throbber
ComprehensiveCancer
`
`Netwark
`
`Naticnal
`
`
`
`
`
`
`ClinicalPracticeGuidelinesinOncology-v.1.2003
` ““““““Continue
`
`AstraZeneca Exhibit 2074 p. 1
`InnoPharma Licensing LLC V. AstraZeneca AB IPR2017-00900
`Fresenius-Kabi USA LLC V. AstraZeneca AB IPR2017-01913
`
`

`

`
`
`xmvc.mmgfinsw
`
`
`
`
`
`00::8ch:mmmfi.
`
`
`
`mmo:EEKms.:.5m
`
`
`
`
`
`u>.m:¢:w:n.Eou:mmEo...‘:03533::
`
`5233.:6.5.$wa:03653::
`
`
`
`(m2do4.23:2...Ewcofi
`
`
`
`:35”::3ch
`
`
`
`5:50:3chmac...:03.0
`
`
`
`as..o.EcwmmEmO
`
`DE.553.I5.01
`
`:3ch35:50
`
`5.5m3..an:
`
`33.3300
`
`
`
`
`
`3.::w9.3.me:3ch:mE$:=I
`
`
`
`5.3...333:3+03352:2553:
`
`
`
`5552::Eflwmactoz:03:ch
`
`$0.23
`
`
`
`
`0:....05.:m>._w.5..353...
`
`
`:3ch50:50m:_:wfiav..:ao.w3:052).
`
`0.2h£33...EOE—U
`
`
`
`
`
`as..95.:0.3.2:...m
`
`
`
`:meo:3chcamcwzuanU"Eu...
`
`
`
`
`
`
`
`
`
`33.55:3ch:wn:m"..m:mn.
`
`DE.553.n.arm
`
`:3::o3352::
`
`
`
`o>_m:m:w:n.::oo59:35.E3332:...
`
`
`
`
`
`:85“::3chwiwcmzflnEcumxzn.
`
`Ea:m:.E:.ma:menmE:03352:...
`
`
`
`:3sz:3ch35:28:63:
`
`
`
`DE.=wnm2.53m...
`
`
`
`
`
`as.60:2,“..1_:o..
`
`
`
`
`
`5:59:mmEEEoUmeat?..
`
`
`
`
`
`mExno:2:0....8:3:an:wucno
`
`
`
`
`
`$655580":.wEEEhuzgmash
`
`05.“£95.0DEB—3Q
`
`
`:Scwo.3..qu3.3:an:03.23.:2
`
`3533::
`
`wscscoo
`
`
`
`
`
`
`
`0::EEgan.50ch50.3.".0.22....
`
`
`
`
`553m:£22233..5min.ds..m>__moufinfim
`
`
`:3chwamcozflnEou$5...:twee”.
`
`as.car—£33m.....EEE;
`
`
`
`
`
`
`
`3.25.5.235..
`
`
`
`5:50:3ch
`
`
`
`«awn—Em:Eran—.50chwwmwhmZUUZ
`
`
`
`
`
`hmocmo“mmmhm
`
`
`meow._..>...6285:_
`
`maEEuEGSwami
`
`
`
`
`
`$.55:5.53onEozsw
`
`
`
`€5.5258:8.3:30:..
`
`
`
`:355.3..qu:BmcEmmg:o3552::
`
`
`
`
`
`
`
`a:53.2mm52...;
`
`
`
`as..:cm:w.uc<.0EEmem.,
`
`
`
`
`
`
`
`
`
`
`
`p.333”.:0".ch:omcEB:I“6:...
`
`:35”.
`
`:2ch:3chm:.:¢twv..:mo.m.mtoEos.
`
`
`:23meaSEE::3chEta:mm....1
`
`
`
`:2£25.50»:Emm..
`
`
`
`05.£00.m.motmzo
`
`
`
`5:8.635.53::a...533.5....
`
`«3:2:
`
`a:693.mEfism..
`
`
`
`
`
`3332:.:35”::wEmmfizwn
`
`
`
`
`
`
`
`33.35.5550fan.=w3mom
`
`
`
`
`
`02data“..mrag—:3.,
`
`
`
`Darn.nn2...5.39:520:5:
`
`
`
`
`
`0.2£me.0533.5
`
`
`:wocmomema655:... :352:02:.523.3....5533.w>o.¢w....Emcoiw.333: 3553::
`
`
`
`
`
`
`
`
`
`
`:8sz$05035.0:8".
`
`
`
`
`
`9.2635300....to...
`
`
`
`
`
`
`
`
`
`
`
`
`
`.zuoz:95.3.5:»:53...;$2939...305.3.58>5:.vgsuoaw:3B:.amE5355:...a...»3m35.3.332....$33»:3%.:.2:5£3.02.6:ch3.832:an.56ngSawQ3.38...83r553.».
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 2
`
`
`

