UNITED STATES INTERNATIONAL TRADE COMMISSION
`WASHINGTON, D.C.
`
` Before The Honorable Charles E. Bullock
`
`Chief Administrative Law Judge
`
`In the Matter of
`
`CERTAIN ELECTROCHEMICAL
`GLUCOSE MONITORING SYSTEMS
`AND COMPONENTS THEREOF
`
`Inv. No. 337-TA-1075
`
`EXPERT REPORT OF RICHARD T. MIHRAN, PH.D., REGARDING
`INFRINGEMENT OF U.S. PATENT NOS. 9,724,045 AND 9,750,460
`
`Dated: April 12, 2018
`
`
` Richard Mihran, Ph.D.
`
`
`
`AGAMATRIX, INC. EXHIBIT NO. 1020
`Page 1 of 19
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`I.
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`II.
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`III.
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`IV.
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`TABLE OF CONTENTS
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`Page
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`INTRODUCTION ............................................................................................................. 1
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`QUALIFICATIONS .......................................................................................................... 3
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`INFORMATION CONSIDERED IN FORMING OPINION ........................................... 6
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`LEGAL STANDARDS ..................................................................................................... 6
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`A.
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`B.
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`C.
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`D.
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`E.
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`Legal Standards for Direct Infringement ............................................................... 7
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`Legal Standards for Infringement under the Doctrine of Equivalents ................... 7
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`Legal Standards for Inducement .......................................................................... 10
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`Legal Standards for Contributory Infringement .................................................. 10
`
`Violations of 19 U.S.C. § 1337 ............................................................................ 11
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`V.
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`OVERVIEW OF THE ASSERTED PATENTS.............................................................. 12
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`VI.
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`The Patent Prosecution History ....................................................................................... 25
`
`A.
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`
`
`B.
`
`
`
`Prosecution history of the ‘045 patent ................................................................. 25
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`Prosecution history of the ‘460 patent ................................................................. 28
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`VII. CLAIM CONSTRUCTION ............................................................................................. 30
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`VIII. Person Having Ordinary Skill in the Art.......................................................................... 37
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`IX.
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`SUMMARY OF OPINIONS ........................................................................................... 38
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`X.
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`OverView of the Accused Products ................................................................................. 39
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`A.
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`B.
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`C.
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`D.
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`E.
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`KeyNote Product Family – AgaMatrix Presto ..................................................... 40
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`Jazz Product Family – CVS Health Advanced Glucose Meter ............................ 44
`
`Jazz Wireless 2 (Kronos) Family of Products – AgaMatrix Jazz Wireless 2 ...... 47
`
`Common Analytical Platform across Accused Products ..................................... 52
`
`Alpha Analytical Platform ................................................................................... 53
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`1.
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`2.
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`3.
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`Overview of Test Strips ........................................................................... 55
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`Test Strip Components and Configuration .............................................. 59
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`Electrochemical Assay ............................................................................. 64
`
`XI.
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`INFRINGEMENT OF THE ‘045 PATENT ................................................................ 82
`
`A.
`
`
`
`Claim 16 – ‘045 Patent ....................................................................................... 82
`
`1.
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`
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`Claim 16(a): A glucose sensor system, the system comprising: ......... 83
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`-i-
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`AGAMATRIX, INC. EXHIBIT NO. 1020
`Page 2 of 19
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`TABLE OF CONTENTS
`(continued)
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`Page
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`2.
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`3.
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`4.
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`5.
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`6.
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`7.
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`8.
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`9.
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`10.
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`11.
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`Claim 16(b): an electrochemical glucose sensor configured to
`be in contact with a biological sample for measuring a glucose
`concentration, wherein the electrochemical glucose sensor
`comprises a first electrode, a second electrode, and an enzyme-
`containing film; ...................................................................................... 95
`
`Claim 16(c): sensor electronics comprising a processor for
`executing a computer program code stored in a memory to
`cause the sensor electronics to: ........................................................... 124
`
`Claim 16(d): apply a voltage to the electrochemical glucose
`sensor at a first setting, ........................................................................ 143
`
`Claim 16(e): switch the voltage applied to the electrochemical
`sensor to a different setting, ................................................................ 186
`
`Claim 16(f): measure a signal response of the electrochemical
`glucose sensor responsive to the switching, ....................................... 217
`
`Claim 16(g): evaluate a severity associated with a signal
`artifact based on the measured signal response of the
`electrochemical glucose sensor to the switching, ............................... 251
`
`Claim 16(h): wherein the signal artifact is associated with a
`non-glucose rate limiting phenomenon, and ...................................... 272
`
`Claim 16(i): generate an estimated glucose concentration value
`when the severity associated with the signal artifact is
`evaluated to be under a predetermined threshold, ........................... 274
`
`Claim 16(j): wherein the estimated glucose concentration
`value accounts for the severity associated with the signal
`artifact; and .......................................................................................... 280
`
`Claim 16(k): a user interface configured to display the
`estimated glucose concentration value. .............................................. 284
`
`B.
