Dr. Reddy’s Laboratories, Inc. v. Celgene Corp.
`IPR2018-01509
`Exhibit 2033, Page 1
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`Dr. Reddy’s Laboratories, Inc. v. Celgene Corp.
`0
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`Exhibit 2033, Page 2
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` || ' iffft
`
`i symbol for 1 iso (def. 3): (as a prefix or superscript in symbols
`and abbreviations for iso compounds or groups; c.g. isopropyl
`can be symbolized as iPr or Pr’). 2 the chemical group 2-
`isopentenyl!; 3,3-dimethylally! (as a prefix to a single-letter
`symbol for a nucleoside residue to designate substitution of
`the base, as in iA). 3 the square root of ~1.
`isymbolfor 1 electric current (alternative to /). 2 van't Hoff fac-
`tor.
`I symbol for 1 iodine. 2 an iodo group in an organic compound.
`3 a residue of the @-aminoacid L-isoleucine (alternative to
`lie). 4 a residue of the ribonucleoside inosine (alternative to
`Ino).
`I symbol for 1 electric current (preferred alternative to1). 2 in-
`tensity; the subscripts e (for energetic), p (for photon), or v
`(for visible) may be added to distinguish between radiant in-
`tensity, photon intensity, and luminous intensity, respectively.
`3 ionic strength; the subscripts ¢ or m may be added to indi-
`cate whether it is expressed based on concentration or molal-
`ity respectively. 4 the inductive effect of a particular chemical
`group in an organic compound.
`iA symbolfor N®-(2-isopentenyl)adenosine, a hypermodified base.
`IAA abbr. for indole-3-acetic acid or indoleacetate.
`IAN abbr. for indoleacetonitrile.
`IAP abbr. for islet-activating protein; sce pertussis toxin.
`iatrogenic describing a condition or disease induced uninten-
`tionally by a physician through his or her diagnosis, manner,
`or therapy. —iatrogenicity 7.
`I-band abbr.for isotropic band. The I-bandsofstriated muscle
`contain the thin filaments and correspond to the light bands.
`The name derives from the fact that they are isotropic in po-
`larized light. See also sarcomere.
`IBMX abbr. for isobutylmethylxanthine.
`ibuprofen 2-(4-isobutylphenyl)propionic acid: a nonsteroidal
`anti-inflammatory agent of the substituted propionic acid
`type; others of this type are flurbiprofen, ketoprofen. and
`naproxen. They inhibit the cyclooxygenase activity of prosta-
`glandin-endoperoxide synthase, reversibly over short time inter-
`vals, followed by time-dependent irreversible inactivation, duc
`probably to conformational rather than covalent changes. The
`racemic mixture is present
`in many over-the-counter drugs,
`but the (S)-enantiomer is the active form. Proprietary names
`include: Advil: Brufen: Motrin.
`
`
`
`| a
`
`kDa, are expressed on B and Tcells, endothelial, epithelial,
`and dendritic cells. fibroblasts. keratinocytes, and chondro-
`cytes. They are inducible in 12-24 hours by cytokines such as
`gammainterferon. interleukin-1B, and tumour necrosis factor-
`a. Example (human, precursors):
`ICAM-1 major group rhi-
`novirus receptor: database code ICA]. HUMAN, 532 amino
`acids (57.76 kDa). ICAM-2 (er CD102), of molecular mass
`55-65 kDa, are constitutively expressed on endothelial cells.
`some lymphocytes, monocytes, and dendritic cells. Example
`(human): database code ICA2,_ HUMAN, 275 amino acids
`(30.62 kDa). ICAM-3 (vr CD50), of molecular mass 116-140
`kDa, are constitutively expressed on monocytes, granulocytes.
`and lymphocytes; upon physiological stimulation they become
`rapidly and transiently phosphorylated on serine residues. Ex-
`ample (human): database code ICA3_HUMAN, 547 amino
`acids (59.32 kDa).
`§CD (in clinical chemistry) abbr. for isocitrate dehydrogenase
`(EC1.1.1.41).
`ice the solid formof water that can exist at temperatures below
`the triple point of water (273.16 K at 101 325 Pa).
`iceberg a metaphor used to describe an interpretation of the
`anomalousentropiesof solution of noble gases and other non-
`polar substances in water, suggesting that water tends to organ-
`ize itself into quasi-solid supramolecular structures aroundthe
`molecules of such substances. In the case of alkyl compounds.
`this tendency increases markedly with the length of the alkyl
`chain.
`ICE-like protease any of a family of endopeptidases that
`structurally resemble interleukin-1B convertase (ICE). They are
`involved in apoptosis, being implicated in the proteolysis that
`causes cell death.
`Icell
`1 or CCK cell anyof a group ofcells, widely distributed
`in the duodenal and jejunal mucosa, that produce cholecysto-
`kinin. So named because their histological features are inter-
`mediate between those of $ cells and L cells. 2 abbr. for
`inclusion cell, See also |-cell disease.
`[-cell disease or inclusion-cell disease vr mucolipidosis I] an
`autosomal recessive disease in which most of the lysosomes in
`the connective tissue (fibroblasts) contain large inclusions of
`glycoaminoglycans and glycolipids as a result of the absence
`of several
`lysosomal hydrolases. These enzymes, which are
`synthesized in the endoplasmic reticulum, are secreted into the
`extracellular medium rather than being directed to the lyso-
`somes. This is due to the absence of a mannose 6-phosphate
`marker on the carbohydrate moieties of these hydrolases be-
`cause of a deficiency in an enzyme required for mannose phos-
`phorylation. The failure of the phosphorylation in the cis
`Golgi network means that the enzymes are not segregated by
`the mannose 6-phosphate receptors into the appropriate transport
`vesicles in the trans Golgi network. The patients have an ab-
`normally high level of lysosomal enzymes in their sera and
`bodyfluids. A milder form of I-cell disease is Hurler’s poly-
`dystrophy (Hurler syndrome).
`for intracutaneous or intracutaneously.
`ic or i.c. abbr.
`ice point the temperature at which ice melts. It is taken as the
`IC abbr. for internal conversion
`temperature (273.15 K) at which ice and water are in equilib-
`ICgq 1 the median inhibitory concentration (in mo] L ') of an
`riumat standard pressure (101 325 Pa). It was used as a reter-
`antagonist, i.e. the concentration that reduces a specified re-
`ence temperature on the Celsius scale. but the kelvin is based
`sponse to 50%ofits former value: compare ECypy. 2 the median
`instead on the temperature at thetriple point of water (273.16 K).
`inhibitory concentration (in mol L-') of an agent (agonist or
`antagonist), i.e. the concentration that causes a 50% reduction CF abbr. for intracellular fluid.
`ichthyotocin an alternative name forisotocin.
`in the specific binding of a radioligand.
`ICAM abbr. for intercellular adhesion molecule: any of several
`icosa+ or (before a vowel) icos+ comb, form recommended for
`denoting twenty or twenty times. Also (formerly): eicosat.
`type | membrane glycoproteins of the immunoglobulin super-
`eicos+. (Note: the eicos(a)+ variant is still always used for the
`family. They act as ligands for leukocyte adhesion to target
`Crp fatty acids and skeletally related compounds, e.g.
`the
`cells,
`in conjunction with LFA-1;
`in fact LFA-!-ICAMlinks
`eicosanoids.)
`mediate adhesion between many cell
`types. There are three
`subclasses.
`ICAM-I
`(or CD54), of molecular mass 90-115
`icosadeltahedron (p/. icosadeltahedra) any solid geometrical
`
` H3C
`
`(S)-ibuprofen
`
`