`
`A method for operating an accelerated cyclic test system for evaluating a valved
`1.
`prosthetic device comprising driving a test system fluid cyclically above a normal physiological
`rate, at an accelerated pulsed rate of greater than 200 beats per minute within the test system;
`storing a volume of test system fluid in an excess volume area during a system driving stroke
`that opens the valved prosthetic device; and releasing the stored volume of test system fluid
`during a return stroke that closes the valved prosthetic device.
`
`The method of claim 1, wherein the excess volume area enlarges in response to a pressure
`2.
`on the test system fluid during the driving stroke and decreases during the return stroke.
`
`The method of claim 2, wherein the excess volume area provides a spring force counter
`3.
`to and in response to the pressure on the test system fluid.
`
`The method of claim 3 further comprising altering a spring factor of the spring force
`4.
`provided by the excess volume area through selection of a material forming at least a portion of a
`boundary of the excess volume area.
`
`The method of claim 4, wherein the material is an elastomeric material that expands and
`5.
`contracts in response to the pressure on the test system.
`
`The method of claim 1, further comprising compressing a volume of a compressible gas
`6.
`with the volume of test system fluid to provide a spring force counter to and in response to a
`pressure on the test system fluid when the volume of test system fluid is stored in the excess
`volume area.
`
`The method of claim 6 further comprising altering a spring factor of the spring force
`7.
`provided by the excess volume area by adjusting the volume of the compressible gas.
`
`PAGE 1 OF 1
`
`WATERS TECHNOLOGIES CORPORATION
`EXHIBIT 1018
`
`
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