throbber

`
`
`
`BIOEPIS EX. 1055
`
`Page 1
`
`BIOEPIS EX. 1055
`Page 1
`
`

`

`{'
`
`Public
`
`National 1
`
`Health
`
`
`I13%
`,Héa
`tutes
`n‘sti
`
`v.7we0,W,,k.
`
`n’w
`
`i
`
`i i
`~·. ·~
`
`BIOEPIS EX. 1055
`
`Page 2
`
`BIOEPIS EX. 1055
`Page 2
`
`

`

`Frontispiece
`
`Ribbon drawing of a human Meg IgG 1 (lambda) immunoglobulin with a hinge
`deletion. The complementarity-determining-regions are marked by spheres in
`appropriate alpha carbon positions at the tips of the Fab arms (only every second
`residue is highlighted). The interchain disulfide bond between the penultimate
`residues of the light chains is represented by a ball and stick model in the space
`between the Fabs. In the CH2 domain on the right, three spheres designate the
`probable region for docking with complement component Clq in antibodies with
`intact hinge regions. The hinge by-pass segment connecting CHI and CH2
`domains is the putative site for attachment to the FcRI receptor of human
`monocytes. Carbohydrate moieties are represented by branched chains between
`the two CH2 domains. The structure of the IgG 1 molecule was determined by
`Luke Guddat and Allen Edmundson at 2.8 Angstrom resolution (model drawn with
`algorithm developed by Mike Carson and Charles Bugg, J. Mol. Graphics, 4, 121-
`122, 1986).
`
`BIOEPIS EX. 1055
`Page 3
`
`

`

`SEQUENCES OF
`,,PROTEINS OF
`IMMUNOLOGICAL
`INTEREST
`
`FIFTH EDITION
`
`Tabulation and Analysis of
`Amino Acid and Nucleic Acid Sequences of Precursors,
`V-Regions, C-Regions, J-Chain, T-Cell Receptors for Antigen,
`T -Cell Surface Antigens, ~2-Microglobulins,
`Major Histocompatibility Antigens, Thy-1, Complement,
`C-Reactive Protein, Thymopoietin, lntegrins, Post-gamma Globulin,
`a 2-Macroglobulins, and Other Related Proteins
`
`1991
`
`Elvin A. Kabat*, TaiTe Wu+, Harold M. Perryt,
`Kay S. Gottesman*, and Carl Foel/ert
`
`*Depts. of Microbiology, Genetics and Development, and Neurology, Cancer Center/Institute of
`Cancer Research, College of Physicians and Surgeons, Columbia University, New York, NY
`1 0032 and the National Institute of Allergy and Infectious Diseases, and the Office of the Director
`National Institutes of Health, Bethesda, MD 20892.
`
`+Depts. of Biochemistry, Molecular Biology, and Cell Biology, and Engineering Sciences and
`Applied Mathematics and Biomedical Engineering, Northwestern University, Evanston, IL 60208
`and the Cancer Center, Northwestern University Medical School, Chicago, IL 60611
`
`tsBN Systems and Technologies, 10 Moulton Street, Cambridge, MA 02138
`
`tFormerly with BBN. Present address Laboratory for Applied Research in Academic Information,
`William H. Welch Medical Library, The Johns Hopkins University, Baltimore, Md 21205
`
`The collection and maintenance of this data base is sponsored under grant 5R01 Al-125616 to
`E.A. Kabat of Columbia University by the following components of the National Institutes of
`Health, Bethesda, MD 20892:
`
`Office of the Director
`National Center for Research Resources
`National C~ncer Institute
`National Institute of Allergy and Infectious Diseases
`National Institute of Diabetes, Digestive and Kidney Diseases
`National Institute of General Medical Sciences
`National Library of Medicine
`
`Work with the PROPHET software package is supported by a subcontract from Columbia
`University to BBN Systems and Techologies, Cambridge, MA 02138
`
`U.S. DEPARTMENT OF HEALTH
`AND HUMAN SERVICES
`
`Public Health Service
`National Institutes of Health
`
`NIH Publication No. 91-3242
`
`BIOEPIS EX. 1055
`Page 4
`
`

