IPR2017-02031, No. 1003-14 Exhibit - 1003C (P.T.A.B. Aug. 31, 2017)

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`LIGHT CHAIN
`KABAT
`1
`KURRLE
`1
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`10
`10
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`20
`20
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`30
`30
`|
`CDR1
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`D I Q M T Q S P S T L S A S V G D R V T I T C R A S Q S I N T W L A
`Q I V LT Q S P S T L S A S V G D R V T I T C S A T S S V
`S Y M H
`Q I V L T Q S P A I M S A S P G E K V T M T C S A T S S V
`S Y M H
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`(cid:3)(cid:43)(cid:36)(cid:47)(cid:40)(cid:3)–(cid:3)EXHIBIT(cid:3)B
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`45
`45
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`55
`35
`55
`35
`|
`CDR2
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`W Y Q Q K P G K A P K L L M Y K A S S L E S G V P S R F I G S G S G
`W Y Q Q K P G T A P K R W I Y D T S K L A S G V P S R F S G S G S G
`W Y Q Q K S G T S P K R W I Y D T S K L A S G V P A R F S G S G S G
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`66
`66
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`EU
`CIV-4
`BMA
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`KABAT
`KURRLE
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`EU
`CIV-4
`BMA
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`79
`79
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`98
`98
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`69
`69
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`KABAT
`KURRLE
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`EU
`CIV-4
`BMA
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`89
`89
`|
`CDR3
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`T E F T L T I S S L Q P D D F A T Y Y C Q Q Y N S D S K M F G Q G
`T S YT L T I S S L Q P E D F A T Y Y C Q Q W S S N P L T F G A G
`T S Y S L T I S S M E A E D A A T Y Y C Q Q W S S N P L T F G A G
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`(cid:43)(cid:36)(cid:47)(cid:40)(cid:3)–(cid:3)EXHIBIT(cid:3)B
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`KABAT
`KURRLE
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`102
`102
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`EU
`CIV-4
`BMA
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`T K V E V K
`T K V E I K
`T K L E L K
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`HEAVY CHAIN
`KABAT
`1
`KURRLE
`1
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`10
`10
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`20
`20
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`30
`30
`| CDR1
`Q V Q L V Q S G A E V K K P G S S V K V S C K A S G G T F S R S A I
`Q V Q L V Q S G A E V K K P G S S V K V S C K A S G Y KF T S Y V M
`E V Q L Q Q S G P E L V K P G A S V K M S C K A S G Y K F T S Y V M
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`(cid:43)(cid:36)(cid:47)(cid:40)(cid:3)–(cid:3)EXHIBIT(cid:3)B
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`45
`45
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`55
`55
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`66
`35
`67
`35
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`CDR2
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`I W V R Q A P G Q G L E W M G G I V P M F G P P N Y A Q K F Q G R V
`H W V K Q K P G Q G L E W I G Y I N P Y N D V T K Y N E K F K G K A
`H W V K Q K P G Q G L E W I G Y I N P Y N D V T K Y N E K F K G K A
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`EU
`CIV-4
`BMA
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`KABAT
`KURRLE
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`EU
`CIV-4
`BMA
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`KABAT
`KURRLE
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`EU
`CIV-4
`BMA
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`KABAT
`KURRLE
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`EU
`CIV-4
`BMA
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`68
`69
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`78
`79
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`85
`89
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`94
`98
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`T I T A D E S T N T A Y M E L S S L R S E D T A F Y F C A G G - Y
`T L T S D K S TS T A Y M E L S S L T S E D T A V H Y C AR G S Y
`T L T S D K S S S T A Y M E L S S L T S E D S A V H Y C A R G S Y
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`103
`110
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`CDR3
`G I Y S P E E Y - - N G G L V T V S S
`Y D Y D G F V Y W G Q G T L V T V S S
`Y D Y D G F V Y W G Q G T L V T V S A
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`(cid:43)(cid:36)(cid:47)(cid:40)(cid:3)EXHIBIT(cid:3)C
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`25L*
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`33L*
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`49L* 53L*
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`90L*
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`97L*
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`(cid:43)(cid:36)(cid:47)(cid:40)(cid:3)EXHIBIT(cid:3)C
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`*25H
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`*33H
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`*52H
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`*56H
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`*95H
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`*102H
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`(cid:43)(cid:36)(cid:47)(cid:40)(cid:3)(cid:40)(cid:59)(cid:43)(cid:44)(cid:37)(cid:44)(cid:55)(cid:3)(cid:39)(cid:3)(cid:11)(cid:43)(cid:60)(cid:43)(cid:40)(cid:47)(cid:16)(cid:24)(cid:12)
`
`5
`4
`3
`2
`1
`
`2HFL
`17-AUG-87
`COMPLEX(ANTIBODY-ANTIGEN)
`HEADER
`31-JUL-95 2HFL
`3HFL
`OBSLTE
`THREE-DIMENSIONAL STRUCTURE OF AN ANTIBODY-ANTIGEN COMPLEX
`TITLE
`MOL_ID: 1;
`COMPND
`2 MOLECULE:;
`COMPND
`3 CHAIN: L;
`COMPND
`4 ENGINEERED: YES;
`COMPND
`5 MOL_ID: 2;
`COMPND
`6 MOLECULE:;
`COMPND
`7 CHAIN: H;
`COMPND
`8 ENGINEERED: YES;
`COMPND
`9 MOL_ID: 3;
`COMPND
`COMPND 10 MOLECULE:;
`COMPND 11 CHAIN: Y;
`COMPND 12 ENGINEERED: YES
`SOURCE
`MOL_ID: 1;
`SOURCE
`2 MOL_ID: 2;
`SOURCE
`3 MOL_ID: 3
`KEYWDS
`COMPLEX(ANTIBODY-ANTIGEN)
`EXPDTA
`X-RAY DIFFRACTION
`AUTHOR
`S.SHERIFF,D.R.DAVIES
`REMARK
`1
`REVDAT
`15-APR-92 2HFL
`COMPND
`1
`REVDAT
`15-APR-90 2HFL
`COMPND
`1
`REVDAT
`19-APR-89 2HFL
`SOURCE JRNL
`1
`REVDAT
`16-JAN-88 2HFL
`0
`REVDAT
`16-OCT-87 2HFL
`JRNL
`AUTH
`S.SHERIFF,E.W.SILVERTON,E.A.PADLAN,G.H.COHEN,
`JRNL
`AUTH 2 4S.J.SMITH-GILL,B.C.FINZEL,D.R.DAVIES
`JRNL
`TITL
`THREE-DIMENSIONAL STRUCTURE OF AN ANTIBODY-ANTIGEN
`JRNL
`TITL 2 COMPLEX
`JRNL
`REF
`PROC.NATL.ACAD.SCI.USA
`V. 84 8075 1987
`JRNL
`REFN
`ASTM PNASA6 US ISSN 0027-8424
`1
`REMARK
`REMARK
`1 REFERENCE 1
`REMARK
`1 AUTH
`D.R.DAVIES,E.A.PADLAN
`REMARK
`1 TITL
`ANTIBODY-ANTIGEN COMPLEXES
`V. 59
`REMARK
`1 REF
`ANNU.REV.BIOCHEM.
