CURRICULUM VITAE
`
`Ned H. Kalin, M.D.
`Hedberg Professor
`Chair, Department of Psychiatry
`University of Wisconsin School of Medicine and Public Health
`6001 Research Park Boulevard
`Madison, WI. 53719
`Tel: 608-263-6079 | Email: nkalin@wisc.edu
`
`Education
`
`1972 BS with Distinction, Pre-Medicine, Pennsylvania State University, State College, PA
`
`1976 MD, Jefferson Medical College, Philadelphia, PA
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`Residency and Fellowships
`
`1979 Psychiatry Residency, University of Wisconsin, Madison, WI
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`1981 Research Fellow, Neuropsychopharmacology, National Institute of Mental Health, Bethesda, MD
`
`Licensure and Certification
`
`1977 Diplomat, National Board of Medical Examiners, Medical License, Wisconsin
`
`1981 American Board of Psychiatry and Neurology
`
`Current Position
`
`Hedberg Professor and Chairman, Department of Psychiatry, University of Wisconsin School of Medicine and
`Public Health, Madison WI, United States
`
`Professor, Department of Psychology, University of Wisconsin School of Medicine and Public Health, Madison
`WI, United States
`
`Director, HealthEmotions Research Institute, University of Wisconsin School of Medicine and Public Health,
`Madison WI, United States
`
`Director, Lane Neuroimaging Laboratory, University of Wisconsin School of Medicine and Public Health,
`Madison WI, United States
`
`Principal Investigator, Conte Adolescence Center, University of Wisconsin, Madison, WI, United States
`
`Affiliate Scientist, Wisconsin Regional Primate Center and Harlow Primate Laboratory, University of Wisconsin,
`Madison WI, United States
`
`Positions Held
`
`Staff Psychiatrist, (Surgeon Lt-04) Clinical Neuropharmacology Branch, National Institute of
`1979 - 1981
`
`
`
` Mental Health, Bethesda, MD
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`1981 - 1983 Assistant Professor of Psychiatry, University of Wisconsin School of Medicine and Public
`
`
`
` Health, Madison WI, United States
`
`1984 - 1986 Associate Professor of Psychiatry, University of Wisconsin School of Medicine and Public
`
`
`
` Health, Madison WI, United States
`
`1986 - present Hedberg Professor of Psychiatry, University of Wisconsin School of Medicine and Public
`
`
`
` Health, Madison WI, United States
`
`Corcept Therapeutics, Inc.
`Exhibit 2017
`Neptune Generics, LLC v. Corcept Therapeutics, Inc.
`Case IPR2018-01494
`
`Ex. 2017-0001
`
`

`

`Ned H. Kalin, MD
`Curriculum Vitae
`April 2019
`
`1987 - 1991 Vice Chairman, Department of Psychiatry, University of Wisconsin School of Medicine and
`
`
`
`
`Public Health, Madison WI, United States
`
`1990 - 1991
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`Chief of Psychiatry Service, William S. Middleton VA Hospital, Madison WI, United States
`
`1991 - present Chairman, Department of Psychiatry, University of Wisconsin School of Medicine and Public
`
`
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` Health, Madison WI, United States
`
`1995 - present Director, HealthEmotions Research Institute, University of Wisconsin School of Medicine and
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`
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`Public Health, Madison WI, United States
`
`2008 - present Director, Lane Neuroimaging Laboratory, University of Wisconsin University of Wisconsin
`
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`
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`School of Medicine and Public Health, Madison WI, United States
`
`2001 – 2013
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`Chief Executive Officer and Founder, Promoter Neurosciences, LLC, Madison, Wisconsin
`
`First-Year Medical Student Small Group Leader
`
`Teaching Activities
`(cid:120) Diagnostic Intake Supervision
`(cid:120) Resident Psychotherapy Supervision
`(cid:120) Resident Research Supervision and Consultation
`(cid:120)
`(cid:120)
`Second-Year Medical Student Small Group Leader
`(cid:120) Resident Seminar Teaching: Affective Disorders and Developmental Psychobiology
`(cid:120)
`Seminar instructor for Residents and Faculty: Advanced Topics in Neuroscience
`(cid:120) Lecture Series 1st Year Medical Students: Neurobiological Basis of Emotion & Behavior
`(cid:120)
`Integrated Neurosciences Lecture - Anxiety: Pathophysiology, Clinical Presentation & Treatment
`(cid:120) Lecture, Zoology-619, Biology of the Mind
`(cid:120) Advisor to numerous residents, post-doctoral fellows, medical students and Ph.D. candidates in Psychology,
`Pharmacology and Neuroscience
`(cid:120) Biweekly case review with faculty and providers
`
`Current Mentoring
`
`Rothem Kovner, Post-doctoral
`
`Do Tromp, Post-doctoral
`
`Joshua Cruz, Pre-doctoral
`
`Margaux Kenwood, Pre-doctoral
`
`Sascha Mueller, Pre-doctoral
`
`Nakul Aggarwal, Pre-doctoral
`
`Rachel Puralewski, Pre-doctoral
`
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`

`Ned H. Kalin, MD
`Curriculum Vitae
`April 2019
`
`National and International Societies
`