`

`anEmmEEwsw
`
`
`
`00.,.3chNamatm
`
`mmucmafimEEEm
`
`
`
`2322.0$3..55530..
`
`wmwfi9.3:Ba:Eu
`
`
`
`KmUEme—wgzw
`
`
`
`
`
`
`
`UEEESOguitar»SHOCKGr:*CWLQ
`
`
`
`
`
`
`
`3.:.0:05...)Emzmam5EEO
`
`
`
`
`
`wasmvsm.mocmoEmmtm
`
`3%
`
`".855”me
`
`
`
`31:.Em
`
`:2wkm5<2
`
` 23225cm
`Efimwt...
`
`
`
`
`
`84,2223-2.52,m:5mama2826A
`
`mgmmusw
`
`
`
`EmfioszU$3meomi
`
`
`
`
`
`
`
`
`
`20“.32-2523,65::.633.252;mocmtzommranéozoufiocmamazm.
`
`
`
`3.525..m:vcm2a.:2womum-UEGEW2E2;Maugham.
`
`
`
`”N322%:mwmmmfi>2mcmwmxmocmtzommp6EwEwmmfi.
`
`
`
`5.3.25mmmwmfi2wEm.
`
`
`
`
`
`mg>2_m225$me$2.3...
`
`
`
`mzwcmmcoo5$20Emu2002wow
`
`303meEmmcozmncmEEcoE=<
`
`.3283$3550mmmE:{N
`
`
`
`”mzmcmmcco.03209502002
`
`
`
`
`
`
`
`,1.3.I..11).)».31.3.3.33).):1.3..r:..3....3)..
`
`
` @252SEQ2,6:02:01Emzm‘mmgsim.
`
`
`
`
`wEEoEmzoEm>:.u<.
`
`
`
`
`
`
`
`
`
`Ems:$20552Em§.u<.
`
`
`
`
`
`
`
`
`
`:m_o_:__o>5....EmEH—mm:9wmzomoaam2930322:95...69.52...559.55%.9053m5.6mnwcmmcooEEwEEfiwmEmmmczwyzmmme.
`
`
`
`_mu_:__u533225.6.waB9:EEmEmwifienwEEwucwamuEmm:BumfimmxmQmmémwfim39:23:8.023w3923m322cm5$55th.0:3223:3959o:$mexEEmz.mocmom>_m:m:mano:3ngm2....EmEHmmb.5$8$233mamw:_E§muEmmucflmEzohu
`
`
`
`
`
`
`
`
`
`
`
`
`
`SE...»3288m5502:?ES.3mE33359mu.0:3EEma:€95.52:9.:ucm353.2%33%6meme3:9.:5.2.0252.3chm>_mcm:m.anu_m:o_2m2.532:92.38
`
`
`
`
`
`
`
`
`EmmmeuSmmmmE.gm?35E33.6Cowmflaam:9:5..3:36:03»...35wEEBmEncmccsmgaam5.mm:.EwES:9:962me2w>momflm23
`
`
`
`
`
`
`
`
`
`
`
`.moow©.2002E:Qwflztwn
`
`2
`!
`I
`
`
`
`
`
`
`
`
`
`
`.232.o:335»..5......$83....5.35....£5.a...5333......E.2.2»...Sagas:"E.2.»$532....33p32%....«2%.48.€2.32.8ch$35538825%:m8.“@3.32.88..5.3.5
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 3
`
`
`
`
`
`
`

`

`
`
`.xqu355326
`
`
`
`00%“mucmuHmmmcm
`
`$055ka.2EEm
`
`
`
`9523.6.56ch$352530m
`
`3:3:90325¢...
`
`
`
`
`
`
`
`udEEtEG«EsccficteacEcmEum5““.chEmwzmZUUZmmww
`
`
`
`
`
`
`
`
`
`
`
`
`
`£353332.3033w_23.:.32505Erasing.55.3220aEE333333a53EmanmcmE$3as“35“Egg20.02”23:.332:0
`
`
`
`
`
`
`
`
`
`
`
`.oflmsufi$_Em:832:....33333EmmcoswucwEEouE:6.“£02
`
`
`
`
`
`
`
`
`
`
`
`
`
`F:202m.2002B5335.5.»5&532432:323....»5.3.Ea5“.3...“6.62an.6:ME...5323:...55“EnRafi—vim$2....3339.mi?.3as83%:.69chgmgfianu323w:mcuw@85w»?.83_comma.»
`
`
`
`
`
`
`
`
`
`
`
`g
`
`AstraZeneca Exhibit 2074 p. 4
`
`
`
`

`

`F332.
`
`
`
`xmus$56220
`
`
`
`09;$0chEmmi
`
`
`
`3055kaAwE"mgmflw
`
`
`
`80:05u535m>_mm>:_:ozsewnwvwsosfism
`
`
`
`
`
`
`
`
`
`
`
`
`
`mas—Ezr—nnimogm_w02w<_n
`
`
`
`EwEfiwfi.«Eta.3m
`
`
`
`«.2073
`
`9.szsz$0sz“mmflm353mm
`
`
`
`
`
`3:32.90323E.
`
`
`
`udmzfima:wEmES
`
`.chwam
`
`nzwnofi
`
`
`
`3:233.»EOE
`
`.68$333
`
`amen—mug;
`
`
`mEmEEEE0552:on.5333,35mg
`353920.gI3:»5new:.mEoEEmo
`
`33:?$9353.....2262AQWMWMM
`
`
`.3929
`
`
`
`-EEmEEwEmcwEmE:3:3353me35.6385359:533:33EmEEmEwémmm:Ewfio2:35EnmELotmamm$2:332539-013
`
`
`
`
`
`
`
`
`
`
`
`
`
`.uEwBuE3.255032...:«wbomafioEm3335:5532=<“En:
`
`.erOZmman—EmamaE5::mwmo
`
`
`
`
`
`xESofimmE.33mam;anzmcofifixmwot
`
`
`
`
`
`
`
`.ummfigug2333mm.333:325.9E5335??“.3..."325.0mE225:359:3EmtoEwEwmwcuE«mun2:5533:32002"withEnEzu
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Nozczm.2092we:o_wa_E..wnc235;3293a...“505::Fun...andE@3335».on5:.amEcos—Ema:£5.23005.35532.;$332NEE..39:.€0nghwucmuwawcwsmEEoo.mcam—mzmgw@Newman?.chwF5:392
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 5
`
`

