`
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`UNITED STATES PATENT AND TRADEMARK OFFICE
`___________________
`
`BEFORE THE PATENT TRIAL AND APPEAL BOARD
`___________________
`
`
`
`
`MODERNA THERAPEUTICS, INC.,
`Petitioner,
`
`v.
`PROTIVA BIOTHERAPEUTICS, INC.,
`Patent Owner.
`
`
`___________________
`
`Case No. IPR2018-00739
`Patent No. 9,364,435
`
`____________________
`
`
`
`PETITIONER’S UPDATED EXHIBIT LIST
`
`
`
`
`
`
`Mail Stop: PATENT BOARD
`Patent Trial and Appeal Board
`U.S. Patent and Trademark Office
`P.O. Box 1450
`Alexandria, VA 22313-1450
`
`10680475
`
`
`
`
`
`
`
`
`IPR2018-00739
`Patent No. 9,364,435
`
`
`PETITIONER’S UPDATED EXHIBIT LIST
`
`Exhibit
`No.
`1001
`1002
`1003
`1004
`1005
`
`1006
`
`1007
`1008
`
`1009
`
`1010
`
`1011
`1012
`1013
`1014
`1015
`1016
`1017
`1018
`1019
`
`1020
`
`
`
`
`References
`
`U.S. Patent No. 9,364,435
`International Publication No. WO 2005/007196
`U.S. Publication No. US2006/0134189
`U.S. Publication No. US2006/0240554
`Lin, Alison J. et al., Three-Dimensional Imaging of Lipid Gene-
`Carriers: Membrane Charge Density Controls Universal
`Transfection Behavior in Lamellar Cationic Liposome-DNA
`Complexes, 84 BIOPHYSICAL JOURNAL, 3307–16 (2003)
`(“Lin”)
`Ahmad, Ayesha et al., New multivalent cationic lipids reveal bell
`curve for transfection efficiency versus membrane charge density:
`lipid-DNA complexes for gene delivery, 7 J GENE MED 739–48
`(2005) (“Ahmad”)
`Declaration of Dr. Andrew S. Janoff
`Gao, Xiang et al., Nonviral Gene Delivery: What We Know and
`What Is Next, 9 AAPS JOURNAL Article 9, pp. E92-E104 ( 2007)
`(“Gao”)
`Bennett, Michael J. et al., Cholesterol Enhances Cationic Liposome-
`Mediated DNA Transfection of Human Respiratory Epithelial Cells,
`15 Bioscience Reports, pp. 47-53 (1995) (“Bennett”)
`Heyes, James et al., Cationic lipid saturation influences
`intracellular delivery of encapsulated nucleic acids, 107 JOURNAL
`OF CONTROLLED RELEASE 276–87 (2005) (“Heyes”)
`U.S. Patent No. 5,753,613
`U.S. Patent No. 7,939,505
`U.S. Publication No. US2007/0042031
`U.S. Publication No. US2006/0008910
`Excerpts from ’069 Patent File History
`’435 Patent File History
`U.S. Patent No. 5,264,618
`Curriculum Vitae of Dr. Andrew S. Janoff
`Deposition Transcript of David H. Thompson – Volume 1 (February
`4, 2019)
`Deposition Transcript of David H. Thompson – Volume 2 (February
`
`- 2 -
`
`
`
`
`
`IPR2018-00739
`Patent No. 9,364,435
`Exhibit
`No.
`
`1021
`1022
`1023
`1024
`
`1025
`
`1026
`1027
`
`
`
`References
`
`5, 2019)
`Reply Declaration of Dr. Andrew S. Janoff
`Janoff Declaration for Opposition to Motion to Amend
`Patent Owner Response in IPR2018-00739
`Kauffman, et al. Optimization of Lipid Nanoparticle Formulations
`for mRNA Delivery in Vivo with Fractional Factorial and Definitive
`Screening Designs, Nano Letters (2015) (“Kauffman”)
`Decision on Appeal, Appeal No. 2016-008388 (P.T.A.B. July 18,
`2018)
`Telephonic Hearing Transcript from April 30, 2019
`Declaration of Morgan Chu iso Unopposed Motion for Pro Hac
`Vice Admission
`
`Dated: May 15, 2019
`
`
`
`
`
`
`
`
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`
`
`
`
`
`
`
`Respectfully submitted,
`
`/Michael R. Fleming/
`Michael R. Fleming, Reg. No. 67,933
`Irell & Manella LLP
`1800 Avenue of the Stars, Suite 900
`Los Angeles, CA 90067-4276
`Telephone: (310) 277-1010
`Fax: (310) 203-7199
`
`Attorney for Petitioner
`
`
`
`
`
`- 3 -
`
`
`
`
`
`IPR2018-00739
`Patent No. 9,364,435
`
`
`CERTIFICATE OF SERVICE
`
`
`I hereby certify, pursuant to 37 C.F.R. section 42.6, that on May 15, 2019, a
`
`complete copy of the PETITIONER’S UPDATED EXHIBIT LIST was served via
`
`electronic mail upon the following:
`
`
`
`
`
`
`
`
`
`
`
`
`WILSON SONSINI GOODRICH & ROSATI
`Michael T. Rosato, Reg. No. 52,182
`mrosato@wsgr.com
`
`Steven W. Parmelee, Reg. No. 31,990
`sparmelee@wsgr.com
`
`Sonja R. Gerrard, Reg. No. 72,802
`sgerrard@wsgr.com
`
`Edward R. Reines
`Edward.reines@weil.com
`
`Derek C. Walter
`Derek.walter@weil.com
`
`
`
`
` /Susan M. Langworthy/
`
`
`
`- 4 -
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`
`
`
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