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`PTO/SB/08 (09-06)
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`Substitute for form 1449/PTO
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`Complete if Known
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`Number 13/875,252
`Aoolication
`Mav 1, 2013
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`Filini:i Date
`First Named Inventor Adrian S. Rav
`Art Unit
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`Examiner Name
`Zenab 0. Olabowale
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`Attorney Docket Number 37 JD-197097-US
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`Examination Report issued in Egyptian Application No. PCT 392/2014 dated July 1, 2015 (with English translation), 7 pages.
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`Date
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`Considered 12/14/2015
`Signature !Zenab
`Olabowale/
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`*EXAMINER: Initial 11 reference considered, whether or not c1tat1on 1s 1n conformance with MPEP 609. Draw line through c1tat1on 1f not 1n conformance and not
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`considered. Include copy of this form with next communication to applicant. 1 Applicant's unique citation designation number (optional). 2 See Kinds Codes of
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`USPTO Patent Documents at www.uspto.gov or MPEP 901.04. 3 Enter Office that issued the document, by the two-letter code (WIPO Standard ST.3). 4 For
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`patent documents, the indication of the year of the reign of the Emperor must precede the serial number of the patent document. 5 Kind of document by
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`Page 2
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`PTO/SB/08 (09-06)
`Approvedfor use through 03/31/2007. OMB 0651-0031
`U.S. Patent and Trademark Office: U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unlessit contains a valid OMB
`control number.
`
`Substitute for form 1449/PTO
`
`
`
`INFORMATION DISCLOSURE
`STATEMENTBY APPLICANT
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`
`.
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`Dat
`:
`ate Submitted: October 14, 2015
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`use as many sheets as necessary)
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`Application Number
`Filing Date
`First Named Inventor
`Art Unit
`Examiner Name
`Attorney Docket Number
`
`
`Complete if Known
`13/875,252
`
`
`May 1, 2013
`
`
`Adrian S. Ray
`
`
`4629
`
`
`OLABOWALE, ZENAB O.
`37JD-197097-US
`
`
`U.S. PATENT DOCUMENTS
`Examin
`Pages, Columns,Lines.
`Nameof Patentee or Applicant of
`| nd Publication Date
`er
`Where Relevant
`Cited Document
`| Number-Kind Code‘
`(if
`MM-YYYY
`initials”
`Passagesor Relevant
`|
`known)
`nitials
`Figures Appear
`|.2011/1 78129
`[07-2011| Canaleset al.
`jt| 2011/306541
`12-2011
`| 8513298
`8-2013
`
`
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`Canaleset al.
`
`
`
`vite
`
`
`
`
`
`
`
`FOREIGN PATENT DOCUMENTS
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`Pages, Columns, Lines,
`
`Examiner|Cite |.Foreign PatentDocument| Publication Date Nameof Patentee or Where Relevant
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`
`Initials”
`No’.
`Country Code Number’
`MNM-DD-YYYY
`Applicant of Cited Documents
`Passages or Relevant
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`Kind Code?
`(ji
`Figures Appear
`
`Examiner
`Initiais*
`
`Include nameof the author (in CAPITAL LETTERS), title of the article (when appropriate), title of the
`item (book, magazine, journal, serial, symposium, catalog, etc.) date, page(s), volume-issue number(s),
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`g
`publisher, city and/or country where published.
`| Lok, et al., “Combination Therapy with BMS-790052 and BMS-650032 Alone or with Pegylated
`| Interferon and Ribavirin (pegIFN/RBV) Results in Undetectable HCV RNA Through 12 Weeksof
`| Therapy in HCV Genotype 1 Null Responders”, AASLD, The Liver Meeting in Boston, MA, October 29-
`_ November 2, 2010, poster.
`| Office Action issued in Eurasian Application No. 201490588 dated August 3, 2015 (with English
`transiation), 4 pages.
`
`| Office Action issued in Mexican Application No. MX/a/2014/003145 dated July 23, 2015 (with English
`
`| translation), 14 pages.
`| Sharp, “BMS-790052/BMS-650032 Combo Cures Hepatitis C without Interferon”, HIV and
`| Hepatitis.com Coverage of the 46" Annual Meeting of the European Association for the Study of the
`| Liver, March 30-April 3, 2011, Berlin, Germany, 3 pages.