`

`
`
`m5mc.m.anEoocozmuo.BEBmcw:mE56.98:35.oxEofiflme53.,
`
`
`
`$2...$5.35
`
`
`
`
`
`00,...Lwocmu“mmmgm
`
`
`
`
`
`m8:5.992Em.
`
`
`
`
`
`hwochummmhm¢>_wm>:_:OZ
`
`
`
`88...:1328:0535.3503.55m
`
`
`
`hzmfibflmmh>md—zEn.
`
`
`
`
`
`«we::nEz.East?aESaEmmE.30»
`gangsta—.32H22.3mm...
`
`
`
`$2892...»EOE
`
`
`
`.5N.3323
`
`33533.5
`
`mug—£92.".
`
`_.£.m.*.bnwuFm+~=owwmnxm
`
`5
`
`Ti
`
`mun::nEm.505.3>E203me.3o...
`
`
`
`
`35.53553.u.".cosummmfi
`
`
`A!!!.2:m...v.=me
`
`«up...26.6.552....
`
`Eamon.mww
`.3.
`
`“5:3wa
`
`#120.me
`
`35.82.3099.H28:33.“.
`
`
`
`ufiwzummm:2.5.55.
`
`
`
`
`Siécfiubong—3.ace.“:o_m_uxm
`EcmzwaE9:99:mémmm:EmfioSrotaE350th3>3:.m.co_fimmw..mmn
`
`
`
`
`o.EnmcmEm.0:Began..yaflmz.@3588Emma.9...:me
`
`
`
`
`
`
`
`
`
`
`9.2%:_Ewmcoo-.mmm..m_38038659200mmw:
`
`
`
`sEBoSmmEEB.3m...2:955563wmtéafiE
`
`
`
`
`
`
`
`23:52:».505.3inguwwmmE.83
`
`
`
`
`
`LG
`
`
`
`3.36.“..5.+1.83mea.2
`
`
`
`«“553».2.96
`
`
`.mmw,mucmtauw..32Exw:cmmmmEE.EEEonS».mucmawoomPEEEa
`
`
`
`
`
`
`m...o.$.29c2623Emsma.8$5.20.cosmfiwé305.2,5.386
`
`
`
`
`
`
`
`.EEwE.ucm“mamadam5E25658:.8wcm
`
`
`
`
`5:02»5mafimzwioms6:39...E.58..53.,cosmEmE5me22>?
`
`39..E3353328633Eawn.8E32Snow63SEE0.Emma
`
`
`
`5.3qum:zmfitaoaamma.3E65man.5.;mEmzmaugoflmmmam92.:
`
`
`
`
`
`
`
`.«-202mman,53.9mE5:.mmwo
`
`9:385mfiocLug....mEEmmm.6mucmEEtmn.9:.989me$53.55
`
`
`Eflmnnm5.33:33B52:30:.=mew.5330...$.0960.93matczmu:9:.0mp...mg..m.35835?...gm;2acne.2E?manBan.
`
`
`
`
`
`
`
`3.3.:we3m_man.95“.Embmnnm5.3Emzma9::3.8.238mmmmE
`
`95aE933:235anEcmmenawEm.9..mewvocFEE:52.53
`
`
`
`
`
`
`cmEEwnm5592..om_w...m:wBumwcmEauoumg2:055:03232an9
`
`
`
`
`.Eflmazcmmg9Emmaam5.669.:ucw5.32.»..255...>823.me5.2,$333Ehwfimcof
`
`
`
`
`
`
`:o_m.oxm-.mon_v.>:nm.mcEEmE5.205-...”th“EmEamfioEEmE
`
`.5339»Bmam8Sn
`
`
`
`
`
`
`
`
`65.0305mus:ES...5533233m.0wocmEBtwn
`
`
`
`co.m_oxw-$ExEBumfimE.EB.mmmmmwfi@335.gm;2vase».£5:me
`who:FEE...mEonE.mmmmwfi=mmflm.6,_$5.3mmm.,nmmmcmEma2,39%
`
`
`
`
`
`
`
`.3305...3.3.2.393.5..«N.5933PaaccznucwEanE..<“$02
`
`
`
`
`
`.mEme
`
`.350350E€am50EEmE
`
`
`
`
`
`
`
`
`
`35553:»3.3333w.2m...REE?:.333...:thit.325.».ac.m.ESE..35"..8.“.bEwfiwuucwE$3a....5535:2.20025.3....$25.0
`
`
`
`
`
`
`
`
`
`
`
`miozm
`
`
`
`
`
`
`
`
`
`.232E5.3.53;25...;$2932:32:3.53a.»s338.3.3E:.5:5.3.2:.«E.a535.859was....32393%,:.3Us.56sz.8chfimcofiaeoo55%:33@Emma.58w..5.3%
`
`
`
`
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 6
`
`
`
`
`