`
`
`
`C.
`
`
`Claim 17 – ‘045 Patent ..................................................................................... 290
`
`Claim 20 – ‘045 Patent: The system of claim 16, wherein the
`measured signal response is a voltage response of the electrochemical
`glucose sensor. .................................................................................................. 294
`
`1.
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`2.
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`
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`3.
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`4.
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`5.
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`
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`KeyNote Product Family - AgaMatrix Presto: Claim 20 ................ 294
`
`Jazz Product Family – CVS Health: Claim 20 ................................. 305
`
`Jazz Wireless 2 Product Family – AgaMatrix Jazz Wireless 2:
`Claim 20 ................................................................................................ 314
`Computation of sample mobility, vtmob ............................................... 326
`
`Calculation of final glucose concentration ......................................... 328
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`-ii-
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`AGAMATRIX, INC. EXHIBIT NO. 1020
`Page 3 of 19
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`D.
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`E.
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`TABLE OF CONTENTS
`(continued)
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`Page
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`Claim 23 – ‘045 Patent: The system of claim 16, wherein the non-
`glucose rate limiting phenomenon is associated with a temperature. ......... 330
`Computation of sample mobility, vtmob ............................................... 331
`
`2.
`
`
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`Claim 24 – ‘045 Patent: The system of claim 16, wherein the non-
`glucose rate limiting phenomenon is associated with an available
`electrode surface area. ..................................................................................... 335
`
`F.
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`
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`Claim 37 – ‘045 Patent ..................................................................................... 336
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`1.
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`2.
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`3.
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`4.
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`5.
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`6.
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`7.
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`8.
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`9.
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`10.
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`11.
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`Claim 37(a): A glucose sensor system, the system comprising: ...... 337
`
`Claim 37(b): an electrochemical glucose sensor configured to
`be in contact with a biological sample for measuring a glucose
`concentration, wherein the electrochemical glucose sensor
`comprises a first electrode, a second electrode, and an enzyme-
`containing film; .................................................................................... 337
`
`Claim 37(c): sensor electronics comprising a processor for
`executing a computer program code stored in a memory to
`cause the sensor electronics to: ........................................................... 337
`
`Claim 37(d): apply a voltage to the electrochemical glucose
`sensor at a first setting, ........................................................................ 337
`
`Claim 37(e): switch the voltage applied to the electrochemical
`sensor to a different setting, ................................................................ 337
`
`Claim 37(f): measure a signal response of the electrochemical
`glucose sensor responsive to the switching, ....................................... 338
`
`Claim 37(g): wherein the measured signal response is a time-
`varying voltage response of the electrochemical glucose sensor ...... 338
`
`Claim 37(h): evaluate a severity associated with a signal
`artifact based on the measured signal response of the
`electrochemical glucose sensor to the switching, ............................... 361
`
`Claim 37(i): wherein the signal artifact is associated with a
`non-glucose rate limiting phenomenon, and ...................................... 361
`
`Claim 37(j): generate an estimated glucose concentration
`value when the severity associated with the signal artifact is
`evaluated to be under a predetermined threshold, ........................... 361
`
`Claim 37(k): wherein the estimated glucose concentration
`value accounts for the severity associated with the signal
`artifact; and .......................................................................................... 361
`
`12.
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`
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`Claim 37(l): a user interface configured to: ..................................... 361
`
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`-iii-
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`AGAMATRIX, INC. EXHIBIT NO. 1020
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`TABLE OF CONTENTS
`(continued)
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`Page
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`13.
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`14.
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`15.
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`16.
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`17.
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`18.