`REMARK
`1 REFN
`ASTM ARBOAW US ISSN 0066-4154
`REMARK
`1 REFERENCE 2
`REMARK
`1 AUTH
`S.SHERIFF,E.SILVERTON,E.PADLAN,G.COHEN,
`REMARK
`1 AUTH 2 S.SMITH-GILL,B.FINZEL,D.R.DAVIES
`REMARK
`1 TITL
`ANTIBODY-ANTIGEN COMPLEXES. THREE DIMENSIONAL
`REMARK
`1 TITL 2 STRUCTURE AND CONFORMATIONAL CHANGE
`REMARK
`1 REF
`STRUCTURE AND EXPRESSION
`V.
`1
`49 1988
`REMARK
`1 REFN
`US ISBN 0-940030-21-7
`REMARK
`1 REFERENCE 3
`REMARK
`1 AUTH
`D.R.DAVIES,S.SHERIFF,E.A.PADLAN
`REMARK
`1 TITL
`ANTIBODY-ANTIGEN COMPLEXES
`C:\Users\lw8\Desktop\MYLAN\MYLAN HERCEPTIN\Carter Presta\Padlan\DECLARATION\Declaration Exhibits\EXH D - HYHEL5.docx
`
`439 1990
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`REMARK
`
`V. 263 10541 1988
`J.BIOL.CHEM.
`1 REF
`ASTM JBCHA3 US ISSN 0021-9258
`1 REFN
`2
`2 RESOLUTION. NULL ANGSTROMS.
`3
`3 REFINEMENT.
`: NULL
`3
`PROGRAM
`: NULL
`3
`AUTHORS
`3
`3 DATA USED IN REFINEMENT.
`3
`RESOLUTION RANGE HIGH (ANGSTROMS) : NULL
`3
`RESOLUTION RANGE LOW (ANGSTROMS) : NULL
`3
`DATA CUTOFF
`(SIGMA(F)) : NULL
`3
`DATA CUTOFF HIGH
`(ABS(F)) : NULL
`3
`DATA CUTOFF LOW
`(ABS(F)) : NULL
`3
`COMPLETENESS (WORKING+TEST)
`(%) : NULL
`3
`NUMBER OF REFLECTIONS
`: NULL
`3
`3 FIT TO DATA USED IN REFINEMENT.
`: NULL
`3
`CROSS-VALIDATION METHOD
`3
`FREE R VALUE TEST SET SELECTION : NULL
`3
`R VALUE
`(WORKING SET) : NULL
`3
`FREE R VALUE
`: NULL
`3
`FREE R VALUE TEST SET SIZE
`(%) : NULL
`3
`FREE R VALUE TEST SET COUNT
`: NULL
`3
`ESTIMATED ERROR OF FREE R VALUE : NULL
`3
`3 FIT IN THE HIGHEST RESOLUTION BIN.
`: NULL
`3
`TOTAL NUMBER OF BINS USED
`3
`BIN RESOLUTION RANGE HIGH
`(A) : NULL
`3
`BIN RESOLUTION RANGE LOW
`(A) : NULL
`3
`BIN COMPLETENESS (WORKING+TEST) (%) : NULL
`3
`REFLECTIONS IN BIN
`(WORKING SET) : NULL
`3
`BIN R VALUE
`(WORKING SET) : NULL
`3
`BIN FREE R VALUE
`: NULL
`3
`BIN FREE R VALUE TEST SET SIZE (%) : NULL
`3
`BIN FREE R VALUE TEST SET COUNT
`: NULL
`3
`ESTIMATED ERROR OF BIN FREE R VALUE : NULL
`3
`3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
`3
`PROTEIN ATOMS
`: 4227
`3
`NUCLEIC ACID ATOMS
`: 0
`3
`HETEROGEN ATOMS
`: 0
`3
`SOLVENT ATOMS
`: 0
`3
`3 B VALUES.
`(A**2) : NULL
`3
`FROM WILSON PLOT
`(OVERALL, A**2) : NULL
`3
`MEAN B VALUE
`3
`OVERALL ANISOTROPIC B VALUE.
`3
`B11 (A**2) : NULL
`3
`B22 (A**2) : NULL
`3
`B33 (A**2) : NULL
`3
`B12 (A**2) : NULL
`
`-2-
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`REMARK
`
`B13 (A**2) : NULL
`3
`B23 (A**2) : NULL
`3
`3
`3 ESTIMATED COORDINATE ERROR.
`(A) : NULL
`3
`ESD FROM LUZZATI PLOT
`(A) : NULL
`3
`ESD FROM SIGMAA
`(A) : NULL
`3
`LOW RESOLUTION CUTOFF
`3
`3 CROSS-VALIDATED ESTIMATED COORDINATE ERROR.
`3
`ESD FROM C-V LUZZATI PLOT
`(A) : NULL
`3
`ESD FROM C-V SIGMAA
`(A) : NULL
`3
`3 RMS DEVIATIONS FROM IDEAL VALUES.
`3
`BOND LENGTHS
`(A) : NULL
`3
`BOND ANGLES
`(DEGREES) : NULL
`3
`DIHEDRAL ANGLES
`(DEGREES) : NULL
`3
`IMPROPER ANGLES
`(DEGREES) : NULL
`3
`3 ISOTROPIC THERMAL MODEL : NULL
`3
`SIGMA
`RMS
`3 ISOTROPIC THERMAL FACTOR RESTRAINTS.
`3
`MAIN-CHAIN BOND
`(A**2) : NULL ; NULL
`3
`MAIN-CHAIN ANGLE
`(A**2) : NULL ; NULL
`3
`SIDE-CHAIN BOND
`(A**2) : NULL ; NULL
`3
`SIDE-CHAIN ANGLE
`(A**2) : NULL ; NULL
`3
`3 NCS MODEL : NULL
`3
`3 NCS RESTRAINTS.