`Society for Neuroscience
`
`International Society for Research in Aggression, Fellow
`
`(cid:120) National Advisory Mental Health Council through September 2007
`(cid:120)
`International Society of Psychoneuroendocrinology
`(cid:120) American College of Psychiatrists
`(cid:120) American College of Neuropsychopharmacology
`(cid:120)
`(cid:120)
`(cid:120)
`Society of Biological Psychiatry
`(cid:120) American Psychiatric Association
`(cid:120) American Association of Chairs of Departments of Psychiatry
`(cid:120)
`State Medical Society of Wisconsin
`(cid:120) American Association for the Advancement of Science
`(cid:120) Anxiety and Depression Association of America
`(cid:120) American Medical Association
`(cid:120)
`International College of Neuropsychopharmacology
`(cid:120) National Academy of Medicine
`
`Honors and Recognitions
`
`1985
`
`
`
` A.E. Bennett Award for Basic Research, Society of Biological Psychiatry
`
`1986 – 1990 Member, Study Section: Neuroscience Research Review Committee, Cellular Neurobiology
`
`
`
`
`and Psychopharmacology Subcommittee, National Institute of Mental Health
`
`1989 – present A.E. Bennett Award Selection Committee, Society of Biological Psychiatry
`
`1992 – 2018
`
`Co-Editor-in-Chief, Psychoneuroendocrinology
`
`1992 – 2008
`
`
`
`
`
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`Curt P. Richter Award Selection Committee, International Society of
`Psychoneuroendocrinology
`
`1992 – 2008 Member Editorial Board, Depression
`
`1993 – 2008 Member Editorial Board, Anxiety
`
`1992 – 1993 Wisconsin/Hilldale Undergraduate/Faculty Research Award, University of Wisconsin
`
`1994
`
`
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` University of Wisconsin Media Award
`
`1995 – present Hedberg Professor of Mind and Health, University of Wisconsin School of Medicine and
`
`
`
`
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`Public Health, Department of Psychiatry
`
`1995 – 2001
`
`Scientific Advisory Board, National Center for Post-Traumatic Stress Disorder
`
`1995 – present
`
`Founder and Director, HealthEmotions Research Institute, University of Wisconsin
`
`1996 – 1998 Member, Program Committee, Society for Neuroscience
`
`1996
`
`
`
` Distinguished Alumni of the Year, Jefferson Medical College, Department of Psychiatry
`
`3
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`

`Ned H. Kalin, MD
`Curriculum Vitae
`April 2019
`
`1996
`
`
`
`
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`Scientific Advisory Board, National Depressive and Manic Depressive Association
`
`1997 – 1999 Member Editorial Board, Neuropsychopharmacology
`
`2001
`
`2001
`
`2001
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`2002
`
`2002
`
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`
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`Fellow, American College of Psychiatrists
`
`Fellow, American College of Neuropsychopharmacology
`
`Chair, Program Committee, American College of Neuropharmacology
`
`Editorial Board, Neuropsychopharmacology
`
` Wisconsin NAMI Research Award
`
`2003 – 2007 Member, National Advisory Mental Health Council, National Institute of Health
`
`2005
`
`2005
`
`
`
`
`
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`
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`Chair, Program Committee, Society of Biological Psychiatry
`
`Edward Strecker Award, University of Pennsylvania
`
`2005 – 2008
`
`President, International Society of Psychoneuroendocrinology
`
`2005 – 2007
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`Field Editor, Neuropsychopharmacology
`
`2007
`
`2007
`
`2007
`
`2008
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` American College of Psychiatrists Award for Research in Mood Disorders
`
` Gerald Klerman Senior Investigator Award, Depression and Bipolar Support Alliance
`
` Advisory Board, International Journal of Sleep and Wakefulness
`
` Director, Lane Neuroimaging Laboratory, University of Wisconsin School of Medicine and
`
`Public Health
`
`2009 – 2010
`
`Finance and Budget Committee, American Psychiatric Association
`
`2010
`
`2012
`
`2013
`
`
`
`
`
`
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` Harold Lawn Memorial Lecture, University of Minnesota
`
` Distinguished Psychiatrist Lecturer, American Psychiatric Association
`
`
`
`Fellow, American Association for the Advancement of Science
`
`2012 – 2016
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`Scientific Council, Anxiety and Depression Association of America
`
`2013 – 2015
`
`Executive Council, Society of Biological Psychiatry
`
`2014 – 2015
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`President, Society of Biological Psychiatry
`
`2015 – 2020
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`Councilor, Society of Biological Psychiatry
`
`2015
`
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`
`
`
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` Anna-Monika Prize, Anna-Monika Foundation, European College of
` Neuropsychopharmacology
`
