`Professor of Chemistry
`
`Purdue University, Department of Chemistry, 560 Oval Drive, West Lafayette, IN 47907
`Phone: 765‐494‐0386; Email: davethom@purdue.edu; Web: www.chem.purdue.edu/thompson
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`University of Missouri, Columbia
`University of Missouri, Columbia
`Research Advisor: John P. McCormick
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`1978
`1978
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`1984
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`Colorado State University
`Thesis Advisor:
`Louis S. Hegedus
`Dissertation:
`Mechanistic Study of π‐Methallyl Nickel Bromide
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`Cross Coupling Reactions with Organic Halides
`
`1984‐1987
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`1987‐1994
`1992
`1994‐2001
`2001‐present
`2003
`2003
`2005
`2008
`2012
`2013 & 2016
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`EDUCATION
`B.A., Biology
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`B.S., Chemistry
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`Ph.D., Organic Chemistry
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`POSITIONS HELD
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`Postdoctoral Research Associate, Oregon Health & Sciences University (OHSU/OGI)
`
` Research Advisor:
`
` James K. Hurst
`
`Assistant Professor, OHSU/OGI – Dept. of Chemical & Biological Sciences
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`Visiting Professor, University of British Columbia – Dept. of Biochemistry
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`Associate Professor, Purdue University – Dept. of Chemistry
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`Professor, Purdue University – Dept. of Chemistry
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`Visiting Professor, University of Florida – Dept. of Pharmaceutics
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`Visiting Professor, Osaka University – Dept. of Applied Chemistry
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`Visiting Professor, Japan Advanced Institute of Science & Technology – Dept. of Biomaterials
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`Professor, Purdue University – Dept. of Biomedical Engineering
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`Visiting Professor, Technical University of Denmark – Dept. of Micro & Nanotechnology
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`Visiting Professor, Chulalongkorn University – Dept. of Pharmaceutics
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`DISTINCTIONS
`1983‐1984
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`Colorado Fellowship
`1999
`Fall MRS Gold Paper Award
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`2001
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`Special Issue Editor, Advanced Drug Delivery Reviews
`2003‐2010
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`Head, Organic Chemistry Division, Department of Chemistry, Purdue University
`2004‐2005
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`Top Ten Outstanding Teachers in the College of Science, Purdue U.
`2005
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`Chair, Chemistry of Supramolecules & Assemblies Gordon Conference
`2006
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`JSPS Fellow, Japan Society for the Promotion of Science
`2006‐2011
` University Faculty Scholar, Purdue University
`2008
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`Award for Undergraduate Advising, College of Science, Purdue U.
`2008‐2018
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`Co‐Director, Chemical & Structural Biology Group, Purdue Center for Cancer Research
`2018‐present
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`Director, Medicinal Chemistry Group, Purdue Center for Cancer Research
`2012‐2015
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`Alternate Counselor, American Chemical Society – Division of Colloid & Surface Science
`2014
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`Chair, HC Brown Symposium in Organic Chemistry
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`Director, NIH‐National Cancer Institute, Experimental Therapeutics – Chemical Biology Consortium,
`Purdue University Specialized Center
`2016‐present
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`PROTIVA - EXHIBIT 2010
`Moderna Therapeutics, Inc. v. Protiva Biotherapeautics, Inc.
`IPR2018-00739
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`
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`GOVERNMENT SERVICE & ADVISORY BOARDS
` NIH Panelist, P50 Cancer Imaging Program (ad hoc)
` NSF Reviewer, IGERT Program (ad hoc)
`Editorial Advisory Board, Langmuir
`
` NIH Study Section, Bioorganic & Natural Products Chemistry (ad hoc)
`Editorial Advisory Board, Bioconjugate Chemistry
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`Associate Editor, WIREs: Nanomedicine & Nanobiotechnology
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` NIH Study Section Panelist, Bioengineering & Physiology SBIR
` NIH Study Section Panelist, Nanoscience & Nanotechnology in Biology & Medicine
` NIH Advisory Board, Nanomedicine Development Center Initiative
` NIH Study Section Charter Member, Gene & Drug Delivery
` NIH Study Section, COBRE Type I (ad hoc)
` NIH Study Section, Major Research Instrumentation ‐ Flow Cytometry Grants
` NIH Study Section, P01 Review
` NIH‐NCI Nanobiology Site‐Visit Program Review
` NIH Study Section, Nano (ad hoc)
` NIH Study Section, MBRS SCORE (ad hoc)
` NSF Division of Materials Research – Biomaterials Panelist
` NSF MRSEC Site Visit Reviewer
` NSF CAREER Award Panelist
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`
`RESEARCH INTERESTS
` Transiently‐stable carrier system development for intracellular drug & nucleic acid delivery
` Applications of energy‐efficient, analytics‐guided continuous synthesis
` Materials for accelerated protein structure elucidation
`
`David H. Thompson, CV
`
`1999
`1996‐2000
`2000‐2005
`2001
`2004‐present
`2005‐present
`2001‐2005
`2004‐2006
`2004‐2006
`2006‐2010
`2008
`2009‐2010
`2009‐2010
`2010
`2010
`2012
`2018
`2018
`2018
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`PROFESSIONAL & SCHOLARLY ASSOCIATIONS
` American Association for the Advancement of Science
` American Chemical Society (Organic and Colloid & Surface Science Divisions)
` American Society for Gene Therapy
` Materials Research Society
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`PUBLICATIONS
` 1. L. S. Hegedus & D. H. Thompson, "Reactions of Organic Halides with (‐Allyl)nickel Halide Complexes:
`A Mechanistic Study" Journal of the American Chemical Society 1985 107, 5663‐5669.
