determining the proper dosage amount of a drug in a particular
`a
`formulation involves understanding at least the pharmaeokineties of the drug and
`dosage form, pharmacodynamies of the drug, drug - receptor interaction, functional
`state, placebo effects, physiological variables, pathological factors, genetic factors,
`interaction with other drugs, development of tolerance, rate and extent of
`absorption, body size and composition, distribution in body fluids, binding in
`plasma and tissues, rate of elimination, patient compliance, medication errors, and
`drug toxicity.
`
`13
`
`Page 1
`
`SHIRE EX. 2072
`KVK v. SHIRE
`IPR2018-00290
`
`
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