`2015 – present Mentor, American Psychiatric Association, Junior Investigators Research Colloquium
`
`2015 – 2021
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`Council on Research, American Psychiatric Association
`
`2015 – present
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`Board of Scientific Advisors, Pritzker Neuropsychiatric Disorders Research Consortium
`
`2015
`
`2015
`
`
`
`
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` Member, National Academy of Medicine (formerly known as Institute of Medicine)
`
` Distinguished Fellow of the American Psychiatric Association
`
`2016 – present Editorial Board, Personalized Medicine in Psychiatry
`
`2016 – present Brain & Behavioral Research Foundation, Scientific Council Member
`
`2016
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`2016
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`Chair Award, 9th Annual Chair Summit
`
`Charles L. Ravaris, MD Memorial Lecture, Dartmouth-Hitchcock Medical Center
`
`4
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`

`

`Ned H. Kalin, MD
`Curriculum Vitae
`April 2019
`
`2017
`
`2017
`
`
`
`
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` Honorary Degree of the Maimonides University, Buenos Aires, Argentina
`
`
`
` Distinguished Life Fellow of the American Psychiatric Association
`
`2017 – present
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`Editorial Board, Journal of Psychiatric Research
`
`2017 - 2018 Member, Board of Trustees Work Group to Review the APA Relationship to Additional
`Funders, American Psychiatric Association
`
`2018
`
`2018
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`George Thompson Award, Society of Biological Psychiatry
`
`Fellow Emeritus of the American College of Neuropsychopharmacology
`
`2019 - present
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`Editor in Chief, American Journal of Psychiatry
`
`2019 - present Accreditation Council for Continuing Medical Education Clinical Content Review
`Committee
`
`2019 - present
`
`International Advisory Board, Canadian Journal of Psychiatry
`
`2019
`
`Chair, 2019 Conference Committee, Anxiety and Depression Association of America
`
`RESEARCH ACTIVITIES
`
`Research Focus:
`(cid:120) Neurodevelopmental underpinnings of the risk to develop anxiety and depressive disorders
`(cid:120) Translational approaches to understand genetic and molecular mechanisms underlying early life anxious
`temperament
`(cid:120) Defining the altered neural circuity mediating childhood anxiety disorders and its heterogeniety
`(cid:120) Using nonhuman primate models to explore novel neurally informed treatments for childhood anxiety
`disorders
`
`Current Funding
`
`Principal Investigator: Extreme Anxiety in Females: The Role of the Bed Nucleus of the Stria Terminalis (BST)
`During the Transition to Adolescence in Human and Nonhuman Primates. R01MH107563, National Institute of
`Mental Health, $3,487,141 (2015 - 2020)
`
`Principal Investigator: Development and Regulation of Emotion in Primates. R01MH046729, National Institute
`of Mental Health, $3,570,223 (2017 - 2022)
`
`Principal Investigator: Brain Mechanisms Mediating Genetic Risk for Anxiety and Depression. R01MH081884,
`National Institute of Mental Health, $3,652,551 (2018 - 2023)
`
`Principal Investigator: Brain Mechanisms Mediating Genetic Risk for Anxiety and Depression Administrative
`Supplement, Irritability and Aggression in Clinically Impaired Youth and Rhesus Monkeys R01MH081884-10S1
`National Institute of Mental Health, $364,384 (2018 - 2020)
`
`Principal Investigator: Studies to understand the pathophysiology of childhood anxiety disorders,
`U01MH112913, National Institute of Mental Health, $3,420,084 (2018 – 2023)
`
`Subproject on a Silvio O. Conte Center for Interdisciplinary Research on Early Neurodevelopment Origins of
`Anxiety: Neural Mechanisms Mediating Adversity's Impact on the Risk for Developing Anxiety. P50
`MH100031, National Institute of Mental Health. Estimated total 5-year cost: $2,533,702 (2013 - 2019)
`
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`Ned H. Kalin, MD
`Curriculum Vitae
`April 2019
`
`Past Funding
`
`Principal Investigator: Brain Mechanisms Underlying Childhood Generalized Anxiety Disorder. R21MH092581,
`National Institute of Mental Health, $404,845, 2012-2014
`
`Principal Investigator: Developmental Mechanisms Underlying the Risk to Develop Anxiety and Depression. P50
`MH84051, Subproject on a Silvio O. Conte Center for Interdisciplinary Research on Neurobehavioral Bases of
`Emotion Regulation and Dysregulation in Adolescence. National Institute of Mental Health, $1,788,850 2008-
`2013
`
`Principal Investigator: Development and Regulation of Emotion in Primates. R01MH046729, National Institute
`of Mental Health, $9,308,127, 1990-2017
`
`Co-Principal Investigator: Neural Substrates of Affective Style and Emotion Regulation. R01MH043454,
`National Institute of Mental Health, $150,000 Supplement, 2008-2010
`
`Principal Investigator: Brain Mechanisms Mediating Genetic Risk Factors for Anxiety and Depression.