`3
`GROUP 1 POSITIONAL
`3
`GROUP 1 B-FACTOR
`3
`3 PARAMETER FILE 1 : NULL
`3 TOPOLOGY FILE 1
`: NULL
`3
`3 OTHER REFINEMENT REMARKS: NULL
`4
`4 2HFL COMPLIES WITH FORMAT V. 2.3, 09-JULY-1998
`5
`5 2HFL IN THE HEAVY CHAIN (CHAIN IDENTIFIER *H*) RESIDUES GLN
`5 H 3, 2HFL GLN H 5, AND TYR H 27 WERE INADVERTENTLY REFINED
`5 AS ALA, 2HFL ALA, AND PHE, RESPECTIVELY. THERE IS DENSITY
`5 IN THE 2HFL CURRENT 2*FO - FC MAP CORRESPONDING TO THE
`5 MISSING SIDE 2HFL CHAIN ATOMS OF GLN, GLN, AND TYR,
`5 RESPECTIVELY. THIS WILL 2HFL BE CORRECTED IN FUTURE
`5 REFINEMENT CYCLES. THESE RESIDUES 2HFL ARE CORRECTLY
`5 IDENTIFIED IN THIS ENTRY. 2HFL
`6
`6 2HFL CORRECTION. UPDATE JRNL REFERENCE TO REFLECT
`6 PUBLICATION. 2HFL CORRECT SOURCE RECORD. 16-JAN-88. 2HFL
`7
`7 2HFL CORRECTION. STANDARDIZE TEXT ON COMPND RECORD. 19-APR-
`7 89. 2HFL
`
`SIGMA/WEIGHT
`RMS
`(A) : NULL ; NULL
`(A**2) : NULL ; NULL
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`8
`REMARK
`8 2HFL CORRECTION. CORRECT COMPND RECORD. 15-APR-90. 2HFL
`REMARK
`9
`REMARK
`9 2HFL CORRECTION. UPDATE REFERENCE 1 TO REFLECT PUBLICATION.
`REMARK
`9 ADD 2HFL NEW PUBLICATIONS AND RENUMBER ALL REFERENCES. 15-
`REMARK
`9 APR-92. 2HFL
`REMARK
`REMARK 200
`REMARK 200 EXPERIMENTAL DETAILS
`REMARK 200 EXPERIMENT TYPE
`: X-RAY DIFFRACTION
`REMARK 200 DATE OF DATA COLLECTION
`: NULL
`REMARK 200 TEMPERATURE
`(KELVIN) : NULL
`REMARK 200 PH
`: NULL
`REMARK 200 NUMBER OF CRYSTALS USED
`: NULL
`REMARK 200
`REMARK 200 SYNCHROTRON
`(Y/N) : NULL
`REMARK 200 RADIATION SOURCE
`: NULL
`REMARK 200 BEAMLINE
`: NULL
`REMARK 200 X-RAY GENERATOR MODEL
`: NULL
`REMARK 200 MONOCHROMATIC OR LAUE
`(M/L) : NULL
`REMARK 200 WAVELENGTH OR RANGE
`(A) : NULL
`REMARK 200 MONOCHROMATOR
`: NULL
`REMARK 200 OPTICS
`: NULL
`REMARK 200
`REMARK 200 DETECTOR TYPE
`: NULL
`REMARK 200 DETECTOR MANUFACTURER
`: NULL
`REMARK 200 INTENSITY-INTEGRATION SOFTWARE : NULL
`REMARK 200 DATA SCALING SOFTWARE
`: NULL
`REMARK 200
`REMARK 200 NUMBER OF UNIQUE REFLECTIONS
`: NULL
`REMARK 200 RESOLUTION RANGE HIGH
`(A) : NULL
`REMARK 200 RESOLUTION RANGE LOW
`(A) : NULL
`REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL
`REMARK 200
`REMARK 200 OVERALL.
`(%) : NULL
`REMARK 200 COMPLETENESS FOR RANGE
`: NULL
`REMARK 200 DATA REDUNDANCY
`(I) : NULL
`REMARK 200 R MERGE
`(I) : NULL
`REMARK 200 R SYM
`REMARK 200 <I/SIGMA(I)> FOR THE DATA SET : NULL
`REMARK 200
`REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
`REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL
`REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : NULL
`REMARK 200 COMPLETENESS FOR SHELL
`(%) : NULL
`REMARK 200 DATA REDUNDANCY IN SHELL
`: NULL
`REMARK 200 R MERGE FOR SHELL
`(I) : NULL
`REMARK 200 R SYM FOR SHELL
`(I) : NULL
`REMARK 200 <I/SIGMA(I)> FOR SHELL
`: NULL
`REMARK 200
`REMARK 200 DIFFRACTION PROTOCOL: NULL
`REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: NULL
`REMARK 200 SOFTWARE USED: NULL
`REMARK 200 STARTING MODEL: NULL
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`REMARK 200
`REMARK 200 REMARK: NULL
`REMARK 280
`REMARK 280 CRYSTAL
`(%): 53.07
`REMARK 280 SOLVENT CONTENT, VS
`REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.62
`REMARK 280
`REMARK 280 CRYSTALLIZATION CONDITIONS: NULL
`REMARK 290
`REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
`REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
`REMARK 290
`REMARK 290
`SYMOP
`SYMMETRY
`REMARK 290
`NNNMMM
`OPERATOR
`REMARK 290
`1555
`X,Y,Z
`REMARK 290
`2555
`-X,1/2+Y,-Z
`REMARK 290
`REMARK 290
`WHERE NNN -> OPERATOR NUMBER
`REMARK 290
`MMM -> TRANSLATION VECTOR
`REMARK 290
`REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
`REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
`REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
`REMARK 290 RELATED MOLECULES.
`REMARK 290
`SMTRY1
`1 1.000000 0.000000 0.000000
`0.00000
`REMARK 290
`SMTRY2
`1 0.000000 1.000000 0.000000
`0.00000
`REMARK 290
`SMTRY3
`1 0.000000 0.000000 1.000000
`0.00000
`REMARK 290
`SMTRY1
`2 -1.000000 0.000000 0.000000
`0.00000
`REMARK 290
`SMTRY2
`2 0.000000 1.000000 0.000000
`37.41000
`REMARK 290
`SMTRY3
`2 0.000000 0.000000 -1.000000
`0.00000
`REMARK 290
`REMARK 290 REMARK: NULL
`REMARK 300
`REMARK 300 BIOMOLECULE: 1
`REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT
`REMARK 300 WHICH CONSISTS OF 3 CHAIN(S). SEE REMARK 350 FOR
`REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S).
