CURRICULUM VITAE
`
`
`
`Hartmut Derendorf
`Name:
`
`August 6, 1953 in Dortmund, Germany
`Born:
`
`100494, College of Pharmacy
`Address:
`University of Florida
`
`
`
`
`Gainesville, Florida 32610
`
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`
`
`Phone (352) 273-7856
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`
`
`Fax (352) 392-3249
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`
`
`E-mail: HARTMUT@COP.UFL.EDU
`
`
`
`
`
`Present Position: Distinguished Professor and Chairman
`V. Ravi Chandran Professor of
`Pharmaceutical Sciences
`University of Florida Distinguished
`Alumini Professor
`Dept. of Pharmaceutics,
`College of Pharmacy
`University of Florida
`
`
`Previous Positions:
`
`1993 - 2003
`
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`1987 - 1995
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`1998 -
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`1987 - 1993
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`1983 - 1987
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`Professor
`Dept. of Pharmaceutics
`College of Pharmacy
`University of Florida
`Chairman
`Dept. of Pharmaceutics
`College of Pharmacy
`University of Florida
`Associate Professor
`Dept. of Pharmaceutics
`College of Pharmacy
`University of Florida
`Assistant Professor
`Dept. of Pharmaceutics
`College of Pharmacy
`University of Florida
`
`Corcept Therapeutics, Inc.
`Exhibit 2015
`Neptune Generics, LLC v. Corcept Therapeutics, Inc.
`Case IPR2018-01494
`
`Ex. 2015-0001
`
`
`
`
`
`Hartmut Derendorf
`Name:
`
`August 6, 1953 in Dortmund, Germany
`Born:
`
`100494, College of Pharmacy
`Address:
`University of Florida
`
`
`
`
`Gainesville, Florida 32610
`
`
`
`
`Phone (352) 273-7856
`
`
`
`
`Fax (352) 392-3249
`
`
`
`
`E-mail: HARTMUT@COP.UFL.EDU
`
`
`
`
`
`Present Position: Distinguished Professor and Chairman
`V. Ravi Chandran Professor of
`Pharmaceutical Sciences
`University of Florida Distinguished
`Alumini Professor
`Dept. of Pharmaceutics,
`College of Pharmacy
`University of Florida
`
`
`Previous Positions:
`
`1993 - 2003
`
`
`
`
`
`
`
`
`
`
`
`
`
`1987 - 1995
`
`1998 -
`
`
`
`
`
`
`
`
`
`
`
`1987 - 1993
`
`
`
`
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`
`
`1983 - 1987
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`
`
`
`
`
`
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`
`
`
`
`
`
`Professor
`Dept. of Pharmaceutics
`College of Pharmacy
`University of Florida
`Chairman
`Dept. of Pharmaceutics
`College of Pharmacy
`University of Florida
`Associate Professor
`Dept. of Pharmaceutics
`College of Pharmacy
`University of Florida
`Assistant Professor
`Dept. of Pharmaceutics
`College of Pharmacy
`University of Florida
`
`Corcept Therapeutics, Inc.
`Exhibit 2015
`Neptune Generics, LLC v. Corcept Therapeutics, Inc.
`Case IPR2018-01494
`
`Ex. 2015-0001
`
`
`
`Education
`
`1972 - 1976
`
`
`1977
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`1977 - 1979
`
`1979
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`1979 - 1980
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`1981 - 1982
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`Awards
`1980
`
`1983
`
`1988
`
`1994
`
`1995
`
`1996
`
`2000
`
`2001
`
`2002
`
`B.S. in Pharmacy,
`University of Münster, Germany
`Registered Pharmacist
`Graduate Study of Pharmacy at
`University of Münster, Germany
`Dr. rer. nat. (Ph.D.) with a
`dissertation on "Biopharmaceutical
`investigations of weak analgesics"
`(summa cum laude)
`Assistant Scientist
`Institute for Pharmaceutical Chemistry,
`University of Münster
`Postdoctoral Fellow with E.R. Garrett,
`College of Pharmacy, University of
`Florida
`
`Award for the best dissertation
`University of Münster, Germany
`Rottendorf-Award for Outstanding Research in
`the Area of Pharmaceutical Sciences
`Fellow of the American College of Clinical
`Pharmacology (ACCP)
`McKeen-Cattell-Award for best publication in
`the Journal of Clinical Pharmacology
`Teaching Improvement Award, University of
`Florida
`Fellow of the American Association of
`Pharmaceutical Scientists (AAPS)
`Honorary Regent, American College of
`Clinical Pharmacology
`Honorary Fellowship, Slovakian Chemotherapy
`Society
`University of Florida Research Foundation
`Professorship
`
`Ex. 2015-0002
`
`
`
`2003
`
`2003
`
`2004
`
`2005
`
`2005
`
`2007-2013
`
`2007
`
`2008
`
`2009
`
`2010
`
`2010
`
`2013
`
`2013
`
`2013-2018
`
`2014
`
`2015
`2015
`
`2015-2017
`
`2016-2019
`
`Nathaniel T. Kwit Distinguished Service
`Award, American College of Clinical
`Pharmacology
`Research Achievement Award in Clinical
`Sciences, American Association of
`Pharmaceutical Scientists
`International Educator of the Year Award
`University of Florida
`Faculty Award in Pharmaceutical Sciences
`University of Utrecht, The Netherlands
`International Educator of the Year Award
`University of Florida
`CVS Professorship, College of Pharmacy,
`University of Florida
`International Educator of the Year Award
`University of Florida
`Howard Hughes Medical Institute
`Distinguished Mentor
`Doctoral Advisor/Mentoring Award
`University of Florida
`Volwiler Research Achievement Award
`American Association of Colleges of Pharmacy
`ACCP Distinguished Investigator Award