`; Suzuki, et al., “Sustained virological response in a patient with chronic hepatitis C treated by
`| monotherapy with the NS3-4A protease inhibitor telaprevir’, Journal of Clinical Virology, 2010, Vol. 47,
`| pages 76-78.
`
`
`
`Inna
`Date
`Examiner |
`12/14/2015
`Considered
`/Zenab Olabowaie/
`Signature |
`“EXAMINER: Initial if reference considered, whether or notcitation is in conformance with MPEP 609. Drawline through citation if not in conformance and not
`considered. Include copy of this form with next communication to applicant. 1 Applicant’s unique citation designation number(optional). 2 See Kinds Codes of
`USPTO Patent Documents at www.uspto.gov or MPEP 901.04. 3 Enter Office that issued the document, by the two-letter code (WIPO Standard ST.3). 4 For
`Japanese patent documents, the indication of the yearof the reign of the Emperor must precedethe serial numberof the patent document. 5 Kind of document by
`the appropriate symbols as indicated on the document under WIPO Standard ST.16 if possible. 6 Applicantis to place a check mark hereif English language
`Translation is attached.
`This collection of information is required by 37 CFR 1.97 and 1.98. The information is required to obtain or retain a benefit by the public whichistofile (and by the
`USPTOto process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including
`gathering, preparing, and submitting the completed application form to the USPTO.Timewill vary depending upon the individual case. Any comments on the amount
`of time you require to complete this form and/or suggestions for reducing this burden, should be sentto the Chief Information Officer, U.S. Patent and Trademark
`Office, P.O. Box 1450, Aloxandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED FORMSTO THIS ADDRESS. SEND TO: Commissioner for Patents,
`P.O. Box 1450, Alexandria, VA 22313-1450.
`if you need assistance in completing the torm, call 1-800-PTO-9199 (1-800- 786-9199) and sefect option 2.
`
`ALL REFERENCES CONSIDERED EXCEPT WHERE LINED THROUGH.
`
`/Z.0,/
`
`

`

`PTO/SB/08 (09-06)
`Approved for use through 03/31/2007, OMB 0651-0031
`U.S. Patent and Trademark Office: U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid
`OMB control number.
`
`Page 3
`
`05-01-2013
`
`Substitute for form 1449/PTO
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`Date Submitted: July 28, 2015
`
`Complete if Known
`
`| 13/875,252
`Application Number
`
`Filing Date
`
`First Named Inventor
`Adrian S. Ray
`
`Art Unit
`1629
`
`(use as many sheets as necessary)
`
`OLABOWALE, ZENAB O
`Examiner Name
`37JD-197097-US
`Attorney Docket Number
`
`U.S. PATENT DOCUMENTS
`Exami | Document Number
`|
`-_
`Pages, Columns, Lines,
`mee
`|
`Gite.
`|AA Publication Date
`Name of Patentee or Applicant of
`Where Relevant
`Initials
`= No,’
`|
` Number-Kind Code?(if
`|
`MM-DD-YYYY
`Passagesor Relevant
`Cited Document
`
`"
`|
`known)
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`|
`Figures Appear
`
`a_US-6475985|24-05-2012
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`
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`
`
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`UNPUBLISHED U.S. PATENT APPLICATION DOCUMENTS
`Exami
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`U.S. Patent Application
`Filing Date of
`Pages, Columns,Lines,
`ner
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`Cite
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`Document
`i
`Cited
`ocument
`Name of Patentee or Applicant of
`Where Relevant
`Initials: No.’
`| Serial Number-Kind Code”
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`MM-DD-YYYY
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`Applicant of Cited Documents
`Passages or Retevant
`5
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`Kind Code? (if known)
`!
`Figures Appear
`O0-1996/029336
`09-26-1996
`Medical Research Council;
`Univeristy College Cardiff
`Consultants Ltd; REGA
`Foundation
`| Newbiotics, Inc.
`:
`Univeristy College Cardiff
`\
`eene|ConsultantsLimitedfo no
`
`WO-2006/121820
`41-16-2006
`Valeant Research &
`
`
`NON PATENT LITERATURE DOCUMENTS
`Exami
`Cite
`include name of the author (in CAPITAL LETTERS),title of the article (when appropriate), title of the
`| ro
`Initials
`No!
`item (book, magazine, journal, serial, symposium,catalog, etc.) date, page(s), volume-issue
`|
`number(s), publisher, city and/or country where published.