`

`Our listing of sequences will be kept up to date. Investigators are
`invited
`to send additional sequence data when accepted for
`publication. Send two copies of the manuscript together with a
`letter of acceptance £rom a journal to:
`
`Dr. E.A. Kabat
`National Institutes of Health
`Building 8, Room 126
`9000 Rockville Pike
`Bethesda, Maryland 20892
`
`It would be extremely helpful if you can send us your sequence data
`on magnetic tapes or floppy diskettes or a clean copy of the
`sequences. The file formats should be such that they can be read by
`a generic word processor.
`If you have access to the internet you
`can
`send your
`sequence data
`to us via electronic mail
`to
`cfoeller@bbn.com or to tt@ttwu.esam.nwu.edu.
`
`When published, three reprints should be provided.
`
`If any published sequences have been overlooked or if any errors
`are found, please bring them to our attention.
`
`BIOEPIS EX. 1055
`Page 5
`
`

`

`iii
`TABLE OF CONTENTS
`
`INTRODUCTION . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xiii
`REf.)';RENCES TO INTRODUCTION ........•...•..•..•.......................••......••.•.....•...•....•...•. lxxiii
`\:f
`, .~ ,--7 r
`f !<siGNAL~ SEQUENCES OF LIGHT CHAINS
`
`HUMAN KAPPA CHAINS . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . 1
`HUMAN LAMBDA CHAINS ................••..•...........................•..•....•.••..•••.••.•.•....•..... 5
`
`MOUSE KAPPA CHAINS . . . . . . . . . . . • . . • • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . • . . . . . . • . . . • • . . . • . . 7
`MOUSE LAMBDA CHAINS . . . . . . . . . • • • . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . 17
`
`MISCELLANEOUS KAPPA CHAINS . . . . • . . • . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . • . 19
`MISCELLANEOUS LAMBDA CHAINS ........................•...•............••.•.••..•.•.•.••..•.•.•••••.... 21
`
`SIGNAL SEQUENCES OF HEAVY CHAINS
`
`HUMAN . . . . . . . . . . . . . . . . . . . . . • . . • . • . • . • . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
`
`MOUSE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . • . . . . . . . • . . . . . . 29
`
`MISCELLANEOUS . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40
`
`SIGNAL SEQUENCES OF T-LYMPHOCYTE RECEPTOR
`
`HUMAN ALPHA CHAINS • . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . • . • . . . . . . . . . • . . . • . . . . . . • • . . • . . • . . . • . • 45
`HUMAN BETA CHAINS . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . • . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . 4 9
`HUMAN GAMMA CHAINS . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . 53
`HUMAN DELTA CHAINS . . . . • • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . 55
`
`MOUSE ALPHA CHAINS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . 57
`MOUSE BETA CHAINS • . . . . . . . . . . . . . . . . . . . . . • . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . • . • . • . . . . . 61
`MOUSE GAMMA CHAINS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . 65
`MOUSE DELTA CHAINS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
`
`MISCELLANEOUS ALPHA CHAINS . . . • . . . . . . . . . . . . . . . . . . . . • . . • • . • . • . • . . . • . . • . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . • . 69
`MISCELLANEOUS BETA CHAINS ........•.••..•....................•..•.........•...•..•.•.•••.•.••..•....• 71
`
`SIGNAL SEQUENCES OF RELATED PROTEINS
`
`BETA-2-MICROGLOBULINS . . . . . . . . . • . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . • . . . . . . . . . . . . . . . . • . • 7 3
`
`MAJOR HISTOCOMPATIBILITY ANTIGENS CLASS I . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . • • • . 7 5
`
`I REGION ANTIGENS CLASS I I • . • . • . • . . . . . . . . . . . . . . • . . • . . . • . • . . • • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 82
`
`COMPLEMENT . . . • . . . . . . . . . • . . . . . • . . • • . • . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • 8 9
`
`T-CELL SURFACE ANTIGENS • . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • • . . . . . . . . . . . • 91
`
`INTEGRINS . . . . . . . • • • . . . . . . . . . . . . . . . . . • • • . • • . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . • . . . . . • . . . . . . . . . . . . . . 9 4
