann-La
`Roche). Pharmacology: Hudson, Wolpert, Arch. Int. Phar-
`macodyn. Ther. 186, 388 (1970). Metabolism: Randall et
`al, Curr. Ther. Res. Clin. Exp. 7, 590 (1965); Van der
`Kleijn, Ann. N.Y. Acad. Sci. 179, 115 (1971). Toxicity: E. I.
`Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Bind-
`ing study in rat brain: R. F. Squires, C. Braestrup, Nature
`266, 732 (1977). Comprehensive description: A. Mac-
`Donald et al, Anal. Profiles Drug Subs. 1, 79-99 (1972).
`Clinical pharmacokinetics: M. Mandelli et al, Clin. Phar-
`macokinet. 3, 72 (1978).
`
`Plates from acetone + petr ether, mp 125-126". pK, 3.4.
`Sol in chloroform, DMF, benzene, acetone, alc; slightly sol
`in water. LDgo orally in rats: 710 mg/kg (Goldenthal).
`Note: This is a controlled substance (depressant) listed in
`ie a Codeof Federal Regulations, Title 21 Part 1308.14
`1995).
`THERAP CAT: Anxiolytic; muscle relaxant (skeletal).
`3043. Diazinon. Phosphorothioic acid O,O-diethyl O-
`[6-methyl-2-(1-methylethyl)-4-pyrimidinyl] ester; thiophos-
`phoric acid 2-isopropyl-4-methyl-6-pyrimidyl diethyl ester;
`O,O-diethyl O-2-isopropyl-4-methyl-6-pyrimidyl thiophos-
`phate; diethyl 2-isopropyl-4-methyl-6-pyrimidyl thiono-
`phosphate; dimpylate; G-24480; Antigal; Basudin; Diazol;
`D-z-n; Garden Tox; HelfaCat; HelfaDog; Neocidol; Parasi-
`tex; Sarolex; Spectracide; Taberdog; Tabergat. C,,H,,N,0;-
`PS; mol wt 304.35. C 47.36%, H 6.95%, N 9.20%, O
`15.77%, P 10.18%, S 10.54%. Prepn: Gysin, Margot, U.S.
`pat. 2,754,243 (1956 to Geigy).
`Insecticidal properties:
`Gasser, Z. Naturforsch. 8b, 225 (1953). Toxicity data: T. B.
`Gaines, Toxicol. Appl. Pharmacol. 14, 515 (1969).
`
`HC
`Q
`Hee.__-O\,-
`Ils
`
`o
`
`CH
`
`CH,
`
`N
`N
`| ZN
`
`CHg
`
`
`
`
`H
`
`mee
`0
`ye
`
`A
`M
`Oo
`ds
`N Oo”cH,
`
`H
`
`o
`
`Orangeneedles from ethanol, mp 230° (dec); also reported
`as yellowish-brown crystals from ethanol decomposing #
`temperatures above 250° (Petersen).
`uv max (methanol):
`340 nm (log € 4.17). Soly in water: 0.5 mg/ml. LD»™
`mice (mg/m?): 30.9 i.v. (Bender).
`THERAP CAT: Antineoplastic.
`3045. Diazoacetic Ester. Ethyl diazoacetate city
`diazoethanoate. C,H,N,O,; mol wt 114.10. C 42.11
`5.30%, N 24.55%, O 28.04%.
`-N=N*=CHCOOG!s
`Prepd by the action of sodium nitrite on glycine ethyl at
`hydrochloride: Curtius J. Prakt. Chem.
`[2] 38, 396Oo
`Silberrad, J. Chem. Soc. 81, 600 (1902); Womack,
`i
`Org. Syn. 24, 56 (1944).
`Yellow oil. Pungent odor. Very volatile. Exp’losive- a
`tillation, even under reduced pressure, is dangerous. ]P ~ 44
`dl76 1.0852. bp, 42°: bpy 45° bpgy 85-86% Pr | ia
`nj1.4588. Slightly sol in water. Neutral reaction|
`:
`tile with steam, ether, and benzene vapors. Miscible wit
`alcohol, benzene,
`ligroin, ether. Explodes on contae
`r
`4
`concd H,SO,.
`Ee
`+
`cent
`3046. Diazoaminobenzene.
`1,3-Diphenyl-14t wi
`anilinoazobenzene; benzeneazoaniline.
`CpyoHuNe giazol
`197.24. C 73.07%, H 5.62%, N 21.30%. Made by dind
`ing aniline dissolved in HCl with NaNO,and then 2° on
`coned soln of sodium acetate: Hartman, Dickey:
`coll. vol, II, 163 (1943).
`
`[2,5-Bis(1-aziridinyl)-3,6-dioxo.4 4.
`3044, Diaziquone.
`cyclohexadiene-1,4-diyl]biscarbamic acid diethyl ester, 25.