` a
`BALZARINI, et al., “Mechanism of anti-HIV action of masked alaninyl d4t-MP derivatives" PNAS, (1996), 93.7295| |
`7299,
`|
`CAHARD,et al., “Aryloxy Phosphoramidate Triesters as Pro-Tides,” Mini-Reviews in Medicinal Chemisty, (2004),
`4:371-381.
`
`
`|
`
`per ERTS
`CLARK, “Design, Synthesis,
`Hepatitis C VirusReplication," Journal of Medicinal Chemistry, (2005), 48(17): 5504-5508_
`
`_
`
`|o
`
`Examiner
`
`Date Signature
`
`12/14/2015
`Considered
`/Zanad Olabowale/
`“EXAMINER: Initialif reference considered, whetheror not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not
`considered. Include copyofthis form with next communication to applicant. 1 Applicant's uniquecitation designation number (optional). 2 See Kinds Codes of USPTO
`Patent Documents at www.uspto.gov or MPEP 901.04. 3 Enter Office that issued the document, by the two-letter code (WIPO Standard ST.3). 4 For Japanese patent
`documents, the indication of the year of the reign of the Emperor must precede the serial numberof the patent document. 5 Kind of document by the appropriate
`symbols as indicated on the document under WIPO Standard ST.16 if passibie. 6 Applicantis to place a check mark here if English language Translation is attached
`This collection of information is required by 37 CFR 1.97 and 1.98. The information is required to obtain or retain a benefit by the public whichis to file (and by the
`USPTO10 process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to complete, including
`gathering, preparing, and submitting the completed application form to the USPTO. Time will vary depending upon the individual case. Any comments on the amount of
`time you require to complete this form and/or suggestions for reducing this burden, should be sent to the Chief information Officer, U.S. Patent and Trademark Office.
`P.O. Box 1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED FORMSTO THIS ADDRESS. SEND TO: Commissionerfor Patents, P.O.
`Box 1450, Alexandria, VA 22313-1450.
`
`4822-1296-2578.1
`
`If you need assistance in completing the torm, call 1-800-P TO-9199 (1-800-786-9199) and select option 2.
`
`ALL REFERENCES CONSIDERED EXCEPT WHERE LINED THROUGH. /2.0,/
`
`

`

`PTO/SB/08 (09-06)
`Page 4
`Approved for use through 03/31/2007. OMB 0651-0031
`U.S. Patent and Trademark Office: U.S, DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid
`OMB control number.
`
`Substitute for form 1449/PTO
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`Date Submitted: July 28, 2015
`
`
`Complete if Known
`
`13/875,252
`lication Number
`
`Filing Date
`05-01-2013
`
`First Named Inventor
`Adrian S. Ray_
`
`Art Unit
`1629
`
`(use as many sheets as necessary)
`
`Examiner Name
`
`OLABOWALE, ZENAB O
`37JD-197097-US
`
`
`NON PATENT LITERATURE DOCUMENTS
`j
`Exam |
`Cite
`include name of the author (in CAPITAL LETTERS),title of the article (when appropriate), title of the
`T°
`Initials
`No!
`item (book, magazine,journal, serial, symposium,catalog, etc.) date, page(s), volume-issue
`
`number(s), publisher, city and/or country where published.
`DEFRANCESCO,et al., "New therapies on the horizon for hepatitis C: are we close?", Clin Liver Dis, (2003), 7:211-
`
`242.
`
`i
`
`
`
`
`YER, et al. "synthesis, in Vitro Anti-Breast Cancer Activity,ond intracellular Decomposition ofAmino Acid Methyl
`Ester and Alkyl Amide Phosphoramidate Monoesters of 3'-Azido-3'-deoxythymidine (AZT)," Journal of Medicinal
`
`Chemistry, (2000}, 43:2266-2274.
`:
`JONES, "Minireview: Nucleotide Prodrugs,” Antiviral Research, (1995), 27:1-17,
`
`
`:
`
`i
`
`|
`
`i
`
`|
`
`|
`jt|
`
`IM, et al., “Direct Measurement of Nucleoside Monophosphate Delivery from a Phosphoramidate
`
`
`| PronucleotidebyStableIsotopeLabelingandLC-ESI--MS/MS,”MolecularPharmaceutics,(2004),1.(2):102-111.|
`LEE, et al., "Selective Intracellular Activation of a Novel Prodrug of the Human Immunodeficiency Virus reverse
`Transcriptase Inhibitor Tenofovir Leads to Preferential Distribution and Accumulation in Lymphatic Tissue,"
`Antimicroblal Agents and Chemotherapy, (2005), 49(5):1898-1906.