`REMARK 350
`REMARK 350 GENERATING THE BIOMOLECULE
`REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
`REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
`REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
`REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
`REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
`REMARK 350
`REMARK 350 BIOMOLECULE: 1
`REMARK 350 APPLY THE FOLLOWING TO CHAINS: L, H, Y
`REMARK 350
`BIOMT1
`1 1.000000 0.000000 0.000000
`REMARK 350
`BIOMT2
`1 0.000000 1.000000 0.000000
`REMARK 350
`BIOMT3
`1 0.000000 0.000000 1.000000
`REMARK 470
`REMARK 470 MISSING ATOM
`REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS(M=MODEL NUMBER;
`
`0.00000
`0.00000
`0.00000
`
`-5-
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`OE1
`OE1
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`NE2
`NE2
`
`CD
`CD
`
`1.96
`1.97
`2.01
`2.01
`2.04
`2.10
`2.12
`2.19
`2.19
`
`REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
`REMARK 470 I=INSERTION CODE):
`REMARK 470
`M RES CSSEQI ATOMS
`REMARK 470
`GLN H
`3
`CG
`REMARK 470
`GLN H
`5
`CG
`REMARK 470
`TYR H 27
`OH
`REMARK 500
`REMARK 500 GEOMETRY AND STEREOCHEMISTRY
`REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
`REMARK 500
`REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
`REMARK 500
`REMARK 500 ATM1 RES C SSEQI
`ATM2 RES C SSEQI
`REMARK 500
`O
`GLU H
`62
`N
`PHE H
`64
`REMARK 500
`O
`ARG L
`209
`O
`GLU L
`211
`REMARK 500
`O
`ILE L
`148
`O
`SER L
`189
`REMARK 500
`NE2 GLN H
`174
`O
`LEU H
`177
`REMARK 500
`OD2 ASP L
`149
`OG
`SER L
`189
`REMARK 500
`OD1 ASN H
`59
`OG1 THR Y
`43
`REMARK 500
`OD2 ASP Y
`119
`NH2 ARG Y
`125
`REMARK 500
`OD1 ASN L
`159
`OG
`SER L
`175
`REMARK 500
`O
`SER H
`189
`OG
`SER H
`193
`REMARK 500
`REMARK 500 GEOMETRY AND STEREOCHEMISTRY
`REMARK 500 SUBTOPIC: TORSION ANGLES
`REMARK 500
`REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
`REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
`REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
`REMARK 500
`REMARK 500 STANDARD TABLE:
`REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
`REMARK 500
`REMARK 500 M RES CSSEQI
`PSI
`PHI
`REMARK 500
`SER L 55
`-116.12
`-2.76
`REMARK 500
`ALA L 107
`128.91
`59.09
`REMARK 500
`ASP L 108
`112.20
`21.89
`REMARK 500
`ARG L 153
`138.29
`127.27
`REMARK 500
`VAL H
`2
`-164.87
`129.94
`REMARK 500
`ALA H
`9
`150.76
`111.38
`SEQRES
`1 L 212 ASP ILE VAL LEU THR GLN SER PRO ALA ILE MET SER ALA
`SEQRES
`2 L 212 SER PRO GLY GLU LYS VAL THR MET THR CYS SER ALA SER
`SEQRES
`3 L 212 SER SER VAL ASN TYR MET TYR TRP TYR GLN GLN LYS SER
`SEQRES
`4 L 212 GLY THR SER PRO LYS ARG TRP ILE TYR ASP THR SER LYS
`SEQRES
`5 L 212 LEU ALA SER GLY VAL PRO VAL ARG PHE SER GLY SER GLY
`SEQRES
`6 L 212 SER GLY THR SER TYR SER LEU THR ILE SER SER MET GLU
`SEQRES
`7 L 212 THR GLU ASP ALA ALA GLU TYR TYR CYS GLN GLN TRP GLY
`SEQRES
`8 L 212 ARG ASN PRO THR PHE GLY GLY GLY THR LYS LEU GLU ILE
`SEQRES
`9 L 212 LYS ARG ALA ASP ALA ALA PRO THR VAL SER ILE PHE PRO
`SEQRES 10 L 212 PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SER VAL
`SEQRES 11 L 212 VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP ILE ASN
`SEQRES 12 L 212 VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN ASN GLY
`SEQRES 13 L 212 VAL LEU ASN SER TRP THR ASP GLN ASP SER LYS ASP SER
`
`-6-
`
`15 of 782
`
`BI Exhibit 1003C
`
`

`SEQRES 14 L 212 THR TYR SER MET SER SER THR LEU THR LEU THR LYS ASP
`SEQRES 15 L 212 GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU ALA THR
`SEQRES 16 L 212 HIS LYS THR SER THR SER PRO ILE VAL LYS SER PHE ASN
`SEQRES 17 L 212 ARG ASN GLU CYS
`SEQRES
`1 H 213 PCA VAL GLN LEU GLN GLN SER GLY ALA GLU LEU MET LYS
`SEQRES
`2 H 213 PRO GLY ALA SER VAL LYS ILE SER CYS LYS ALA SER GLY
`SEQRES
`3 H 213 TYR THR PHE SER ASP TYR TRP ILE GLU TRP VAL LYS GLN
`SEQRES
`4 H 213 ARG PRO GLY HIS GLY LEU GLU TRP ILE GLY GLU ILE LEU
`SEQRES
`5 H 213 PRO GLY SER GLY SER THR ASN TYR HIS GLU ARG PHE LYS
`SEQRES
`6 H 213 GLY LYS ALA THR PHE THR ALA ASP THR SER SER SER THR
`SEQRES
`7 H 213 ALA TYR MET GLN LEU ASN SER LEU THR SER GLU ASP SER
`SEQRES
`8 H 213 GLY VAL TYR TYR CYS LEU HIS GLY ASN TYR ASP PHE ASP
`SEQRES
`9 H 213 GLY TRP GLY GLN GLY THR THR LEU THR VAL SER SER ALA
`SEQRES 10 H 213 LYS THR THR PRO PRO SER VAL TYR PRO LEU ALA PRO GLY
`SEQRES 11 H 213 SER ALA ALA GLN THR ASN SER MET VAL THR LEU GLY CYS
`SEQRES 12 H 213 LEU VAL LYS GLY TYR PHE PRO GLU PRO VAL THR VAL THR
`SEQRES 13 H 213 TRP ASN SER GLY SER LEU SER SER GLY VAL HIS THR PHE
`SEQRES 14 H 213 PRO ALA VAL LEU GLN SER ASP LEU TYR THR LEU SER SER
`SEQRES 15 H 213 SER VAL THR VAL PRO SER SER PRO ARG PRO SER GLU THR
`SEQRES 16 H 213 VAL THR CYS ASN VAL ALA HIS PRO ALA SER SER THR LYS
`SEQRES 17 H 213 VAL ASP LYS LYS ILE
`SEQRES
`1 Y 129 LYS VAL PHE GLY ARG CYS GLU LEU ALA ALA ALA MET LYS
`SEQRES
`2 Y 129 ARG HIS GLY LEU ASP ASN TYR ARG GLY TYR SER LEU GLY
`SEQRES
`3 Y 129 ASN TRP VAL CYS ALA ALA LYS PHE GLU SER ASN PHE ASN
`SEQRES
`4 Y 129 THR GLN ALA THR ASN ARG ASN THR ASP GLY SER THR ASP
`SEQRES
`5 Y 129 TYR GLY ILE LEU GLN ILE ASN SER ARG TRP TRP CYS ASN
`SEQRES
`6 Y 129 ASP GLY ARG THR PRO GLY SER ARG ASN LEU CYS ASN ILE
`SEQRES
`7 Y 129 PRO CYS SER ALA LEU LEU SER SER ASP ILE THR ALA SER
`SEQRES
`8 Y 129 VAL ASN CYS ALA LYS LYS ILE VAL SER ASP GLY ASP GLY
`SEQRES
`9 Y 129 MET ASN ALA TRP VAL ALA TRP ARG ASN ARG CYS LYS GLY
`SEQRES 10 Y 129 THR ASP VAL GLN ALA TRP ILE ARG GLY CYS ARG LEU
`MODRES 2HFL PCA H
`1 GLU PYROGLUTAMIC ACID
`FTNOTE
`1 RESIDUES PRO L 8, PRO L 139, PRO H 150, AND PRO H 152 ARE
`FTNOTE
`1 CIS-PROLINES.