`
`MISCELLANEOUS PROTEINS . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . • . . . . . . . • . . . • . . . • . . . . . • . . . . . . . . . . . • . . . . . . 96
`
`VARIABLE REGION LIGHT CHAIN SEQUENCES
`
`HUMAN KAPPA CHAINS
`HUMAN KAPPA CHAINS
`HUMAN KAPPA CHAINS
`HUMAN KAPPA CHAINS
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`I ••.••................•.••......................•.•.•..••.•.••..•...... 103
`II . . • . . . . • . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . • . . . . . • • • . . . . . . . . . . . . . . . . . 113
`III. . . • . . . . . . . . • . . . . . . . . . . . . . . . . . . . . • . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . 118
`IV . • • . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . • . . • . . . . • . . • . • . • . . . . . . . . . . . . . . . 128
`
`HUMAN LAMBDA CHAINS
`HUMAN LAMBDA CHAINS
`HUMAN LAMBDA CHAINS
`HUMAN LAMBDA CHAINS
`HUMAN LAMBDA CHAINS
`HUMAN LAMBDA CHAINS
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`I . . . . . . . . . . . . • • . . . . . . . . . . . . . • . . . . . . • • . . • . . . . . . . . . . . . . . . . . • . . . . • . . . • • . • 131
`II ..........••....................•••..••......................•.••••• 135
`III . • . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . • . . . . . . . . . • . . . • . . . . . . . . . . . 139
`IV . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . • • . . . . . . . . . . . . . . . _ .....•••. 144
`v ..................................................................... 146
`VI . . . . . . . . . . • . . . • . . . . . . . . . . . . . • . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . • • • • • . • 148
`
`MOUSE KAPPA CHAINS
`MOUSE KAPPA CHAINS
`MOUSE KAPPA CHAINS
`MOUSE KAPPA CHAINS
`MOUSE KAPPA CHAINS
`MOUSE KAPPA CHAINS
`MOUSE KAPPA CHAINS
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`I . • . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • • . • . 151
`II . . . . . . . . . . • . • • . . . . . . . . . . . . . . . . . . . . . . . . . • . . . • . . . . . . . . . . • • . • . . . • . . . . . . . 163
`III ...•.....•......•...•..•..••..•....................••.••••.......... 190
`IV . • . • • • . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . • . . . . • • • . • . • . . . . . . . . . . . . . . . . . . . 201
`v .................. '• ................................................... 208
`VI. . . . . . . . . . . . . . • . . . . . . . . . . . . . . . • . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • • • 239
`VII. . . . . . • . . • . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . • • . . . . • • . 257
`
`MISCELLANEOUS MOUSE KAPPA CHAINS . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . • . • . . • . • . . . . . . . . . . . . . . . . . . . • . • . . . 259
`
`MOUSE LAMBDA CHAINS . . . • • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . • . . . . . . . . • . . . . • . . . . . . . . . . . . • . . . . 2 63
`
`RAT KAPPA CHAINS . . . • . . . • . . . . . . . . . . . . . . . . • . . • • . . . . . . . . . . . . . . . . . . . • • . • . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271
`
`RAT LAMBDA CHAINS . • • . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . • • . • . • . . • . • • • . . • . . . • . 274
`
`RABBIT KAPPA CHAINS •.......••.....•................•......•........................•....••.•••.•.•. 276
`
`RABBIT LAMBDA CHAINS ....••..•...••.•....•.....................•.•.••..•.......................•..•. 290
`
`CHICKEN LAMBDA CHAINS . . . . . . . . • . . . . . . • . . . . . . . . . . . . • . . . . . . . . • . . • . • . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • • . • 2 93
`
`MISCELLANEOUS KAPPA CHAINS . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . • • . . . . . . . . . . . . 303
`
`MISCELLANEOUS LAMBDA CHAINS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . • • . . • . . • . . . . • . . . . 306
`
`MISCELLANEOUS LIGHT CHAINS • . • . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . • . • . . . . • . . • . • • . . . . . . . . . . . . . . . . . . • . . • 308
`
`BIOEPIS EX. 1055
`Page 6
`
`