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` 2.
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` 3.
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` 4.
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`J. K. Hurst & D. H. Thompson, "Mechanisms of Oxidation‐Reduction Across Vesicle Bilayer
`Membranes: An Overview" Journal of Membrane Science 1986 28, 3‐29.
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`J. K. Hurst, D. H. Thompson & J. S. Connolly, "Oxidative Quenching of Photoexcited ZnTPPS4‐ Ion by
`Dihexadecylphosphate Vesicle‐Bound Viologens" Journal of the American Chemical Society 1987
`109, 507‐515.
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`J. K. Hurst & D. H. Thompson, “One‐Electron Reduction of Dihexadecylphosphate‐Bound Viologens by
`Pentacyanocobaltate Ions” Inorganic Chemistry 1987 26, 39‐43.
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`2
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`David H. Thompson, CV
` 5. D. H. Thompson, W. C. Barrette & J. K. Hurst, “One‐Electron Reduction of Dihexadecylphosphate
`Vesicle‐Bound Viologens by Dithionite Ions” Journal of the American Chemical Society 1987 109,
`2003‐2009.
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` 6. M. J. Colaneri, L. Kevan, D. H. Thompson & J. K. Hurst, “Variation of Alkylmethylviologen Radical
`Cation‐Water Interactions in Micelles and Vesicles from ESEM Spectroscopy: Effect of Alkyl Chain
`Length” Journal of Physical Chemistry 1987 91, 4072‐4077.
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` 7. T. Lu, T. M. Cotton, J. K. Hurst & D. H. Thompson, "A Raman and Surface‐Enhanced Raman Study of
`Asymmetrically‐Substituted Viologens" Journal of Physical Chemistry 1988 92, 6978‐6985.
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` 8. T. Lu, T. M. Cotton, J. K. Hurst & D. H. Thompson, “A Voltammetric Study of Asymmetric Viologen in
`an Organic Solvent, Aqueous Solution and Vesicle Systems” Journal of Electroanalytical Chemistry
`1988 246, 337‐347.
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` 9. D. H. Thompson & J. K. Hurst, “Intermolecular Transmembrane Redox‐‐Electron Tunneling or
`Molecular Diffusion?” in Molecular Electronic Devices III, F. L. Carter, R. Siatkowski, and H. Wohltjen,
`Eds., Elsevier, Amsterdam, 1988, pp. 413‐425.
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`10. B. C. Patterson, D. H. Thompson & J. K. Hurst, “Methyl Viologen‐Mediated Oxidation‐Reduction
`Across Dihexadecylphosphate Vesicles Involves Transmembrane Diffusion” Journal of the American
`Chemical Society 1988 110, 3656‐3657.
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` 11. B. C. Patterson, D. H. Thompson & J. K. Hurst, “Pathways of Transmembrane Redox Reactions for
`Dihexadecylphosphate Vesicle‐Bound Viologens” in Molecular Electronics—Science and Technology,
`Aviram, A., Ed., Engineering Foundation Publications, New York, 1989, pp. 385‐392.
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`12. P. L. Camacho, E. Geiger, G. Vigh, R. Webster & D. H. Thompson, “Separation of the Enantiomeric
`Intermediates of Some Platelet‐Activating Factor Analogues on a Naphthylalanine‐Type Pirkle
`Column” Journal of Chromatography 1990 506, 611‐616.
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` 13. R. Humphry‐Baker, D. H. Thompson, Y. Lei, M. Hope & J. K. Hurst, "Structural Investigations of
`Dihexadecylphosphate Small Unilamellar Vesicles" Langmuir 1991 7, 2592‐2601.
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` 14.
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`J. M. Kim & D. H. Thompson, "Tetraether Bolaform Amphiphiles as Models of Archaebacterial
`Membrane Lipids: Synthesis, Differential Scanning Calorimetry, and Monolayer Studies” Langmuir
`1992 8, 637‐644.
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` 15. A. Heuer, D. Fink, V. Laraia, J. Arias, P. Calvert, K. Kendall, G. Messing, J. Blackwell, P. Rieke, D. H.
`Thompson, A. Wheeler, A. Veis & A. Caplan, "Innovative Materials Processing Strategies: A
`Biomimetic Approach" Science 1992 255, 1098‐1105.
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` 16. V. C. Anderson & D. H. Thompson, "Photoinduced Morphology Changes in Plasmalogen Liposomes
`Using Visible Light" in Macromolecular Assemblies, P. Stroeve & A. C. Balazs, Eds., ACS Symposium
`Series 1992 493, 154‐170.
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` 17. V. C. Anderson & D. H. Thompson, "Triggered Release of Hydrophilic Agents from Plasmalogen
`Liposomes Using Visible Light or Acid" Biochimica et Biophysica Acta 1992 1109, 33‐42.
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`3
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`David H. Thompson, CV
` 18. D. H. Thompson & J.‐M. Kim, "Photoinduced Charge Transfer Studies in Bolaamphiphile‐Gramicidin‐
`Porphyrin Membranes" MRS Symposium Proceedings, Macromolecular Host‐Guest Complexes:
`Optical & Optoelectronic Properties and Applications 1992 277, 93‐98.
