1/8/2019
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`2017 Top Ten Awardees - Clinical Research Forum
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`The Clinical Research Forum hosted its sixth annual Top Ten Clinical Research Achievement Awards
`Ceremony at the National Press Club on April 18, 2017. See press release
`(http://www.clinicalresearchforum.org/news/341349/Innovative-Asthma-Study-Wins-CR-Forums-Clinical-
`Excellence-Award.htm).
`The Top Ten Clinical Research Achievement Awards recognize major research advances that involve
`both innovation and impact on human diseases. These studies represent a portion of the annual return
`on the nation’s investment in the health and future welfare of its citizens.
`
`Over 60 institutions in the U.S. and from around the world are represented in this year's Top Ten
`Awardees. The awardees are:
`
`Baricitinib in Patients with Refractory Rheumatoid Arthritis – award accepted by Dr. Mark
`Genovese from Stanford University. This study looked at a new drug for rheumatoid arthritis, and
`tested it in over 500 patients with hard-to-treat disease. This new drug was found to be safe and
`effective, significantly improving disease in over 50% of patients within 12 weeks.
`Extended Release Naltrexone to Prevent Opioid Relapse in Criminal Justice Offenders –
`award accepted by Dr. Charles O’Brien from the University of Pennsylvania. This study looked at a
`completely different approach to opioid addiction using naltrexone, which is not an opioid like
`methadone. It doesn’t produce side effects, such as drowsiness, and can be stopped without
`withdrawal symptoms. It also helped significantly to prevent relapse and overdose in opioid
`patients. This study was further recognized with the Distinguished Clinical Research
`Excellence Award. See press release. (http://clinicalresearchforum.org/news/341349/Innovative-
`Asthma-Study-Wins-CR-Forums-Clinical-Excellence-Award.htm)
`
`Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease – award accepted by
`Dr. Maurizio Fava from Massachusetts General Hospital. This study is the first to use large data
`sets to discriminate the effects of genes and lifestyle in heart disease. The researchers found that
`genes can double the risk of heart disease, but a good lifestyle cuts that risk in half.
`
`https://www.clinicalresearchforum.org/page/2017TopTen
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`1/8/2019
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`2017 Top Ten Awardees - Clinical Research Forum
`Helmet Ventilation Reduces the Need for Endotracheal Ventilation in ARDS – award
`accepted by Dr. Bhakti Patel from the University of Chicago. This clinical trial found that the use of
`a helmet for treatment of patients with ARDS reduced the need for ventilator use compared to the
`use of the standard face mask, and also prevented one death out of every five patients. This study
`was further recognized with the Distinguished Clinical Research Excellence Award. See press
`release (http://clinicalresearchforum.org/news/341349/Innovative-Asthma-Study-Wins-CR-
`Forums-Clinical-Excellence-Award.htm).
`
`How Environmental Exposures Protect Against Asthma – award accepted by Dr. Anne
`Sperling from the University of Chicago. This study looked at the prevalence rate of asthma by
`examining Amish children with Hutterite children, who have similar lifestyles but different farming
`practices. The study found that the more mechanized farming practices led to greater prevalence
`of asthma in Hutterite children, while the Amish environment provides protection against asthma
`by shaping the innate immune response. This study received the Herbert Pardes Clinical
`Research Excellence Award. See press release
`(http://clinicalresearchforum.org/news/341349/Innovative-Asthma-Study-Wins-CR-Forums-
`Clinical-Excellence-Award.htm).
`
`HSD3B1 and Resistance to Androgen Deprivation Therapy in Prostate Cancer: A
`Retrospective Multi-cohort Study – award accepted by Dr. Nima Sharifi from the Cleveland
`Clinic. This study established the clinical relevance of the first example of a genetic variant in an
`androgen synthesizing enzyme for lethal prostate cancer (CRPC) and overall survival. These
`findings will allow doctors to consider different treatment options for patients with this genetic
`variant.
`
`Life Expectancy After Myocardial Infarction, According to Hospital Performance – award
`accepted by Dr. Emily Bucholz from Boston Children’s Hospital. This study accessed the largest,
`most comprehensive evaluation of hospital quality, the Cooperative Cardiovascular Project, and
`found what we all thought was true – that hospital quality does matter in terms of life expectancy.
`The article in the New England Journal of Medicine stimulated national conversation about the
`lifespan cost of poor quality care and the potential to save years by improving quality.
`A Randomized Trial Comparing Skin Antiseptic Agents at Cesarean Delivery – award
`accepted by Dr. Methodius Tuuli from the Washington University School of Medicine in St. Louis.
`Through a randomized, clinical trial, the researchers found that chlorhexidine alcohol reduces by
`nearly half the risk of surgical site infection following a cesarean, compared to iodine alcohol. This
`is significant because cesarean section is both the most common major surgical procedure among
`U.S. women and is associated with higher rates of surgical site infection than other surgical
`procedures.
`
`Re-engineering Chimeric Antigen Receptor T Cells for Targeted Therapy of Autoimmunity –
`award accepted by Dr. Aimee Payne from the University of Pennsylvania. Dr. Payne and
`colleagues have devised an exceptionally innovative approach to re-engineer chimeric antigen
`receptor (CAR) T cells for therapy of autoimmunity. As a result, these researchers have developed
`a breakthrough technology that can now be applied to a broad range of antibody-mediated
`diseases.
`The Use of Focused Ultrasound for Essential Tremor – award accepted by Dr. Paul Fishman,
`University of Maryland School of Medicine. These investigators developed and implemented a
`new treatment for essential tremor consisting of using focused ultrasound applied to the brain to
`create a lesion in a part of the brain that regulates movement.
`
`https://www.clinicalresearchforum.org/page/2017TopTen
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`1/8/2019
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`2017 Top Ten Awardees - Clinical Research Forum
`For full study descriptions, complete list of authors, and journal article citations, click here
`(/resource/resmgr/docs/news_&_announcements/Top_Ten_Press_Booklet.pdf).
`
`News
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`12/13/2018
`CCTS Newsletter | December 13, 2018 (/news/430556/CCTS-Newsletter--December-13-2018.htm)
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`12/4/2018
`CCTS DREAM Challenge | December 4 2018 (/news/429236/CCTS-DREAM-Challenge--December-4-
`2018.htm)
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`11/18/2018
`CCTS Newsletter | November 16, 2018 (/news/427446/CCTS-Newsletter--November-16-2018.htm)
`
`11/9/2018
`Deadline Extended for 2019 Top 10 Nominations (/news/426297/Deadline-Extended-for-2019-Top-10-
`Nominations.htm)
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`3/5/2019 » 3/6/2019
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`3/5/2019
`2019 Top Ten Clinical Research Achievement Awards Ceremony and Dinner
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`3/6/2019 » 3/8/2019
`Translational Science 2019 (/events/EventDetails.aspx?id=1047237)
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`CR Forum Membership Dinner 2019 (/events/EventDetails.aspx?id=1125939)
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`2017 Top Ten Awardees - Clinical Research Forum
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