`

`iv
`
`TABLE OF CONTENTS (cont'ct>
`
`VARIABLE REGION HEAVY CHAIN SEQUENCES
`
`HUMAN
`HUMAN
`HUMAN
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`I .•........•.•••.....••.....•••••......••........•.....••...•.•.........•.•••....•.. 310
`II . . . . . . . . . • . . . . . . . . . • . . . . . . • . • . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . • . . . . . . . . . . . . . • . . . . . . . 317
`III . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . • • . . . . • • • . . . . • . • . . 324
`
`MOUSE
`MOUSE
`MOUSE
`MOUSE
`MOUSE
`MOUSE
`MOUSE
`MOUSE
`MOUSE
`MOUSE
`MOUSE
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`(A) .......••.....•.•.....••••........•..••..•.....•.•......••....••.....•....•••.. 339
`I
`(B) .....•.......•........•.................•..............•...........•.....••••.. 362
`I
`II (A) ...•.•.......•.••............................................••.....••...••..• 375
`II (B) .....•••.......•.•..............•.•..................•••....•.......•....•.•.. 398
`II (C) •.••......••.......•••.....••.......•.•.....•................•..••.....•....•. 421
`III (A) . . . . • • . . . . . . . • . . . . . . . . . • . . . . . . . • . • . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . • . . . . 430
`III (B) ..•.....••.•.......•.........•......•....................................•.... 451
`III (C) ....••........••................•..............................••...•......•. 458
`III (D) ••......•••..•....••.......................•.•......••.....••.....•......•... 464
`V
`(A) . . • . . . . . . . • . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 475
`V(B) .....•.•.•....••.•.......•.•.......•........•.............•.....•••....••...... 494
`
`MOUSE MISCELLANEOUS .........•.......•••......•••• : . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . • . 498
`
`RAT ...•.••.....•••.......•••.•....•..•....•••........................•.........•....•......•......• 512
`
`RABBIT • . . . . . . . . . . • . . . . . . . . • . . . . . . . . • • • . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . • . . . . . . • . . . . . • . . . . . . . . . . . . . . 514
`
`GUINEA PIG .....•.......•.•......•..•.....•................... · ........•.....•.......•...........••.. 521
`
`CAT ..••.•........•.•.•.....•••.....•••......•.................•......•.......•....••......••...••.• 523
`
`DOG .......••.........•.....•...••..•...••..•....•......•..................•.....•......••......••.. 525
`
`CHICKEN ....•••••.•.......•.•......•....•..•••......•.......•........•.............•......•......•.. 527
`
`SHARK .......•••.........•••.......••......•••..............................••...•..•......•.....•.. 530
`
`MISCELLANEOUS .....•........••••......••......••.......•.......•........•........................... 533
`
`VARIABLE REGION T-LYMPHOCYTE RECEPTOR (TCR) FOR ANTIGEN
`
`HUMAN ALPHA
`HUMAN ALPHA
`HUMAN ALPHA
`HUMAN ALPHA
`
`CHAINS
`CHAINS
`CHAINS
`CHAINS
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`I. ..•••.................•............................•.......••...•.... 540
`II ...••......•..•................................•.....•....•.•.....•.. 543
`III ..••.......•..................•......•......•.....•••....•.......... 546
`MISCELLANEOUS .••....•.............•..............•......•......•....•.. 548
`
`HUMAN BETA
`HUMAN BETA
`HUMAN BETA
`
`CHAINS
`CHAINS
`CHAINS
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`I ..••......••••.......•...............•......•.......•.................. 552
`II ..••......•..........•....•................••......•.......•....•..... 55 9
`MISCELLANEOUS . . . . . . . . . . . . . . . · . . . . . . . . . . . . . . • . . . . . . . . . . . • . . . . . • . . . . . · .•..•. 562