`MA, “Characterization of the Metabolic Activation of Hepatitis C Virus Nucleoside Inhibitor B-D-2'--Deoxy-2-Fluro-
`2' -C-Methylcytidine (PS!-6130) and Identification of a Novel Active 5'-Triphosphate Species," The Journal of
`Biological Chemistry, (2007), 282(41): 29812-29820.
`MA,et al., “Characterization of the Intracellular Metabolism of B-d-2’-Deoxy-2’-Fluoro-2’-C-Methyl-Cytidine and
`the Inhibition of HCV Polymerase NS5Bbyits 5’-Triphosphate Species,” Antiviral Research, (2007), 74(3): A326;
`
`Abstract 23.
`McGUIGAN, et al., “Sub Micromolar Inhibitors of HCV Generated from Inactive Nucleosides by Application of
`nnonn| ProTideTechnology,”AntiviralResearch, (2007), 74(3):A36; Abstract24.
`McGUIGAN, “Phosphoramidate derivatives of d4T as inhibitors of HIV: The effect of amino acid variation,”
`|Antiviral Research, (1997), 35(3):95-204.
`McGUIGAN, et al. “Aryl Phosphoramidate Derivatives of d4T Have Improved Anti-HIV Efficacy in Tissue Culture
`and May Act by the Generation of a Novel Intracellular Metabolite,” Journal of Medicinal Chemistry, (1996),
`(39:1748-4753,
`McGUIGAN,et al." Application of Phosphoramidate Pro Tide Technology Significantly improves Antiviral Potency|
`
`of Carbocyclic Adenosine Derivatives” Journal of Medicinal Chemistry, (2006), 49:7215-7726.
`MCGUIGAN,et al., "Certaln Phosphoramidate Derivatives of Dideoxy Uridine (ddU} Are Active Against HIV and
`|
`:
`Successfully By-pass Thymidine Kinase," FEBS Letters, (1994), 351:11-14.
`|
`MURAKAMI, et al., "The Mechanism of Action of beta-D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine Involves a
`Second Metabolic Pathway Leading to beta-D-2'-Deoxy-2'-Fiuoro-2’-C-Methyluridine 5'-Triphosphate, a Potent
`inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase," Antimicrobial Agents and Chemotherapy,
`(2008), 52(2):458-464.
`
`
`
`
`
`
`
`
`|4
`
`
`
`
`
`|
`
`fe
`
`iZenao Olabowaie/
`
`
`
`imlague
`Date
`Examiner
`12/14/2015
`Considered
`Signature |
`“EXAMINER: Initial if reference considered. whetheror notcitation is in conformance with MPEP 609. Draw iine through citation if not in conformance and not
`considered. Include copy of this form with next communication to applicant. 1 Applicant's unique citation designation number(optional). 2 See Kinds Codes of USPTO
`Patent Documenis at www.uspto.gov or MPEP 901.04. 3 Enter Office that issued the document, by the two-letter code (WIPO Standard ST.3), 4 For Japanese patent
`documerts,the indication of the year of the reign of the Emperor must precede the serial numberof the patent document. 5 Kind of document by the appropriate
`symbols as indicated on the docusnent under WIPO Standard ST.16 i! possible. 6 Applicantis to place a check mark here if English language Translation is attached.
`This collection of information is required by 37 GFR 1.97 and 1.98. The information is required to obtain or retain a benefit by the public whichjs to file (and by the
`USPTO to process} an application. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to compiete, including
`gathering, preparing, and submitting the completed application form to the USPTO. Timewill vary depending upontheindividual case. Any comments on the ammount of
`time you require to complete this form and/or suggestions for reducing this burden, should be sentto the Chief Information Officer, U.S. Patent and Trademark Office,
`P.O. Box 1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED FORMSTO THIS ACDRESS. SEND TO: Commissionerfor Patents, P.O.
`Box 1450, Alexandria, VA 22313-1450.
`
`4822-1296-2578.1
`
`it you need assistance in completing the form, call 1-800-P TO-9199 (1-800-786-9199) and select option 2.
`
`ALL REFERENCES CONSIDERED EXCEPT WHERE LINED THROUGH. /2.0./
`
`

`

`PTO/SB/08 (09-06)
`Approved for use through 03/31/2007. OMB 0651-0031
`U.S. Patent and Trademark Office: U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid
`OMB control number.