`American College of Clinical Pharmacology
`ISOP Leadership Award
`International Society of Pharmacometrics
`International Educator of the Year Award
`University of Florida
`V. Ravi Chandran Professorship in
`Pharmaceutical Sciences
`Honorary Membership, Brazilian Association
`of Pharmaceutical Sciences
`Merit Medal, Westphalian Chamber of Pharmacy
`Bristol-Myers Squibb Mentorship Award,
`American College of Clinical Pharmacology
`18th Distinguished Alumni Professor,
`University of Florida
`University of Florida Research Foundation
`Professorship
`
`Ex. 2015-0003
`
`
`
`2016-2019
`
`2017-2018
`2018
`
`Honorary Adjunct Professor, Medical
`University Vienna, Austria
`University of Florida Term Professor
`American Society for Clinical Pharmacology
`and Therapeutics Mentor Award
`
`
`
`Teaching Experience
`1983 - present Teacher for Biopharmaceutics,
`Pharmacokinetics (undergraduate and graduate
`courses) and Clinical Pharmacokinetics,
`University of Florida
`1981 - present Instructor at more than 30 courses on
`Pharmacokinetics, Biopharmaceutics and
`Clinical Pharmacokinetics in Germany,
`England, Brazil and U.S.A
`Adjunct Professor for Pharmacokinetics at
`the Federal University of Rio Grande do Sul,
`Porto Alegre, Brazil
`Adjunct Lecturer for Pharmacokinetics and
`Biopharmaceutics at the University of
`Münster, Germany
`Teaching assistant for courses in Medicinal
`Chemistry, Pharmacology for Pharmacists,
`Biochemistry for Pharmacists and Analytical
`Chemistry at University of Münster; Teacher
`for Pharmacology for Pharmacists at
`University of Münster; Teacher for
`Pharmacology and Toxicology at Schools for
`Pharmacy Technicians in Münster and
`Osnabrück
`
`1990 - 2000
`
`1983 - 1990
`
`1977 - 1980
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`
`Textbooks
`1983
`
`1987
`
`H. Derendorf, Drugs - Applied Pharmacology
`for Pharmacists and Pharmacy Technicians (in
`German), 280 p., Deutscher Apotheker-Verlag,
`Stuttgart, Germany
`H. Derendorf and E.R. Garrett,
`Pharmacokinetics - Introduction into Theory
`
`Ex. 2015-0004
`
`
`
`1988
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`1994
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`1995
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`1995
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`1997
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`1998
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`1998
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`2001
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`2002
`
`2002
`
`and Practice" (in German), 175 p., Deutscher
`Apotheker -Verlag, Stuttgart, Germany
`H. Derendorf, Drugs - Applied Pharmacology
`for Pharmacists and Pharmacy Technicians (in
`German), 4th edition, 286 p., Deutscher
`Apotheker Verlag, Stuttgart, Germany
`H. Derendorf, Drugs - Applied Pharmacology
`for Pharmacists and Pharmacy Technicians (in
`German), 5th edition, 264 p., Deutscher
`Apotheker Verlag, Stuttgart, Germany
`E. Mutschler and H. Derendorf, Drug Actions
`(in English), 799 p., Deutscher Apotheker
`Verlag, Stuttgart, Germany
`H. Derendorf and G. Hochhaus, Handbook of
`Pharmacokinetic-Pharmacodynamic Correlations
`(in English), 483 p., CRC Press, Boca Raton,
`Florida
`J. Framm, M. Schäfer, H. Derendorf,
`Pharmaceutical Care (in German), 118 p.,
`Deutscher Apotheker Verlag, Stuttgart,
`Germany
`H. Derendorf, M. Schmidt, Drugs - Applied
`Pharmacology for Pharmacists and Pharmacy
`Technicians (in German), 6th edition, 269
`p., Deutscher Apotheker Verlag, Stuttgart,
`Germany
`J. Framm, M. Anschütz, H. Derendorf, D.
`Hammersdorfer, E. Heydel, A. Mehrwald, G.
`Schomaker, Drug Profiles (in German), 252
`p., Deutscher Apotheker Verlag, Stuttgart,
`Germany
`J. Framm, M. Anschütz, H. Derendorf, D.
`Hammersdorfer, E. Heydel, A. Mehrwald, G.
`Schomaker, Drug Profiles (in German), 2nd
`edition, 294 p., Deutscher Apotheker Verlag,
`Stuttgart, Germany
`H. Derendorf, T. Gramatte, H.G. Schaefer,
`Pharmacokinetics - Introduction into Theory
`and Practice" (in German), 2nd edition, 175
`p., Deutscher Apotheker -Verlag, Stuttgart,
`Germany
`J. Framm, D. Placek, M. Anschütz, H.
`Derendorf, D. Hammersdorfer, E. Heydel, A.
`
`Ex. 2015-0005
`
`
`
`2003
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`2011
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`2011
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`2011
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`2013
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`2014
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`2015
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`2015
`
`2017
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`
`
`Mehrwald, G. Schomaker, Profily leciv (Drug
`Profiles, in Czech), 277 p., Grada
`Publishing, Prague, Czech Republic
`H. Derendorf, M. Schulz, R. Wemhöner
`Pharmacology for Pharmacists and Pharmacy
`Technicians (in German), 7th edition, 304
`p., Deutscher Apotheker Verlag, Stuttgart,
`Germany
`M. Rowland, T.N. Tozer
`Clinical Pharmacokinetics and
`Pharmacodynamics, with Online Simulations by
`H. Derendorf and G. Hochhaus, 4th edition,
`839 p., Wolters Kluwer Lippicott,
`Philadelphia
`H. Derendorf, T. Gramatté, H.G. Schäfer, A.
