`Exhibit 4
`
`
`
`
`
`NUVASIVE - EXHIBIT 2029
`Alphatec Holdings Inc. et al. v. NuVasive, Inc.
`IPR2019-00362
`
`
`
`Case 3:08-cv-01512-CAB-MDD Docu ment 407-5 Filed 10/27/11 PageiD.19250 Page 1 of 9
`
`EXHIBIT DTX-5134-R
`
`A TEC _LLI FOOO 137288
`
`
`
`:9'Miiil:""\\;""'"'')1f!~ase 3:08-cv-01512-CAB-MDD Document 407-5 Filed 10/27/11 PageiD.19251 Page 2 of 9
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`Request for Individual Custom Device
`(As required by Section 520 (b)
`of t:he Food, Drug & Cosmetic J\ct)
`
`. '
`I have determined thnt n special device will be necessary to
`provide most effective rcelief of a pati-ent condition described
`below. Available sta.nclard production devices are not completely
`suitable for this purpos-e.
`I agree that the custom devic.e will
`be used only by me for use for the patient named below.
`
`Please type or print:
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`Patient Name:
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`Patient Condition:
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`rf11\ll=ln~I\ITIAI INFORMATION
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`DTX-5134-R
`Page 5
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`DdUWinf'_. Mblblr
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`DTX-5134
`
`BR0002730
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`A TEC _LLI FOOO 137289
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`Case 3:08-cv-01512-CAB-MDD Document 407-5 Filed 10/27/11 PageiD.19252 Page 3 of9 .
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`;/:~. AcroMed" Corporation
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`. : 3303 CAI?NEGIE AVE . CLEVELAND. 01110 tl/111.'",
`
`Request for Individual Custom Device
`(As required by Section 520 (b)
`of the F'ood, Drug & Cosmetic Act)
`
`• '
`
`I have determined Ulilt a special device will be necessary to
`provide most effective relief of a patient condition described
`below. Available standnrd production devices are not completely
`suitable for this purpose.
`I agree that the custom device will
`be used only by me for use for the patient named below.
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`r:nNFinFNTIAL INFORMATION
`
`DTX-5134-R
`Page 6
`
`BR0002731
`
`A TEC _LLI FOOO 137290
`
`
`
`~~~Y€ase 3:08:.cv-01512-CAB-MDD Document 407-5 Filed 10/27/11 PageiD.19253 Page 4 of 9 _
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`•. 3JOJ CARNEGIE AVE. CLEVElAND, 01110 4.111~>
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`Request for Individual Custom Device
`(As required by Section 520 (b)
`of the Food, Drug & Cosmetic Act)
`
`I have determined tl1~t ~ special device will be necessary to
`provide most effective relief of a patient condition described
`below. Available standard production devices are not completely
`sui table for this purpose.
`I agree that the custom device will
`be used only by me for use for the patient named below.
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`Please type or print:
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`Patient Name:
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`DTX-5134-R
`Page 7
`
`BR0002732
`
`A TEC _LLI FOOO 137291
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`rnJ\ll=lnr=J\ITIAI 11\IFORMATION
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`Case 3:08-cv-01512-CAB-MDD Document 407-5 Filed 10/27/11 PageiD.19254 Page 5 of 9
`
`,~[ AcroMecr Corporation
`
`3303 CAI'?NEGIE AVE . CI.EVEI.AND. 01110 t1t111 ~1
`
`Request for Individual Custom Device
`(As required by Section 520 (b)
`of the Food, Drug & Cosmetic Act)
`
`I have determined thilt i1 special device will be necessary to
`provide most effective relief of a pntient condition described
`below. Available stilndurd production devices are not completely
`suitable for this purpose.
`I agree that the custom device will
`be used only by me for use for the patient named below.
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`·Please type or print:
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`DTX-5134-R
`Page 8
`
`BR0002733
`
`A TEC _LLI FOOO 137292
`
`
`
`~ ..;.::."''~~'~;,"'Case 3:os.::cv-01512-CAB-MDD Document 407-5 Filed 10/27/11 PageiD.19255 Page 6 of 9
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`3303 C/\RNEGIE AVE. CLEVELAND. 01110 lll111~i
`
`Request for Individual custom Device
`(As required by Section 520 (b)
`of the Food, Drug & Cosmetic Act)
`
`I have determined that a special device will be necessary to
`provide most effective relief of a patient condition described
`below. Available standard production devices are not completely
`suitable for this purpose.
`I agree that the custom device will
`be used only by me for use for the patient named below.
`
`Please type or print:
`
`· · · Patient Name:
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`Patient Condition:
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`DTX-5134-R
`Page 9
`
`BR0002734
`
`A TEC _LLI FOOO 137293
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`• .e-~:~"""-- t~~e 3:08-cv-01512-CAB-MDD Document 407-5 Filed 10/27/11 PageiD.19256 PagY~t-ftfJ
`
`Pesign of anterior cages. lumbar and cervical: • John W .. Brantigan, M.D.
`June 20, 1990
`
`Morphometric studies of lumbar vertebrae (Berry, J.L., Moran, J.M,, ' Berg,
`W.S .• Steffee, A.D. Spine 12:362-367, 1987) indicate that at LS, the ratio
`of A- P width to M- L width of vertebrae averages 0. 66. This ratio increases
`as follows:
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`.-73
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`I feel that the ratio of dimension of the cages should duplicate the known
`average dimensions of lumbar vertebrae. _For simplicity, the different sizes
`should maintain about the same ratio.
`-
`
`In the cervical area, -the M-L width is relatively greater~ with ratio closer
`to 0. 60, though I have not found published data reflecting this difference.
`Maintaining the anatomic ratio seems prudent.
`
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`_ Anterior lumbar cages;
`
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`' D - 3.0 mm
`E - 4.0 mm
`F- 2.0 mm
`G-0.75mm .
`H - 4.0 mm
`
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`42 mm
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`42 mm
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`36 mm
`
`36 mm
`
`33 mm
`
`33 mm
`
`33 mm
`
`28 mm
`
`28 mm
`
`24 mm
`
`24 mm
`
`22 mm
`
`22 mm
`
`22 mm
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`~
`
`15 mm
`
`14 mm
`
`14 mm
`
`12 mm
`
`14 mm
`
`12 mm
`
`10 mm
`
`CONFIDENTIAL INFORMATION
`
`. ·.
`
`DTX-5134-R
`Page 10
`
`BR0002735
`
`A TEC _LLI FOOO 137294
`
`
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`Case 3 : 08- cv-01512~AB - MDD
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`BR0002736
`
`A TEC _LLI FOOO 137295
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`DTX-5134-R .
`Page 12
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`A TEC _LLI FOOO 137296
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