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`Claim 37(m): display a first screen presenting generated
`glucose concentration data over a first time period, ......................... 367
`
`Claim 37(n): display a second screen presenting generated
`glucose concentration data over a second time period, .................... 374
`
`Claim 37(o): where the second time period is different in
`length from the first time period, ....................................................... 382
`
`Claim 37(p): display a third screen presenting estimated
`glucose concentration value, ............................................................... 393
`
`Claim 37(q): allow a user to toggle between the first screen,
`the second screen, and the third screen, ............................................ 402
`
`Claim 37(r): and generate an alert responsive to the detection
`of a hyperglycemic condition or hypoglycemic condition. ............... 412
`
`G.
`
`
`
`H.
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`
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`I.
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`
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`Claim 38 – ‘045 Patent: The system of claim 37, wherein the biological
`sample is blood. ................................................................................................ 424
`
`Claim 41 – ‘045 Patent: The system of claim 37, wherein the non-
`glucose rate limiting phenomenon is associated with a temperature. ......... 424
`
`Claim 42 – ‘045 Patent: The system of claim 37, wherein the non-
`glucose rate limiting phenomenon is associated with an available
`electrode surface area. ..................................................................................... 424
`
`XII.
`
`INFRINGEMENT OF THE ‘460 PATENT .............................................................. 424
`
`A.
`
`
`
`Claim 20 – ’460 Patent ..................................................................................... 424
`
`1.
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`2.
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`3.
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`4.
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`5.
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`
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`Claim 20(a): A glucose sensor system, the system comprising: ....... 425
`
`Claim 20(b): an electrochemical glucose sensor configured to
`be in contact with a biological fluid to obtain a glucose
`measurement, wherein the electrochemical glucose sensor
`comprises a first electrode, a second electrode, and an enzyme-
`containing film; and ............................................................................. 437
`
`Claim 20(c): sensor electronics comprising a processor for
`executing computer program code stored in a memory to cause
`the processor to: ................................................................................... 466
`
`Claim 20(d): apply a voltage to the electrochemical glucose
`sensor, wherein applying the voltage comprises at least one
`process selected from the group consisting of switching,
`cycling, and pulsing a voltage applied to the electrochemical
`glucose sensor, ...................................................................................... 484
`
`Claim 20(e): measure a signal response of the electrochemical
`glucose sensor responsive to the applying, ......................................... 560
`
`
`
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`-iv-
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`AGAMATRIX, INC. EXHIBIT NO. 1020
`Page 5 of 19
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`TABLE OF CONTENTS
`(continued)
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`Page
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`6.
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`7.
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`8.
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`Claim 20(f): detect an erroneous signal based at least in part
`on the signal response of the electrochemical glucose sensor to
`the applying, ......................................................................................... 594
`
`Claim 20(g): wherein the erroneous signal is associated with
`an available electrode surface area, ................................................... 624
`
`Claim 20(h) and 20(i): determine a value associated with a
`severity of the erroneous signal, and discard a glucose
`measurement when the value associated with the severity of the
`erroneous signal is outside of a predetermined threshold value. ..... 625
`
`B.
`
`
`
`Claim 24 – ‘460 Patent: The system of claim 20, wherein the measured
`signal response is a voltage response of the electrochemical glucose
`sensor. ................................................................................................................ 638
`
`1.
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`
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`2.
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`
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`3.
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`
`
`4.
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`
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`5.
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`
`
`KeyNote Product Family - AgaMatrix Presto: Claim 24 ................ 638
`
`Jazz Product Family – CVS Health: Claim 24 ................................. 649
`
`Jazz Wireless 2 Product Family – AgaMatrix Jazz Wireless 2:
`Claim 24 ................................................................................................ 658
`Computation of sample mobility, vtmob ............................................... 670
`
`Calculation of final glucose concentration ......................................... 672
`
`C.
`
`
`Claim 26 – ’460 Patent ..................................................................................... 674
`
`1.
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`2.
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`
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`3.
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`4.
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`
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`5.
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`
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`Claim 26(a): A glucose sensor system, the system comprising: ....... 675
`
`Claim 26(b): an electrochemical glucose sensor configured to
`be in contact with a biological fluid to obtain a glucose
`measurement, wherein the electrochemical glucose sensor
`comprises a first electrode, a second electrode, and an enzyme-
`containing film; and ............................................................................. 675
`
`Claim 26(c): sensor electronics comprising a processor for
`executing computer program code stored in a memory to cause
`the processor to: ................................................................................... 675
`
`Claim 26(d): apply a voltage to the electrochemical glucose
`sensor, wherein applying the voltage comprises at least one
`process selected from the group consisting of switching,
`cycling, and pulsing a voltage applied to the electrochemical
`glucose sensor, ...................................................................................... 675
`
`Claim 26(e): measure a signal response of the electrochemical
`glucose sensor responsive to the applying, ......................................... 675
`
`
`
`
`
`-v-
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`AGAMATRIX, INC. EXHIBIT NO. 1020
`Page 6 of 19
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`
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`TABLE OF CONTENTS
`(continued)
`
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`Page
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`6.