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` 19. D. H. Thompson, K. Wong, R. Humphry‐Baker, J. Wheeler, J. M. Kim & S. B. Rananavare, "Tetraether
`Bolaform Amphiphiles as Models of Archaebacterial Membrane Lipids: Raman Spectroscopy, 31P‐
`NMR, X‐Ray Scattering and Electron Microscopy" Journal of the American Chemical Society 1992
`114, 9035‐9042.
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` 20. D. H. Thompson, J.‐M. Kim & C. DiMeglio, "Photoinduced Charge Transfer Properties of
`Bolaamphiphile Membrane‐Gramicidin Diad and Triad Composites" SPIE Proceedings, Organic and
`Biological Optoelectronics 1993 1853, 142‐147.
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` 21. P. L. Camacho‐Torralba, G. Vigh & D. H. Thompson, "High Performance Chiral Displacement
`Chromatographic Separations in the Normal Phase Mode. Part 1. Retention and Adsorption Studies
`of Potential Displacers Developed for the Pirkle‐Type Naphthylalanine Silica Stationary Phase"
`Journal of Chromatography 1993 641, 31‐38.
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` 22. P. L. Camacho‐Torralba, M. D. Beeson, G. Vigh & D. H. Thompson, "High Performance Chiral
`Displacement Chromatographic Separations in the Normal Phase Mode. Part 2. Separation of the
`Enantiomers of 1,2‐O‐Dihexadecyl‐rac‐glycerol‐3‐O‐(3,5‐dinitrophenyl)carbamate Using the Pirkle‐
`Type Naphthylalanine Silica Stationary Phase" Journal of Chromatography 1993 646, 259‐266.
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` 23. D. H. Thompson, C. B. Svendsen, C. DiMeglio & V. C. Anderson, "Synthesis of Chiral Diether and
`Tetraether Phospholipids. Regiospecific Ring Opening of Epoxides Derived from Asymmetric
`Epoxidation" Journal of Organic Chemistry 1994 59, 2945‐2955.
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` 24. Y. Rui & D. H. Thompson, "Stereocontrolled Synthesis of Plasmalogen‐Type Lipids from Glyceryl Ester
`Precursors" Journal of Organic Chemistry 1994 59, 5758‐5762.
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` 25. D. H. Thompson, O. V. Gerasimov, J. J. Wheeler & V. C. Anderson, "Triggerable Plasmalogen
`Liposomes: Improvement of System Efficiency" Biochimica et Biophysica Acta 1996 1279, 25‐34.
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` 26. Y. Rui & D. H. Thompson, “Efficient Stereoselective Synthesis of Plasmenylcholines” Chemistry—A
`European Journal 1996 2, 1505‐1508.
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` 27. D. H. Thompson, Y. Rui & O. V. Gerasimov, "Triggered Release from Liposomes Mediated by
`Physically‐ and Chemically‐Induced Phase Transitions" Surfactant Science Series: Vesicles, M. Rosoff,
`Ed.; Marcel Dekker: New York, NY, 1996, pp. 679‐746.
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` 28. O. Gerasimov, A. Schwan & D. H. Thompson, “Acid‐Catalyzed Plasmenylcholine Hydrolysis and its
`Effect on Bilayer Permeability: A Quantitative Study” Biochimica et Biophysica Acta 1997 1324, 200‐
`214.
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` 29. E. Barklis, J. McDermott, S. Wilkens, E. Schabtach, M. Schmid, S. Fuller, S. Karanjia, Z. Love, R. Jones,
`X. Zhao, Y. Rui & D. H. Thompson, “Structural Analysis of Membrane‐Bound Retrovirus Capsid
`Proteins” EMBO Journal 1997 16, 1199‐1213.
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` 30.
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`David H. Thompson, CV
`I. Szleifer, O. V. Gerasimov & D. H. Thompson, “Spontaneous Liposome Formation Induced by
`Grafted Poly(ethylene oxide) Layers: Theoretical Prediction and Experimental Verification”
`Proceedings of the National Academy of Sciences USA 1998 95, 1032‐1037.
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` 31. N. Wymer, O. V. Gerasimov & D. H. Thompson, “Cascade Liposomal Triggering: Light‐Induced Ca2+
`Release from Plasmenylcholine Liposomes Triggers PLA2‐Catalyzed Hydrolysis and Contents Leakage
`from DPPC Liposomes” Bioconjugate Chemistry 1998 9, 305‐308.
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` 32. E. Barklis, J. McDermott, S. Wilkens, S. Fuller, & D. H. Thompson, “Organization of HIV‐1 Capsid
`Proteins on a Lipid Monolayer” Journal of Biological Chemistry 1998 273, 7177‐7180.
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` 33. S. Svenson & D. H. Thompson, “Facile and Efficient Synthesis of Bolaamphiphilic Tetraether
`Phosphocholines” Journal of Organic Chemistry 1998 63, 7180‐7182.
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`34. Y. Rui, S. Wang, P. S. Low & D. H. Thompson, “Diplasmenylcholine‐Folate Liposomes: An Efficient
`Vehicle for Intracellular Drug Delivery” Journal of the American Chemical Society 1998 120, 11213‐
`11218.
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` 35. O. V. Gerasimov, N. Wymer, D. Miller, Y. Rui, & D. H. Thompson, “Intracellular Delivery of Liposomal
`Contents Using pH‐ and Light‐Activated Plasmenyl‐Type Liposomes” S.M. Dinh, J.D. DeNuzzio, A.R.