`R01MH081884. National Institute of Mental Health, $8,664,920, 2008-2018
`
`Principal Investigator: Defining corticotropin-releasing factor (CRF) system changes in amygdala and medial
`temporal cortex in association with depression and suicide. The Stanley Medical Research Institute, $150,000,
`2009-2011
`
`Principle Investigator: Combining mouse and monkey models to understand human risk for psychopathology.
`MH091550. National Institute of Mental Health, $275,000, 2010-2012
`
`Co-Principal Investigator: Neural Substrates of Affective Style and Emotion Regulation. R01, MH043454,
`National Institute of Mental Health, $150,000 Supplement, 2008-2011
`
`Principal Investigator: The Role of Central and Peripheral Neuroendocrine Systems in Nonhuman Primates
`Undergoing Social Stress. University of Wisconsin Medical School Research Committee, $10,000, 1981-1982
`
`Principal Investigator: Hormones in the CSF of Rhesus Monkeys. University of Wisconsin Graduate School,
`$19,000, 1981-1982
`
`Principal Investigator: Peptide Hormones in Nonhuman Primate Models of Psychopathology and in Depressed
`Humans. Veterans Administration RAG Start-Up Funds, $49,000, 1981-1982
`
`Principal Investigator: TCDD Exposed Rhesus Monkeys: Effects on Behavior and Stress Hormones. Veterans
`Administration Bureau of Medicine and Surgery, $120,000, 1982-1985
`
`Principal Investigator: Peripheral and Central Peptides in the Behavior of Nonhuman Primates. Veterans
`Administration Bureau of Medicine and Surgery, $150,000, 1982-1985
`
`Principal Investigator: Peptide Hormones in Monkey Cerebrospinal Fluid. National Institute of Neurological and
`Communicative Disorders, $150,000, 1983-1986
`
`Principal Investigator: Stressor Control: Peptides and Cardiovascular Function. National Heart Lung and Blood
`Institute, $320,000, 1985-1988
`
`Principal Investigator: CRH Systems in Primates. National Institute of Arthritis, Diabetes, and Digestive and
`Kidney Disease, $427,000, 1985-1989
`
`Principal Investigator: Brain Release Compared to CSF Levels of CRH, ACTH and CLIP in Monkeys. Veterans
`Administration Merit Review, $340,000, 1986-1989
`
`Principal Investigator: Role of Central CRF in Stress-Induced Behavior. National Institutes of Health, $690,000,
`1986-1994
`
`6
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`

`

`Ned H. Kalin, MD
`Curriculum Vitae
`April 2019
`
`Principal Investigator: Prenatal Stress: HPA Function and Behavior in Offspring. National Institute of Mental
`Health, $317,000, 1989-1992
`
`Principal Investigator: Neurobiological Mechanisms in the Development of the Fear Response in Primates.
`Veterans Administration Merit Review, $790,000, 1990-1993
`
`Principal Investigator: Neurobiological Basis of the Development of Fear and Anxiety in Primates. University of
`Wisconsin Graduate School, $22,400, 1994-1995
`
`Principal Investigator: Effects of Stress and Mood on Disease Progression and Mortality. Hedberg Foundation,
`University of Wisconsin Medical School, $100,000, 1995-1996
`
`Principal Investigator: Effects of Exercise on Health in Breast Cancer Patients. Hedberg Foundation, University
`of Wisconsin Medical School, $100,000, 1995-1997
`
`Co-Principal Investigator: Wisconsin Study of Families and Work: Cortisol, Psychosocial Factors, and Child
`Development. MacArthur Foundation, $123,783, 1995-1997
`
`Principal Investigator: The Functional Role of the Amygdala in Mediating the Behavioral and Physiological
`Responses Associated with Fearful Temperament. As Part of the Center for Behavioral Science Research,
`National Institute of Mental Health, $808,767, 1998-2003
`
`Principal Investigator: Social Stress in Primates: Vulnerability and Resilience. As Part of the Center for
`Mind/Body Interactions and Health, National Institute of Mental Health, $1,808,366, 1999-2005
`
`Principal Investigator: Biological Measures Core. As Part of the Center for Mind/Body Interactions and Health,
`National Institute of Mental Health, $495,213, 1999-2005
`
`Principal Investigator: CRF influences on the amygdala in schizophrenia, bipolar disorder and major depression:
`an in situ hybridization study of the complete corticotropin-releasing factor system in human postmortem tissue.