`FTNOTE
`2 SEE REMARK 5.
`HET
`PCA H
`1
`8
`HETNAM
`PCA PYROGLUTAMIC ACID
`FORMUL
`2 PCA
`C5 H7 N O3
`82 5
`HELIX
`1 GLU L
`78 ALA L
`1
`HELIX
`2
`2 SER L 119 THR L 124 1
`HELIX
`3
`3 LYS L 181 GLU L 185 1
`HELIX
`4
`4 THR H
`28 TYR H
`32 5
`HELIX
`5
`5 PRO H
`53 GLY H
`56 5
`HELIX
`6
`6 THR H
`74 SER H
`76 5
`HELIX
`7
`7 SER H 189 GLU H 194 1
`HELIX
`8
`8 GLY Y
`4 HIS Y
`15 1
`HELIX
`9
`9 ASN Y
`19 TYR Y
`23 5
`HELIX
`10 10 SER Y
`24 SER Y
`36 1
`HELIX
`11 11 PRO Y
`79 SER Y
`85 5
`HELIX
`12 12 ILE Y
`88 ASP Y 101 1
`HELIX
`13 13 GLY Y 102 GLY Y 102 5
`HELIX
`14 14 ASP Y 103 ALA Y 107 5
`HELIX
`15 15 TRP Y 108 CYS Y 115 1
`
`-7-
`
`5
`6
`5
`5
`4
`3
`6
`12
`5
`13
`7
`14
`1
`5
`8
`
`16 of 782
`
`BI Exhibit 1003C
`
`

`7
`
`HELIX
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SHEET
`SSBOND
`SSBOND
`SSBOND
`SSBOND
`SSBOND
`SSBOND
`SSBOND
`SSBOND
`
`16 16 ASP Y 119 ARG Y 125 5
`1
`A 3 LEU L
`4 SER L
`7 0
`2
`A 3 VAL L 19 VAL L 29 -1 O SER L 24
`3
`A 3 PHE L 61 ILE L 74 -1 O LEU L 72
`1
`B 6 ILE L 10 ALA L 13 0
`2
`B 6 THR L 100 ILE L 104 1 O GLU L 103
`3
`B 6 ALA L 83 GLN L 89 -1 N ALA L 83
`4
`B 6 TYR L 33 GLN L 37 -1 N TYR L 35
`5
`B 6 LYS L 44 TYR L 48 -1 O LYS L 44
`6
`B 6 LYS L 52 LEU L 53 -1 O LYS L 52
`1
`C 4 ILE L 10 ALA L 13 0
`2
`C 4 THR L 100 ILE L 104 1 O GLU L 103
`3
`C 4 ALA L 83 GLN L 89 -1 N ALA L 83
`4
`C 4 THR L 95 PHE L 96 -1 O THR L 95
`1
`D 4 THR L 112 PHE L 116 0
`2
`D 4 GLY L 127 PHE L 137 -1 O VAL L 131
`3
`D 4 TYR L 171 THR L 180 -1 O TYR L 171
`4
`D 4 VAL L 157 TRP L 161 -1 N LEU L 158
`1
`E 3 ASN L 143 LYS L 147 0
`2
`E 3 TYR L 190 THR L 195 -1 O GLU L 193
`3
`E 3 ILE L 203 PHE L 207 -1 O PHE L 207
`1
`F 4 GLN H
`3 GLN H
`6 0
`2
`F 4 VAL H 18 SER H 25 -1 O LYS H 23
`3
`F 4 THR H 78 LEU H 83 -1 O MET H 81
`4
`F 4 ALA H 68 ASP H 73 -1 N THR H 69
`1
`G 6 GLU H 10 MET H 12 0
`2
`G 6 THR H 110 VAL H 114 1 O THR H 113
`3
`G 6 GLY H 92 LEU H 97 -1 N GLY H 92
`4
`G 6 ILE H 34 GLN H 39 -1 N GLU H 35
`5
`G 6 LEU H 45 LEU H 52 -1 O GLU H 46
`6
`G 6 SER H 57 TYR H 60 -1 O ASN H 59
`1
`H 4 SER H 123 LEU H 127 0
`2
`H 4 VAL H 139 TYR H 148 -1 O LEU H 144
`3
`H 4 LEU H 177 VAL H 186 -1 O LEU H 180
`4
`H 4 VAL H 166 THR H 168 -1 N HIS H 167
`1
`I 4 SER H 123 LEU H 127 0
`2
`I 4 VAL H 139 TYR H 148 -1 O LEU H 144
`3
`I 4 LEU H 177 VAL H 186 -1 O LEU H 180
`4
`I 4 VAL H 172 GLN H 174 -1 N GLN H 174
`1
`J 3 THR H 154 TRP H 157 0
`2
`J 3 THR H 197 HIS H 202 -1 O ASN H 199
`3
`J 3 THR H 207 LYS H 212 -1 O VAL H 209
`1
`K 3 THR Y 43 ARG Y 45 0
`2
`K 3 THR Y 51 TYR Y 53 -1 O ASP Y 52
`3
`K 3 ILE Y 58 ASN Y 59 -1 O ILE Y 58
`1 CYS L
`23
`CYS L
`87
`2 CYS L 132
`CYS L 192
`3 CYS H
`22
`CYS H
`96
`4 CYS H 143
`CYS H 198
`5 CYS Y
`6
`CYS Y 127
`6 CYS Y
`30
`CYS Y 115
`7 CYS Y
`64
`CYS Y
`80
`8 CYS Y
`76
`CYS Y
`94
`
`-8-
`
`5
`N THR L
`N MET L 21
`N MET L 11
`O LEU L 102
`O TYR L 86
`N GLN L 36
`N TYR L 48
`N MET L 11
`O LEU L 102
`N GLN L 89
`N PHE L 116
`N PHE L 137
`O THR L 176
`N LYS L 145
`N TYR L 190
`N GLN H
`5
`N ILE H 20
`O GLN H 82
`N GLU H 10
`O LEU H 112
`O LEU H 97
`N LYS H 38
`N GLU H 50
`N TYR H 125
`N VAL H 145
`O SER H 183
`N TYR H 125
`N VAL H 145
`O LEU H 177
`N THR H 156
`N VAL H 200
`N ASN Y 44
`N TYR Y 53
`
`17 of 782
`
`BI Exhibit 1003C
`
`

`2
`
`CISPEP
`CISPEP
`CISPEP
`CISPEP
`CRYST1
`ORIGX1
`ORIGX2
`ORIGX3
`SCALE1
`SCALE2
`SCALE3
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`
`-2.54
`0
`8
`PRO L
`7
`1 SER L
`2.54
`0
`PRO L 139
`2 TYR L 138
`-0.66
`0
`PRO H 150
`3 PHE H 149
`0.79
`0
`PRO H 152
`4 GLU H 151
`78.950 90.00 101.82 90.00 P 1 21 1
`54.790
`74.820
`1.000000 0.000000 0.000000
`0.00000
`0.000000 1.000000 0.000000
`0.00000
`0.000000 0.000000 1.000000
`0.00000
`0.018252 0.000000 0.003820
`0.00000