`Comfort, Eds., ACS Symposium Series 1999 728, 164‐178.
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` 36.
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`J. A. Boomer & D. H. Thompson, “Synthesis of Acid‐Labile Diplasmenyl Lipids for Drug and Gene
`Delivery Applications” Chemistry and Physics of Lipids 1999 99, 145‐153.
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` 37. A. Patwardhan & D. H. Thompson, “Efficient Synthesis of 40‐ and 48‐Membered Tetraether
`Macrocyclic Bisphosphocholines” Organic Letters 1999 1, 241‐244.
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` 38. O. Gerasimov, J. Boomer, M. Qualls & D. H. Thompson, “Cytosolic Drug Delivery Using pH‐ and Light‐
`Sensitive Liposomes” Advanced Drug Delivery Reviews 1999 38, 317‐338.
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` 39. C. DiMeglio, S. B. Rananavare, S. Svenson & D. H. Thompson, “Phosphocholine Analogs of
`Bolaamphiphiles: Phase Structure and Mesomorphism” Langmuir 2000 16, 128‐133.
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` 40. A. Patwardhan & D. H. Thompson, “Novel Flexible and Rigid Tetraether Acyclic and Macrocyclic
`Bisphosphocholines: Synthesis and Monolayer Properties” Langmuir 2000, 16, 10340‐10350.
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`41.
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`J. Shin, M. M. Qualls, J. A. Boomer, J. Robarge & D. H. Thompson, “An Efficient New Route to
`Plasmenyl‐Type Lipids: Synthesis and Cytotoxicity of a Plasmenylcholine Analog of the Antitumor
`Ether Lipid ET‐18‐OCH3” Journal of the American Chemical Society 2001 123, 508‐509.
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`42. M. M. Qualls & D. H. Thompson, “Synergistic Phototoxicity of Chloroaluminum Phthalocyanine
`Tetrasulfonate Delivered via Acid‐Labile Diplasmenylcholine‐Folate Liposomes” International Journal
`of Cancer 2001 93, 384‐392.
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`43.
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`J.‐M. Kim & D. H. Thompson, “Acid‐ & Oxidatively‐Labile Vinyl Ether Lipids: Synthesis & Drug Delivery
`Applications” Surfactant Science Series: Reactions & Synthesis in Surfactant Systems, J. Texter, Ed.;
`Marcel Dekker: New York, NY, 2001, pp. 145‐154.
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`5
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`44.
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` 45.
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`David H. Thompson, CV
`J. H. Collier, B.‐H. Hu, J. W. Ruberti, Z.‐Y. Zhang, P. Shum, D. H. Thompson & P. B. Messersmith,
`“Thermally and Photochemically Triggered Self‐Assembly of Peptide Hydrogels” Journal of the
`American Chemical Society 2001 123, 9463‐9464.
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`J.‐M. Kim, J. Shin, P. Shum & D. H. Thompson, “Acid‐ and Oxidatively‐Labile Vinyl Ether Surfactants:
`Synthesis and Drug Delivery Applications” Journal of Dispersion Science and Technology 2001 22,
`399‐407.
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` 46. P. Shum, J.‐M. Kim & D. H. Thompson, “Phototriggering of Liposomal Drug Delivery Systems”
`Advanced Drug Delivery Reviews 2001 53, 273‐284. (JOURNAL COVER, ISSUE #3, DEC 31, 2001)
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`47. Z.‐Y. Zhang, P. Shum, M. Yates, P. B. Messersmith & D. H. Thompson, “Formation of Fibrinogen‐Based
`Hydrogels Using Phototriggerable Diplasmalogen Liposomes” Bioconjugate Chemistry 2002 13, 640‐
`646. (JOURNAL COVER, ISSUE #3, APR 4, 2002)
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` 48.
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` 49.
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`J. A. Boomer, D. H. Thompson & S. Sullivan, “Formation of Plasmid‐Based Transfection Complexes
`with an Acid‐Labile Cationic Diplasmenyl Lipid: In Vitro and In Vivo Gene Transfer” Pharmaceutical
`Research 2002 19, 1289‐1298.
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`J. Shin, O. Gerasimov & D. H. Thompson, “Facile Synthesis of Plasmalogens via Barbier‐type Reactions
`of Vinyl Dioxolanes with Alkyl Halides in LiDBB Solution” Journal of Organic Chemistry 2002 67,
`6503‐6508.
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` 50. M. Rovira‐Bru, D. H. Thompson & I. Szleifer, “Size and Structure of Spontaneously Forming Liposomes
`in Lipid:PEG‐Lipid Mixtures” Biophysical Journal 2002 82, 2419‐2439.
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` 51.
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`J.‐C. Kim, K. Park & D. H. Thompson, “Synthesis of Tris(amino acid)‐Substituted ‐Cyclodextrins
`Derivatives”, Macromolecular Chemistry Symposium 2002 15, 303‐312.
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` 52. N. Bergstrand, M. C. Arfvidsson, J.‐M. Kim, D. H. Thompson & K. Edwards, “Interactions Between pH‐
`Sensitive Liposomes and Model Membranes”, Biophysical Chemistry 2003 104, 361‐379.
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`53.
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` 54.
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` 55.
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` 56.