`Staab, Pharmacokinetics compact (in German),
`3rd edition, 378 p., Wissenschaftliche
`Verlagsgesellschaft, Stuttgart, Germany
`H. Derendorf, R. Wemhöner, H. Steen, A.J.
`Schrank, Pharmacology for Pharmacists and
`Pharmacy Technicians (in German), 8th
`edition, 304 p., Deutscher Apotheker Verlag,
`Stuttgart, Germany
`A.A. Vinks, H. Derendorf, J.W. Mouton
`Fundamentals of Antimicrobial
`Pharmacokinetics and Pharmacodynamics, 467
`p., Springer, New York
`H. Derendorf
`POP – Patient-oriented Pharmacy, Vol. 1 (in
`German), 160 p., Deutscher Apotheker Verlag,
`Stuttgart, Germany
`S. Schmidt, H. Derendorf
`Applied Pharmacometrics, 570 p., Springer,
`New York
`H. Derendorf
`POP – Patient-oriented Pharmacy, Vol. 2 (in
`German), 136 p., Deutscher Apotheker Verlag,
`Stuttgart, Germany
`H. Derendorf
`POP – Patient-oriented Pharmacy, Vol. 3 (in
`German), 146 p., Deutscher Apotheker Verlag,
`Stuttgart, Germany
`
`Ex. 2015-0006
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`Present Research Interest
`
`Pharmacokinetics and pharmacodynamics of glucocorticoids
`and antibiotics drugs.
`Use of pharmacokinetic/pharmacodynamic modeling in drug
`development.
`
`
`Affiliations
`
`American College of Clinical Pharmacology
`American Association of Pharmaceutical Scientists
`American Pharmacists Association
`Florida Pharmacy Association
`German Pharmaceutical Society
`American Society for Clin. Pharmacology and Therapeutics
`American Association of Colleges of Pharmacy
`American Society for Microbiology
`American Society of Pharmacometrics
`International Society for Anti-infective Pharmacology
`Paul Ehrlich Society
`
`Other Activities
`
`
`President, American College of Clinical Pharmacology (2006-
`2008)
`
`President, International Society for Anti-infective
`Pharmacology (2004-2006)
`
`Member of NASA Exploration Medical Capabilities (ExMC)
`Element’s Pharmacy Project Expert Review Panel (2016-18)
`
`Program Co-Chair, ISSX Annual Meeting, Orlando (2015)
`
`Member, Nutrition and Therapeutics Committee of the NASA
`Space Medicine Program (2008-2011)
`
`Member, Scientific Organizing Committee, 2nd Symposium on
`Antimicrobial Resistance in Animals and the Environment,
`Tours (2007)
`
`Ex. 2015-0007
`
`
`
`
`Co-Chair, EUFEPS Conference on Optimizing Drug Discovery
`and Development- Integrating Systems Approaches into
`Pharmaceutical Sciences, Basel (2007)
`
`Member, Program Committee, Pharmaceutical Sciences World
`Congress, Amsterdam (2007)
`
`Member, Advisory Committee for Pharmaceutical Science
`Clinical Pharmacology Subcommittee, FDA (2002-2006)
`
`Member, Scientific Advisory Board, Bavarian Academy of
`Clinical Pharmacy (2006-present)
`
`Program Chairman, National Meeting of the American College
`of Clinical Pharmacology (2003)
`
`Member of the International Pharmaceutical Education
`Advisory Committee of the American Association of Colleges
`of Pharmacy (2001-03)
`
`Chair, AAPS Microdialysis Focus Group (2003)
`
`Secretary, American College of Clinical Pharmacology (1996-
`00)
`
`Council Member, International Society for Anti-infective
`Pharmacology (1999-02)
`
`Member of the Board of Regents, American College of
`Clinical Pharmacology (1991-00)
`
`Member of the FDA Expert Panel on Oral Inhalation and Nasal
`Drug Products (OINDP) (1999-00)
`
`Member of AAPS/PPDM Program Committee (1996/97)
`
`Member, National RCMI Advisory Board, Florida A&M
`University (1992-05).
`
`Member of Credentials Committee, American College of
`Clinical Pharmacology (1990-00).
`
`Member of the Nutrition and Therapeutics Integrated Project
`Team of the NASA-JSC Space Medicine Program (1997-04).
`
`Member of the AAPS Globalization Committee (1995)
`
`Ex. 2015-0008
`
`
`
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`National Chair of the AACP Meeting of Department Chairs of
`Pharmaceutics (1992).
`
`Member of the Graduate Education and Research Committee
`(PDD) of the American Association of Pharmaceutical
`Scientists (1992-1993).
`
`Program Chairman, National Meeting of the American College
`of Clinical Pharmacology (1992).
`
`Chairman, Southeastern Regional Meeting of the American
`Association of Pharmaceutical Scientists 1991 and 1992.
`
`President of the Southeastern Chapter of the American
`College of Clinical Pharmacology (1990-91).
`
`Member of Scientific Excellence Committee, American
`Association of Pharmaceutical Scientists (1990-91).
`
`Member of Scientific Program Committee, American College of
`Clinical Pharmacology (1989-1992, 1997).