`

`
`
`anc.mmgfivfiw
`
`wmocmpwh—mmmE
`
`
`
`Gehggaém.uammwhmw>_mm>:_:oz
`
`
`
`82...E,..828:0585.2330muzomi
`
`
`
`Emozjimxfinwhzmfiqumh4<u_wm:mhm0mEDD
`
`
`
`
`
`Hmwmzm3:5am
`$553.5~3ch
`
`
`3:3:503wish
`
`
`
`
`
`$.355AESuEmmE2:2,2.5335“mafia.mbmwmfibcouE:E25,_,m:v,_>_u£fiflmbngwu:338:mm:mmficmgm$323wonw.cozmtmmccu.nmeEvswcozuzummx2150chEmmzm200286mam”.Emtoné33:33gm8%,:E:ozEwEmcop
`
`
`
`
`
`
`
`
`
`
`
`
`.uflmuifi3.3333&5«a3%quEmacozwucwifigfi=<$32
`
`
`
`cozwzwwcou33.55:?35¢:$35$55.539:E533%.gm:$25.3.cwtonmE
`
`
`
`
`
`
`333:..s3:.E0353.E.95.EEoSmnEsa pmEEmoEEmE.Eu:3:Eam.80:25529335.3333:flcmwmm.V332:
`
`
`
`
`
`
`
`
`SEE:mEEwmcogmmEn5:3:23:3:35.“..
`
`5:33..me35:5$33.:2.
`mczmmczou.a”5.3055:35595:osfiwEmcoomEEmmE
`
`
`
`
`
`53ch53.5200202m3m.3332gm:.8
`
`
`
`mmo233532.5:35...qume
`
`
`
`
`
`".3;Emmam.5;:mronE3:550
`
`
`
`3:953:Egamui
`
`
`
`
`
`
`
`uomflagcm233%»m_Eat“3353Ecozwfifitun.35335.9mEm_23330:8ham3EwEwmucwE“man2:$5$33392002“with$25.0
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Giza—ZN.3902BSEES".:35?$2933:,33:!.53an»E30:023..35:ha...cassava...35v...»35.3393.2:.323985m:.3GE.EafimzL85023353an“33w:8cm®«Qmmar.88.vcam—w»,
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 7
`
`
`
`
`

`

`
`
`anc.$5.359
`
`
`
`DO....3chEmmam
`
`mvcmfiwwmms.53m
`
`u.mmofiw>.mm>:_:oz
`
`
`88.E.I.8285c.
`
`35.0.9.3.3:03.”.
`
`manc.3.55£9.22
`
`
`
`
`
`25mm:m.o:o...:..m.u3..9.553.33......3.32.3....mzcfimnsm
`
`
`
`
`
`
`
`
`
`3...o33:30.39;3....0So35.53.32200.9095E93:
`
`
`
`.833....mcouficcu3.3.93»;.0E33333:3.5.33.3...:.
`
`
`
`
`
`
`
`
`
`
`3.23.36.wucno«maxim35:52
`
`3:33.....93%...
`
`:3.3.3..333.26.3.5.3.3m33:3352......3339.33.95Emmw.
`
`
`
`
`
`
`
`
`
`3.555..3585...BEEmoo.mEEomm».m3umw.>3...ucm
`
`
`
`
`
`.EE3.«Em_.5333.3.5.3..mEuEmw.
`
`
`
`
`
`5:33.mm3333..2%.?3wEE3cm....33.».353.2.an.
`
`
`
`
`
`
`
`
`
`Sn.:03......3.5360...mumskumc..355.93:3...6cozmuo.3..
`
`
`
`
`
`
`
`
`
`.3336...3.3.5.5032:...«N30933.3....mco.wuu:wEEouw...<.352
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`633:3...»2388mmw.m5....336c.5333...“....3...ESE...ac.a.2.5.5...35..a...“.b.555..an$3.2:5533:3...zuoz3.3....325.0
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`{Izozm.zuoz.95.3.5.3.can...»32......a....35.?5.35....2.303.8533.3.a»...5:33...a...».253:23.3333....323...3am:.3u....fiofimz.350gficmnEnEoo.9032Saw®NEmfloF.moow.5.93...
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`.
`
`AstraZeneca Exhibit 2074 p. 8
`
`
`
`