`|
`bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-dicarbam;,
`j
`acid diethyl ester; 2,5-diaziridiny!-3,6-bis(ethoxycarbony,,
`amino)-1,4-benzoquinone; aziridinylbenzoquinone; AZO;
`CI-904; NSC-182986. CH»N,Og mol wt 364.36, 6
`52.74%, H 5.53%, N 15.38%, O 26.35%. Quinone-contaip.
`White or slightly red crysta
`ing lipophilic alkylating agent. Prepn as intermediatei,
`py heat, a blow, or on rubbing
`dyestuffs:
`S. Petersen et al, U.S. pat. 2,913,453 (1959 to
`Slightly sol in cold water, alcot
`Schenley Ind.). Synthesis and antitumor activity: A.
`alkalies, HCl.
`Khan, J. S. Driscoll, J. Med. Chem. 19, 313 (1976); 1.5
`use: As reagentfor phenol,i
`Driscoll et al, U.S, pat. 4,146,622 (1979 to U.S. Gov't).
`In
`aldehydes, and albumin; also
`vivo antitumor studies:
`J. S. Driscoll et al, J. Pharm. Sci
`dyes.
`68, 185 (1979).
`Intracerebral penetration and tissue dis.
`i
`tribution in humans: N.Savaraj et al, J. Neuro-Oncol. 1, 15
`0 ”a Zateas,
`(1983). LC determn: B. A. Allen et al, J. Chromatog. 221,
`Prepd from chloroform and
`146 (1981). Pharmacokinetics: S. Zimm et al, Cancer Res
`potassium hydroxide: Staud
`|
`44, 1698 (1984). Clinical studies in treatment of CNSneo-
`1912); McM
`t
`plasms: R. T. Eagan et al, J. Neuro-Oncol. 5, 309 (1987); B.
`Tapazoglou et al, Am. J. Clin. Oncol. 11, 474 (1988). Re- esie
`view: J. F. Bender et al., Invest. New Drugs 1, 71-84 (1983).
`Chim. France 1963, 41. These
`a
`|
`methane. The following pro.
`diazomethane. From N-niti
`methyl ketone in ether and i:
`sodium isopropoxide or from
`Teaction with sodium cyclohex:
`Syn, 25, 28 (1945). By KO
`methylurea in ether: Arndt,
`(1943), or of nitrosomethyluret
`Ber. 27, 1888 (1894); 28, 855
`Ber. 61, 1845 (1928).
`In the 1
`be Prepd most simply by the
`mercially available N-methyl-
`McKay, J. Am. Chem. Soc
`e Can, J. Res. 28, 683 (195C
`; emistry (Reinhold, New Yo
`ete intermediate:
`p-toly
`5 lazald” Aldrich Chemical
`"8. Syn. coll. vol, IV, 250 (16
`lous
`poj
`:
`_'¥ toxic yellow gas. Explc
`Bold mae 2 well-ventilated
`
`solns may
`exnj> — 145°; bp
`
`Y explode violently, es
`100°
`osseous diazomethane
`
`or on r
`and glass sti ‘ough glass surfac
`ay O
`lrers with glass sl
`Plosionswren not be used
`8olns deg ote diazomethane.
`
`if alcohols
`Y slowly at lowte
`tive
`Or water are pres
`Mation ofmeen with the evolu
`calc:
`insol white flakes
`of
`(Sy
`:
`akes 0:
`
`Thispp chloride or boiling s
`
`Of diag
`vomenon appears to 0
`; eaeethane on solid subsi
`
`IN, Shortaertential symptom
`Chest
`peness Of breath; head
`%8thma.Pulmonary edema.
`Nazargs atigue.
`See NIOSE
`Pbira¢OAHS/NIOSH 90-1
`QorO
`
`ficken, Sek
`276”Mterscience’ Noeee
`wit
`Usp.
`des
`0,
`t
`: p
`
`Golden-yellow, small crystals. mp 98°; explo th
`8 carp, OWerful
`—
`heated to 150°.
`Insol in water; freely sol in bem! me
`RomaneHc acids,pres!
`
`Liquid. Faint ester-like odor. d3? 1.116-1.118. bppoq. 83-
`(193
`e se,
`e
`nd
`hot alc.
`gfe
`ed ~ Bist, = the reviews by
`84°.
`n#0 1.4978-1.4981. Vapor pressure at 20° 1.4 10-4
`Z. An
`3047. p-Diazobenzenesulfonic Acid. 4-sulfnOre
`.
`>Pa:
`-
`Angew. Chen
`at 40°: 1.1> 10-3 (~5 times vapor pressure of parathion).
`Regrtry at in Newer Me
`diazonium inner salt; sulfanilic acid diazide. Ce 600%
`Volatility at 20°: 2.4 mg/m3; at 40°: 17.6 mg/m3. Decom-
`ew York, 1948)
`poses above 120°. Soly in water at 20°: 0.004%. Méiscible
`mol wt 184.18. C 39.13%, H 2.19%, N 15.21%,
`nd 5
`*2Gohn Wiley,
`with alcohol, ether