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`J. A. Boomer, H. D. Inerowicz, Z.‐Y. Zhang, N. Bergstrand, K. Edwards, J.‐M. Kim & D. H. Thompson,
`“Acid‐Triggered Release from Sterically‐Stabilized Fusogenic Vesicles: A Novel DePEGylation
`Strategy”, Langmuir 2003 19, 6408‐6415.
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`J. Shin, P. Shum & D. H. Thompson, “Acid‐Triggered Release via DePEGylation of DOPE Liposomes
`Containing Acid‐Labile Vinyl Ether PEG‐Lipids”, Journal of Controlled Release 2003 91, 187‐200.
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`J. Shin & D. H. Thompson, “Direct Synthesis of Plasmalogens from Allyl Substituted Glycerols”,
`Journal of Organic Chemistry 2003 68, 6760‐6766.
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`J. Shin & D. H. Thompson, “Intracellular Delivery of DNA and Proteins Using Vinyl Ether‐Based Drug
`Delivery Vehicles” ACS Symposium Series 2003 879, 50‐60.
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` 57. D. H. Thompson, H. D. Inerowicz, J. Groves & T. Sarna “Characterization of Plasmalogen
`Photooxidation Products”, Photochemistry and Photobiology 2003 78, 323‐330.
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`6
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`David H. Thompson, CV
`58. H. Seong, W.‐M. Choi, J.‐C. Kim, D. H. Thompson & K. Park, “Preparation of Liposomes With Glucose
`Binding Sites: Liposomes Containing Di‐branched Amino Acid Derivatives”, Biomaterials 2003 24,
`4487‐4493.
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` 59. M. D. Kennedy, K. N. Jallad, D. H. Thompson, P. S. Low & D. Ben‐Amotz, “Optical Imaging of Folate‐
`Receptor Positive Tissues and Tumors Targeted with a Folate‐Fluorescein Conjugate”, Journal of
`Biomedical Optics 2003 8, 636‐641.
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` 60.
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`J.‐M. Kim, A. Patwardhan, A. Bott & D. H. Thompson, “Preparation and Electrochemical Behavior of
`Gramicidin Bipolar Lipid Monolayer Membranes Supported on Gold Electrodes”, Biochimica et
`Biophysica Acta 2003 1617, 10‐21.
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` 61. D. H. Thompson, J. Shin, J. A. Boomer & J.‐M. Kim, “Preparation of Plasmenylcholine Lipids and
`Plasmenyl‐Type Liposome Dispersions”, Methods in Enzymology 2004 387, 153‐168.
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` 62. M. Zhou, S. Haldar, J. Franses, J.‐M. Kim & D. H. Thompson, “Synthesis and Self‐Assembly Properties
`of Acylated Cyclodextrins and Nitrilotriacetic Acid (NTA)‐Modified Inclusion Ligands for Interfacial
`Protein Crystallization”, Supramolecular Chemistry 2005 17, 101‐111.
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` 63. C. Wang, S. Leffler, D. H. Thompson & C. A. Hrycyna, “A General Assay for S‐adenosyl Methionine–
`dependent Enzymes Using a Thiol‐activated Fluorescent Molecular Beacon”, Biochemical and
`Biophysical Research Communications 2005 331, 351‐356.
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` 64. H. B. Hodges, M. Zhou, J. L. Anderson, D. H. Thompson & C. A. Hrycyna, “Inhibition of Membrane‐
`Spanning Metalloproteins by Hydrophobic Metal Chelators”, Bioconjugate Chemistry 2005 16, 490‐
`493.
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` 65. G. Acharya, K. Park & D. H. Thompson, “Synthesis and Evaluation of ‐Cyclodextrin‐Aldonamide
`Conjugates for D‐Glucose Recognition”, Journal of Drug Delivery Science and Technology 2006 16,
`45‐48.
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` 66. V. Dixit, J. Van den Bossche, D. M. Sherman, D. H. Thompson & R. P. Andres, “Synthesis and Grafting
`of Thioctic Acid‐PEG‐Folate Conjugates onto Au Nanoparticles for Selective Targeting of Cancer
`Cells”, Bioconjugate Chemistry 2006 17, 603‐609.
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` 67. T. Ooya, D. Inoue, H. S. Choi, Y. Kobayashi, S. Loethen, D. H. Thompson, Y. Ho Ko, K. Kim & N. Yui,
`“pH‐Responsive Movement of Cucurbit[7]uril in a Dual Polypseudorotaxane: Contribution of
`Dimethyl ‐Cyclodextrin”, Organic Letters 2006 8, 3159‐3162.
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` 68. S. Loethen, T. Ooya, H. S. Choi, N. Yui & D. H. Thompson, “Synthesis, Characterization and pH‐
`Triggered Dethreading of ‐Cyclodextrin Polyethylene Glycol Polyrotaxanes Bearing Cleavable
`Stoppers”, Biomacromolecules 2006 7, 2501‐2506.
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` 69. C. Huguet, E. C. Hopmans, W. Febo‐Ayala, D. H. Thompson, J. S. Sinninghe Damsté & S. Schouten, “An
`Improved Method to Determine the Absolute Abundance of Glycerol Dibiphytanyl Glycerol
`Tetraether Lipids”, Organic Geochemistry 2006 37, 1036‐1041.
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` 70. R. Wampler, M. Zhou, D. H. Thompson & G. J. Simpson, “Mechanism of the Chiral SHG Activity of
`Bacteriorhodopsin Films”, Journal of the American Chemical Society 2006 128, 10994‐10995.