`
`Reviewer for J. Pharm. Sci., Int. J. Pharm., Pharm. Res.,
`J. Pharmacokin. Biopharm., Life Sci., Biopharm. Drug Disp.
`and J. Pharm. Biomed. Anal.
`
`Member of several ad-hoc NIH Study Sections (NCI, NIAID).
`Grant-Reviewer for the National Science Foundation.
`Grant Reviewer for the Italian Ministry for University and
`Research.
`
`Book-Reviewer for Am. J. Pharm. Ed., J. Am. Chem. Soc. and
`J. Pharm. Sci.
`
`
`Editorial Advisory Boards
`
`Editor, International Journal of Clinical Pharmacology and
`Therapeutics.
`
`US-Editor, Editorial Board, Die Pharmazie.
`
`Associate Editor, Journal of Clinical Pharmacology.
`
`Editor, International Journal of Antimicrobial Agents.
`
`
`Ex. 2015-0009
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`
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`Member, Honorary Editorial Board, Clinical
`Pharmacokinetics.
`
`Member, Editorial Board, Journal of Pharmacokinetics and
`Pharmacodynamics.
`
`Member, Editorial Board, Journal of Pharmaceutical Sciences
`
`Member, Editorial Board, Planta Medica
`
`Member, Editorial Board, CPT: Pharmacometrics and Systems
`Pharmacology
`
`Member, Editorial Board, GMS Infectious Diseases.
`
`Member, Editorial Board, Clinical Research and Regulatory
`Affairs.
`
`Member, Editorial Board, Clinical Pharmacology in Drug
`Development
`
`Member, Editorial Board, Antimicrobial Agents and
`Chemotherapy (until 2012)
`
`Associate Editor, European Journal of Pharmaceutical
`Sciences (until 2016)
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`Special Issues - Guest Editorships
`
`V. Butterweck, H. Derendorf
`Herb-Drug Interactions, Planta Medica 78, September 2012.
`
`W. Couet, H. Derendorf
`7th International Symposium on Microdialysis
`Eur. J. Pharm. Sci. 57, June 2014.
`
`Patents
`
`H. Derendorf, M. Müller: Patent US 6,904,309 B2 (June 7,
`2005), Microdialysis probes and methods of use.
`
`
`Ex. 2015-0010
`
`
`
`List of Publications
`
`h-index 55 (Scopus); 63 (Google Scholar)
`
`
`1. P. Rohdewald, H. Derendorf, C.E. Elger, O. Knoll
`Quantification of the attenuation of pain sensation
`through evoked potentials after the application of
`mild analgesics.
`Z. EEG-EMG 11, 199-204 (1980).
`
`2. H. Derendorf
`Electroencephalography in drug research.
`Dtsch. Apoth. Ztg. 120, 1474-1476 (1980).
`
`3. H. Derendorf, P. Rohdewald
`Pharmaceutical availability of analgesic derivatives
`of salicylic acid.
`Dtsch. Apoth. Ztg. 121, 493-498 (1981).
`
`4. H. Derendorf, P. Rohdewald
`Pharmaceutical availability of analgesic derivatives
`of pyrazolone.
`Dtsch. Apoth. Ztg. 121, 549-552 (1981).
`
`5. H. Derendorf, P. Rohdewald
`Measurement of analgesic action by subjective and
`objective parameters.
`In "Pain research - Pain measurement - Chest pain",
`ed. by A. Struppler and M. Gessler, pg. 143-150,
`Springer (1981).
`
`6. H. Derendorf, P. Rohdewald
`Pharmaceutical availability of analgesic derivatives
`of p-aminophenol in tablets.
`Dtsch. Apoth. Ztg. 121, 653-656 (1981).
`
`7. P. Rohdewald, H. Derendorf, C.E. Elger, O. Knoll
`Evoked potentials as objective parameters for the
`analgesic response of weak analgesics.
`Adv. in Neurology 32, 375-381 (1982).
`
`8. P. Rohdewald, H. Derendorf, G. Drehsen, C.E. Elger, O.
`Knoll
`Changes in cortical evoked potentials as correlates of
`the efficacy of weak analgesics.
`Pain 12, 329-34l (1982).
`
`Ex. 2015-0011
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`9. H. Derendorf, G. Drehsen, P. Rohdewald
`Cortical evoked potentials and saliva levels as basis
`for the comparison of pure analgesic to analgesic
`combinations.
`Pharmacology 25, 227-236 (1982).
`
`10. H. Derendorf
`Phencyclidine - angel dust or devil's drug?
`Dtsch. Apoth. Ztg. 122, 2642-2646 (1982).
`
`11. H. Derendorf, E.R. Garrett
`HPLC-Assay of methadone, phencyclidine and metabolites
`by post-column ion-pair extraction and "on-line"
`fluorescence detection of the counter-ion with
`applications.
`J. Pharm. Sci. 72, 630-635 (1983).
`
`12. P. Rohdewald, G. Drehsen, E. Milsmann, H. Derendorf
`Relationship between saliva levels of metamizol
`metabolites, bioavailability and analgesic efficacy.
`Arzneimittelforschung (Drug Research) 33(II), 985-988
`(1983).
`
`13. H. Derendorf, G. Drehsen, P. Rohdewald
`In vivo- in vitro- correlations of salicylate saliva
`levels and continuous flow cell dissolution rates.
`Int. J. Pharm. 15, 167-175 (1983).
`
`14. H. Derendorf, A.A. El-Koussi, E.R. Garrett
`Electrochemical chromatographic determination of
`morphine - antagonists in biological fluids with
`applications.
`J. Pharm. Sci. 73, 621-624 (1984).