`

`
`
`00k.8ch.mm.m.
`
`
`
`5......85.8.26,
`
`$39,939..ms.5Emmocu._..>I.Sofiuzo:.
`
`
`
`
`
`
`
`DEMOwwwwhmw>_mm>:_35.23363.55m
`
`
`
`
`
`
`
`maize...4.4.2230
`
`maxim
`
`Emma5.55“..—.mz...5
`
`
`mum—wan..UmU.-a:.62.E:
`.3:..mama
`
`
`3:93.8ch53.3mmmmu.3:3“mafia.323.3%5.3.x.23.3.5.2....62“N...
`
`
`Ewmmwfiwfi230.33.852...@33335.3:.m:«mm
`
`
`
`3336:..53:aanewwcom.om.5a...mafia.8.3250.E:.om:.6ho.mEEovnd.2.....oz.2.as“....ms.42.2.t.5mmsuiwwsagnaw...“35:03as.“3,..u...E.£3Ewuwfiiuo.up.
`
`
`
`
`
`.3“Eu«.mm....25mswflm”KENBEEv.05.355.290.aaw32>»:.330:qu.22.2Fr
`
`
`
`
`.35.<..amfim.3:mm5:33.95....Em..moEEmE.5323£323.50.a:.2....8he-..
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`$5323.1650an$353:3me
`
` MES:Q*0$33,.
`
`
`
`
`
`0....5.,ImE83cmDI.9.6..9.2.mg23%95mm.wimlm
`
`
`
`.19“..3Egacoom...2.5%+N.622$.
`
`
`
`.z,2w..5wwfimznmosn3.35m355.»t53.3.35.9
`
`
`
`.AnnEomfinv.as...\2.3
`
`
`
`
`
`
`
`
`
`638%....$259.333:...«N289338w32333.53“::4..83..
`
`
`
`
`
`
`
`
`
`3353...»3.3.43.3m.«it».3.c..oc.533.9...3.3....3_:._owc.w.333.....5058.85.bEwEwmnan33.2:$5waamfinzouz6.5....$256
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`7.325.282.53.3.;5...;$298a...32...;EB.26a.332.9.36...as::ofiawz...3...«in$5.333.2:,83$!9.......38.SEE....8anafisfiasou.23.»:we...”a.mama...doom4SE?
`
`
`
`
`
`
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 9
`
`
`

`

`mam
`
`
`
`gm:
`
`3.3%
`
`acmfiammfi
`
`“Yfizmmw
`
`
`
`.36....$5.350
`
`
`
`00F50ch.mem
`
` mm5.6%.”.9....EEm
`
`?_wm>c_$532303.8an
`
`
`
`
`noon.S;..323:0:.
`
`
`
`
`
`0.230".0szfihqmmhJiZQGNKOUOJ
`
`95:3".wm
`
`ummwo:
`
`..
`
`sEoSunfiz..._,wave:udcosuwmmfiEnzim_$3:onm;=u..30.
`
`
`
`
`
`
`
`mane:“$3.“..me
`
`
`
`
`
`22.3waa309.8.$2833..32:5“
`
`
`
`
`
`8.3.286.2.go:EmEEmE.mEmE.m...Bcmzmmg2.6%cozmfifimazmmb9.305.6memg..mw.Ema3mEEmE.mEEEw...o.EmEEE.9..
`
`
`
`
`
`
`
`.5....3352.2.8.905352.8.5.".9m33:FEE».EmEEmE.mEmEEw
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`.23man:cast...EmEEmE.mEEE9:B853.3mm._.DEm...».EEBDFD.mEEonnw
`3.3.2:.32::<~Bowman».En333332539.:4“302
`.3323.
`
`
`
`
`
`w..E83>...wmmmo,..mc.33......mp230%,mcEcmaEwEEw:.5..m,.,mo.oocc«Em5%mg".9620:.mEmEm.mcozfiumB:36mm39:confimgmcovu
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`$52.»...$23.16.$553.:sz$35309.
`
`
`
`Samson.$85.5.2.8::2:5..252aE=
`
`
`
`
`
`w»?.3Ewuxm.6805mEEwmcou
`
`:o.§=.:m:auw._
`
`....3.5.5.;5°53»?.50..
`
`3
`LO
`
`
`AstraZeneca Exhibit 2074 p. 10
`
`
`
`
`
`
`
`N525.23:35.3.5:..53.;32%.»2:52:?E3ing.as...3a:3.3.has5:333...3...2585.35".82:..3282£9..2.8.Saga328wyacmzensoo$5.32”S“@Neg....83.78.2%
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`.3353...»3.5933n.23.:32....»:.:o.3n.u.tun.62....nfiEEac.m..533.6953>5“.5«55anan“mg.a...»«a...35.35200:unit...23.5.0
`
`
`
`
`
`
`
`
`
`
`
`
`