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` 71. W. Febo‐Ayala, S. Morera‐Felix, C. A. Hrycyna & D. H. Thompson, “Functional Reconstitution of the
`Integral Membrane Enzyme, Isoprenylcysteine Carboxyl Methyltransferase, in Synthetic Bolalipid
`Membrane Vesicles”, Biochemistry 2006 45, 14683‐14694.
`
`David H. Thompson, CV
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` 72. W. Febo‐Ayala, D. P. Holland, S. A. Bradley, D. H. Thompson, “Lateral Diffusion Coefficients of an
`Eicosanyl‐Based Bisglycerophosphocholine Determined by PFG‐NMR and FRAP”, Langmuir 2007 23,
`6276‐6280.
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`73. E. Kang, J.‐w. Park, S. McClellan, J.‐M. Kim, D. P. Holland, G. U. Lee, E. Franses, K. Park, D. H.
`Thompson, “Specific Adsorption of Histidine‐Tagged Proteins on Silica Surfaces Modified with
`Ni2+:NTA‐Derivatized Poly(ethylene glycol)”, Langmuir 2007 23, 6281‐6288.
`
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`74.
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`J. Van den Bossche, J. Shin, D. H. Thompson, “Improved Plasmalogen Synthesis Using Organobarium
`Intermediates”, Journal of Organic Chemistry 2007 72, 5005‐5007.
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`
` 75. S. Loethen, J.‐M. Kim, D. H. Thompson, “Biomedical Applications of Cyclodextrin‐Based
`Polyrotaxanes”, Journal of Macromolecular Science C—Polymer Reviews 2007 47, 383‐418.
`
`
` 76. D. H. Thompson, M. Zhou, J. Grey, H.‐k. Kim, “Design, Synthesis and Performance of NTA‐Modified
`Lipids as Templates for Histidine‐Tagged Protein Crystallization”, Chemistry Letters 2007 36, 956‐975.
`
`
` 77. G. S. Longo, D. H. Thompson, I. Szleifer, “Stability and Phase Separation in Mixed Bola‐Linear Lipid
`Layers” Biophysical Journal 2007 93, 2609‐2621.
`
`
` 78. G. Acharya, C.‐L. Chang, D. Holland, D. H. Thompson, C. A. Savran, “Rapid Detection of S‐Adenosyl
`Homocysteine Using Self‐Assembled Optical Diffraction Gratings”, Angewandte Chemie,
`International Edition 2008 47, 1051‐1053.
`
`
` 79. D. P. Holland, A. V. Struts, M. F. Brown, D. H. Thompson, “Bolalipid Membrane Structure Revealed by
`Solid‐State 2H NMR Spectroscopy”, Journal of the American Chemical Society 2008 130, 4584‐4585.
`
`
`80. D. H. Thompson, “Adenovirus in a Synthetic Membrane Wrapper: An Example of Hybrid Vigor?”, ACS
`Nano 2008 2, 821‐826.
`
`
` 81. G. Longo, D. H. Thompson, I. Szleifer, “Ligand‐Receptor Interactions Between Surfaces: The Role of
`Binary Polymer Spacers”, Langmuir 2008 24, 10324‐10333.
`
`
` 82.
`
`J. J. Bozell, N. C. Tice, N. Sanyal, D. H. Thompson, J.‐M. Kim & S. Vidal, “Synthesis and Self‐Assembly
`of Glycal‐based Bolaforms”, Journal of Organic Chemistry 2008 73, 8763‐8771.
`
`
` 83. R. D. Wampler, D. J. Kissick, C. J. Dehen, E. J. Gualtieri, J. L. Grey, H.‐F. Wang, D. H. Thompson, J.‐X.
`Cheng & G. J. Simpson, “Selective Detection of Protein Crystals by Second Harmonic Microscopy”,
`Journal of the American Chemical Society 2008 130, 14076‐14077.
`
`
` 84.
`
`
`
`
`
`J. A. Boomer, M. M. Qualls, H. D. Inerowicz, R. Haynes, G. V. Patri, J.‐M. Kim & D. H. Thompson,
`“Cytoplasmic Delivery of Liposomal Contents Mediated by an Acid‐Labile Cholesterol‐Vinyl Ether‐PEG
`Conjugate”, Bioconjugate Chemistry 2009 20, 47‐59.
`
`8
`
`
`
`David H. Thompson, CV
` 85. H. Chen, R. Ahn, J. Van den Bossche, D. H. Thompson & T. V. O’Halloran, “Folate‐mediated
`Intracellular Drug Delivery Increases the Anti‐cancer Efficacy of Nanoparticulate Formulation of
`Arsenic Trioxide”, Molecular Cancer Therapeutics 2009 8, 1955‐1963.
`
`
` 86. D. P. Brownholland, G. S. Longo, A. V. Struts, M. J. Justice, I. Szleifer, H. I. Petrache, M. F. Brown, D. H.
`Thompson, “Phase Separation in Binary Mixtures of Bipolar and Monopolar Lipid Dispersions
`Revealed by 2H NMR Spectroscopy, Small Angle X‐ray Scattering, and Molecular Theory”, Biophysical
`Journal 2009 97, 2700‐2709.
`
`
` 87. K. Mulligan, D. Brownholland, A. Carnini, D. H. Thompson, L. Johnston, “AFM Investigations of Phase
`Separation
`in Supported Membranes of Binary Mixtures of POPC and an Eicosanyl‐based
`Bisphosphocholine Bolalipid”, Langmuir 2010 26, 8525‐8533.