`
`Page 5
`
`Substitute for form 1449/PTO
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`Date Submitted: July 28, 2015
`
`(use as many sheets as necessary)
`
`Complete if Known
`
`13/875,252
`Application Number
`Filing Date
`
`First Named Inventor
`Adrian S. Ray
`Art Unit 1629
`
`
`05-01-2013
`
`
`
`OLABOWALE, ZENAB O
`Examiner Name
`37)D-197097-US
`Attorney Docket Number
`heet
`
`NON PATENTLITERATURE DOCUMENTS
`.
`exami
`Include name of the author (in CAPITAL LETTERS), title of the article (when appropriate), title ofthe
`|
`nes
`initials
`item (book, magazine, journal, serial, symposium,catalog, etc.) date, page(s), volume-issue
`|
`
`*
`number(s), publisher, city and/or country where published.
`MURAKAMI, et al,, "The Mechanism of Action of 8-D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine Inhibition of
`|__|HepatitisCVirus NS5B RNAPolymerase,"Antimicrobial Agents and Chemotherapy, (2007), 52(2):458 -464.
`PERRONE,et al. "First Example of Phosphoramidate Approach Applied to a 4’ Substituted Purine Nucleoside (4'-
`Azidoadenosine): Conversion of an Inactive Nucleoside to a Submicromolar Compound versus Hepatitis C Virus"
`Journal of Medicinal Chemistry, (2007), 50:5463-5470.
`SABOULARD,et al. “Characterization of the Activation Pathway of Phosphoramidate Triester Prodrugs of
`Stavudine and Zidovudine” American Society for Pharmacology and Experimental Therapeutics, (1999), 56, 693-
`704
`SOFIA, et al., “B-D-2’-Deoxy-2;fluro-2’-C-methyluridine Phosphoramidates: Potent and Selective Inhibitors of HCV
`RNA Replication,” (Sept. 2007), Poster P-259, 1 page.
`‘
`
`
`
`i
`
`
`
`|
`|
`:
`
`|
`
`Date Signature—‘Zenab Olabowale/
`
`Examiner |
`
`12/4/2015
`Considered
`“EXAMINER: Initial if reference considered, whether or notcitation is in conformance with MPEP 609. Draw Jine throughcitation if nat in conformance and not
`considered. Include copyof this form with next communication to applicant. 1 Applicant's unique citation designation number (optional). 2 See Kinds Codes of USPTO
`Patent Documents at www.uspto.gov or MPEP 901.04. 3 Enter Office that issued the document, by the two-letter code (WIPO Standard ST.3). 4 For Japanese patent
`documents. the indication of the yearof the reign of the Emperor must precedethe serial numberof the patent document. 5 Kind of document by the appropriate
`symbols as indicated on the document under WIPO Standard ST.16 il possible. 6 Applicant is to place a check mark here if English language Translation is attached.
`This collection of information is required by 37 CFR 1.97 and 1.98. The information is required to obtain or retain a benefit oy the public whichis to file (and by the
`USPTOto process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 GFR 1.14. This collection 's estimated to take 2 hours to complete, including
`gathering. preparing, and submitting the completed application form to the USPTO. Timewill vary depending uponthe individual case. Any comments on the amount of
`time you require to complete this form and/or suggestions for reducing this burden, should be sent to the Chief Information Officer, U.S. Patent and Trademark Office.
`P.O. Box 1450, Alexandria, VA 22313-1456. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS, SEND TO: Commissioner for Patents,P.O.
`Box 1450, Alexandria, VA 22313-1450.
`
`4822-1296-2578.1
`
`it you need assistance in completing the form, call 1-800-P TO-9199 (1-800-786-9199) and select option 2.
`
`ALL REFERENCES CONSIDERED EXCEPT WHERE LINED THROUGH. /Z.0./
`
`

`

`PTO/SB/08 (09-06)
`Approved for use through 03/31/2007. OMB 0651-0031
`U.S. Patent and Trademark Office: U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unlessit contains a valid
`
`Page 6
`
`Substitute for form 1449/PTO
`Complete if Known
`
`INFORMATION DISCLOSURE
`Application Number
`13/875252
`
`STATEMENT BY APPLICANT
`Filing Date
`05-01-2013
`
`Date Submitted: July 1, 2015
`First Named Inventor
`Adrian S. Ray
`
`Art Unit
`1629
`
`(use as many sheets as necessary)
`Examiner Name
`OLABOWALE, ZENAB O
`Attorney Docket Number
`37j/D-197097-US
`
`U.S. PATENT DOCUMENTS
`
`Exami
`|
`:
`Document Nurnber
`Pages, Columns, Lines,
`
`Name of Patentee or Applicant of
`Publication Date
`ner Cite...__
`Where Relevant
`Initials
`= No.’