`
`Principal Investigator: Investigating the Role of the Lateral Prefrontal Cortex in Modulating Emotion and in
`Mediating the Behavioral and Physiological Characteristics of the Anxious Endophenotype. DHHS, PHS P50
`MH069315, Subproject on a Interdisciplinary Behavioral Science Center for Mental Health, $2,038,820, 2004-
`2008, The Stanley Medical Research Institute, $100,000, 2001-2003
`
`Principal Investigator: Treating Stress Disorders with CRF Receptor DNA Enzymes. Promoter Neurosciences,
`LLC, $54,587, 2004-2005
`
`Principal Investigator: Role of Central CRF in Stress-Induced Behavior. R01MH040855 National Institutes of
`Health, $1,868,722, 2003-2007
`
`Patents
`
`Promoter sequences for corticotropin-releasing factor CRF2alpha and method of identifying agents that alter the
`activity of the promoter sequences: U.S. Patent issued on 07-04-06; patent #7,071,323 and U.S. Patent issued on
`05-12-09; patent #7,531,356
`
`Promoter sequences for urocortin II and the use thereof: U.S. Patent issued on 08-08-06; patent #7,087,385
`
`Promoter sequences for corticotropin-releasing factor binding protein and use thereof: U.S. Patent issued on 10-
`17-06; patent #7,122,650
`
`7
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`Ex. 2017-0007
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`

`

`Ned H. Kalin, MD
`Curriculum Vitae
`April 2019
`
`Reviewer
`
`Ad hoc reviewer for NIH, NSF, and VA grants
`
`Neuroendocrinology
`
`American Journal of Physiology
`
`American Journal of Psychiatry
`
`Archives of General Psychiatry
`
`Behavioral Neuroscience
`
`Biological Psychiatry
`
`Brain Research
`
`Child Development
`
`Journal of Neurosciences
`
`Life Sciences
`
`Neuropharmacology
`
`Neuropsychopharmacology
`
`Peptides
`
`Proceedings of the National Academy of Sciences
`
`Psychiatry Research
`
`Psychoneuroendocrinology
`
`Psychopharmacology
`
`Regulatory Peptides
`
`Science Journal of Reproductive Biology
`
`Synapse
`
`Journal Articles
`
`BIBLIOGRAPHY
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`Kalin NH. Frustrations of a medical student: A new approach to disease. The New Physician Oct. 1976
`
`Jefferson JW, Kalin NH. Serum lithium levels and long-term diuretic use. JAMA 241:1134-6, 1979
`
`Kalin NH. Genital and abdominal self-surgery. A case report. JAMA 241:2188-9, 1979
`
`Insel TR, Kalin NH, Risch SC, Cohen RM, Murphy DL. Abducens palsy after lumbar puncture. (Letter) New
`England Journal of Medicine 303:703, 1980
`
`Kalin NH, Cohen, RM, Murphy DL. Circadian variation in the CSF cortisol concentration of the rhesus
`monkey. Life Sciences 26:1485-7, 1980
`
`Kalin NH, Risch SC, Cohen RM, Insel T, Murphy DL. Dexamethasone fails to suppress beta-endorphin
`plasma concentrations in humans and rhesus monkeys. Science 209:827-8, 1980
`
`Marshall JR, Kalin NH, Tariot AM. An organic psychosis associated with electroconvulsive therapy.
`Psychiatric Opinion 17:33-9, 1980
`
`Murphy DL, Kalin NH. Biological and behavioral consequences of alterations in monoamine oxidase activity.
