NUVASIVE - EXHIBIT 2025
`Alphatec Holdings Inc. et al. v. NuVasive, Inc. - IPR2019-00362
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`Copyright © 1995
`Williams & Wilkins
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`Copyright © by William Wood and Company: 1911, Ist ed.; 1912, 2nd ed.; 1914, 3rd ed.; 1916, 4th ed.; 1918, 5th ed.; 1920, 6th ed.; 1922, 7th ed.;
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`Guide to Pharmaceutical Names copyright ©1995 by Medical Economics CompanyInc., 5 Paragon Drive, Montvale, NJ 07645.
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`Physician’s Desk Reference® and PDR®are registered trademarks used herein underlicense.
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`Indications, adverse reactions and dosage schedulesfor drugsset forth in this dictionary are provided by the authors. Williams & Wilkins has not
`independently verified the accuracy of that information and does not makeanyrepresentation in regardto its accuracy. The reader should review
`the package information data of the manufacturers of the medications mentioned.
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`
`meconate
`
`1074
`medication
`
`[G.
`
`mec:o-nate (mek’6-nat). A salt or ester of meconic acid.
`mékon, poppy]
`3-Hydroxy-4-oxy-4H-pyran-2,6-
`me-con‘ic ac-id (me-kon’ik).
`dicarboxylic acid; obtained from opium; it forms soluble salts
`(meconates) with manyof the alkaloids of opium.
`mec-o-nin (mek’5-nin). Cj) 9H, 904; the lactone of meconic acid,
`found also in Hydrastis canadensis; a hypnotic. syn opianyl.
`me-co-ni-or-rhea (mé-k6’né-6-ré’4)._ Passage, by the newborn
`infant, of an abnormally large amount of meconium. [meconium
`+ G. rhoia, flow]
`me-co-nism (mé’k6-nizm). Rarely used term for opium addic-
`tion or poisoning. [G. mékdn, poppy]
`me-co-ni-um (mé-k6’né-tim). 1. The first intestinal discharges of
`the newborn infant, greenish in color and consisting of epithelial
`cells, mucus, and bile. 2. sYN opium.
`[L., fr. G. mékdnion, dim.
`of mék6n, poppy]
`_7-Chloro-
`me-daz-e-pam hy-dro-chlo-ride (mé-daz’é-pam).
`2,3-dihydro- 1-methyl-5-phenyl-1H-1,4-benzodiazepine monohy-
`drochloride; an antianxiety agent.
`med-fal-an (med’fal-an).
`syN medphalan.
`me-dia (mé’dé-a). 1. sYN tunica media. 2. Plural of medium. [L.
`fem. of medius, middle]
`me-di-ad (mé’dé-ad). Toward the middle line.
`me-di-al (mé’dé-al). Relating to the middle or center; nearer to
`the median or midsagittal plane. syN medialis [NA].
`[L. media-
`lis, middle]
`me-di-a-lec-i-thal (mé’dé-d-les’i-thail). Denoting an egg with a
`moderate amountof yolk, as in amphibians. [L. medialis, medial,
`+ G. lekithos, egg yolk]
`[L.]
`syN medial, medial.
`me-di-a-lis (mé-dé-a’lis) [NA].
`me-di-an (mé’dé-an).
`1. Central; middle; lying in the midline.
`SYN medianus [NA]. 2. The middle value in a set of measure-
`ments; like the mean, a measure of central tendency. [L. media-
`nus, middle]
`[L.]
`syN median (1).
`me-di-a-nus (mé-dé-a’/niis) [NA].
`me-di-as-ti-nal (mé’dé-as-ti’nal). Relating to the mediastinum.
`me-di-as-ti-ni-tis (mé’dé-as-ti-ni‘tis).
`Inflammation of the cellu-
`lar tissue of the mediastinum.
`fibrosing m., sYN mediastinal fibrosis.
`fibrous m., scarring of mediastinal structures of unknownorigin
`or due to infection.
`
`idiopathic fibrous m., syN mediastinal fibrosis.
`me-di-as-ti-nog-ra-phy (mé’dé-as-ti-nog’ri-fé). Radiography of
`the mediastinum. [mediastinum + G. graphd, to write]
`gaseous m., radiography of the mediastinum after injection of air
`(artificial pneumomediastinum), an obsolete procedure.
`me-di-as-tin-o-per-i-car-di-tis (me’dé-as’tin-6-per’i-kar-di'tis).
`Inflammation of the pericardium and of the surrounding medias-
`tinal cellular tissue.
`me-di-as-tin-o-scope (mé-dé-as’tin’--sk6p). An endoscope for
`inspection of mediastinum through a suprasternalincision.
`me-di-as-ti-nos-co-py (mé’dé-as-ti-nos’k6-pé). Exploration of
`the mediastinum through a suprasternal incision, for biopsy of
`paratracheal lymph nodes. [mediastinum + G. skoped, to view]
`me-di-as-ti-not-o-my (mé’dé-as-ti-not’6-mé).
`Incision into the
`mediastinum. [mediastinum + G. tomé, incision]
`anterior m., SYN Chamberlain procedure.