`|
`Number-Kind Code?(if
`MM-DD-YYYY
`Cited Document
`Passages or Relevant
`
`|
`.
`known)
`|
`Figures Appear
`
`| Al 10-25-2001|SHEPARD ET AL.| US-2001/0034440 i
`
`
`
`
`
`
`
`
`| 11-08-2001|RYBACK ET AL.A2 |_&S-2001/0038833 i |
`
`
`A3 01-24-2002|EDMOND ET AL.i US-2002/0008241
`
`
`
`1 A4 05-16-2002|AVERETT| US-2002 /0058635 |
`
`
`
`
`AS 10-10-2002|BHAT ETAL.| US-2002/0147160
`
`
`
`
`
`
`AG 12-26-2002|SCHINAZIET AL.| US-2002 /0198173 i
`
`1 03-13-2003|SOMMADOSS! ET AL.AT | US-2003/0050229 i
`
`
`
`
`L Ag
`|
`US-2003/0060400
`|
`03-27-2003 | LACOLLA ETAL.
`
`. 07-12-2003|SHEPARD ET AL,AS US-2003/0109697 L
`
`
`
`
`
`
`
`
`_ Alo 06-26-2006|FARMER ETAL.| US-2003/0119752 |
`: All 07-31-2003|PIETRZKOWSKI ET AL.US-2003/0144502 i
`
`
`
`| Al2 08-14-2003|MEKOUAR ETAL.US-2003/0153744 |
`
`
`
`
`| A13 09-18-2003|BEAULIEU ET AL.US-2003/0176433 |
`
`
`
`| Al4 10-02-2003|LLINAS-BRUNET ET AL.| US-2003/0187018 i
`
`
`
`» AIS 11-06-2003|NEUNER ETAL.| US-2003/0207922 [
`
`
`
`
`Alé
`US-2004/0006007
`|
`01-08-2004 | GOSSELIN ET AL.
`
`__Al7
`| US-2004/0014108
`01-22-2004 | ELORUP ET AL.
`
`1 Al8 02-05-2004|COOK ET ALUS-2004/0023901 L
`
`
`
`
`1 02-05-2004|BEAULIEU ET AL.A1S | US-2004/0024190 i
`
`
`
`
`
`
`+ A20
`I US-2004/0059104
`03-25-2004 | COOK ET AL.
`
`A21 04-01-2004|SOMMADOSSIET AL.| _US-2004/0063622 |
`
`
`
`A22 04-08-2004|BHAT ETAL.L US-2004/0067901
`
`
`
`
`
`
`
`1 04-15-2004|BHATETAL.A23___ | _US-2004/0072788 | 4
`
`
`
`
`
`i 05-06-2004|JONAITIS ET AL.A24 [ US-2004/0087541 |
`
`» A25___ US-2004/0097461 05-20-2004|SOMMADOSSI ET AL.|
`
`
`
`_ 05-20-2004|SOMMADOSSIET AL.A226 | _US-2004/0097462 i
`
`
`
`
`
`: A27 05-27-2004|SOMMADOSS! ET AL.i US-2004/0101535 :
`
`
`
`
`
`
`
`| A28 05-27-2004|SOMMADOSS!ET AL.| US-2004/0102414 ! |
`
`
`» A29 06-10-2004|CARROLL ET AL.| -US-2004/0110717 |
`
`
`
`
`
`_ 07-22-2004|FINZEL ETAL.A380 US-2004/0142989 :
`
`
`
`
`
`
`| 07-22-2012|BATTISTINI ET AL.| A31 | -US-2004/0142993 i
`
`
`
`
`
`| A32__|_US-2004/0167140__ 08-26-2004|SCHINAZI ET AL.|
`
`
`
`| A33___| US-2004/0171570 09-02-2004|ALLERSON ETAL.