`

`
`
`xmewwczwflse
`
`
`
`
`
`
`
`
`
`mwfifigsw3305...".m8:EEK92EfimMOON—.5I>mO_Ou:O:_09588395hwnufimomewhm0>_wm>:_
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`m9.33:EmEEmE.2:me
`
`3.335353+=m§“menuS.535236953853200
`
`
`
`
`
`EmEEwE.wESE.mEmcou635m_.Etw:30333$352E3;m;
`
`5252:33..m>“PM0::fl$53559mmBangui.Emono:
`
`
`
`
`
`
`anEomfimuwby.«we:EmEEwE.mEEE522.35E0333
`EwEEmE.mEEE.33223:9;EE0::m_$53.23umwuoz
`
`
`
`9.3.3:
`
`
`
`“35$535.35...»+=w;“was“.3.EEEmzuoEwe—fimom
`
`02:33.vN
`
`
`
`
`
`
`
`
`
`Ofiézfi...MOmm<mwaM:ED.<=._mmdhwsac—2.1.0“—0hszH<NMhJ<205mm0004
`
`
`
`
`
`.33“3:".B.5.mnmhmfioszfimon..oc.Bommfiwfimwflflwmfi
`
`
`
`.36:go::aEbEmEEmE
`
`
`
`a;mmno.55.8At!ucmEummhoEB=an“by.u.Uucmmwuo:«35mm:
`
`AEEVV»3292:95:
`
`kma2iii...“EaEumw.5qu
`
`
`
`ucmmwuo:magma:
`
`EEFN2.53:.
`
`
`
`:ozmfiuacooBEwEHmw:9:023.35:23go:EmEEmE352Ea»:3cmzmmm230%.......~u.E.3353
`
`
`
`3366538352532m$3::35meEmE.mEmEEw.m.>z~m3:035i=3vcm€43.25
`EESE05S393:32‘EEms;mmmmo=mE“55:3we23%9.2.53EwEHmm:Po.Emoflouco.fimwbommwmuv.55szM\mDPOEEEoEm
`
`
`
`
`
`
`
`
`
`
`
`
`c0559mczmw:9:B:25me9:Hm.2Ba;EmEEmEREES9:”cmom$2033620:.9:me.mcozfium2cw>_m_M%>mE
`
`
`
`52.x,“.meSmmmwn
`
`
`
`,ucm$33£5EEmcmn,_w>_>._:w:085,23_¢>w_-cmE32332592P555
`
`
`
`
`
`
`
`PmEmocmwnm9:E:6.m_85:39.30.Exm:
`
`
`
`£2355$535032::S.“Eonfig3wmausancaEEooo.=<"302
`
`
`
`
`
`magma;wEmEE5:025:0quH
`
`EumASE3.
`
`5:3>E£uflmmE.58.
`
`
`
`
`
`
`
`
`
`
`
`“Kwanzaa—5233333Eat»335.9Ecozwfiumtmm.35535.»nEEE33:.50cha...»EEwEomncwE“was3:«up:3532.2002"with$25.0
`
`
`
`
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 11
`
`
`
`
`
`
`
`
`
`”dig—m.2092*0:2mwwntwn5&5Swan»3:Eons;55*>5Eragga?3S:33:cos—Ems:£5E.»33:0an32:,,qu$2$59...3.Q....éoioz$950gmwzququo58memam@QO$ov.33P:23»)
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`

`

`
`
`
`
`.ufizmm.mmsgww,‘sg.cEa:uEgan...Eu3%;zafigfimfi.258
`
`
`
`
`
`
`
`
`
`
`
`,.Ew>zmud@a@
`
`
`
`33:.$55,926
`
`
`
`
`
`00.,5050Emma.
`
`mmocmafims.c.Em
`
`o5“En.
`
`Sn.5.NE.E.
`
`
`
`.bu...xmEENw.
`
`
`
`.szn.5:2...van
`
`
`
`.flmfimflwfiwuoc
`
`
`
`
`
`m.>2.moww.3.35.3.EOE.o953EENAw.mEmEmEEOE
`
`
`
`.80:3$3.52.932
`
`
`
`
`
`”mafia:sacs.Em...xw
`
`
`
`
`
`3-5.252.36:0“.0mm
`
`
`
`
`
`.ENEamofiu.gamma....9309306.9.,cofimmawaE
`
`
`
`
`
`
`Nim...693m29.05.:cm....wme530:;no...6233.ozmnnEzoagqm
`
`
`
`
`
`
`
`323m:«Sm:as;$5.95.mmsmao:mEma:.co_wwm.n_a:w.co..m.nm
`
`
`
`
`6.33::m.EwafioEwcoEm>ivm
`
`
`EB.Emcmn.£20me9...5330...$2.639mamtxcEm.BvanEmEEoEmzoEEcmcmn25.89385ch9.35:0.cwthm.5.3>._m:cm:wmm
`
`
`
`
`
`52mmm.220%3.32.Egaummm.52.amtonm..3533.2.0520.
`
`
`
`
`
`
`
`
`
`
`
`cmtonm.BmeLmEDszovumo.co.m.omum5......mEman.me3938.:ch
`
`@3393m5.3$9..c.5.303%.nmw..m:o.>.,n:.mg2.5%.....mEmmm.Eca.0Emcwn..mEmEEuEm...was;5an52o,5gm2830.5
`
`
`
`
`
`
`
`
`
`
`.3335...3.3.3332::3Eomfiwc8w30:355....»wa..<”$02
`
`
`
`man....3macswucwEEoum.EEmfioEmzommeo.EmuEwfiEfiEEm05;?
`
`
`
`
`
`
`
`
`
`
`
`.oxm.....mEmm...:m.c.E_.uo.ucm5:0...quxm:B.5:3835238+mm:5
`
`
`
`@3958.mwmmmfi
`
`
`
`
`
`.mcoEwcoo
`
`
`
`22.0an35.552385.;33.3239...9...2:95.cwEHme6.0m;a....26
`
`
`
`
`
`
`
`.uwmflacuco2.33%...w.mi...».33.".:.co..an.o_twn..35.32....»uc.m.22.3.uocwua...“.6«52.3%.»...«mg.m...»:2:35.2.3zuuz“with.uu.:_.o
`
`
`
`
`
`
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 12
`
`
`
`
`
`
`
`
`
`
`
`Vl>7=m.2002B.5.3.25...avg...)323$2..53¢?E335:.3033;.anon.S:has.again...a...»a...»35.3.339.;328253m....36:.£23235ch33555:.8.mcomwzmeow@3&3?58w...egg...
`
`
`
`
`
`
`
`
`
`
`
`
`
`