`Schizophrenia Bulletin 6:355-7, 1980
`
`Risch SC, Cohen RM, Janowsky DS, Kalin NH, Murphy DL. Mood and behavioral effects of physostigmine
`on humans are accompanied by elevations in plasma beta-endorphin and cortisol. Science 209:1545-6, 1980
`
`Risch SC, Cohen RM, Kalin NH. Propranolol, chlorpromazine, and tardive dyskinesia. (Letter) American
`Journal of Psychiatry 137:1125, 1980
`
`Risch SC, Kalin NH, Janowsky DS, Huey LY. Indications and guidelines for plasma tricyclic antidepressant
`concentration monitoring. Journal of Clinical Psychopharmacology 1:59-63, 1981
`
`Kalin NH, Risch SC, Janowsky DS, Murphy DL. Use of dexamethasone suppression test in clinical
`psychiatry. Journal of Clinical Psychopharmacology 1:64-9, 1981
`
`Kalin NH, Insel TR, Cohen RM, Risch SC, Murphy DL. Diurnal variation in the cerebrospinal fluid prolactin
`concentration of the rhesus monkey. Journal of Clinical Endocrinology & Metabolism 52:857-8, 1981
`
`8
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`Ned H. Kalin, MD
`Curriculum Vitae
`April 2019
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`Naber D, Pickar D, Davis GC, Cohen RM, Jimerson DC, Elchisak MA, De Fraites EG, Kalin NH, Risch SC,
`Buchsbaum MS. Naloxone effects on beta-endorphin, cortisol, prolactin, growth hormone, HVA, and MHPG
`in plasma of normal volunteers. Psychopharmacology 74:125-8, 1981
`
`Kalin NH, Cohen, RM, Kraemer GW, Risch SC, Shelton S, Cohen M, McKinney WT, Murphy DL. The
`dexamethasone suppression test as a measure of hypothalamic-pituitary feedback sensitivity and its
`relationship to behavioral arousal. Neuroendocrinology 32:92-5, 1981
`
`Kalin NH, Risch SC, Murphy DL. Involvement of the central serotonergic system in affective illness. Journal
`of Clinical Psychopharmacology 1:232-7, 1981
`
`Naber D, Cohen RM, Pickar D, Kalin NH, Davis G, Bunney WE Jr. Episodic secretion of opioid activity in
`human plasma and monkey CSF: Evidence for a diurnal rhythm. Life Sciences 28:931-5, 1981
`
`Pickar D, Naber D, Post RM, van Kammen DP, Ballinger J, Kalin NH, Bunney WE Jr. Measurement of
`endorphins in CSF: Relationship to psychiatric diagnosis. Modern Problems in Pharmacopsychiatry. 17:246-
`62, 1981
`
`Risch SC, Cohen RM, Janowsky DS, Kalin NH, Sitaram N, Gillin JC, Murphy DL. Physostigmine induction
`of depressive symptomatology in normal human subjects. Psychiatry Research 4:89-94, 1981
`
`Risch SC, Janowsky DS, Kalin NH, Cohen RM, Murphy DL. Cholinergic-endogenous opioid mechanisms in
`mood and cognition in man. Psychopharmacology Bulletin 17:132-7, 1981
`
`Risch SC, Kalin NH, Cohen RM, Weker JL, Insel TR, Cohen ML, Murphy DL. Muscarinic cholinergic
`influences on ACTH and beta-endorphin release mechanisms in human subjects. Peptides 2:95-7, 1981
`
`Risch SC, Kalin NH, Janowsky DS. Cholinergic challenges in affective illness: Behavioral and
`neuroendocrine correlates. Journal of Clinical Psychopharmacology 1:186-92, 1981
`
`Risch SC, Kalin NH, Murphy DL. Neurochemical mechanisms in the affective disorders and neuroendocrine
`correlates. Journal of Clinical Psychopharmacology 1:180-5, 1981
`
`Risch SC, Kalin NH, Murphy DL. Pharmacological challenge strategies: Implications for neurochemical
`mechanisms in affective disorders and treatment approaches. Journal of Clinical Psychopharmacology 1:238-
`43, 1981
`
`Insel TR, Kalin NH, Guttmacher LB, Cohen RM, Murphy DL. The dexamethasone suppression test in patients
`with primary obsessive-compulsive disorder. Psychiatry Research 6:153-60, 1982
`
`Kalin NH, Burns RS, Risch SC, Cosgrove SA, Warden D, Murphy DL. The relationship between blood and
`cerebrospinal fluid prolactin in nonhuman primates. Life Sciences 31:159-63, 1982
`
`Kalin NH, Shelton SE, Kraemer GW, McKinney WT Jr. Corticotropin-releasing factor causes hypotension in
`rhesus monkeys. Lancet 2:1042, 1982
`
`Kalin NH, Weiler SJ, McKinney WT, Kraemer GW, Shelton S. Where is the lesion in patients who fail to
`suppress plasma cortisol concentrations with dexamethasone? Psychopharmacology Bulletin 18:219-21, 1982
`
`Kalin NH, Weiler SJ, Shelton SE. Plasma ACTH and cortisol concentrations before and after dexamethasone.
`Psychiatry Research 7:87-92, 1982
`
`Siever LJ, Uhde TW, Silberman EK, Lake CR, Jimerson DC, Risch SC, Kalin NH, Murphy DL. Evaluation of
`alpha-adrenergic responsiveness to clonidine challenge and noradrenergic metabolism in the affective
`disorders and their treatment. Psychopharmacology Bulletin 18:118-9, 1982
`
`Carnes M, Smith JC, Kalin NH, Bauwens SF. Effects of chronic medical illness and dementia on the
`dexamethasone suppression test. Journal of the American Geriatric Society 31:269-71, 1983
`
`Carnes M, Smith JC, Kalin NH, Bauwens SF. The dexamethasone suppression test in demented outpatients
`with and without depression. Psychiatry Research 9:337-44, 1983
`
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`Ned H. Kalin, MD
`Curriculum Vitae
`April 2019
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`Kalin NH, Gonder, JC, Shelton SE. Effects of synthetic ovine CRF on ACTH, cortisol and blood pressure in
`sheep. Peptides 4:221-3, 1983
`
`Kalin NH, Shelton SE, Kraemer GW, McKinney WT. Associated endocrine, physiological and behavioral
`changes in rhesus monkeys after intravenous corticotropin-releasing factor administration. Peptides 4:211-5,
`1983
`
`Kalin NH, Shelton SE, Kraemer GW, McKinney WT. Corticotropin-releasing factor administered
`intraventricularly to rhesus monkeys. Peptides 4:217-20, 1983
`
`Kalin NH, Shelton SE, McKinney WT, Kraemer, GW, Scanlon J, Suomi SJ. Stress alters the dexamethasone
`suppression test in rhesus monkeys. Psychopharmacology Bulletin 19:542-5, 1983
`
`Kalin NH, Weiler SJ, Shelton SE. Pituitary ACTH secretion altered in cortisol nonsuppression. Author's reply.