`
`15. H. Derendorf, G. Drehsen, P. Rohdewald
`Antipyrine - new light on an old drug.
`Pharm. Res. 1, 225-229 (1984).
`
`16. P. Rohdewald, G. Drehsen, H. Derendorf
`Phenazone, the underestimated analgesic.
`Pharm. Ztg. 129, 552-558 (1984).
`
`17. G. Drehsen, H. Derendorf, P. Rohdewald
`Pain relief- but when ?
`Münch. Med. Wschr. 126, 736-738 (1984).
`
`
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`Ex. 2015-0012
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`18. P. Rohdewald, J. Rehder, G. Drehsen, G. Hochhaus, H.
`Derendorf, H. Möllmann
`Simultaneous determination of glucocorticoid
`alcohols, their succinates and hydrocortisone in
`plasma.
`J. Pharm. Biomed. Anal. 3, 565-573 (1985).
`
`19. H. Derendorf, H. Möllmann, P. Rohdewald, J. Rehder,
`E.W. Schmidt
`Kinetics of methylprednisolone and its hemisuccinate
`ester.
`Clin. Pharm. Ther. 37, 502-507 (1985).
`
`20. R.L. Yost, H. Derendorf
`Rapid chromatographic determination of cefotaxime and
`its metabolite in biological fluids.
`J. Chromatogr. 341, 131-138 (1985).
`
`21. H. Derendorf, P. Rohdewald, H. Möllmann, J. Rehder, J.
`Barth, D. Neveling
`Pharmacokinetics of prednisolone after high doses of
`prednisolone hemisuccinate.
`Biopharm. Drug Disp. 6, 423-432 (1985).
`
`22. E.R. Garrett, H. Derendorf, A. Mattha
`Pharmacokinetics of morphine and its surrogates VI:
`HPLC-Analyses and pharmacokinetics of methadone and
`its derived metabolites in dogs.
`J. Pharm. Sci. 74, 1203-1214 (1985).
`
`23. H. Möllmann, P. Rohdewald, E.W. Schmidt, V. Salomon,
`H. Derendorf
`Pharmacokinetics of triamcinolone acetonide and its
`phosphate ester.
`Eur. J. Clin. Pharmacol. 29, 85-89 (1985).
`
`24. P. Rohdewald, H. Derendorf, G. Drehsen, H.W.
`Granitzki, E. Neddermann
`The attenuation of experimental pain by pyrazolones.
`In "100 years pyrazolones", ed. by K. Brune and R.
`Lanz, Urban & Schwarzenberg, pg. 61-67 (1985).
`
`25. H. Möllmann, J. Barth, K.M. Müller, P. Rohdewald, A.
`Grüner, H. Derendorf
`Pulmonary complications in intensive care patients-
`therapeutic approaches for the treatment of ARDS
`BGA-Schriften 486, 193-207 (1986).
`
`Ex. 2015-0013
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`26. H. Derendorf, P. Rohdewald, G. Hochhaus, H. Möllmann
`HPLC determination of glucocorticoid alcohols, their
`phosphates and hydrocortisone in aqueous solutions and
`biological fluids.
`J. Pharm. Biomed. Anal. 4, 197-206 (1986).
`
`27. H. Derendorf, G. Mullersman, J. Barth, A. Grüner, H.
`Möllmann
`Pharmacokinetics of diclofenac sodium after
`intramuscular administration in combination with
`triamcinolone acetate.
`Eur. J. Clin. Pharmacol. 31, 363-365 (1986).
`
`28. G. Mullersman, H. Derendorf
`Ranitidine - rapid analysis in biological fluids and
`determination of erythrocyte partitioning.
`J. Chromatogr. 381, 385-391 (1986).
`
`29. G. Mullersman, V.P. Gotz, W.L. Russell, H. Derendorf
`Lack of clinically significant in vitro and in vivo
`interactions between ranitidine and sucralfate.
`J. Pharm. Sci. 75, 995-998 (1986).
`
`30. R.L. Yost, H. Derendorf
`Pharmacokinetics of cefotaxime and its metabolite in
`normal and morbidly obese patients.
`Ther. Drug Monitor. 8, 189-194 (1986).
`
`31. H. Derendorf, H. Möllmann, A. Grüner, D. Haack, G.
`Gyselby
`Pharmacokinetics and pharmacodynamics of
`glucocorticoid suspensions after intraarticular
`administration.
`Clin. Pharm. Ther. 39, 313-317 (1986).
`
`32. H. Möllmann, J. Rehder, P. Rohdewald, B.E. Braun, J.
`Barth, H. Derendorf, B. Holtmann, A. Grüner
`Exogenous and endogenous glucocorticoid plasma level
`after intramuscular administration of diclofenac and
`triamcinolone diacetate
`Med. Welt 37, 371-377 (1986).
`
`
`
`Ex. 2015-0014
`
`
`
`33. H. Möllmann, J. Barth, D. Haack, A. Grüner, D.
`Stroband G. Gyselby, P. Rohdewald, H. Derendorf
`Comparison of the kinetics and dynamics of
`intraarticular glucocorticoid suspensions.
`Akt. Rheumatol. 11, 55-60 (1986).
`
`34. H. Derendorf, M. Kaltenbach
`Coulometric high-performance liquid chromatographic-
`analysis morphine in biological fluids.
`J. Pharm. Sci. 75, 1198-1200 (1986).
`
`35. P. Rohdewald, H. Möllmann, J. Barth, J. Rehder, H.
`Derendorf
`Pharmacokinetics of dexamethasone and its phosphate
`ester.