`

`
`
`
`$525“3525520“$33.258.52m
`
`
`
`Sun....5:Ego:Em>=.u<mam
`
`i:infifiofimso
`
`
`
`xmwc.$56236
`
`
`
`GDP50ch“mmfim
`
`wmuzmnflw.m"mE,mcfimfl
`
`
`
`.52805350232..mommgfismfivg
`
`..is
`
`
`
`
`
`
`
`.rzmfiqum...h2<>31fl<U_Em.—.m>m
`
`
`
`mac—130:0.»wwm_
`
`«53.53“
`
`
`
`anus—#3530@353:533255561
`
`
`
`2.Beam—m3.633azfiwonmuoz
`
`
`
`EEK—En:29E.6983EENAEmfimfimE20E
`
`
`
`
`
`
`
`.6302.3259+.mfigm.8.u.aI39:an.5255“?mate:Aiii.Egan?.2:.man.FEE).32:5“
`
`
`.
`
`
`
`
`
`5:3wwflfizgzuEmgEzozwEmemmt.20m;on5.5$05L8mcozmucmEESmLmamEEoEwsowme9Emu“56555mamEmit
`
`
`
`
`
`
`
`
`
`mcoEvcooEEoEoc55395238
`
`
`
`magnumEmcmtonE“6newEEwEoszu32.6529mg...»5an52o5“am.£35052599mmm:23$9:5.m__m_omamm,umwzmacsfigmm220%cwtonEBEEQEOEwLoBum.Bc22339.?.=mEmma3EEEwEaEwfiEn:E38328%$5,535.81
`
`
`
`
`
`
`
`
`
`
`
`
`
`.3950:5;,$an.mmzmaoEEmaEcongacargoc2569.5135%E35955E35::mem5ESmtaansmmucus}?
`
`
`
`
`
`
`
`.__mEm83EEmifioEmEE59.3358995m5
`
`
`
`
`
`co_mww.a%mcwtmpoEat35:3gszfi3333@83163mmmin.5“;nm>mEom$585:553.60ch5.35magmoufioamomb
`
`
`
`
`
`
`
`0:35an53805069.”.Ecgwwmauammcozwfim5:30”6E339:.585%cargoEatmmcmEomflcm.8E53IKE:3”.
`
`
`
`
`
`
`
`
`3525‘55:REES:E333mmm.5:on33c230:m8522333Eymho»,EmErm6~o=mmc§
`
`
`
`
`
`
`
`
`
`.5353:BifimfioEmzuEw>=€w“53on«>2
`
`
`
`.ufimflui33.55032::(aEpmafio2nmcozmvfiEEaua.=<"3oz
`
`
`
`
`
`
`
`SHEEESEEQmgaozscwtonESEgmzcmscmm52m32...chEEQEEminfimmmmum:cmtonE“EmhnmthSEmzu.
`
`
`
`
`
`
`
`
`
`
`
`
`
`.vwmflznuco3.3233m_£33335.0Ecozméumtam.3:325.9mE332:3.353Ag3EwEwmman$32:55392.3:00:"flat...325.0
`
`
`
`
`
`
`
`
`
`
`
`
`
`mu>7=mion...3comafig2%$9.989552E;:5»a.»5vacavOEE35:>2:comings35E.»35333Sat.33323:?as.05Sofia:.8503mmcw§u500mwcogmzmeowGmeNBw.83‘F5%.?
`
`
`
`
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 13
`
`
`
`

`

`xquwmczmnsw
`
`wmucmkmuwwmEEEm
`
`8%ngth280$35m>_mm>:_
`
`
`
`Saw.vsa323:05mmEEuSE3:03.".
`
`
`
`hair—03>445—230
`
`mwdfim
`
`
`
`
`
`$53330Emir—3E2“.3:52.02;
`
`mumww
`
`5030:“;L0):0mafia.a_fl_mum”2252.”,
`
`5.$3
`
`mmunsamfirz.EEmoEEwE.532323053:.22.2....3.
`
`
`huh-Kammo—U.m:meM
`
`
`
`
`
`
`
`
`
`
`1.33%.53$.6:35922.9335»is$2...wEtawmwflaw:up.”mSEmmnEmBEBJMhommflprhmfim.22“r2.2.
`
`
`325..$2055;.as.a:m...
`
`
`
`
`
`
`
`
`
`3”.quth.sac—v.3332E:mEEmwcooEmmiu
`
`
`E.35.32=333.3:220.33:3»25m.cw
`
`
`
`mwch—EOU‘*0fits“.
`
`
`
`
`
`
`
`.vBSWuE33¢qu32::(a399.500.5«cozmucwEEooE=<"30:
`
`
`
`
`
`
`
`55%9.:9%:mcouma232mmczmfl«-mmxm
`
`wczwwmzw.3ch“33m3Eamm.ImEEnmcbccoo82.6%+N3:320:.Ex.19;
`
`
`
`
`
`._.6mum—mimosawczwiw3353.5.5mEoEEhm
`
`mEEmmcoo nmwBowman.Pt3mmflwfigi3:3.»3533=333.953...”SEE=mmfim:835%.»;E:._ow:.6._.UfiEEouna...3*Emaxw>593
`
`
`
`
`
`
`
`
`EN3035363.5.3wrath.Ezra“.
`
`
`
`
`
`
`
`.uwmfisoucm3535mm3Ear:Rug—uEcozwégtma.EE_3_E_uaEEESE:59:33.5“aEmEommzaE«was955535:2...2002“withHESS
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`@525.28:.333.5.2.55:3$230.5sons;E5.a."533.92%.on8...3:5,553.:.359;Reign32:.82me“2%"a.9:€2.3252.8aficwnwaeou35%:88g«232.88VEma:
`
`
`
`
`
`
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 14
`
`
`
`

