`IB0@[1@@W
`
`THE IMMUNE SYSTEM IN HEALTH AND DISEASE
`
`Charles A. Janeway, Jr.
`Yale University Medical School
`
`Paul Travers
`Anthony Nolan Research Institute, London
`
`Mark Walport
`Imperial College School of Medicine, London
`
`•
`•
`•
`
`J. Donald Capra
`Oklahoma Medical Research Foundation
`
`CB
`
`CURRENT
`BIOLOGY
`PUBLICATIONS
`
`1 of 3
`
`BI Exhibit 1109
`
`
`
`Text Editors:
`Editorial Assistant:
`Copyedltor:
`Production Editor:
`Indexer:
`Illustration and Layout:
`
`Penelope Austir., Eleanor Lawrence
`Richard Woof
`Bruce Goatly
`Emma Hunt
`Liza Weinkove
`Blink Studk>, London
`
`© 1999 by Elsevier Science Ltd/Garland Publishing.
`All rights reserved. No part of this publication may be reproduced, stored
`in a retrieval system or transmitted iti any form or by any means-electronic,
`mechanical, photocopying, recording, or otherwise-without the prior written
`permission of the copyright holders.
`
`Distributors:
`
`Inside North America: Garland Publishing, 19 Union Square West,
`New York, NY 10Q03, US.
`Inside Japan: N1!.nkodo Co. Ltd., 42-6, Hongo 3-Chome, Bunkyo-ku,
`Tokyo 113, ~apan.
`Outside NGrth America and Japan: Churchill Livingstone, Robert Stevenson
`House, 1-3 Baxter'~ Pl~c~. Lgith Wall<, Edinburgt1, EH1 3AF.
`
`ISBN 0 8153 3217 3 (paperback) Garland
`ISBN 0 4430 6275 7 (paperback) Churchill Livingstone
`ISBN 0 4430 6274 9 (paperback) International Student Edition
`
`A catalog record for this book is available from the British Library.
`
`Library of Congress Cataloging-in-Publication Data
`Janeway, Charles.
`lmmunobiology: the immune system in health and disease I
`Charles A. Janeway, Jr., Paul Travers, Mark Walport;
`with the assistance of J. Donald Capra.-4th ed.
`p.cm.
`ISBN 0-8153-3217-3 (pbk.)
`1. Immunity.I. Travers, Paul, 1956-11. Walport, Mark.
`Ill. Title.
`QR181.J37 1999
`616.07'9- - dc21
`
`98-30316
`CIP
`
`This book was produced using QuarkXpress 3.32 and Adobe Illustrator 7.0.
`
`Printed in United States of America.
`
`Published by Current Biology Publications, part of Elsevier Science London
`Middlesex House, 34-42 Cleveland Street, London W1 P 6LB, UK
`and Garland Publishing, a member of the Taylor & Francis Group,
`19 Union Square West, New York, NY 10003, US.
`
`2 of 3
`
`BI Exhibit 1109
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`
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`CONTENTS
`
`I
`
`I PART I I AN INTRODUCTION TO IMMUNOSIOLOGY
`
`Ch~ 1: Bas~ Coocepts in lm.,..,notogy
`Chap<et 2: The lntllc:::tion. t.leasuremenc, Wld 11\anipulation
`of !he Immune. Response
`
`I PART II ] THE RECOGNITION OF ANTIGEN
`Cha!14er 3: Strua..-o a 1he An;l>ody Molec~e and
`lmmuooglobulin Genes
`Chai>«< 4: An6goo Recogr>tion by T Lymphocytes
`Chapl« 5: Signaling lllrough LymphOCyle Recept<l<S
`
`(!Aiif'iiij THE DEVELOPMENT OF LYMPHOCYTE REPERTOIRES
`Chapier 6: The D9Yelopmenl a 8 Lympliocy1es
`Ch~1 7: The Thymus and 1he Development ol
`T Lymphocytes
`
`! PAR'[ IV] THE ADAPTIVE IMMUNE RESPONSE
`
`T·Cell Mediated lll"1111lty
`
`Chapier 8
`Chac:it« 9. The Humo1a' lmnune ResJX)Ose
`
`I /ART V ' THE IMMUNE SYSTEM IN HEALTH AND DISEASE
`Chapter 10; Host Defense AgatiS1 tn!ecbl:ln
`C~pter 11· Fabes o1 Host Delense f\!echarnsms
`Chapter 12: Allergy and Hypersensibvf!y
`Immune Response:s in the Abseooe of Infection
`Cllapter 13:
`Chapter 14: ManiptJaoon of 1he lmmJne Response
`
`Appendices
`810!1"Pi>eS
`Glossary
`ll'ldox
`
`33
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`115
`
`163
`
`195
`227
`
`283
`307
`
`363
`417
`461
`489
`537
`
`57ll
`592
`59<3
`615
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`3 of 3
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`BI Exhibit 1109
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