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`7.
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`8.
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`
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`Claim 26(f): detect an erroneous signal based at least in part
`on the signal response of the electrochemical glucose sensor to
`the applying, ......................................................................................... 675
`
`Claim 26(g): wherein the erroneous signal is caused by a
`temperature associated with the electrochemical glucose
`sensor, .................................................................................................... 675
`
`Claim 26(h) and 26(i): determine a value associated with a
`severity of the erroneous signal, and discard a glucose
`measurement when the value associated with the severity of the
`erroneous signal is outside of a predetermined threshold value. ..... 677
`
`D.
`
`
`Claim 30 – ‘460 Patent: The system of claim 30, wherein the measured
`signal response is a voltage response of the electrochemical glucose
`sensor. ................................................................................................................ 677
`
`E.
`
`
`
`Claim 32 – ’460 Patent ..................................................................................... 678
`
`1.
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`2.
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`3.
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`4.
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`5.
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`6.
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`7.
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`Claim 32(a): A glucose sensor system, the system comprising: ....... 678
`
`Claim 32(b): an electrochemical glucose sensor configured to
`be in contact with a biological fluid to obtain a glucose
`measurement, wherein the electrochemical glucose sensor
`comprises a first electrode, a second electrode, and an enzyme-
`containing film; and ............................................................................. 678
`
`Claim 32(c): sensor electronics comprising a processor for
`executing computer program code stored in a memory to cause
`the processor to: ................................................................................... 679
`
`Claim 32(d): apply a voltage to the electrochemical glucose
`sensor, wherein applying the voltage comprises at least one
`process selected from the group consisting of switching,
`cycling, and pulsing a voltage applied to the electrochemical
`glucose sensor, ...................................................................................... 679
`
`Claim 32(e): measure a signal response of the electrochemical
`glucose sensor responsive to the applying, ......................................... 679
`
`Claim 32(f): detect an erroneous signal based at least in part
`on the signal response of the electrochemical glucose sensor to
`the applying, ......................................................................................... 679
`
`Claim 32(g): wherein the erroneous signal is associated with a
`local environment associated with the electrode surface of the
`first electrode, ....................................................................................... 679
`
`
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`-vi-
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`AGAMATRIX, INC. EXHIBIT NO. 1020
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`TABLE OF CONTENTS
`(continued)
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`Page
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`8.
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`
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`Claim 32(h) and 32(i): determine a value associated with a
`severity of the erroneous signal, and discard a glucose
`measurement when the value associated with the severity of the
`erroneous signal is outside of a predetermined threshold value. ..... 680
`
`F.
`
`
`
`Claim 36 – ‘460 Patent: The system of claim 32, wherein the measured
`signal response is a voltage response of the electrochemical glucose
`sensor. ................................................................................................................ 680
`
`G.
`
`
`
`Claim 38 – ’460 Patent ..................................................................................... 680
`
`1.
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`2.
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`3.
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`4.
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`5.
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`6.
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`7.
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`8.
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`Claim 38(a): A glucose sensor system, the system comprising: ....... 681
`
`Claim 38(b): an electrochemical glucose sensor configured to
`be in contact with a biological fluid to obtain a glucose
`measurement, wherein the electrochemical glucose sensor
`comprises a first electrode, a second electrode, and an enzyme-
`containing film; and ............................................................................. 681
`
`Claim 38(c): sensor electronics comprising a processor for
`executing computer program code stored in a memory to cause
`the processor to: ................................................................................... 681
`
`Claim 38(d): apply a voltage to the electrochemical glucose
`sensor, wherein applying the voltage comprises at least one
`process selected from the group consisting of switching,
`cycling, and pulsing a voltage applied to the electrochemical
`glucose sensor, ...................................................................................... 681
`
`Claim 38(e): measure a signal response of the electrochemical
`glucose sensor responsive to the applying, ......................................... 681
`
`Claim 38(f): detect an erroneous signal based at least in part
`on the signal response of the electrochemical glucose sensor to
`the applying, ......................................................................................... 681
`
`Claim 38(g): wherein the erroneous signal is associated with a
`diffusion transport of glucose or a measured species, ...................... 682
`
`Claim 38(h) and 38(i): determine a value associated with a
`severity of the erroneous signal, and discard a glucose
`measurement when the value associated with the severity of the
`erroneous signal is outside of a predetermined threshold value. ..... 688
`
`H.