`0.000000 0.013365 0.000000
`0.00000
`0.000000 0.000000 0.012941
`0.00000
`1 N
`ASP L
`1
`17.883 -14.042 36.096 1.00 21.11
`2 CA ASP L
`1
`17.166 -12.951 35.359 1.00 21.09
`3 C
`ASP L
`1
`15.737 -13.450 35.184 1.00 20.77
`4 O
`ASP L
`1
`15.404 -14.407 35.945 1.00 21.24
`5 CB ASP L
`1
`17.981 -12.505 34.166 1.00 21.77
`6 CG ASP L
`1
`19.396 -12.032 34.479 1.00 21.93
`7 OD1 ASP L
`1
`20.001 -11.233 33.732 1.00 21.07
`8 OD2 ASP L
`1
`19.946 -12.480 35.518 1.00 21.72
`9 N
`ILE L
`2
`14.897 -12.858 34.360 1.00 19.92
`10 CA ILE L
`2
`13.517 -13.334 34.177 1.00 18.85
`11 C
`ILE L
`2
`13.168 -13.302 32.685 1.00 18.13
`12 O
`ILE L
`2
`13.686 -12.441 31.971 1.00 18.25
`13 CB ILE L
`2
`12.387 -12.726 35.049 1.00 18.27
`14 CG1 ILE L
`2
`11.024 -13.213 34.461 1.00 17.67
`15 CG2 ILE L
`2
`12.376 -11.198 35.236 1.00 18.83
`16 CD1 ILE L
`2
`9.756 -12.536 35.022 1.00 15.74
`17 N
`VAL L
`3
`12.333 -14.258 32.283 1.00 17.23
`18 CA VAL L
`3
`11.923 -14.360 30.883 1.00 16.07
`19 C
`VAL L
`3
`10.394 -14.254 30.760 1.00 15.39
`20 O
`VAL L
`3
`9.682 -14.815 31.585 1.00 15.28
`21 CB VAL L
`3
`12.357 -15.665 30.173 1.00 14.51
`22 CG1 VAL L
`3
`11.617 -15.770 28.831 1.00 12.14
`23 CG2 VAL L
`3
`13.850 -15.819 30.018 1.00 13.09
`24 N
`LEU L
`4
`10.014 -13.598 29.686 1.00 14.83
`25 CA LEU L
`4
`8.611 -13.395 29.328 1.00 13.74
`26 C
`LEU L
`4
`8.387 -14.042 27.952 1.00 13.28
`27 O
`LEU L
`4
`9.070 -13.585 27.018 1.00 13.44
`28 CB LEU L
`4
`8.310 -11.903 29.283 1.00 12.48
`29 CG LEU L
`4
`8.295 -11.041 30.503 1.00 11.85
`30 CD1 LEU L
`4
`7.406 -9.815 30.272 1.00 11.21
`31 CD2 LEU L
`4
`7.741 -11.823 31.708 1.00 13.18
`32 N
`THR L
`5
`7.511 -15.013 27.905 1.00 12.94
`33 CA THR L
`5
`7.164 -15.721 26.663 1.00 12.56
`34 C
`THR L
`5
`5.817 -15.177 26.179 1.00 12.25
`35 O
`THR L
`5
`4.873 -15.158 26.986 1.00 12.14
`36 CB THR L
`5
`7.130 -17.281 26.818 1.00 12.93
`37 OG1 THR L
`5
`8.513 -17.787 26.808 1.00 13.47
`38 CG2 THR L
`5
`6.300 -17.949 25.702 1.00 13.15
`39 N
`GLN L
`6
`5.745 -14.734 24.940 1.00 12.21
`40 CA GLN L
`6
`4.500 -14.184 24.373 1.00 12.22
`41 C
`GLN L
`6
`3.754 -15.226 23.543 1.00 12.50
`42 O
`GLN L
`6
`4.316 -16.075 22.864 1.00 12.45
`
`-9-
`
`N
`C
`C
`O
`C
`C
`O
`O
`N
`C
`C
`O
`C
`C
`C
`C
`N
`C
`C
`O
`C
`C
`C
`N
`C
`C
`O
`C
`C
`C
`C
`N
`C
`C
`O
`C
`O
`C
`N
`C
`C
`O
`
`18 of 782
`
`BI Exhibit 1003C
`
`

`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`
`6
`43 CB GLN L
`6
`44 CG GLN L
`6
`45 CD GLN L
`6
`46 OE1 GLN L
`6
`47 NE2 GLN L
`7
`48 N
`SER L
`7
`49 CA SER L
`7
`50 C
`SER L
`7
`51 O
`SER L
`7
`52 CB SER L
`7
`53 OG SER L
`8
`54 N
`PRO L
`8
`55 CA PRO L
`8
`56 C
`PRO L
`8
`57 O
`PRO L
`8
`58 CB PRO L
`8
`59 CG PRO L
`8
`60 CD PRO L
`9
`61 N
`ALA L
`9
`62 CA ALA L
`9
`63 C
`ALA L
`9
`64 O
`ALA L
`9
`65 CB ALA L
`66 N
`ILE L 10
`67 CA ILE L 10
`68 C
`ILE L 10
`69 O
`ILE L 10
`70 CB ILE L 10
`71 CG1 ILE L 10
`72 CG2 ILE L 10
`73 CD1 ILE L 10
`74 N
`MET L 11
`75 CA MET L 11
`76 C
`MET L 11
`77 O
`MET L 11
`78 CB MET L 11
`79 CG MET L 11
`80 SD MET L 11
`81 CE MET L 11
`82 N
`SER L 12
`83 CA SER L 12
`84 C
`SER L 12
`85 O
`SER L 12
`86 CB SER L 12
`87 OG SER L 12
`88 N
`ALA L 13
`89 CA ALA L 13
`90 C
`ALA L 13
`91 O
`ALA L 13
`92 CB ALA L 13
`93 N
`SER L 14
`94 CA SER L 14
`95 C
`SER L 14
`
`4.679 -12.885 23.607 1.00 9.93
`5.062 -11.720 24.479 1.00 8.60
`4.736 -10.388 23.878 1.00 9.56
`5.558 -9.477 23.815 1.00 10.29
`3.487 -10.265 23.434 1.00 9.32
`2.436 -15.135 23.617 1.00 13.36
`1.517 -16.023 22.938 1.00 14.39
`0.290 -15.352 22.304 1.00 15.04
`-0.489 -14.593 22.906 1.00 14.95
`0.951 -17.073 23.909 1.00 15.80
`-0.457 -17.141 23.626 1.00 17.85
`0.068 -15.665 21.050 1.00 15.44
`0.906 -16.545 20.196 1.00 15.50
`1.890 -15.645 19.471 1.00 15.23
`1.652 -14.415 19.501 1.00 15.22
