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`
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`
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`
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`or
`capsule
`
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`
`dissolution
`
`gastric
`absorption
`
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`
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`___ _i ________ __ /
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`
`1
`
`BMS 2019
`MYLAN v. BMS
`IPR2018-00892
`
`
`
`Modern
`Modern
`Pharmaceutics
`Pharmaceutics
`
`2
`
`
`
`Modern
`Pharmaceutics
`and Expanded
`Revised
`Edition,
`Fourth
`
`edited by
`S. Banker
`Gilbert
`University
`of Iowa
`Iowa City, Iowa
`
`Christopher
`T. Rhodes
`of Rhode Island
`University
`Rhode Island
`Kingston,
`
`MARCEL
`
`nMARCEL DEKKER, INC.
`
`DEKKER
`
`3
`
`NEW YORK. BASEL
`
`
`
`ISBN: 0-8247-0674-9
`
`
`
`This book is printed on acid-free paper.
`
`Headquarters
`
`Marcel Dekker, Inc.
`
`
`270 Madison Avenue, New York, NY 10016
`
`tel: 212-696-9000; fax: 212-685-4540
`
`Eastern Hemisphere Distribution
`
`
`Marcel Dekker AG
`Hutgasse 4, Postfach 812, CH-4001 Basel, Switzerland
`
`
`
`tel: 4 l-61-261-8482; fax: 41-6 l-261-8896
`
`
`World Wide Web
`http://www.dekker.com
`
`
`
`
`
`The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/
`
`
`
`
`
`
`
`
`
`Professional Marketing at the headquarters address above.
`
`Copyright © 2002 by Marcel Dekker, Inc. All Rights Reserved.
`
`
`
`Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical,
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in
`
`writing from the publisher.
`
`Current printing (last digit):
`
`
`10 9 8 7 6 5 4 3 2
`
`PRINTED IN THE UNITED ST ATES OF AMERICA
`
`4
`
`
`
`Contents
`
`Preface
`Contributors
`
`l.Drug Products: Their Role in the Treatment of Disease, Their Quality, and
`
`
`
`
`Their Status and Future as Drug-Delivery Systems
`
`Gilbert S. Banker
`
`2.Principles of Drug Absorption
`
`
`Michael Mayersohn
`
`3.Pharmacokinetics
`David W. A. Bourne
`
`4.Factors Influencing Drug Absorption and Drug Availability
`
`
`
`
`
`Betty-mm Hoener and Leslie Z. Benet
`
`5.The Effect of Route of Administration and Distribution on Drug Action
`
`
`
`
`
`Svein 0ie and Leslie Z. Benet
`
`6.Chemical Kinetics and Drug Stability
`
`
`
`
`J.Keith Guillory and Rolland I. Foust
`
`7.Preformula tion
`
`Jens T. Carstensen
`
`
`
`
`
`and Systems of DeliveryDelivery-Processes 8.Cutaneous and Transdermal
`
`
`
`Gordon L. Flynn
`
`9.Disperse Systems
`
`
`
`
`
`
`
`
`Wandee Im-Emsap, Ornlaksana Paeratakul, and Juergen Siepmann
`
`Ill
`
`ix
`
`23
`
`67
`
`93
`
`119
`
`139
`
`167
`
`187
`
`237
`
`V
`
`5
`
`
`
`vi
`
`Contents
`
`10.Tablet Dosage Forms
`
`Mary J. Kottke and Ed\Vard M. Rudnic
`
`11.Hard and Soft Shell Capsules
`
`Larry L. Augsburger
`
`12.Parenteral Products
`
`James C. Boylan and Steven L. Nail
`
`13.Design and Evaluation of Ophthalmic Pharmaceutical Products
`
`
`
`
`
`
`John C. Lang, Robert E. Roehrs, Denise P. Rodeheaver, Paul J. Missel, Rajni Jani, and
`Masood A. Choll'han
`
`Route14.Delivery of Drugs by the Pulmonary
`
`
`
`
`Anthony J. Hickey
`
`15.Sustained-and Controlled-Release Drug Delivery Systems
`
`
`
`
`GlVen M. Jantzen and Joseph R. Robinson
`
`16.Target-Oriented Drug-Delivery Systems
`
`
`
`Vijay Kumar and Gilbert S. Banker
`
`17.Packaging of Pharmaceutical Dosage Forms
`
`
`Thomas J. Ambrosio
`
`18. Optimization Techniques in Pharmaceutical Formulation and Processing
`
`
`
`
`
`
`Joseph B. Schll'artz, Robert E. O'Connor, and Roger L. Schnaare
`
`287
`
`335
`
`381
`
`415
`
`479
`
`501
`
`529
`
`587
`
`607
`
`627
`
`645
`
`667
`
`695
`
`725
`
`735
`
`751
`
`
`
`and19.Food and Drug Laws that Affect Drug Product Design, Manufacture,
`
`
`
`
`Distribution
`Gamet E. Peck and Roland Foust
`
`
`
`Referencewith Particular of Drug Products 20.European Aspects of the Regulation
`
`
`
`
`
`
`to Development Pharmaceutics
`Brian R. Matthews
`
`21.Pediatric and Geriatric Aspects of Pharmaceutics
`
`
`
`
`
`Michelle Danish and Mary Kathryn Kottke
`
`22.Biotechnology-Based Pharmaceuticals
`
`
`
`Paul R. Dal Monte, S. Kathy Edmond Rouan, and Narendra B. Bam
`
`23.The Pharmacist and Veterinary Pharmaceutical Dosage Forms
`
`
`
`
`
`J.Patrick McDonnell and Lisa Blair Banker
`
`24.Dietary Supplements
`
`
`Teresa Bailey Klepser
`
`25.Bioequivalency
`
`Christopher T. Rhodes
`
`6
`
`
`
`Contents
`
`26.Drug Information
`Hazel H. Seaba
`
`27.Managed Care and Pharmacotherapy Management
`
`
`
`Julie A1. Ganther and William R. Doucette
`
`28.A View to the Future
`
`
`
`Gilbert S. Banker and Christopher T. Rhodes
`
`Index
`
`vii
`
`767
`
`799
`
`813
`
`833
`
`7
`
`
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