`Biopharm. Drug Disp. 8, 205-212 (1987).
`
`36. S.A. Stout, H. Derendorf
`Local treatment of respiratory infections with
`antibiotics.
`Drug Intel. Clin. Pharm. 21, 322-329 (1987).
`
`37. H. Derendorf
`Erythrocyte - binding of cepholosporins.
`J. Pharm. Pharmacol. 39, 129-131 (1987).
`
`38. P. Rohdewald, J. Rehder, H. Möllmann, J. Barth, H.
`Derendorf
`Pharmacokinetics and pharmacodynamics of prednisolone
`after extremely high doses of prednisolone
`hemisuccinate.
`Arzneimittelforschung (Drug Research), 37 (I), 194-198
`(1987).
`
`39. G. Mullersman, S. Toufflin, H. Derendorf
`HPLC analysis of buprenorphine in plasma and urine
`using coulometric detection.
`J. Pharm. Biomed. Anal. 5, 303-308 (1987).
`
`40. S.A. Stout, C.M. Riley, H. Derendorf
`The correlation between the pharmacokinetics of
`melphalan and the pharmacodynamic response of
`neuroblastoma cells treated in vitro.
`Proc. Biopharm. Pharmacokin. II, 252-260 (1987).
`
`
`
`Ex. 2015-0015
`
`
`
`41. H. Derendorf
`Pharmacokinetic evaluation of cefotaxime in normal and
`obese subjects.
`Proc. Biopharm. Pharmacokin. III, 11-18 (1987).
`
`42. H. Möllmann, P. Rohdewald, J. Barth, H. Derendorf
`Effect of high doses of glucocorticoids on the
`kinetics of human white blood cells in vivo.
`Med. Klinik 83, 159-163 (1988).
`
`43. G. Mullersman, H. Derendorf, M.E. Brewster, K.S.
`Estes, N. Bodor
`HPLC-Assay of a CNS directed estradiol chemical
`delivery system and its application after intravenous
`administration to rats.
`Pharm. Res. 5, 172-177 (1988).
`
`44. H. Möllmann, P. Rohdewald, J. Barth, H. Derendorf, C.
`Möllmann, M. Verho.
`Comparative pharmacokinetics of methylprednisolone
`phosphate and hemisuccinate in high doses.
`Pharm. Res. 5, 509-513 (1988).
`
`45. L.A. Berglund, H. Derendorf, J.W. Simpkins
`Desensitation of brain opiate receptor mechanisms by
`gonadal steroid treatments that stimulate luteinizing
`hormone secretion.
`Endocrinology 122, 2718-2726 (1988).
`
`46. R.W. Townsend, V. Keuth, K. Embil, G. Mullersman, J.H.
`Perrin, H. Derendorf
`High-performance liquid chromatographic determination
`of conjugated estrogens in tablets.
`J. Chromatogr. 450, 414-419 (1988).
`
`47. J. Limberg, H. Derendorf
`Pharmacy education in the U.S.A.
`Deut. Apoth. Ztg. 128, 2458-2461 (1988).
`
`48. E.W. Schmidt, H.W. Möllmann, B.E. Braun, J. Barth, H.
`Derendorf
`Circadian theophylline levels after single and
`multiple administration of a sustained released dosage
`form.
`Therapiewoche 38, 2046-2051 (1988).
`
`
`
`Ex. 2015-0016
`
`
`
`49. M.E. Brewster, K.S. Estes, T. Loftsson, R. Perchalski
`H. Derendorf, G. Mullersman, N. Bodor
`Improved delivery through biological membranes XXXI:
`Solubilization and stabilization of an estradiol
`chemical delivery system by modified ß-cyclodextrins.
`J. Pharm. Sci. 77, 981-985 (1988).
`
`50. H. Derendorf
`Pharmacokinetic evaluation of (cid:69)-lactam antibiotics.
`J. Antimicrob. Chemother. 24, 407-413 (1989).
`
`51. H. Möllmann, J. Barth, D. Schött, W.T. Ulmer, H.
`Derendorf, G. Hochhaus
`Differential therapeutic aspects of the treatment of
`toxic gas poisoning with glucocorticoids.
`Intensivmed. 26, 2-15 (1989).
`
`52. M.E. Brewster, T. Loftsson, K.E. Estes, G. Mullersman,
`H. Derendorf, N. Bodor
`Water soluble complexes of a brain-targeted drug
`delivery system.
`Proc. Intl. Symp. Cyclodextr. 4, 399-405 (1989).
`
`53. H. Möllmann, P. Rohdewald, J. Barth, M. Verho, H.
`Derendorf
`Pharmacokinetics and dose linearity testing of
`methylprednisolone phosphate.
`Biopharm. Drug Disp. 10, 453-464 (1989).
`
`54. H. Derendorf, H. Möllmann, P. Rohdewald, D. Strohband,
`J. Barth, G. Hochhaus
`Pharmacokinetic aspects of intra-articular
`administration of glucocorticoids.
`in Willert, Heuck (ed.), New Results in Osteology,
`Springer, Berlin, pp. 474-481 (1989).
`
`55. J. Barth, H.W. Möllmann, H. Derendorf, G. Hochhaus
`Pharmacodynamic interactions in systemic
`glucocorticoid therapy.
`in Willert, Heuck (ed.), New Results in Osteology,
`Springer, Berlin, pp. 533-541 (1989).
`
`56. J. Barth, A. Möllmann, G. Hochhaus, H. Derendorf, H.W.
`Möllmann
`Absorption and transfer of water-soluble
`glucocorticoids through pulmonary membranes.
