`
`1111111111111111111111111111111111111111111111111111111111111
`US009492393B2
`
`c12) United States Patent
`McKenna et al.
`
`(10) Patent No.:
`(45) Date of Patent:
`
`US 9,492,393 B2
`*Nov. 15, 2016
`
`(54) TAMPER RESISTANT DOSAGE FORMS
`
`(71) Applicants:Purdue Pharma L.P., Stamford, CT
`(US); Purdue Pharmaceuticals L.P.,
`Wilson, NC (US)
`
`(72)
`
`Inventors: William H. McKenna, Yonkers, NY
`(US); Richard 0. Mannion, Furlong,
`PA (US); Edward P. O'Donnell,
`Basking Ridge, NJ (US); Haiyong H.
`Huang, Princeton, NJ (US)
`
`(73) Assignees: PURDUE PHARMA L.P., Stamford,
`CT (US); PURDUE
`PHARMACEUTICALS L.P., Wilson,
`NC (US)
`
`( *) Notice:
`
`Subject to any disclaimer, the term of this
`patent is extended or adjusted under 35
`U.S.C. 154(b) by 0 days.
`This patent is subject to a terminal dis-
`claimer.
`
`(21) Appl. No.: 14/729,660
`
`(22) Filed:
`
`Jun. 3, 2015
`
`(65)
`
`Prior Publication Data
`US 2015/0265600 Al
`Sep. 24, 2015
`
`Related U.S. Application Data
`(60) Continuation of application No. 14/515,924, filed on
`Oct. 16, 2014, now Pat. No. 9,084,816, which is a
`continuation of application No. 13/803,132, filed on
`Mar. 14, 2013, now abandoned, which is a division of
`application No. 11/844,872, filed on Aug. 24, 2007,
`now Pat. No. 8,894,987.
`(60) Provisional application No. 60/840,244, filed on Aug.
`25, 2006.
`
`(51)
`
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`
`Int. Cl.
`A61K 311485
`A61K 9128
`A61K 47110
`A61K 9120
`A61K 9116
`A61J 3106
`A61K 9100
`A61K 47134
`A61K 9124
`A61K 45106
`A61J 3110
`B29C 43100
`(52) U.S. Cl.
`CPC .. A61K 9128 (2013.01); A61J 3106 (2013.01);
`A61J 3110 (2013.01); A61K 910002 (2013.01);
`A61K 911641 (2013.01); A61K 91209
`(2013.01); A61K 912013 (2013.01); A61K
`912018 (2013.01); A61K 912031 (2013.01);
`A61K 912054 (2013.01); A61K 912077
`(2013.01); A61K 912095 (2013.01); A61K
`912853 (2013.01); A61K 912866 (2013.01);
`
`A61K 912893 (2013.01); A61K 311485
`(2013.01); A61K 45106 (2013.01); A61K 47110
`(2013.01); A61K 47134 (2013.01); B29C
`431003 (2013.01); A61K 9/2072 (2013.01)
`(58) Field of Classification Search
`CPC .. A61K 31/485; A61K 9/2893; A61K 47/10;
`A61K 51/1258
`See application file for complete search history.
`
`(56)
`
`References Cited
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`U.S. PATENT DOCUMENTS
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`FOREIGN PATENT DOCUMENTS
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`CA
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`OTHER PUBLICATIONS
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`Mai et al. (Materiaux et Constructions 1982. 15(2); pp. 99-106).*
`(Continued)
`
`Primary Examiner- Misook Yu
`Assistant Examiner- Kauser Akhoon
`(74) Attorney, Agent, or Firm- Troutman Sanders LLP
`
`(57)
`
`ABSTRACT
`
`The present invention relates to pharmaceutical dosage
`forms, for example to a tamper resistant dosage form includ-
`ing an opioid analgesic, and processes of manufacture, uses,
`and methods of treatment thereof.
`
`30 Claims, 27 Drawing Sheets
`
`KASHIV1001
`IPR of Patent No. 9,492,393
`
`
`
`(56)
`
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`KASHIV1001
`IPR of Patent No. 9,492,393
`
`
`
`US 9,492,393 B2
`Page 3
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`(56)
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