`-0.156 -17.218 19.351 1.00 15.69
`-1.366 -16.323 19.355 1.00 15.94
`-1.071 -15.140 20.283 1.00 15.62
`2.939 -16.147 18.869 1.00 15.33
`3.931 -15.293 18.173 1.00 15.57
`3.392 -14.750 16.857 1.00 15.82
`3.765 -13.650 16.409 1.00 15.59
`5.265 -15.981 17.988 1.00 14.18
`2.543 -15.545 16.244 1.00 16.42
`1.882 -15.184 14.972 1.00 16.99
`0.387 -15.445 15.180 1.00 17.04
`-0.020 -16.539 15.597 1.00 16.87
`2.569 -15.860 13.753 1.00 17.93
`4.094 -15.532 13.779 1.00 18.65
`1.997 -15.400 12.381 1.00 18.03
`4.408 -14.004 13.732 1.00 18.69
`-0.397 -14.415 14.925 1.00 17.23
`-1.849 -14.427 15.103 1.00 17.47
`-2.550 -13.523 14.098 1.00 17.67
`-2.038 -12.448 13.748 1.00 17.68
`-2.158 -13.997 16.540 1.00 19.27
`-3.199 -12.894 16.540 1.00 20.10
`-3.652 -12.641 18.307 1.00 20.35
`-4.563 -14.185 18.570 1.00 20.57
`-3.716 -13.992 13.683 1.00 17.88
`-4.604 -13.362 12.704 1.00 17.81
`-6.011 -13.180 13.285 1.00 17.98
`-6.398 -13.934 14.194 1.00 18.15
`-4.739 -14.211 11.443 1.00 18.27
`-5.304 -13.489 10.374 1.00 18.50
`-6.722 -12.211 12.722 1.00 17.89
`-8.083 -11.907 13.167 1.00 18.01
`-8.792 -10.929 12.241 1.00 17.89
`-8.183 -9.983 11.739 1.00 18.23
`-8.030 -11.308 14.582 1.00 19.12
`-10.071 -11.176 12.069 1.00 17.84
`-10.948 -10.310 11.238 1.00 17.43
`-11.286 -9.134 12.154 1.00 17.33
`
`-10-
`
`C
`C
`C
`O
`N
`N
`C
`C
`O
`C
`O
`N
`C
`C
`O
`C
`C
`C
`N
`C
`C
`O
`C
`N
`C
`C
`O
`C
`C
`C
`C
`N
`C
`C
`O
`C
`C
`S
`C
`N
`C
`C
`O
`C
`O
`N
`C
`C
`O
`C
`N
`C
`C
`
`19 of 782
`
`BI Exhibit 1003C
`
`

`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`
`SER L 14
`96 O
`97 CB SER L 14
`98 OG SER L 14
`99 N
`PRO L 15
`100 CA PRO L 15
`101 C
`PRO L 15
`102 O
`PRO L 15
`103 CB PRO L 15
`104 CG PRO L 15
`105 CD PRO L 15
`106 N
`GLY L 16
`107 CA GLY L 16
`108 C
`GLY L 16
`109 O
`GLY L 16
`110 N
`GLU L 17
`111 CA GLU L 17
`112 C
`GLU L 17
`113 O
`GLU L 17
`114 CB GLU L 17
`115 CG GLU L 17
`116 CD GLU L 17
`117 OE1 GLU L 17
`118 OE2 GLU L 17
`119 N
`LYS L 18
`120 CA LYS L 18
`121 C
`LYS L 18
`122 O
`LYS L 18
`123 CB LYS L 18
`124 CG LYS L 18
`125 CD LYS L 18
`126 CE LYS L 18
`127 NZ LYS L 18
`128 N
`VAL L 19
`129 CA VAL L 19
`130 C
`VAL L 19
`131 O
`VAL L 19
`132 CB VAL L 19
`133 CG1 VAL L 19
`134 CG2 VAL L 19
`135 N
`THR L 20
`136 CA THR L 20
`137 C
`THR L 20
`138 O
`THR L 20
`139 CB THR L 20
`140 OG1 THR L 20
`141 CG2 THR L 20
`142 N
`MET L 21
`143 CA MET L 21
`144 C
`MET L 21
`145 O
`MET L 21
`146 CB MET L 21
`147 CG MET L 21
`148 SD MET L 21
`
`-11.123 -9.278 13.380 1.00 17.27
`-12.173 -11.077 10.804 1.00 16.48
`-11.752 -12.310 10.207 1.00 16.32
`-11.668 -8.033 11.570 1.00 17.33
`-12.013 -6.840 12.376 1.00 17.54
`-13.310 -7.218 13.070 1.00 17.92
`-14.033 -8.042 12.452 1.00 18.51
`-12.152 -5.705 11.386 1.00 17.37
`-11.622 -6.252 10.087 1.00 17.44
`-11.889 -7.770 10.142 1.00 17.47
`-13.561 -6.673 14.240 1.00 17.76
`-14.807 -7.013 14.954 1.00 17.50
`-14.603 -8.387 15.586 1.00 17.69
`-15.571 -8.975 16.081 1.00 18.02
`-13.379 -8.876 15.508 1.00 17.83
`-13.056 -10.188 16.147 1.00 18.02
`-12.389 -9.725 17.450 1.00 17.87
`-11.699 -8.692 17.464 1.00 17.88
`-12.201 -11.131 15.373 1.00 19.46
`-12.062 -12.602 15.729 1.00 21.22
`-11.018 -13.425 15.032 1.00 22.08
`-10.046 -13.959 15.564 1.00 21.90
`-11.216 -13.549 13.804 1.00 22.12
`-12.692 -10.400 18.512 1.00 17.94
`-12.174 -10.068 19.870 1.00 17.58
`-10.857 -10.811 20.020 1.00 17.30
`-10.803 -12.026 19.726 1.00 17.60
`-13.235 -10.438 20.884 1.00 18.34
`-12.866 -10.265 22.343 1.00 19.86
`-13.534 -11.321 23.226 1.00 20.11
`-12.651 -11.613 24.426 1.00 21.24
`-11.795 -10.408 24.698 1.00 22.29
`-9.822 -10.089 20.412 1.00 16.70
`-8.475 -10.668 20.529 1.00 16.07
`-7.958 -10.626 21.953 1.00 15.69
`-8.362 -9.752 22.735 1.00 15.75
`-7.574 -9.969 19.490 1.00 15.74