`Atemw.-Lungenkrkh. 15, 412-416 (1989).
`
`Ex. 2015-0017
`
`
`
`
`57. E.W. Schmidt, H. Derendorf, B. Rasche, H.W. Möllmann
`Clinical and pharmacokinetic evaluation for the
`replacement therapy of (cid:68)1-protease-inhibitor in
`patients with congenital (cid:68)1-protease-inhibitor
`deficiency and lung emphysema.
`Atemw.-Lungenkrkh. 15, 479-488 (1989).
`
`58. H.G. Schaefer, D. Harrison, M.P. Hocking, J. Limberg,
`H. Derendorf
`Effect of truncal vagotomy and partial gastrectomy on
`the pharmacokinetics of propranolol enantiomers in
`dogs.
`J. Pharm. Sci. 79, 292-294 (1990).
`
`59. H. Schreier, G. Hochhaus, R.J. Prankerd, H. Derendorf,
`M.E. Brewster, R.A. Baughman
`Pharmaceutical Biotechnology: A new graduate course at
`the University of Florida College of Pharmacy.
`Am. J. Pharm. Educ. 54, 46-50 (1990).
`
`60. J. Limberg, M. LeBel, H. Derendorf
`Evaluation of free tissue concentrations of fleroxacin
`after oral administration.
`Pharm. Res. 7, 422-424 (1990).
`
`61. E. Brunt, J. Limberg, H. Derendorf
`High performance liquid chromatographic-assay and
`erythrocyte partitioning of fleroxacin, a new
`fluoroquinolon antibiotic.
`J. Pharm. Biomed. Anal. 8, 67-71 (1990).
`
`62. H. Derendorf, H. Möllmann, J. Barth
`Comparative pharmacokinetic evaluation of
`glucocorticoids after intraarticular administratation.
`Akt. Rheumatol. 15, 145-153 (1990).
`
`63. F.F.T. Ververs, H.G. Schaefer, J.F. Lefevre, L.M.
`Lopez, H. Derendorf
`Simultaneous HPLC-assay of propranolol, diltiazem and
`diltiazem-metabolites in human plasma with
`application.
`J. Pharm. Biomed. Anal. 8, 535-539 (1990).
`
`
`
`Ex. 2015-0018
`
`
`
`64. P. Adland-Davenport, M.P. Brown, J.D. Robinson, H.
`Derendorf
`Pharmacokinetics of amikacin in critically ill
`neonatal foals treated for presumed or confirmed
`sepsis.
`Equine Vet. J. 22, 18-22 (1990).
`
`65. H. Derendorf, H. Möllmann, G. Voortman, F.A. van den
`Ouweland, L.B.A. van de Putte, G. Gevers, J. Dequeker,
`E. van Vliet-Daskalopoulou
`Pharmacokinetics of rimexolone after intra-articular
`administration.
`J. Clin. Pharmacol. 30, 476-479 (1990).
`
`66. K. Dietzel, V. Keuth, K.S. Estes, M.E. Brewster, R.
`Clemmons, R. Vistelle, N.S. Bodor, H. Derendorf
`A redox-based system that enhances delivery of
`estradiol to the brain: Pharmacokinetic evaluation in
`the dog.
`Pharm. Res. 7, 879-883 (1990).
`
`67. H.G. Schaefer, H. Spahn, L.M. Lopez, H. Derendorf
`Simultaneous determination of propranolol and 4-
`hydroxypropranolol enantiomers after chiral
`derivatization using reversed phase high-performance
`liquid chromatography.
`J. Chromatogr. 527, 351-359 (1990).
`
`68. J. Limberg, D. Harrison, M.P. Hocking, H. Derendorf
`Theophylline absorption and gastric emptying after
`partial gastrectomy in dogs.
`J. Pharm. Sci. 79, 968-969 (1990).
`
`69. M. Kaltenbach, S.H. Curry, H. Derendorf
`Extent of drug absorption at the time of peak plasma
`concentration in an open one-compartment body model
`with first-order absorption.
`J. Pharm. Sci. 79, 462 (1990).
`
`70. K. Dietzel, K.S. Estes, M.E. Brewster, N.S. Bodor, H.
`Derendorf
`The use of hydroxypropyl-(cid:69)-cyclodextrin as a vehicle
`for intravenous administration of dexamethasone in
`dogs.
`Int. J. Pharm. 59, 225-230 (1990).
`
`
`
`Ex. 2015-0019
`
`
`
`71. J. Barth, H. Fett, M. Pörtner, B.E. Braun, H.
`Möllmann, P. Rohdewald, J. Krämer, H. Derendorf
`Exogenous and endogenous glucocorticoid levels after
`epidural administration of glucocorticoid crystal
`suspensions in different volumes.
`Orthop. Praxis 26, 729-736 (1990).
`
`72. H. Möllmann, B. Armbruster, J. Barth, H. Derendorf,
`O.W. Flörke, G. Hochhaus, C.R. Möllmann, P. Rohdewald,
`E.W. Schmidt
`Distribution and aggregation of crystals in
`glucocorticoid suspensions.
`Akt. Rheumatol. 15, 101-124 (1990).
`
`73. C.D. Hepler, L.M. Strand, H. Derendorf
`The pharmacist and pharmaceutical care - future
`opportunities and responsibility.
`Pharmazeutische Zeitung 135, 3087-3092 (1990).
`
`74. K.S. Estes, V. Keuth, K. Dietzel, M.E. Brewster, N.S.