`
`
`
`Claim 42 – ‘460 Patent: The system of claim 38, wherein the measured
`signal response is a voltage response of the electrochemical glucose
`sensor. ................................................................................................................ 688
`
`I.
`
`
`
`Claim 56 – ’460 Patent ..................................................................................... 689
`
`1.
`
`
`
`Claim 56(a): A glucose sensor system, the system comprising: ....... 689
`
`
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`-vii-
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`TABLE OF CONTENTS
`(continued)
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`Page
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`2.
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`3.
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`4.
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`5.
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`6.
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`7.
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`8.
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`Claim 56(b): an electrochemical glucose sensor configured to
`be in contact with a biological fluid to obtain a glucose
`measurement, wherein the electrochemical glucose sensor
`comprises a first electrode, a second electrode, and an enzyme-
`containing film; and ............................................................................. 689
`
`Claim 56(c): sensor electronics comprising a processor for
`executing computer program code stored in a memory to cause
`the processor to: ................................................................................... 690
`
`Claim 56(d): apply a voltage to the electrochemical glucose
`sensor, wherein applying the voltage comprises at least one
`process selected from the group consisting of switching,
`cycling, and pulsing a voltage applied to the electrochemical
`glucose sensor, ...................................................................................... 690
`
`Claim 56(e): measure a signal response of the electrochemical
`glucose sensor responsive to the applying, ......................................... 690
`
`Claim 56(f): detect an erroneous signal based at least in part
`on the signal response of the electrochemical glucose sensor to
`the applying, ......................................................................................... 690
`
`Claim 56(g): wherein the erroneous signal is associated with
`an oxygen deficit, .................................................................................. 690
`
`Claim 56(h) and 56(i): determine a value associated with a
`severity of the erroneous signal, and discard a glucose
`measurement when the value associated with the severity of the
`erroneous signal is outside of a predetermined threshold value. ..... 695
`
`J.
`
`
`Claim 60 – ‘460 Patent: The system of claim 30, wherein the measured
`signal response is a voltage response of the electrochemical glucose
`sensor. ................................................................................................................ 695
`
`K.
`
`
`
`Claim 63 – ’460 Patent ..................................................................................... 695
`
`1.
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`
`
`2.
`
`
`
`3.
`
`
`
`Claim 63(a): A glucose sensor system, the system comprising: ....... 697
`
`Claim 63(b): an electrochemical glucose sensor configured to
`be in contact with a blood sample to obtain a glucose
`measurement, wherein the electrochemical glucose sensor
`comprises a first electrode, a second electrode, and an enzyme-
`containing film; and ............................................................................. 697
`
`Claim 63(c): sensor electronics comprising a processor for
`executing computer program code stored in a memory to cause
`the processor to: ................................................................................... 725
`
`
`
`
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`-viii-
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`TABLE OF CONTENTS
`(continued)
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`Page
`
`Claim 63(d): apply a voltage to the electrochemical glucose
`sensor, wherein applying the voltage comprises at least one
`process selected from the group consisting of switching,
`cycling, and pulsing a voltage applied to the electrochemical
`glucose sensor, ...................................................................................... 725
`
`Claim 63(e): measure a signal response of the electrochemical
`glucose sensor responsive to the applying, ......................................... 725
`
`Claim 63(f): detect an erroneous signal based at least in part
`on the signal response of the electrochemical glucose sensor to
`the applying, ......................................................................................... 725
`
`Claim 63(g): wherein the erroneous signal is associated with
`an available electrode surface area, ................................................... 725
`
`Claim 63(h): determine a value associated with a severity of
`the erroneous signal, ............................................................................ 725
`
`Claim 63(i): generate a glucose value for display when the
`value associated with the severity of the erroneous signal
`satisfies a predetermined threshold value, and ................................. 725
`
`Claim 63(j): discard a glucose measurement when the value
`associated with the severity of the erroneous signal is outside of
`a predetermined threshold value; and ............................................... 732
`
`Claim 63(k): a user interface configured to display the
`generated glucose value when the value associated with the
`severity of the erroneous signal satisfies a predetermined
`threshold value, .................................................................................... 732
`
`Claim 63(l): wherein the user interface allows a user to toggle
`between a first screen, a second screen, and a third screen, ............ 739
`
`Claim 63(m): wherein the first screen presents the generated
`glucose value in a glucose measurement trend graph extending
`over a first time period, ....................................................................... 748
`
`Claim 63(n): wherein the second screen presents the generated
`glucose value in a glucose measurement trend graph extending
`over a second time period that is different in length from the
`first time period, ................................................................................... 755
`
`Claim 63(o): wherein the third screen presents the generated
`glucose value as a numerical value, and,............................................ 772
`
`Claim 63(p): wherein the user interface is configured to
`generate an alert responsive to detection of a hypoglycemic
`condition or a hypoglycemic condition based on the generated
`glucose value. ........................................................................................ 781
`
`4.