`me-di-as-ti-num (me’dé-as-ti’ntim) [NA]. 1. A septum between
`two parts of an organ or a cavity. 2. The median partition of the
`thoracic cavity, covered by the mediastinal pleura and containing
`all
`the thoracic viscera and structures except
`the lungs.
`It
`is
`divided arbitrarily into five parts: anterior mediastinum, inferior
`mediastinum, middle mediastinum, posterior mediastinum, and
`superior mediastinum. syn interpleural space,
`interpulmonary
`septum, mediastinal space, septum mediastinale.
`[Mod. L. a
`middle septum, fr. Mediev. L. mediastinus, medial, fr. L. medias-
`tinus, a lowerservant, fr. medius, middle]
`anterior m., anterior m., the narrow region between the pericar-
`dium and the sternum containing the thymus or its remnants,
`some lymph nodes and vessels and branches of the internal
`thoracic artery. SYN m. anterius.
`
`m. ante’rius, SYN anterior m.
`inferior m., the region below a plane transecing the Ty5 interver-
`tebral disc posteriorly and the sternal angle anteriorly, demarcat-
`ing the inferior limit of the superior mediastinum. It is subdi-
`vided into three regions: middle, anterior, and posterior. syn m,
`inferius.
`m.infe’rius, syN inferior m.
`m. me’dium, syn middle m.
`middle m., the central portion of the inferior m. which contains
`the pericardium and its contents and the phrenic nerves and
`accompanying vessels. SYN m. medium.
`posterior m.,
`lies between the pericardium and the vertebral
`column, below the level of the Ty; intervertebral disc. It contains
`the descending aorta, thoracic duct, esophagus, azygos veins, and
`vagus nerves. SYN m. posterius, postmediastinum.
`m. poste’rius, sYN posterior m.
`superior m., that part lying above,i.e., above the pericardium; it
`contains the arch of the aorta and the vessels arising from it, the
`brachiocephalic veins, and upper portion of the superior vena
`cava, the trachea, the esophagus, the thoracic duct, the thymus,
`and the phrenic, vagus, cardiac, and left recurrent
`laryngeal
`nerves. SYN m. superius.
`m.supe’rius, SYN superior m.
`m.tes’tis [NA], a mass of fibrous tissue continuous with the
`tunica albuginea, projecting into the testis from its posterior
`border. syN corpus highmori, corpus highmorianum, Highmore’s
`body, septum oftestis.
`me-di-ate.
`1 (mé’dé-it). Situated between; intermediate. 2 (mé’
`dé-at). To effect something by means of an intermediary sub-
`stance, as in complement-mediated phagocytosis. [L. mediatus,
`fr. medio, pp. -atus, to divide in the middle]
`me-di-a-tion (mé-dé-a’shiin). The action of an intermediary sub-
`stance (mediator).
`me-di-a-tor (mé’dé-a-ter, -t6r). An intermediary substance or
`thing.
`pharmacologic m.’s of anaphylaxis, substances released from
`mast (and other) cells by the reaction of antigen and specific
`homocytotropic antibody on their surfaces;
`they include hista-
`mine, slow-reacting substance of anaphylaxis (SRS-A), bradyki-
`nin, and (in some species of animals) serotonin.
`med-i-ca-ble (med’i-ka-bl). Treatable, with hope of a cure.
`med-i-cal (med’i-kal). 1. Relating to medicine or the practice of
`medicine. SYN medicinal (2). 2. syN medicinal (1).
`[L. medical-
`is, fr medicus, physician]
`med-i-cal corps. The subdivision of a military organization,
`such as the U.S. Army, devoted to medical care of the troops.
`med-i-cal
`tran-scrip-tion-ist. An individual who performs
`machine transcription of physician-dictated medical reports con-
`cerning a patient’s health care, which become part of the pa-
`tient’s permanent medical record; a certified m. t. (CMT) has
`satisfied the requirements for certification by the American As-
`sociation for Medical Transcription.
`me-dic-a‘ment (me-dik’d-ment, med’i-ki-ment). A medicine,
`medicinal application, or remedy. [L. medicamentum, medicine]
`med-i-ca-‘men-to-sus (med’i-ki-men-t0’siis). Relating to a drug:
`denoting a drug eruption. [L.]
`med-i-cate (med’i-kat).
`1. To treat disease by the giving of
`drugs. 2. To impregnate with a medicinal substance. [L. medico,
`pp. -atus, to heal]
`med-i-cat-ed (med’i-kat-ed).
`stance.
`
`Impregnated with a medicinal sub-
`
`1. The act of medicating. 2. A
`med.i-ca-tion (med-i-ka’shtin).
`medicinal substance, or medicament.
`arrhenic m., treatment of disease by meansof the organic prepa
`rations of arsenic, the cacodylates, and methylarsinates.
`ionic m., SYN iontophoresis.
`maintenance medication, m.
`symptomsofillness.
`preanesthetic m., drugs administered prior to an anesthetic tO
`decrease anxiety and to obtain a smoother induction of, mainte
`nance of, and emergence from anesthesia.
`
`taken to stabilize an illness OF
`
`