NUVASIVE - EXHIBIT 2024
`Alphatec Holdings Inc. et al. v. NuVasive, Inc.
`IPR2019-00362
`
`

`

`NA Mosby
`
`An Affiliate of Elsevier
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`Vice President, Publishing Director: Sally Schrefer
`Executive Editor, Nursing: Darlene Como
`Developmental Editor: Tamara A. Myers
`Project Manager: Pat Joiner
`Manager: Intellectual Property Resources: Tripp Narup
`Designer: Mark A. Oberkrom
`J
`Permission Assistant: Allen K. Berry
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`Cover illustrations:
`
`Cardiac nuclear scanning from Cannobio MM:
`Cardiovascular disorders. St. Louis, 1990, Mosby.
`Chromobacteriosis from Baron EJ, Peterson LR, Finegold SM:
`Bailey and Scotti: diagnostic microbiology, ed 9, St. Louis,
`1994, Mosby.
`Cryosurgery from Jafi‘e ND: Atlas of ophthalmic surgery. ed 2,
`St. Louis, 1996, Mosby.
`Duodenal ulcer from Seidel HM, Benedict GW, Ball JW, and
`Dains JE: Mosby's guide to physical examination, ed 4.
`St. Louis, 1999, Mosby.
`Fluorescent antibody test from Baron EJ, Peterson LR,
`Finegold SM: Bailey and Scottie diagnostic microbiology,
`ed 9, St. Louis, 1994, Mosby.
`Single-photon emission computed tomography from Chipps EM,
`Clanln NJ, Campbell VG: Neurologic disorders, St. Louis,
`1992, Mosby.
`
`SIXTH EDITION
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`Copyright © 2002 by Mosby
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`
`1020
`'
`loop colostomyW
`long-acting drug
`
`operative positioning and immobilization of the knee, distal
`leg, and ankle; and for correcting or maintaining the correc-
`tion of the foot, distal leg, and knee. See also cast. Compare
`short-leg cast.
`an orthopedic cast applied to
`long-leg cast with walker,
`immobilize the leg from the toes to the upper thigh in treat-
`ing certain leg fractures. This type of cast is the same as the
`long-leg cast but
`incorporates a rubber walker, enabling
`the patient
`to walk while the leg is encased-in the cast
`and when weight-bearing ambulation is allowed. See also
`cast.
`
`.
`
`‘
`
`
`
`an inherited cardiac disorder charac-
`long QT syndrome,
`terized by prolongation of the QT interval. The disorder is
`associated with ventricular tachycardia, cardiac arrhythmias,
`syncope, and sudden death. Syncopal episodes often occur 5
`during physical exercise in young, otherwise healthy per-
`sons.
`
`
`
`(sag;
`
`long-acting drug [A3, lang + L, agere, to do; Fr, drogue,
`drug],
`a pharmacologic agent with a prolonged effect be-
`cause of a formulation resulting in the slow release of the
`active principle or
`the continued absorption of
`small
`amounts of the dosage of the drug over an extended period.
`long-acting insulin,
`a preparation of insulin modified by
`an interaction with zinc under specific chemical conditions
`and supplied as a suspension with a prolonged action. An in—
`jection of the preparation takes effect within 8 hours,
`reaches a peak of action in 16 to 24 hours, and has a dura-
`tion of action of more than 36 hours. Also called slow-
`acting insulin, ultralente insulin. See also insulin. Com-
`pare intermediate-acting insulin, short-acting insulin.
`long-acting thyroid stimulator (LATS),
`an immuno-
`globulin, probably an autoantibody, that exerts a prolonged
`stimulatory effect on the thyroid gland, causing rapid
`growth of the gland and excess activity of thyroid function,
`resulting in hyperthyroidism. It is found circulating in the
`blood of 50% of people with Graves’ disease.
`(LATS-P),
`long-acting thyroid stimulator protector
`an antibody that inhibits the neutralization of long-acting
`thyroid stimulator and is found in the serum of persons with
`Graves’ disease LATS-P interferes with the binding of
`thyroid-stimulating hormone to its receptor on the plasma
`membrane of thyroid cells. See also long-acting thyroid
`stimulator.
`
`an
`long-arm cast [A5, lang + earm, arm; ONorse, kasra],
`orthopedic cast applied to immobilize the arm from the hand
`to the upper arm. It is used in treating fractures of the fore-
`arm, elbow, and humerus; for maintaining postoperative po—
`sitioning of the distal arm, elbow, or upper arm; and for cor-
`recting or maintaining the correction of deformities of the
`distal arm, wrist, or elbow. See also cast. Compare short-
`arm cast.