`Psychiatry Research 6:156, 1983
`
`Risch SC, Kalin NH, Janowsky DS, Cohen RM, Pickar D, Murphy DL. Co-release of ACTH and beta-
`endorphin immunoreactivity in human subjects in response to central cholinergic stimulation. Science 222:77,
`1983
`
`Russ CS, Hendricks TA, Chrisley BM, Kalin NH, Diskell JA. Vitamin B-6 status of depressed and obsessive-
`compulsive patients. Nutrition Reports International 27:867-73, 1983
`
`Scallet AC, Rush DR, Kalin NH, Risch SC, Suomi SJ, Zaas T. Shuttlebox avoidance in rhesus monkeys:
`Effects on plasma cortisol and beta-endorphin. Peptides 4:19-24, 1983
`
`Bullinger M, Naber D, Pickar D, Cohen RM, Kalin NH, Pert A, Bunney WE Jr. Endocrine effects of the cold
`pressor test: Relationships to subjective pain appraisal and coping. Psychiatry Research 12:227-33, 1984
`
`Carnes M, Kalin NH. Further remarks on the dexamethasone suppression test in the elderly. Clinical
`Gerontology 3:28-35, 1984
`
`Kalin NH, Carnes M. Biological correlates of attachment bond disruption in humans and nonhuman primates.
`Progress in Neuro-Psychopharmacology & Biological Psychiatry 8:459-69, 1984
`
`Kalin NH, Shelton SE. Acute behavioral stress affects the dexamethasone suppression test in rhesus monkeys.
`Biological Psychiatry 19:113-7, 1984
`
`Kalin NH. Animal models of depression. Introduction to symposium. Progression of Neuro-Psychopharmacol
`Biological Psychiatry 8:423-4, 1984
`
`46. Wamboldt FW, Weiler SJ, Kalin NH. Cyclosporin-associated mania. (Letter) Biological Psychiatry 19:1161-3,
`1984
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`47.
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`48.
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`49.
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`50.
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`Kalin NH, Carnes M, Barksdale CM, Shelton SE, Stewart RD, Risch SC. Effects of acute behavioral stress on
`plasma and cerebrospinal fluid ACTH and beta-endorphin in rhesus monkeys. Neuroendocrinology 40:97-
`101, 1985
`
`Kalin NH, Gibbs DM, Barksdale CM, Shelton SE, Carnes M. Behavioral stress decreases plasma oxytocin
`concentrations in primates. Life Sciences 36:1275-80, 1985
`
`Kalin NH, Shelton SE, Barksdale CM, Carnes M. The diurnal variation of immunoreactive
`adrenocorticotropin in rhesus monkey plasma and cerebrospinal fluid. Life Sciences 36:1135-40, 1985
`
`Kalin NH. Behavioral effects of ovine corticotropin-releasing factor administered to rhesus monkeys.
`Federation Proceedings 44:249-53, 1985
`
`51. Wamboldt MZ, Kalin NH, Weiler SJ. Consistent reversal of abnormal DSTs after different antidepressant
`therapies in a patient with dementia. American Journal of Psychiatry 142:100-3, 1985
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`Ned H. Kalin, MD
`Curriculum Vitae
`April 2019
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`Carnes M, Brownfield MS, Kalin NH, Lent S, Barksdale CM. Episodic secretion of ACTH in rats. Peptides
`7:219-23, 1986
`
`Kalin NH, Dawson GW. Neuroendocrine dysfunction in depression: Hypothalamic-anterior pituitary systems.
`Trends in Neuroscience 9:261-6, 1986
`
`Kalin NH, Shelton SE, Thompson RM, Barksdale, CM. A rostral-caudal concentration gradient in
`cerebrospinal fluid adrenocorticotropin. Neuroendocrinology 43:348-51, 1986
`
`Kalin NH. ACTH in plasma and CSF in the rhesus monkey. A.E. Bennett Award for Basic Research in
`Biological Psychiatry. Biological Psychiatry 21:124-40, 1986
`
`56. Maier SF, Ryan SM, Barksdale CM, Kalin NH. Stressor controllability and the pituitary-adrenal system.
