9/18/2019
`
`A pill for relapsing MS | Tecfidera® (dimethyl fumarate)
`
`Important Safety Information
`
`Patient Information & Prescribing Information
`
`*Based on prescriptions.
`
`opens up possibilities
`
`Laura S., living with relapsing MS
`
`®
`Tecfidera (dimethyl fumarate) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically
`isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
`
`*Based on number of prescriptions from IMS NPA™ Weekly Data
`(September 27, 2013 – March 29, 2019).
`IMPORTANT SAFETY INFORMATION AND INDICATION
`
`https://www.tecfidera.com
`
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`

`

`9/18/2019
`
`A pill for relapsing MS | Tecfidera® (dimethyl fumarate)
`
`TECFIDERA
`effectiveness
`
`❯
`
`
`
`Prepare for
`your next visit
`
`❯
`
`Where could yes take you?
`Say yes to TECFIDERA—a twice-daily pill for relapsing MS
`that was shown to be effective in 3 different ways:
`
`Cut
`RELAPSES
`IN HALF
`*
`
`Know more ❯
`
`In 2
`*
`separate
`two-year
`studies,
`compared
`with
`placebo,
`TECFIDERA
`reduced
`risk of
`relapse by
`49% and
`34%, and
`reduced
`number of
`relapses by
`53% and
`44%.
`
`Delay
`PROGRESSION
`OF
`PHYSICAL DISABILITY
`
`Discover how ❯
`
`Slow
`DEVELOPMENT
`OF BRAIN LESIONS
`
`Get the details ❯
`
`In 2 separate two-year studies, compared with placebo, TECFIDERA reduced risk of relapse by 49% and 34%,
`*
`and reduced number of relapses by 53% and 44%, respectively.
`
`TECFIDERA has up to 10 years of combined clinical trial and real-world experience. Learn about TECFIDERA
`†
`
`Based on data on file.
`
`† S
`
`tay connected
`Get the latest information from MS experts and hear from others who have taken TECFIDERA.
`
`Sign Up ❯
`
`IMPORTANT SAFETY INFORMATION AND INDICATION
`
`https://www.tecfidera.com
`
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`9/18/2019
`
`A pill for relapsing MS | Tecfidera® (dimethyl fumarate)
`
`IMPORTANT SAFETY INFORMATION AND INDICATION
`
`https://www.tecfidera.com
`
`EXPAND
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`9/18/2019
`
`A pill for relapsing MS | Tecfidera® (dimethyl fumarate)
`
`Personal stories
`People living with relapsing multiple sclerosis (MS) have a lot to share. Learn about their struggles, lessons, victories, and why they
`IMPORTANT SAFETY INFORMATION AND INDICATION
`EXPAND
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`

`9/18/2019
`
`said yes to TECFIDERA.
`
`A pill for relapsing MS | Tecfidera® (dimethyl fumarate)
`
`See their stories ❯
`Antonia S.,
`living with relapsing MS
`
`We also recommend
`
`Questions to ask your healthcare provider while on TECFIDERA
`
`Start here ❯
`
`Could you be eligible for the $0 Copay Program?
`IMPORTANT SAFETY INFORMATION AND INDICATION
`
`https://www.tecfidera.com
`
`EXPAND
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`

`9/18/2019
`
`A pill for relapsing MS | Tecfidera® (dimethyl fumarate)
`
`Find out now ❯
`
`Newly diagnosed?
`TECFIDERA may help
`
`Learn more ❯
`
`IMPORTANT SAFETY INFORMATION
`Do not use Tecfidera (dimethyl fumarate) if you have had an allergic reaction (such as welts, hives, swelling of the face, lips, mouth or
`®
`tongue, or difficulty breathing) to TECFIDERA or any of its ingredients.
`
`Before taking and while you take TECFIDERA, tell your healthcare provider about any low white blood cell counts or infections or any other
`medical conditions. 
`
`What are the possible side effects of TECFIDERA?
`
`TECFIDERA may cause serious side effects including:
`Allergic reactions
`PML, which is a rare brain infection that usually leads to death or severe disability.
`Decreases in your white blood cell count. Your healthcare provider should check your white blood cell count before you take TECFIDERA
`and from time to time during treatment
`Liver problems. Your healthcare provider should do blood tests to check your liver function before you start taking TECFIDERA and
`during treatment if needed. Tell your healthcare provider right away if you get any symptoms of a liver problem during treatment,
`including:
`severe tiredness
`loss of appetite
`pain on the right side of your stomach
`dark or brown (tea color) urine
`yellowing of your skin or the white part of your eyes
`
`The most common side effects of TECFIDERA include flushing and stomach problems. These can happen especially at the start of
`treatment and may decrease over time. Taking TECFIDERA with food may help reduce flushing. Call your healthcare provider if these
`symptoms bother you or do not go away. Ask your healthcare provider if taking aspirin before taking TECFIDERA may reduce flushing.
`
`These are not all the possible side effects of TECFIDERA. Call your healthcare provider for medical advice about side effects. You may
`IMPORTANT SAFETY INFORMATION AND INDICATION
`report side effects to FDA at 1-800-FDA-1088. For more information go to dailymed.nlm.nih.gov.
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`

`

`9/18/2019
`A pill for relapsing MS | Tecfidera® (dimethyl fumarate)
`Tell your healthcare provider if you are pregnant or plan to become pregnant, or breastfeeding or plan to breastfeed. It is not known if
`TECFIDERA will harm your unborn baby or if it passes into your breast milk. Also tell your healthcare provider if you are taking prescription
`or over-the-counter medicines, vitamins, or herbal supplements. If you take too much TECFIDERA, call your healthcare provider or go to
`the nearest hospital emergency room right away.
`
`Please see full Prescribing Information and Patient Information.
`
`This is not intended to replace discussions with your healthcare provider.
`
`Indication
`Tecfidera (dimethyl fumarate) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically
`®
`isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
`
`WHAT IS TECFIDERA?
`
`Effectiveness
`
`Safety
`
`Talking to your healthcare provider
`
`STARTING TECFIDERA
`
`Dosage
`
`Common side effects
`
`Staying on track
`
`SUPPORT & EVENTS
`
`Support program
`
`Financial & insurance information
`
`Find events
`
`What is relapsing MS?
`
`Resources for care partners
`
`PERSONAL STORIES
`
`Living with relapsing MS
`
`SIGN UP
`
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`IMPORTANT SAFETY INFORMATION AND INDICATION
`
`https://www.tecfidera.com
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