`
`
` 88. W. Deng & D. H. Thompson, “pH and Cation‐responsive Supramolecular Gels Formed by Cyclodextrin
`Amines in DMSO”, Soft Matter 2010 6, 1884‐1887.
`
`
` 89. T. L. Andresen, D. H. Thompson, T. Kaasgaard, “Enzyme‐triggered Nanomedicine: Drug Release
`Strategies in Cancer Therapy”, Molecular Membrane Biology 2010 27, 353‐363.
`
`
` 90.
`
`J. Grey, D. H. Thompson, “Challenges and Opportunities for New Protein Crystallization Strategies in
`Structure‐Based Drug Design”, Current Opinion in Drug Discovery 2010 5, 1039‐1045.
`
`
` 91. S.‐H. Hyun, H.‐k. Kim, J.‐M. Kim, D. H. Thompson, “Oriented Insertion of phi29 N‐Hexahistidine‐
`tagged gp10 Connector Protein Assemblies into C20BAS Bolalipid Membrane Vesicles”, Journal of the
`American Chemical Society 2010 132, 17053‐17055. (JOURNAL COVER, ISSUE #48, DEC 8, 2010)
`
`
` 92. A. Broniec, R. Klosinski, A. Pawlak, M. Wrona‐Krol, D. H. Thompson, T. Sarna, “Interactions of
`Plasmalogens and Their Diacyl Analogs with Singlet Oxygen in Selected Model Systems”, Free Radical
`Biology & Medicine 2011 50, 892‐898.
`
`
` 93. B. G. Coon, S. Crist, A. González‐Bonet, H.‐k. Kim, J. Sowa, D. H. Thompson, T. L. Ratliff, R. C. Aguilar,
`“Fibronectin Attachment Protein (FAP) from Bacillus Calmette‐Guerin as a Targeting Agent for
`Bladder Tumor Cells”, International Journal of Cancer 2012 131, 591‐600.
`
`
` 94. H.‐k. Kim, H. Wei, A. Kulkarni, R. M. Pogranichniy, D. H. Thompson, “Effective Targeted Gene Delivery
`to Dendritic Cells via Synergistic Interaction of Mannosylated Lipid with DOPE and BCAT”,
`Biomacromolecules 2012 13, 636‐644.
`
`
` 95. D. Wei, J. Chen, A. Kulkarni, D. H. Thompson, “Poly(ethylene glycol)‐Poly(vinyl alcohol)‐
`Adamantanate: Synthesis and Stimuli‐Responsive Micelle Properties”, Soft Matter 2012 8, 5843‐
`5846.
`
`
` 96. A. Kulkarni, D. Wei, S.‐H. Hyun, D. H. Thompson, “Development of a Safe and Effective pDNA Vector
`Based on Non‐covalent Assembly of Bioresponsive Amino‐‐Cyclodextrin:Adamantane‐Poly(vinyl
`alcohol)‐Poly(ethylene glycol) Transfection Complexes”, Bioconjugate Chemistry 2012 23, 933‐940.
`
`
` 97. A. Kulkarni, K. DeFrees, S.‐H. Hyun, D. H. Thompson, “Pendant Polymer:Amino‐‐Cyclodextrin:siRNA
`Guest:Host Nanoparticles as Efficient Vectors for Gene Silencing”, Journal of the American Chemical
`Society 2012 134, 7596‐7599.
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`9
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` 98. H. Wei, S.D. Lenz, D. H. Thompson, R. M. Pogranichniy, “DNA Vaccine Development Against H1N1
`Subtype Swine Influenza Viruses”, Viral Immunology 2012 25, 297‐305.
`
`David H. Thompson, CV
`
`
` 99.
`
`J. Shin, P. Shum, J. Grey, G. S. Malhotra, S. Fujiwara, A. M. González‐Bonet, E. Moase, T. M. Allen, D.
`H. Thompson, “Acid‐labile PEG‐Vinyl Ether‐Lipids with Tunable pH Sensitivity: Synthesis and
`Structural Effects on Hydrolysis Rates, Calcein Release Performance and Biodistribution of Their
`DOPE Dispersions”, Molecular Pharmaceutics 2012 9, 3266‐3276.
`
`
`
`100. H.‐k. Kim, J. Van den Bossche, S.‐H. Hyun, D. H. Thompson, “Acid‐triggered Release via DePEGylation
`of Fusogenic Liposomes Mediated by Tunable pH Sensitive Phenyl Substituted Vinyl Ether PEG‐
`Lipids”, Bioconjugate Chemistry 2012 23, 2071‐2077.
`
`
`
`101. A. Kulkarni, K. DeFrees, R. A. Schuldt, A. Vlahu, R. VerHeul, S.‐H. Hyun, D. Wei, D. H. Thompson,
`“Multi‐Armed Cationic Cyclodextrin:Poly(ethylene glycol) Polyrotaxanes as Efficient Gene Silencing
`Vectors”, Integrative Biology 2013 5, 115‐121.
`
`
`
`102. N. Morimoto, S. Hirano, H. Takahashi, S. Loethen, D. H. Thompson, K. Akiyoshi, “Self‐assembled pH‐
`sensitive Cholesteryl Pullulan Nanogel as a Protein Delivery Vehicle”, Biomacromolecules 2013 14,
`56‐63.