`-6.213 -10.601 19.326 1.00 15.41
`-8.282 -9.896 18.138 1.00 16.98
`-7.053 -11.553 22.231 1.00 14.86
`-6.456 -11.716 23.555 1.00 14.36
`-5.023 -12.207 23.437 1.00 13.90
`-4.805 -13.340 22.972 1.00 14.76
`-7.308 -12.762 24.401 1.00 15.17
`-8.524 -12.068 24.822 1.00 15.11
`-6.544 -13.417 25.556 1.00 13.94
`-4.097 -11.394 23.841 1.00 12.97
`-2.658 -11.630 23.825 1.00 11.91
`-2.248 -12.018 25.241 1.00 11.18
`-2.837 -11.528 26.209 1.00 11.12
`-1.939 -10.351 23.364 1.00 12.56
`-1.814 -10.268 21.873 1.00 13.91
`-1.746 -8.523 21.345 1.00 15.72
`
`-11-
`
`O
`C
`O
`N
`C
`C
`O
`C
`C
`C
`N
`C
`C
`O
`N
`C
`C
`O
`C
`C
`C
`O
`O
`N
`C
`C
`O
`C
`C
`C
`C
`N
`N
`C
`C
`O
`C
`C
`C
`N
`C
`C
`O
`C
`O
`C
`N
`C
`C
`O
`C
`C
`S
`
`20 of 782
`
`BI Exhibit 1003C
`
`

`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`ATOM
`
`149 CE MET L 21
`150 N
`THR L 22
`151 CA THR L 22
`152 C
`THR L 22
`153 O
`THR L 22
`154 CB THR L 22
`155 OG1 THR L 22
`156 CG2 THR L 22
`157 N
`CYS L 23
`158 CA CYS L 23
`159 C
`CYS L 23
`160 O
`CYS L 23
`161 CB CYS L 23
`162 SG CYS L 23
`163 N
`SER L 24
`164 CA SER L 24
`165 C
`SER L 24
`166 O
`SER L 24
`167 CB SER L 24
`168 OG SER L 24
`169 N
`ALA L 25
`170 CA ALA L 25
`171 C
`ALA L 25
`172 O
`ALA L 25
`173 CB ALA L 25
`174 N
`SER L 26
`175 CA SER L 26
`176 C
`SER L 26
`177 O
`SER L 26
`178 CB SER L 26
`179 OG SER L 26
`180 N
`SER L 27
`181 CA SER L 27
`182 C
`SER L 27
`183 O
`SER L 27
`184 CB SER L 27
`185 OG SER L 27
`186 N
`SER L 28
`187 CA SER L 28
`188 C
`SER L 28
`189 O
`SER L 28
`190 CB SER L 28
`191 OG SER L 28
`192 N
`VAL L 29
`193 CA VAL L 29
`194 C
`VAL L 29
`195 O
`VAL L 29
`196 CB VAL L 29
`197 CG1 VAL L 29
`198 CG2 VAL L 29
`199 N
`ASN L 30
`200 CA ASN L 30
`201 C
`ASN L 30
`
`-1.947 -8.694 19.570 1.00 15.95
`-1.261 -12.871 25.367 1.00 10.74
`-0.782 -13.282 26.686 1.00 10.07
`0.744 -13.300 26.702 1.00 9.99
`1.404 -13.746 25.762 1.00 9.83
`-1.360 -14.671 27.140 1.00 8.73
`-0.432 -15.644 26.587 1.00 8.92
`-2.796 -14.895 26.687 1.00 8.20
`1.226 -12.802 27.818 1.00 9.85
`2.652 -12.680 28.152 1.00 9.34
`2.906 -13.545 29.375 1.00 9.28
`2.148 -13.345 30.341 1.00 9.55
`2.910 -11.204 28.471 1.00 8.40
`4.637 -10.784 28.644 1.00 8.48
`3.860 -14.449 29.368 1.00 9.31
`4.078 -15.264 30.588 1.00 9.40
`5.462 -14.945 31.132 1.00 9.50
`6.371 -14.764 30.318 1.00 9.34
`3.915 -16.751 30.362 1.00 9.01
`2.562 -17.002 30.033 1.00 10.37
`5.523 -14.873 32.454 1.00 9.49
`6.835 -14.572 33.064 1.00 9.95
`7.368 -15.876 33.655 1.00 10.46
`6.613 -16.821 33.944 1.00 10.56
`6.729 -13.401 33.995 1.00 8.98
`8.676 -15.921 33.790 1.00 10.80
`9.407 -17.050 34.356 1.00 11.26
`9.203 -16.962 35.872 1.00 11.74
`9.044 -18.012 36.473 1.00 12.32
`10.889 -17.042 34.059 1.00 12.11
`11.147 -17.101 32.661 1.00 14.23
`9.223 -15.734 36.344 1.00 11.99
`9.043 -15.390 37.760 1.00 12.09
`7.896 -14.387 37.894 1.00 12.74
`7.335 -13.942 36.874 1.00 13.17
`10.329 -14.858 38.358 1.00 10.79
`11.379 -15.758 38.077 1.00 11.06
`7.550 -14.059 39.126 1.00 12.69
`6.477 -13.126 39.458 1.00 12.31
`6.865 -11.673 39.207 1.00 12.23
`8.054 -11.313 39.281 1.00 12.82
`6.005 -13.345 40.891 1.00 12.10
`4.697 -13.891 40.917 1.00 10.75
`5.859 -10.876 38.904 1.00 11.67
`5.941 -9.450 38.603 1.00 11.01
`4.635 -8.771 39.034 1.00 10.92
`3.546 -9.303 38.761 1.00 11.16
`6.240 -9.249 37.098 1.00 9.61
`7.452 -10.007 36.622 1.00 7.20
`5.002 -9.568 36.282 1.00 9.09
`4.771 -7.622 39.667 1.00 10.37
`3.648 -6.852 40.209 1.00 9.75
`2.791 -6.185 39.137 1.00 9.07
`
`-12-
`
`C
`N
`C
`C
`O
`C
`O
`C
`N
`C
`C
`O
`C
`S
`N
`C
`C
`O
`C
`O
`N
`C
`C
`O
`C
`N
`C
`C
`O
`C
`O
`N
`C
`C
`O
`C
`O
`N
`C
`C
`O
`C
`O
`N
`C
`C
`O
`C
`C
`C
`N
`C
`C
`
`21 of 782
`
`BI Exhibit 1003C
`
`

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