`
`Estimating the minimum therapeutically effective dose of a compound via regression modelling and percentile estimation. - PubMed - NCBI
`
`PubMed
`
`NCBI will begin redirecting all HTTP traffic to HTTPS on Thursday, November 10 at 9 AM EST (2 PM UTC).
`Read more.
`
`Format: Abstract
`
`Stat Med. 1995 May 15-30;14(9-10):925-32; discussion 933.
`Estimating the minimum therapeutically effective dose of a compound via
`regression modelling and percentile estimation.
`1
`Filloon TG .
`Author information
`1
`Biometrics & Statistical Sciences Department, Procter & Gamble Pharmaceuticals, Miami Valley
`Laboratories, Cincinnati, Ohio 45239-8707, USA.
`
`Abstract
`Estimation of the minimum effective dose (MED) of a compound from a typical placebo-controlled
`dose-response study can be carried out in several ways. Current approaches compare treatment
`doses against a placebo dose via selected contrasts to determine the lowest dose level at which the
`contrast is statistically significant. Ruberg shows how this approach works for various choices of
`contrasts. Instead, the MTED (minimum therapeutically effective dose) might be defined as the
`lowest dose level that yields a therapeutic benefit to patients, on average, or to a given percentage of
`patients. One could use a lower confidence limit for the mean approach to determine the dose
`yielding (on average) a therapeutic benefit via regression modelling of the continuous treatment dose
`response. More importantly, a patient relevant approach would be to actually estimate regression
`percentiles or construct regression tolerance intervals. Such an approach addresses the question
`'What percentage of patients are receiving therapeutic (yet safe) doses', instead of just knowing that
`a dose is effective 'on average', and thus would help to understand the distribution of patient
`responses at a given treatment dose. This further enables one to better evaluate the efficacy versus
`safety trade-off as dose increases and provides better guidelines for prescribed dose levels.
`
`PMID: 7569511
`[PubMed - indexed for MEDLINE]
`
`MeSH Terms
`
`PubMed Commons
`https://www.ncbi.nlm.nih.gov/pubmed/7569511
`
`PubMed Commons home
`
`1/2
`
`ATI 1012-0001
`
`ATI v. ICOS
`IPR2018-01183
`
`
`
`11/9/2016
`
`Estimating the minimum therapeutically effective dose of a compound via regression modelling and percentile estimation. - PubMed - NCBI
`
`0 comments
`
`How to join PubMed Commons
`
`https://www.ncbi.nlm.nih.gov/pubmed/7569511
`
`2/2
`
`ATI 1012-0002
`
`