`
`
`| A34 10-28-2004|OTTO ETAL.| US-2004/0214844
`
`
`
`A35 11-18-2004|BABU ETAL.i US-2004/0229839
`
`
`_ A36_|_US-2004/0229840 11-18-2004|BHAT ETAL.i
`
`
`A37 12-16-2004|SCHINAZI ET AL.| US-2004/0254141 |
`
`
`
`
`OMB control number.
`
`
`
`
`
`
`
`
`
`
`Date
`.
`Examiner |
`12/44/2015
`Considered
`/Zenab Olabowale/
`Signature |
`
`“EXAMINER: Initial if reference considered, whetheror notcitation is in canformance with MPEP 609. Draw line through citation if not in conformance and not
`considered. Include copy of this form with next communication to applicant. 1 Applicant's unique citation designation number(optional). 2 See Kinds Codes of USPTO
`Patent Documents at www.uspto.gov or MPEP 901.04. 3 Enter Office that issued the document, bythe two-letter code (WIPO Standard ST.3). 4 For Japanese patent
`documents. the indication of the year of the reign of the Emperor must precede the serial numberof the patent document, 5 Kind of document by the appropriate
`symbols as indicated on the document under WIPO Standard ST.16 if possible. 6 Applicantis to place a check mark here if English language Translation is attached.
`This collection of information is required by 37 CFR 1.97 and 1.98. The information is required to obtain or retain a benefit oy the public whichis to file (and by the
`USPTOto process) an application. Confidentiality is governed by 35 U.S.C. 122 and 37 GFR 1.14 This collection is estimated to take 2 hours to complete, including
`gathering, preparing. and submitting the completed application form to the USPTO. Time will vary depending uponthe individual case. Any comments on the amount of
`time yourequire to complete this form and/or suggestions for reducing this burden, should be sent to the Chiet Information Officer, U.S. Patent and Trademark Office,
`P.O. Box 1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: Commissionerfor Patents, P.O.
`Box 1450, Alexandria, VA 22313-1450,
`
`SMRH:439072992. 1
`
`it you need assistancein completing the form, call 1-800-P TO-9199 (1-800-786-9199) and select option 2.
`
`ALL REFERENCES CONSIDERED EXCEPT WHERE LINED THROUGH.
`
`/Z.0./
`
`

`

`PTO/SB/08 (09-06)
`Approved for use through 03/31/2007. OMB 0651-0031
`U.S. Patent and Trademark Office: U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respondto a collection of information unless it contains a valid
`OMB control number.
`
`Page 7
`
`Substitute for form 1449/PTO
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`Date Submitted: July 1, 2015
`(use as many sheets as necessary)
`
`
`Complete if Known
`
`| 13/875252
`Application Number
`
`Filing Date
`05-01-2013
`
`First Named Inventor
`Adrian S, Ray
`
`Art Unit
`1629
`
`Examiner Name
`| OLABOWALE, ZENAB O
`Attorney Docket Number
`37JD-197097-US
`
`
`
`
`02-16-2006|CANNIZZAROETAL. A66
`
`
`U.S. PATENT DOCUMENTS
`
` Exami Cite Document Number Publication Date Name of Patentee or Applicant of
`
`
`
`Pages, Columns,Lines,
`
`ner Citec| Document}WhereRalavant_»—Nia i MM.DN-YYYY.
`
`
`
`i A38 12-23-2004|OLSEN ETAL. US-2004/0259934
`
`
`12-30-2004 | LIFT AL.
`US-2004/0265969
`
`02-03-2005|ALLERSON ETAL.
`US-2005/0026160
`
`02-03-2005 | MEKOUARET AL.
`__US-2005/0026853
`US-2005/0031588
`_
`02-10-2005 |SOMMADASSIET AL.
`02-24-2005|BRAVIET AL.
`US-2005/0043390
`
`
`| _US-2005/0069522 03-31-2005|COLONNO ETAL,|
`
`
`
`| 04-07-2005|STORER ETAL.| US-2005/0075309 |
`
`
`
`_US-2005/0080034 04-14-2005|STANDRING ET AL.
`
`
`| 04-21-2005|MAUPIN ETAL,|_US-2005/0082144
`
`
`
`
`
`
`
`| A48 04-28-2008|MCPHEE ETAL.___US-2005/0090432 | L
`
`| Aag 05-05-2005|ROMINE ETAL.: US-2005/0096364 |
`
`
`
`
`© 05-12-2005|HATHAWAYET AL.A5O0 | US-2005/0098125 |
`
`
`
`
`
`| ASI 06-09-2005|SOMMADOSSIET AL.| US-2005/0124532
`
` US-2005/0137161
`| AS2___US-2005/0130923
`06-16-2005
`
`
`AS3__|_US-2005/0130931
`06-16-2005|
`
`.
