`Thousands
`
`12,000
`
`11,000
`
`10,000
`
`9,000
`
`8,000
`
`7,000
`
`6,000
`
`5,000
`
`4,000
`
`3,000
`
`2,000
`
`1,000
`
`0
`2005
`
`2006
`
`2007
`
`2008
`
`2009
`
`2010
`
`2011
`
`2012
`
`2013
`
`2014
`
`2015
`
`2016
`
`2017
`
`2018
`
`........ Basaglar KwikPen
`........ Levemir Pens
`........ Tresiba FlexTouch
`
`........ Lanius OpliClik
`e--e
`Toujeo Max SoloSTAR
`
`........ Lanius SoloSTAR
`----- Toujeo SoloSTAR
`
`Source: IMS Health
`Note: The long-acting category includes drugs listed under the IMS USC5 codes 39123 (Human Insulins Long Acting), 39133 (Analogs of Human Insulin Long Acting), and 39135
`(Analogs of Human Insulin Ultra Long Acting). Lantus OptiClik is defined as records with Product Summary "LANTUS" and Form TLC3 "FCC DISP SYR REGULAR SC.OL Y." Levemir
`Pens include Levemir FlexPen and Levemir FlexTouch. Products are designated as "Levemir FlexPen" if IMS Health data indicates that Product Summary is "LEVEMIR FLEXPEN" or if
`both Product Summary is "LEVEMIR" and TLC3 code is "GCC DISP SYR LG ACT SC ONLY." Toujeo Max SoloSTAR was first introduced in April 2018.
`
`Sanofi Exhibit 2198.001
`Mylan v. Sanofi
`IPR2018-01676
`
`