`
`HUMAN GAMMA CHAINS ..••......•••......•••....•.•...............•........•......•............•....... 566
`
`HUMAN DELTA CHAINS . . • . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . • • . . . . . . . • . . . . . . . . . . . . . . • . . . . . . . . . . . . . • . . . . • • . . 570
`
`MOUSE ALPHA
`MOUSE ALPHA
`MOUSE ALPHA
`MOUSE ALPHA
`
`CHAINS
`CHAINS
`CHAINS
`CHAINS
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`I ....•.......•................•.....•.•......•.....•.....•••......•...• 575
`II. .....••....•..•.....•........•......•....................•....•.••.. 579
`III ......•......•.............................•......••.....••....•.•.. 582
`MISCELLANEOUS . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . • . . . . . . • . . . . • • . . . . . . . 585
`
`MOUSE BETA
`MOUSE BETA
`MOUSE BETA
`MOUSE BETA
`
`CHAINS
`CHAINS
`CHAINS
`CHAINS
`
`SUBGROUP
`SUBGROUP
`SUBGROUP
`SUBGROUP
`
`I . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . • • . . . . . • • . . . . . • . . . . . . . . 590
`I I. .....••....•.......•......•.•.....•........•.......•.....••...•...... 5 95
`III ...•......•.......•.....•................••.............•....••...... 598
`MISCELLANEOUS .........•.....................•.......••••.....•......•... 600
`
`MOUSE GAMMA CHAINS ...•.......•........•.........•.••.•......•...............•.....•... , ..•......... 611
`
`MOUSE DELTA CHAINS •.....•.......•.......•.......•.....••.......................•......•...•.•...... 616
`
`RAT ALPHA CHAINS SUBGROUP II ..••.....••.......••.....................•..............•....•••....••. 628
`
`I ••.....••......•......•.......•.......•................•....•.••...•.•... 630
`RAT BETA CHAINS SUBGROUP
`RAT BETA CHAINS SUBGROUP II . . . • . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . • . . . . . . • . . . . . . . . . . . . . • . . 632
`RAT BETA CHAINS SUBGROUP MISCELLANEOUS ......•.......•....•.•.......•......•.....••......•••...•••.. 634
`
`RABBIT ALPHA CHAINS SUBGROUP I ...••....•.•..............••........•.....••.....•......••........... 636
`
`RABBIT BETA CHAINS SUBGROUP I . . . . . . • . . . . . • • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • • . . . . . . . . . . . . . • . . 638
`
`BOVINE ALPHA CHAINS SUBGROUP I ..•......••......••.........•......•............•.•......••.....••... 640
`BOVINE ALPHA CHAINS SUBGROUP III .••..............•......••......•........•.............•........•.. 642
`BOVINE ALPHA CHAINS SUBGROUP MISCELLANEOUS •.................................•.....•....•••....•••.. 644
`
`CONSTANT REGION SEQUENCES
`
`KAPPA LIGHT CHAINS •....••............•....•..........•.....................•.•...•........•.....•.. 64 7
`
`LAMBDA LIGHT
`
`CHAINS............................................... . ......•.•....•......••.....•... 653
`
`HEAVY CHAINS
`HEAVY CHAINS
`HEAVY CHAINS
`HEAVY CHAINS
`HEAVY CHAINS
`HEAVY CHAINS
`HEAVY CHAINS
`
`CH1 REGION .....•••......••...•..........•.............•.............•............•.•.. 661
`HINGE REGION ....••......•......•..•....................•.......•......•...........•... 670
`CH2 REGION . . . . • . • . . . . . . . • . . . . . • . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . 67 9
`CH3 REGION •...•..••......•....•...•..................•..............•.•.....••.....••. 688
`EXTRA LONG CH3 REGION ..•.•.•.••...............•.......•.......•.....••.............•.. 697
`CH4 REGION ...••.....••......••................•.........................•.......•.•... 700
`EXTRA LONG CH4 AND MEMBRANE BOUND REGIONS ....................•.••...•.....•••.....•... 709
`
`BIOEPIS EX. 1055
`Page 7
`
`