`06-23-2005
`07-07-2005|CASTELLINO ETAL.
`
`ASS
`US-2005/0148534
`
`|
`ASS
`US-2005/0154056
`07-14-2005 | YANG ET AL
`
`A57 07-28-2005|OLSEN ETAL.US-2005/0164960
`
`
`
`A58 09-29-2005|BOOJAMRAET AL.__US-2005/0215513
`
`
`
`PASS 09-29-2005|SINGH ETAL.| _US-2005/0215614
`
`
`
`___A6O 10-13-2005|CHEN ET AL.US-2005/0227947
`
`
`
`
`L 10-13-2005|THURKAUFET AL.A61 US-2005/0228013
`
`
`
`A62 11-24-2005|BOOJAMRAETAL.| US-2005/0261237
`
`
`
`
`» A63__| US-2006/0003951 01-05-2006|MEKOQUARET AL. |
`
`
`
`__AG4|US-2006/0004063 01-05-2006 |FINZELETAL neeenettac|
`A65
`US-2006/0035866
`
`__US-2006/0040890 02-23-2006|MARTIN ETAL.
`
`
`
`A67 02-23-2006|BLAKE ETAL._|_US-2006/0040927 i
`
`
`
`
`A68__,_US-2006/0040944 02-23-2006|GOSSELIN ET AL.
`i
`
`"AGI 03-02-2006|HUDYMA ET AL. | _US-2006/0046983
`
`
`
`_A7O | 04-13-2006|BOOJAMRAET AL,-US-2006/0079478 |
`
`
`A71 05-04-2006|PARUCH ET AL. | US-2006/0094706
`
`
`
`
`
`
`A?72 05-25-2006|BURKHARDT ET AL.US-2006/0110724 i
`
`
`
`
`Az | US-2006/0122154 06-08-2006|OLSEN ETAL.i L
`
`2 A74 08-31-2006|KEICHER ETAL.L US-2006/0194749 |
`
`
`
`: A75 07-27-2006|HUDYMAUS-2006/0166964 :
`
`
`:
`i
`A76__|_US-2006/0234962 10-19-2006|OLSEN ETAL.
`
`
`
`
`
`
`
`i
`
`Examiner
`
`Date Signature|
`
`12/14/2015
`Considered
`iZenab Olabowale/
`“EXAMINER: Initial if reference considered, whetheror not citation is in conformance with MPEP 609. Draw fine throughcitation if not in conformance and not
`considered, Include copyof this form with next communication to applicant. 1 Applicant’s unique citation designation number (optional). 2 See Kinds Codes of USPTO
`Patent Documents at www.uspto.gov or MPEP 901.04. 3 Enter Oifice that issued the document, by the two-letter code (WIPO Standard $T.3). 4 For Japanese patent
`documents, the indication of the year of the reign of the Emperor must precedethe serial numberof the patent document. 5 Kind of document by the appropriate
`symbols as indicated on the document under WIPO Standard ST.16 if possible. 6 Applicant is to place a check mark here if English language Translationis attached.
`This collection of information is required by 37 CFR 1.97 and 1.98. The information is required to obtain or retain a benefit by the public which is to file (and by the
`USPTOto process) anapplication. Confidentiality is governed by 35 U.S.C. 122 and 37 CFR 1.14. This collection is estimated to take 2 hours to compiete, including
`gathering. preparing, and submitting the completed application form to the USPTO.Time will vary depending uponthe individual case. Any comments on the amount of
`time you require 10 complete this form and/or suggestionsfor reducing this burden, shouid be sent to the Chiet Information Officer, U.S. Patent and Trademark Office,
`P.O, Box 1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: Commissionerfor Patents, P.O.
`Box 1450, Alexandria, VA 22313-1450.
`
`SMRH:439072992. 1
`
`it you need assistancein completing the form, call 1-800-P TO-9199 (1-800-786-9199) and seleci option 2.
`
`ALL REFERENCES CONSIDERED EXCEPT WHERE LINED THROUGH, /Z.0./
`
`

`

`PTO/SB/08 (09-06)
`Approved for use through 03/31/2007. OMB 0651-0031
`U.S. Patent and Trademark Office: U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unles