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`5.
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`6.
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`7.
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`8.
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`9.
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`10.
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`11.
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`12.
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`13.
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`14.
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`AGAMATRIX, INC. EXHIBIT NO. 1020
`Page 10 of 19
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`TABLE OF CONTENTS
`(continued)
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`Page
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`L.
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`Claim 64 – ’460 Patent ..................................................................................... 792
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`2.
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`3.
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`4.
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`11.
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`Claim 64(a): A glucose sensor system, the system comprising: ....... 794
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`Claim 64(b): an electrochemical glucose sensor configured to
`be in contact with a blood sample to obtain a glucose
`measurement, wherein the electrochemical glucose sensor
`comprises a first electrode, a second electrode, and an enzyme-
`containing film; and ............................................................................. 794
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`Claim 64(c): sensor electronics comprising a processor for
`executing computer program code stored in a memory to cause
`the processor to: ................................................................................... 794
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`Claim 64(d): apply a voltage to the electrochemical glucose
`sensor, wherein applying the voltage comprises at least one
`process selected from the group consisting of switching,
`cycling, and pulsing a voltage applied to the electrochemical
`glucose sensor, ...................................................................................... 794
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`Claim 64(e): measure a signal response of the electrochemical
`glucose sensor responsive to the applying, ......................................... 794
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`Claim 64(f): detect an erroneous signal based at least in part
`on the signal response of the electrochemical glucose sensor to
`the applying, ......................................................................................... 794
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`Claim 64(g): wherein the erroneous signal is associated with a
`temperature associated with the electrochemical glucose
`sensor, .................................................................................................... 795
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`Claim 64(h): determine a value associated with a severity of
`the erroneous signal, ............................................................................ 795
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`Claim 64(i): generate a glucose value for display when the
`value associated with the severity of the erroneous signal
`satisfies a predetermined threshold value, and ................................. 795
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`Claim 64(j): discard a glucose measurement when the value
`associated with the severity of the erroneous signal is outside of
`a predetermined threshold value; and ............................................... 795
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`Claim 64(k): a user interface configured to display the
`generated glucose value when the value associated with the
`severity of the erroneous signal satisfies a predetermined
`threshold value, .................................................................................... 795
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`12.
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`Claim 64(l): wherein the user interface allows a user to toggle
`between a first screen, a second screen, and a third screen, ............ 795
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`AGAMATRIX, INC. EXHIBIT NO. 1020
`Page 11 of 19
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`TABLE OF CONTENTS
`(continued)
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`Page
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`13.
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`14.
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`Claim 64(m): wherein the first screen presents the generated
`glucose value in a glucose measurement trend graph extending
`over a first time period, ....................................................................... 795
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`Claim 64(n): wherein the second screen presents the generated
`glucose value in a glucose measurement trend graph extending
`over a second time period that is different in length from the
`first time period, ................................................................................... 795
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`Claim 64(o): wherein the third screen presents the generated
`glucose value as a numerical value, and,............................................ 796
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`Claim 64(p): wherein the user interface is configured to
`generate an alert responsive to detection of a hypoglycemic
`condition or a hypoglycemic condition based on the generated
`glucose value. ........................................................................................ 796
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`M.
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`Claim 65 – ’460 Patent ..................................................................................... 796
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`1.
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`2.
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`3.
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`4.
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`Claim 65(a): A glucose sensor system, the system comprising: ....... 797
`
`Claim 65(b): an electrochemical glucose sensor configured to
`be in contact with a blood sample to obtain a glucose
`measurement, wherein the electrochemical glucose sensor
`comprises a first electrode, a second electrode, and an enzyme-
`containing film; and ............................................................................. 797
`
`Claim 65(c): sensor electronics comprising a processor for
`executing computer