(12) United States Patent
`Carter et al.
`
`(54) METHOD FOR MAKING HUMANIZED
`ANTIBODlliS
`Inventors: Paul J. Carter; Leonard G. Presta,
`botb of San Francisco, CA (US)
`
`(75)
`
`(73) Assignee: Genentech, Inc., Soutb San Francisco,
`CA(US)
`
`( * ) Notice:
`
`Subject to any disclaimer, the term o( this
`patent is extended or adjusted under 35
`U.S.C. 154(b) by 0 days.
`
`(21) Appl. No.:
`
`08/146,206
`
`(22) PCT Filed:
`(86) PCT No.:
`
`Jun. 15, 1992
`
`PCT/US92/05126
`
`§ 371 (c)(l),
`(2), (4) Date: Nov. 17, 1993
`
`(63)
`
`(51)
`(52)
`
`(58)
`
`(56)
`
`Related U.S. Application Data
`Continuatioo-in-part of applicatioo No. 07n15,272, filed on
`Jun. 14, 1991, now abandoned.
`
`Int. Cl.7 .......•......................••..•.•.......•.•• C07K 16/00
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`FOREIGN PAJENT DOCUMENTS
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`El'
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`EP
`EP
`EP
`EP
`
`85058/91
`120694
`125023 Al
`0 239 400
`323806 Al
`328404 Al
`338745 Al
`365209 A2
`365997 A2
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`368684
`403156 Al
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`438310 A2
`438312 A2
`44035L A2
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`0 460 167 Bl
`0 519 596 Al
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`...... ..... C07K/15/12
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`........... Cl2N/15/00
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`......... A61K/39/395
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`3/1992
`10/1984
`11/1984
`* 9/1987
`7/1989
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`10/1989
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`I lllll llllllll Ill lllll lllll lllll lllll lllll 111111111111111111111111111111111
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`US006407213Bl
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`(10) Patent No.:
`(45) Date of Patent:
`
`US 6,407,213 Bl
`Jun.18,2002
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`0 592 106 Al
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`WO 93/02191
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`4/1994
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`(Lisi continued on next page.)
`Primary Examiner---1\nthony C. Caputa
`Assistant Examiner-Minh-Tam Davis
`(74) Attorney, Agent, or Firm-Wendy M. Lee
`ABSTRACT
`(57)
`
`Variant immunoglobulins, particularly humanized antibody
`polypeptides are provided, along with metbo ds for their
`preparation and use. Consensus immunoglobulin sequences
`and structural models are also provided.
`
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`

`

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