`

`v
`
`TABLE OF CONTENTS (cont'ctl
`
`MAJOR HISTOCOMPATIBILITY ANTIGENS CLASS I SEQUENCES
`
`HUMAN A-LOCUS OF THE ALPHA-1 REGION .•••.•.........•.••...................•..••••••.•••••••...•..... 724
`HUMAN A-LOCUS OF THE ALPHA-2 REGION ..............................•...••••...•............••..•.•••• 727
`HUMAN A-LOCUS OF THE ALPHA-3 REGION ..•.•..••...... · ........•.•.•..................•.•..••••••....... 730
`HUMAN A-LOCUS OF THE MEMBRANE REGION ••••••...........••.•...............•..•.•••.•••••........•.... 733
`HUMAN A-LOCUS OF THE CYTOPLASMIC REGION .•.••...........•.•.•..................••••.•.•...•.......•. 735
`
`HUMAN B-LOCUS OF THE ALPHA-1 REGION ....••.•••.........•..•.•.•................•...•••.••..•....•..• 738
`HUMAN B-LOCUS OF THE ALPHA-2 REGION .......•••...............•.•.....................•••••.•.•••.•.• 741
`HUMAN B-LOCUS OF THE ALPHA-3 REGION ..•...•..............•.•..•..•.......•.....•...•.•.•............. 744
`HUMAN B-LOCUS OF THE MEMBRANE REGION .......•.•.•..........•...••...•.........•.•.••.••.•......•••.. 747
`HUMAN B-LOCUS OF THE CYTOPL!I.SMIC REGION .•.•••..............•..•...............•••.•••••.••...•.•.•. 749
`
`HUMAN C-LOCUS OF THE ALPHA-1 REGION ••••.•...........•............•.••••..••.••...............•..•.. 752
`HUMAN C-LOCUS OF THE ALPHA-2 REGION ...........•••.........•.••....•..........•.•...•.••.......•..•. 754
`HUMAN C-LOCUS OF THE ALPHA-3 REGION ...•..•.•.............••......•..••...•.•............•........•. 756
`HUMAN C-LOCUS OF THE MEMBRANE REGION .........•........••.••......•...•.•.•••••••................... 758
`HUMAN C-LOCUS OF THE CYTOPLASMIC REGION ......•.•...........................•..•••.•................ 759
`
`HUMAN MISCELLANEOUS LOCUS OF THE ALPHA-1 REGION ...•................••.••........•...••.•.•••••.••.• 761
`HUMAN MISCELLANEOUS LOCUS OF THE ALPHA-2 REGION ................•...••.•............•....••....•.••• 763
`HUMAN MISCELLANEOUS LOCUS OF THE ALPHA-3 REGION ••••..............•.................•••••....••..•.. 765
`HUMAN MISCELLANEOUS LOCUS OF THE MEMBRANE REGION ..............•......•.....•.....•.•..•............ 767
`HUMAN MISCELLANEOUS LOCUS OF THE CYTOPLASMIC REGION ...................•.............••.••.•........ 768
`
`MOUSE K-LOCUS OF THE ALPHA-1 REGION ........................•..........•...•••.•..............•....• 770
`MOUSE K-LOCUS OF THE ALPHA-2 REGION ••.........•..............................•••••.• .' .......•...... 772
`MOUSE K-LOCUS OF THE ALPHA-3 REGION •.•...........••...........•................••••.•••.........•.. 774
`MOUSE K-LOCUS OF THE MEMBRANE REGION .....•............•.............••...............••.•...•••.... 776
`MOUSE K-LOCUS OF THE CYTOPLASMIC REGION ..........•.•.........•...•..................•....•.......•. 777
`
`MOUSE D-LOCUS OF THE ALPHA-1 REGION ...•••........................•...••..............•.•.•....•.... 779
`MOUSE D-LOCUS OF THE ALPHA-2 REGION ..•........................•.•.•••.•............•.•...•....•.... 781
`MOUSE D-LOCUS OF THE ALPHA-3 REGION .........•........••.............•.•••..........•.••••.......... 783
`MOUSE D-LOCUS OF THE MEMBRANE REGION ...........•.•............•..•...........•.•..•..•....•••..•••• 785
`MOUSE D-LOCUS OF THE CYTOPLASMIC REGION . . . . . . • . . . . . . . . . . . • . . . . . . . . . . . . . . . • • . . . . . . . . . . . . . . . . . • . . • . . . 786
`
`MOUSE MISCELLANEOUS LOCUS OF THE ALPHA-1 REGION . . . . . . . . . . • . . . . . . . . . . . . . . • • . . . . . . . . . . . . . . • . . . • . . . . . . 788
`MOUSE MISCELLANEOUS LOCUS OF THE ALPHA-2 REGION ........•.•............•••...•..........•.•.•.•.•... 791
`MOUSE MISCELLANEOUS LOCUS OF THE ALPHA-3 REGION .........•..........•..•..•........•...•••.•...•.... 794
`MOUSE MISCELLANEOUS LOCUS OF THE MEMBRANE REGION ....•....••.........•••••••............•••.•••..... 7 97
`MOUSE MISCELLANEOUS LOCUS OF THE CYTOPLASMIC REGION ....••.............•..•..•.•........•••••....... 799
`
`MISCELLANEOUS ALPHA-1 REGION .•........................•.•............•...•••...............•••..•.. 802
`MISCELLANEOUS ALPHA-2 REGION . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . • • . . . . . . . . . . 805
`MISCELLANEOUS ALPHA-3 REGION .•.•..........................................•.•...............•••.••. 808
`MISCELLANEOUS MEMBRANE REGION ..•.••........•...•...........•.•...•................•.....•.......... 811
`MISCELLANEOUS CYTOPLASMIC REGION ..................•...•.•.........•.•••.•..•.............. · .••.••••• 813
`
`I REGION GENE PRODUCTS CLASS II SEQUENCES
`
`HUt-'I.AN A-CHAIN DR-LOCUS OF THE ALPHA-1 REGION ...•.............•••••.•••..•............•..•••••...... 816
`HUMAN A-CHAIN DR-LOCUS OF THE ALPHA-2 REGION .............•••.................•..••.•.............•• 817
`HUMAN A-CHAIN DR-LOCUS OF THE MEMBRANE REGION .............•.••..................•••.•.........•.••• 818
`
`HUMAN A-CHAIN DQ-LOCUS OF THE ALPHA-1 REGION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • • . . . . . . . . . • . . . • • • 820
`HUMAN A-CHAIN DQ-LOCUS OF THE ALPHA-2 REGION .......................•...•.............•.••••......•. 823
`HUMAN A-CHAIN DQ-LOCUS OF THE MEMBRANE REGION .....•.....•..............•••..••.........••••...••... 826
`
`HUMAN A-CHAIN DP-LOCUS OF THE ALPHA-1 REGION .............................•••.••.............•.•.•.• 830
`HUMAN A-CHAIN DP-LOCUS OF THE ALPHA-2 REGION ..........•...............•...•••.....•.....•...••.•••. 831
`HUMAN A-CHAIN DP-LOCUS OF THE MEMBRANE REGION ....................•••.••....•.......••..•.•......... 832
`
`HUMAN A-CHAIN MISCELLANEOUS LOCUS OF THE ALPHA-1 REGION .......•.•.••................•.•.••........• 834
`HUMAN A-CHAIN MISCELLANEOUS LOCUS OF THE ALPHA-2 REGION .........•...•...............•••..•....•.... 835
`HUMAN A-CHAIN MISCELLANEOUS LOCUS OF THE MEMBRANE REGION . . . . . . • . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . 836
`
`MOUSE A-CHAIN A-LOCUS OF THE ALPHA-1 REGION •....•...............•••.•.•.•...........•.•.•.•••...... 838
`MOUSE A-CHAIN A-LOCUS OF THE ALPHA-2 REGION .....••..............••..••••.•.•.............•.•....... 840
`MOUSE A-CHAIN A-LOCUS OF THE MEMBRANE REGION .•...............•••......................•••.•........ 842
`
`MOUSE A-CHAIN E-LOCUS OF THE ALPHA-1 REGION .......•.•.............•..•..••.•..•.............••••... 845
`MOUSE A-CHAIN E-LOCUS OF THE ALPHA-2 REGI,ON .......••.........................••.•............•••.•. 846
`MOUSE A-CHAIN E-LOCUS OF THE MEMBRANE REGION ....•.•...................•.•••••................••.... 847
`
`MISCELLANEOUS A-CHAIN OF THE ALPHA-1 REGION .•......................•.•..••.•............•..•..•.•.. 849
`MISCELLANEOUS A-CHAIN OF THE ALPHA-2 REGION ..............•.......•.............•....•.•••.•........ 850
`MISCELLANEOUS A-CHAIN OF THE MEMBRANE REGION . . . . • . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . 851
`
`HUMAN B-CHAIN DR-LOCUS OF THE BETA-1 REGION . . . . . . . . . . . • . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . 853
`HUMAN B-CHAIN DR-LOCUS OF THE BETA-2 REGION . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . • • . . • . • . . . . . . . . . . . . . • . . . 861
`HUMAN B-CHAIN DR-LOCUS OF THE MEMBRANE REGION . • . . . . . . . . . . . . . . . . . . . . • . • . • . . . . . . . . . . . . . . . . . . . . • . . . • . . 870
`
`HUMAN B-CHAIN DQ-LOCUS OF THE BETA-1 REGION . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 881
`HUMAN B-CHAIN DQ-LOCUS OF THE BETA-2 REGION ......•...•....................•....•••.•....•.•.•.••.•• 888
`HUMAN B-CHAIN DQ-LOCUS OF THE MEMBRANE REGION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 895
`
`HUMAN B-CHAIN DP-LOCUS OF THE BETA-1 REGION . . . . . . . . . . . • . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 905
`HUMAN B-CHAIN DP-LOCUS OF THE BETA-2 REGION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 909
`HUMAN B-CHAIN DP-LOCUS OF THE MEMBRANE REGION . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 913
`
`HUMAN B-CHAIN MISCELLANEOUS LOCUS OF THE BETA-1 REGION ......................•.....•.•.....••.•.••.. 919
`HUMAN B-CHAIN MISCELLANEOUS LOCUS OF THE BETA-2 REGION .....•.•.•..••••••••.••••.•.•.•.••...•.•..... 920
`HUMAN B-CHAIN MISCELLANEOUS LOCUS OF THE MEMBRANE REGION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • 921
`
`BIOEPIS EX. 1055
`Page 8
`
`