`Behavioral Neuroscience 100:669-74, 1986
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`57.
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`Sherman JE, Kalin NH. ICV-CRH potently affects behavior without altering antinociceptive responding. Life
`Sciences 39:433-41, 1986
`
`Swift WJ, Kalin NH, Wamboldt FS, Kaslow N, Ritholz ML. Depression in bulimia at 2- to 5-year follow-up.
`Psychiatry Research 16:111-22, 1985
`
`Tariot P, Kalin NH. Psychiatric disorders in fibromyalgia. (Letter) American Journal of Psychiatry 143:812-3,
`1986
`
`60. Wamboldt MZ, Kalin NH, Weiler SJ. Response to Dr. Jenike. Dementia and depression. (Letter) American
`Journal of Psychiatry 143:254-5, 1986
`
`61.
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`Carnes M, Barksdale CM, Kalin NH, Brownfield MS, Lent SJ. Effects of dexamethasone on central and
`peripheral ACTH systems in the rat. Neuroendocrinology 45:160-4, 1987
`
`Kalin NH, Dawson G, Tariot P, Shelton S, Barksdale C, Weiler S, Thienemann M. Function of the adrenal
`cortex in patients with major depression. Psychiatry Research 22:117-25, 1987
`
`Kalin NH, Shelton SE, Barksdale CM, Brownfield MS. A diurnal rhythm in cerebrospinal fluid corticotropin-
`releasing hormone different from the rhythm of pituitary-adrenal activity. Brain Research 426:385-91, 1987
`
`Kalin NH, Shelton SE, Barksdale CM. Separation distress in infant rhesus monkeys: Effects of diazepam and
`Ro 15-1788. Brain Research 408:192-8, 1987
`
`Robins HI, Kalin NH, Shelton SE, Martin PA, Shecterle LM, Barksdale CM, Neville AJ, Marshall J. Rise in
`plasma beta-endorphin, ACTH, and cortisol in cancer patients undergoing whole body hyperthermia.
`Hormone & Metabolic Research 19:441-3, 1987
`
`Robins HI, Kalin NH, Shelton SE, Shecterle LM, Barksdale CM, Martin PA, Marshall J. Neuroendocrine
`changes in patients undergoing whole body hyperthermia. International Journal of Hyperthermia 3:99-105,
`1987
`
`Sherman JE, Kalin NH. The effects of ICV-CRH on novelty-induced behavior. Pharmacology Biochemistry &
`Behavior 26:699-703, 1987
`
`Swift WJ. Kalin NH. A follow-up study of thirty hospitalized bulimics. Psychosomatic Medicine 49:45-55,
`1987
`
`Brooks BR, Kalin NH, Beaulieu DA, Barksdale CM, Sufit RL, Dills DG. Thyrotropin releasing hormone
`uptake into serum and cerebrospinal fluid following intravenous or subcutaneous administration. Neurology
`Research 10:236-8, 1988
`
`Carnes M, Kalin NH, Lent SJ, Barksdale CM, Brownfield MS. Pulsatile ACTH secretion: Variation with time
`of day and relationship to cortisol. Peptides 9:325-31, 1988
`
`11
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`Ex. 2017-0011
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`

`

`Ned H. Kalin, MD
`Curriculum Vitae
`April 2019
`
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`Kalin NH, Shelton SE, Barksdale CM. Opiate modulation of separation-induced distress in non-human
`primates. Brain Research 440:285-92, 1988
`
`Kalin NH, Shelton SE. Effects of clonidine and propranolol on separation-induced distress in infant rhesus
`monkeys. Brain Research 470:289-95, 1988
`
`Kalin NH, Sherman JE, Takahashi LK. Antagonism of endogenous CRH systems attenuates stress-induced
`freezing behavior in rats. Brain Research 457:130-5, 1988
`
`Shelton SE, Kalin NH, Gluck JP, Keresztury MF, Schneider VA, Lewis MH. Effect of age on cisternal CSF
`concentrations of monoamine metabolites in nonhuman primates. Neurochem International 13:353-7, 1988
`
`Sherman JE, Kalin NH. ICV-CRH alters stress-induced freezing behavior without affecting pain sensitivity.
`Pharmacology, Biochemistry & Behavior 30:801-7, 1988
`
`Takahashi LK, Kalin NH, Barksdale CM, Vanden Burgt JA. Stressor controllability during pregnancy
`influences pituitary-adrenal hormone concentrations and analgesic responsiveness in offspring. Physiology &
`Behavior 42:323-9, 1988
`
`Barksdale CM, Takahashi LK, Kalin NH, Brownfield MS. A diurnal rhythm in rat cerebrospinal fluid
`corticotropin-releasing hormone similar to the rhythm of pituitary-adre