`
`the bones that contribute to the height or
`long bones,
`length of an extremity. particularly the bones of the legs and
`arms.
`
`the
`long, avaum. age],
`longus,
`[L,
`longevity llonjev’ité/
`number of years an average person of a particular age is ex~
`pected to continue living.
`It
`is determined by statistical
`tables based on mortality rates of various population groups.
`longissimus /lon-jis‘i‘mos/ [L, longest, very long],
`a gen—
`eral term denoting a long structure, as a muscle.
`length],
`longitudinal
`/lon'jat<fi'danol/
`[L,
`longitudo,
`1. pertaining to a measurement in the direction of the long
`axis of an object, body, or organ, such as the longitudinal
`arch of the foot. 2. pertaining to a scientific study that is
`conducted over a long period of time, such as the Framing—
`ham (Massachusetts) Study of heart disease.
`longitudinal diffusion,
`the diffusion of solute molecules
`in the direction of flow of the mobile phase.
`longitudinal dissociation,
`the insulation of parallel path-
`ways of cardiac impulses from each other, usually in the
`atrioventricular junction.
`length, fissura, cleft],
`longitudinal fissure [L, Iongitudo,
`the largest and deepest groove between the medial surfaces
`of the cerebral hemispheres.
`longitudinal presentation [L, longitudo, length, praesen-
`tare, to show],
`the normal presentation of a fetus, with the
`long axis of the infant body parallel to that of the mother.
`longitudinal sound waves,
`pressure waves formed by the
`oscillation of particles or molecules parallel to the axis of
`wave propagation. The compression and expansion of such
`waves at high frequencies is the principle on which ultra-
`
`a high-kilovolt radiographic image
`long-scale contrast,
`containing a wide range and great number of shades of gray
`with little difference in the adjacent tones.
`long-term care (LTC),
`the provision of medical, social,
`and personal care services on a recurring or continuing basis
`to persons with chronic physical or mental disorders. The
`care may be provided in environments ranging from institu-
`tions to private homes. Long-term care services usually in-
`clude symptomatic treatment, maintenance, and rehabilita- w
`tion for patients of all age groups.
`sensations,
`long-term memory,
`the ability to recall
`events, ideas, and other information for long periods of time
`without apparent effort. It is generally the last memory store
`to be destroyed in patients with Alzheimer’s disease. Com~
`pare short-term memory.
`long thoracic nerve,
`one of a pair of supraclavicular
`branches from the roots of the brachial plexus. It arises by
`three roots, from the fifth, the sixth, and the seventh cervical
`nerves. The fibers from the fifth and the sixth cervical nerves
`join just after they pierce the scalenus medius and are united
`with the fibers from the seventh cervical nerve at the level of
`the first rib. Compare phrenic nerve.
`long thoracic nerve injury,
`damage to the nerve (CS-7)
`that innervates the serratus muscle, which anchors the apex
`of the scapula to the posterior of the rib cage. Symptoms in—
`clude an abnormally prominent scapula and difficulty in
`flexing the outstretched arm above the shoulder level, pro
`tracting the shoulder, or performing scapula abduction and
`adduction.
`
`
`
`:
`,3
`
`
`
`,
`
`neurologic signs such as clonus, muscle
`long tract signs,
`spasticity, or bladder involvement that usually indicate a le-
`sion in the middle or upper parts of the spinal cord or in the
`brain.
`
`trademark for an antihypertensive (minoxidil).
`Loniten,
`loop [ME, loupe],
`a set of instructions in a computer pro-
`gram that causes certain commands to be executed repeat-
`edly if specified criteria are met.
`loop colostomy [ME, Ioupe + Gk, kolon, colon, stoma,
`mouth],
`a type of temporary colostomy performed as pan
`of the surgical treatment for repair of some colon diseases.
`The procedure involves bringing an intact segment of colon
`anterior to the repair through an abdominal incision and su-
`turing it onto the abdomen. A loop is formed and held in po-
`sition by placing a piece of glass rod between the segment
`and the abdomen. The two ends of the rod are connected
`with a piece of rubber tubing to prevent the rod from slip-
`ping. The stomal opening is made on the exterior surface of
`the segment. The colostomy is reversed after resolution of
`
`
`
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