`Bodor, H. Derendorf
`A redox-based chemical delivery system that enhances
`estradiol to the brain: Disposition studies in the
`rat.
`Pharm. Res.8, 1180-1185 (1991).
`
`75. O. Makil, M. Kaltenbach, J. Limberg, D. Harrison, M.P.
`Hocking, H. Derendorf
`Pharmacokinetics of ranitidine after partial
`gastrectomy in dogs.
`J. Pharm. Sci. 80, 1034-1036 (1991).
`
`76. H. Derendorf, H. Möllmann, J. Barth, C. Möllmann, S.
`Tunn, M. Krieg
`Pharmacokinetics and oral bioavailability of
`hydrocortisone.
`J. Clin. Pharmacol. 31, 473-476 (1991).
`
`77. H. Möllmann, J. Barth, C. Möllmann, S. Tunn, M. Krieg,
`H. Derendorf
`Pharmacokinetics and rectal bioavailability of
`hydrocortisone acetate.
`J. Pharm. Sci. 80, 835-836 (1991).
`
`
`
`Ex. 2015-0020
`
`
`
`78. H. Derendorf, H. Möllmann, M. Krieg, S. Tunn, C.
`Möllmann, J. Barth, H.J. Röthig
`Pharmacodynamics of methylprednisolone phosphate after
`single intravenous administration to healthy
`volunteers.
`Pharm. Res. 8, 263-268 (1991).
`
`79. B. Wichert, H. Schreier, H. Derendorf
`Sensitive HPLC-assay for the determination of amikacin
`in human plasma.
`J. Pharm. Biomed. Anal. 9, 251-254(1991).
`
`80. C.D. Page, M. Mautino, H. Derendorf, W. Mechlinski
`Multiple-dose pharmacokinetics of ketoconazole
`administered orally to gopher tortoises (Gopherus
`polyphemus).
`J. Zoo & Wildlife Med. 22, 191-198 (1991).
`
`81. T. Loftsson, M.E. Brewster, H. Derendorf, N. Bodor
`2-Hydroxypropyl-(cid:69)-cyclodextrin: Properties and usage in
`pharmaceutical formulations.
`PZ Wissenschaft 4, 5-10 (1991).
`
`82. C.D. Page, M. Mautino, H. Derendorf, J.P. Anhalt
`Comparative pharmacokinetics of trimethoprim-
`sulfamethoxazole administered intravenously and orally
`to captive elephants.
`J. Zoo & Wildlife Med. 22, 409-416 (1991).
`
`83. K.H. Rand, K. Gibbs, H. Derendorf, J. Graham-Pole
`Pharmacokinetics of intravenous immunoglobulin in bone
`marrow transplant patients.
`J. Clin. Pharmacol.31, 1151-1154 (1991).
`
`84. K.S. Estes, P. Dewland, M.E. Brewster, H. Derendorf,
`N. Bodor
`A redox-based chemical delivery system (CDS) applied
`to estradiol.
`PZ Wissenschaft 4, 153-158 (1991).
`
`85. G. Hochhaus, H. Derendorf, H. Möllmann, J. Barth
`A selective HPLC/RIA for dexamethasone and its prodrug
`dexamethasone-21-isonicotinate in biological fluids.
`J. Pharm. Biomed. Anal.9, 761-767 (1991).
`
`
`
`Ex. 2015-0021
`
`
`
`86. M.A. Longer, H.G. Schaefer, H. Derendorf
`Fundamentals of assessing bioequivalence studies.
`PZ Wissenschaft 5, 15-22 (1992).
`
`87. G. Hochhaus, L.S. Chen, A. Ratka, P. Druzgala, J.
`Howes, N. Bodor, H. Derendorf
`Pharmacokinetic characterization and tissue
`distribution of the new glucocorticoid soft drug
`loteprednol etabonate in rats and dogs.
`J. Pharm. Sci. 81, 1210-1215 (1992).
`
`88. H. Schreier, K.J. McNicol, M. Ausborn, D.M. Soucy, H.
`Derendorf, A.A. Stecenko, R.J. Gonzalez-Rothi
`Pulmonary delivery of amikacin liposomes and acute
`liposome toxicity in the sheep.
`Int. J. Pharmac. 87, 183-193 (1992).
`
`89. S. Tunn, H. Möllmann, J. Barth, H. Derendorf, M. Krieg
`Simultaneous measurement of cortisol in serum and
`saliva after different forms of cortisol
`administration.
`Clin. Chem. 38, 1491-1494 (1992).
`
`90. G. Hochhaus, R. Hochhaus, G. Werber, H. Derendorf, H.
`Möllmann
`A selective HPLC/RIA for dexamethasone and its prodrug
`dexamethasone-21-sulphobenzoate sodium in biological
`fluids
`Biomedical Chromatography 6, 283-286 (1992).
`
`91. H. Möllmann, H. Derendorf, J. Barth, C. Möllmann, S.
`Tunn, M. Krieg
`Bioavailability of hydrocortisone after rectal
`administration of hydrocortisone acetate foam.
`Med. Welt 43, 609-615 (1992).
`
`92. H. Derendorf
`Choice of appropriate pharmacokinetic-pharmacodynamic
`models for predicting drug effects.
`Klin. Pharmakol. aktuell 3, 19-21 (1992).
`
`93. J. Barth, M. Damoiseaux, H. Möllmann, K.H. Brandis, G.
`Hochhaus, H. Derendorf
`Pharmacokinetics and pharmacodynamics of prednisolone
`after intravenous and oral administration.
`Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 317-324
`(1992).
`
`Ex. 2015-0022
`
`
`
`
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