`
`
`
`103. A. Kulkarni, K. DeFrees, R. A. Schuldt, S.‐H. Hyun, K. J. Wright, C. K. Yerneni, R. VerHeul, D. H.
`Thompson, “Cationic ‐Cyclodextrin:Poly(ethylene glycol) Polyrotaxanes for siRNA Delivery”,
`Molecular Pharmaceutics 2013 10, 1299‐1305.
`
`
`
`104. C. J. Collins, L. McCauliff, S.‐H. Hyun, Z. Zhang, L. N. Paul, A. Kulkarni, K. Zick, M. Wirth, J. Storch, D. H.
`Thompson, “Synthesis, Characterization, and Evaluation of Pluronic‐based ‐Cyclodextrin
`Polyrotaxanes for Mobilization of Accumulated Cholesterol from Niemann‐Pick Type C Fibroblasts”,
`Biochemistry 2013 52, 3242‐3253.
`
`
`105. A. Kulkarni, R. VerHeul, K. DeFrees, C. J. Collins, R. A. Schuldt, A. Vlahu, D. H. Thompson, “Microfluidic
`Assembly of Cationic ‐Cyclodextrin:Hyaluronic Acid‐Adamantane Host:Guest pDNA Nanoparticles”,
`Biomaterials Science 2013 1, 1029‐1033.
`
`
`
`106. H.‐k. Kim, D. H. Thompson, H. S. Jang, Y. J. Chung, J. Van den Bossche, “pH‐Responsive Biodegradable
`Assemblies Containing Tunable Phenyl Substituted Vinyl Ethers for Use as Efficient Gene Delivery
`Vehicles”, ACS Applied Materials & Interfaces 2013 5, 5648‐5658.
`
`
`107. Y. A. Mondjinou, L. McCauliff, A. Kulkarni, L. Paul, S.‐H. Hyun, Z. Zhang, Z. Wu, M. Wirth, J. Storch, D.
`H. Thompson, “Synthesis of 2‐Hydroxypropyl‐‐Cyclodextrin and Pluronic Based Polyrotaxanes in
`Heterogeneous Reactions for Niemann‐Pick Type C Therapy”, Biomacromolecules 2013 14, 4189‐
`4197.
`
`
`
`108. T. C. Flynn, D. H. Thompson, S.‐H. Hyun, “Molecular Weight Analyses and Enzymatic Degradation
`Profiles of the Soft‐Tissue Fillers Belotero Balance, Restylane, and Juvéderm Ultra”, Plastic and
`Reconstructive Surgery 2013 132, 22S‐32S.
`
`
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`10
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`
`
`David H. Thompson, CV
`109. A. Kulkarni, V. Badwaik, K. DeFrees, R. A. Schuldt, D. S. Gunasekera, C. Powers, A. Vlahu, R. VerHeul,
`D. H. Thompson, “Effect of Pendant Group on pDNA Delivery by Cationic‐‐Cyclodextrin:Alkyl‐PVA‐
`PEG Pendant Polymer Complexes”, Biomacromolecules 2014 15, 12‐19.
`
`
`110. H. Wei, S.D. Lenz, D. H. Thompson, R. M. Pogranichniy, “DNA‐Epitope Vaccine Provided Efficient
`Protection to Mice Against Lethal Dose of Influenza A Virus H1N1”, Viral Immunology 2014 27, 14‐
`19.
`
`
`111. G. Yu, F. Vago, D. Zhang, J. E. Snyder, R. Yan, C. Zhang, C. Benjamin, X. Jiang, R. J. Kuhn, P. Serwer,
`D. H. Thompson, W. Jiang, “Single‐step Antibody‐based Affinity Cryo‐Electron Microscopy for Imaging
`and Structural Analysis of Macromolecular Assemblies”, Journal of Structural Biology 2014 187, 1‐9.
`
`
`112. J. H. Byeon, A. Kulkarni, H.‐k. Kim, D. H. Thompson, J. Roberts, “Photoassisted One‐Step Aerosol
`Fabrication of Zwitterionic Chitosan Nanoparticles”, Biomacromolecules 2014 15, 2320‐2325.
`
`
`113. J. H. Byeon, H.‐k. Kim, D. H. Thompson, J. Roberts, “Aerosol‐based Fabrication of Modified Chitosans
`and Their Application for Gene Transfection”, ACS Applied Materials & Interfaces 2014 6, 4597‐
`4602.
`
`
`114. Y. Cui, A. Naz, D. H. Thompson, J. Irudayaraj, “Decitabine Nanoconjugate Sensitizes Human
`Glioblastoma Cells to Temozolomide”, Molecular Pharmaceutics 2015 12, 1279‐1288.
`
`
`115. Y. A. Mondjinou, S.‐H. Hyun, M. Xiong, C. J. Collins, P. L. Thong, D. H. Thompson, “Impact of Mixed ‐
`Cyclodextrin Feeds on Pluronic Rotaxanation Efficiency and Product Solubility”, ACS Applied
`Materials & Interfaces 2015 7, 23831‐23836.
`
`
`
`116. Z. Zhou, Y. Mondjinou, S.‐H. Hyun, A. Kulkarni, Z.‐R. Lu, D. H. Thompson, “Gd3+‐1,3,7,10‐
`Tetraazacyclododecane‐1,4,7‐triacetic‐2‐Hydroxypropyl‐‐Cyclodextrin/Pluronic Polyrotaxane as a
`Long Circu