`

`vi
`
`TABLE OF CONTENTS (cont'ctl
`
`I REGION GENE PRODUCTS CLASS II SEQUENCES (cont'd)
`
`MOUSE B-CHAIN A-LOCUS
`MOUSE B-CHAIN A-LOCUS
`MOUSE B-CHAIN A-LOCUS
`
`OF THE
`OF THE
`OF THE
`
`BETA-1 REGION ..............•.••...••....•.........•.•.••••.••••.••.••• 923
`BETA-2 REGION .....................••.•••.•••.•.•.•.•.................. 927
`MEMBRANE REGION ................•...•.......••.••..•.•.•.......•....... 931
`
`MOUSE B-CHAIN E-LOCUS
`MOUSE B-CHAIN E-LOCUS
`MOUSE B-CHAIN E-LOCUS
`
`OF THE
`OF THE
`OF THE
`
`BETA-1 REGION .............•...•....•......•..•••..•..•...•.•.......... 937
`BETA-2 REGION . • • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 939
`MEMBRANE REGION • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . 941
`
`MISCELLANEOUS B-CHAIN
`MISCELLANEOUS B-CHAIN
`MISCELLANEOUS B-CHAIN
`
`OF THE
`OF THE
`OF THE
`
`BETA-1 REGION ...................•.....•...•.•••.......•............... 944
`BETA-2 REGION . . . • . . . . . . . . . . . . . . . . . . • . . . • . . . • . . . • . . . • . . . . . . . . . . . . . . . . . . 94 6
`MEMBRANE REGION ..•..•..••••.•.•.................•••••.•.•.•••.•....••. 94 8
`
`SEQUENCES OF RELATED PROTEINS
`
`J CHAIN .................•••.••.•.•.•••...•.•.•.••••••.•••.•.•.•............................•..•.•.• 951
`
`BETA-2-MICROGLOBULINS ..•...•..•.......•........•.................•..........•••.••..•..•........... 953
`
`THY-1 ANTIGENS ..•.......••..•...•..........................•.....••..•.••.•.•...•.•.••..•.......... 956
`
`HUMAN COMPLEMENT COMPONENTS .•..•.•••••••.••.•..•..........•..........................•..••••.•.•.•. 959
`
`OTHER COMPLEMENT COMPONENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 981
`
`T-LYMPHOCYTE RECEPTOR FOR ANTIGEN CONSTANT REGION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . 1004
`
`T-CELL SURFACE ANTIGENS . . . . . . • . . . . . . . . . . . . . . . . . . • . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . • 1019
`
`INTEGRINS .••...•.••.••.••••.•.•.•.••••.••..••..•.•.•. , .....•...•....•...•.•.•......•.............. 1034
`
`MISCELLANEOUS HUMAN PROTEINS ASSOCIATED WITH THE IMMU

This document is available on Docket Alarm but you must sign up to view it.


Or .

Accessing this document will incur an additional charge of $.

After purchase, you can access this document again without charge.

Accept $ Charge
throbber

Still Working On It

This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.

Give it another minute or two to complete, and then try the refresh button.

throbber

A few More Minutes ... Still Working

It can take up to 5 minutes for us to download a document if the court servers are running slowly.

Thank you for your continued patience.

This document could not be displayed.

We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.

Your account does not support viewing this document.

You need a Paid Account to view this document. Click here to change your account type.

Your account does not support viewing this document.

Set your membership status to view this document.

With a Docket Alarm membership, you'll get a whole lot more, including:

  • Up-to-date information for this case.
  • Email alerts whenever there is an update.
  • Full text search for other cases.
  • Get email alerts whenever a new case matches your search.

Become a Member

One Moment Please

The filing “” is large (MB) and is being downloaded.

Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.

Your document is on its way!

If you do not receive the document in five minutes, contact support at support@docketalarm.com.

Sealed Document

We are unable to display this document, it may be under a court ordered seal.

If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.


Access Government Site

We are redirecting you
to a mobile optimized page.





Document Unreadable or Corrupt

Refresh this Document
Go to the Docket

We are unable to display this document.

Refresh this Document
Go to the Docket