`

`xwuc_mwc=m2:m
`
`3m
`
`mmocmkmkmmE:ESm
`
`6.5m>_mm>:_
`
`moow.w.)I328:0E3552303209;.
`
`
`
`
`
`hzszmEESE;mezzo—9300335300.:—
`
`
`cosuwwmzu£sz
`
`
`
`mEEuflmmEwww
`
`:2_m>w_ncm
`
`@525
`
`
`
`.533meszmE..93"van
`
`
`
`mason—gym“:wow
`
`Sfizav
`
`MEa“uwm‘Eaangagwsmim
`cczuammmfiwzmxw
`
`
`=23%::33
`
`@4925
`
`acmEmmwcmE
`
`
`
`
`
`EEansmzo339%9.33firm».3:52.cozmzomua
`
`
`
`
`035.335A-.5”.awn.6554.2!:=qu=o*0A415mm...“
`
`mac:
`
`9.3%an:mwon
`
`*0gang—moo...<2...H$353:35
`
`”6333San.
`
`
`
`
`
`3.5.25newT>2_.m:jmocmu5wa=2%.gmymgm5.uwn
`
`
`
`
`
`
`
`:o.«339:.mum...
`
`
`
`
`
`.885E:5338gm:mszEm.mambmfioszoEmma‘2memancBEEnEouB55:5:<5
`
`
`
`
`
`wzzwumzw.35chawn—«Em.353mm
`
`
`
`
`
`
`wacwwEOU*0Mina?
`
`
`
`39a6293wam5%323%..a:5ESE»B03:00.acm5cmwmwmmfim>,_,mw9m9am_9?::c
`
`
`
`
`
`.xEBomfime
`
`
`
`@399:REES:.8”mm333mg
`
`
`
`fimawgufigiant".3.2::«a63339amcozwucuEEaQE:<“302
`
`
`
`
`
`
`
`
`
`yawnLE$955$55.02wéfiwaoma.wEwcoU.mcEmm$3930me9:EvwfiEwcoo3Amp:
`
`
`
`
`
`
`EEmcEszo235qu5..Smtnoanm5:9m.5méumuon;90589.mac—EonEamon
`
`
`
`
`
`
`
`
`
`
`
`
`mmmlwmvmcfimwE93?9:EnwwcwEEoom.mcmEaEEmLmEoEmzwmmofi“$5chEacfiwm
`
`
`
`
`
`
`
`
`
`
`
`
`
`flank-.3523033E2?:332:".E:Safifimtum.35.3250nEESEE:53:33.5339:39.9:332:E5mw>m=32002"with.$25.0
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`hn>7=mion:3=£w£§¢n=33»?33:32a“3233.53at"c.392352anan:awn.23.533:35vanwufifiggawash.33va3:9.51.05.fuéwz53:8aficwfianU.mcauwz83..Q“989.mSw._.egg}
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 15
`
`
`
`
`

`

`
`
`
`
`EmEEm:.5336305.3699.59..m....uE:go:59:...EmEEwE.mEmE.9...o.3536....w..9.$9.»...$28..mc..uwfiazmg2.6%9:56...
`
`
`
`
`
`
`
`
`
`
`
`
`
`Pm.3........w.:o.>m.ow.n.:w+:5352.0.
`
`
`
`xmvc.meEnSG
`
`
`
`aw;..>I>moon::.
`
`
`
`
`wig“....3chEmmim>.mm>:.85:35vases...
`
`EmEfiE545:3...Emsfimmp>35?«5.2.50338302.".
`
`
`
`PF.EaEEwE353:.5233
`
`
`
`
`
`
`
`:.Eomwawo.magma.mmxcwtonw.....
`
`
`
`cmcoznom.by.anwoflmmEumon
`
`.25
`
`
`
`
`
`Du>2_mn.—..E.ECO—FET—wcm>=.—u<wwm
`
`6.5.$35.333%...3+53.5.
`
`
`
`
`
`.5.EmEEmE.anE.5.9.33
`
`
`
`
`
`2.3333.3:32..«Ew.=9...on3..
`
`“Em
`
`D525
`
`
`
`
`
`Eur:.mcoEEIEgzha.mam
`
`
`
`
`
`
`
`
`
`
`
`@525.23:33.8.5.353...;$2332...35.;EB.25a.wasps?3.2.>3.5.33:...a....2...85.8.3$2»3E9.2.......40:.£33.....828gmcucmaend.233.88a33298,F6.29
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`m>:5.on:m.5.63.330”m5.333..05.car.>533.me
`3:.:5a2.uhw.E2..wn.5”mono:386:3...»an5.535339.a
`
`
`
`EmEEuEEEeETé.LwEmzou:*1.mcowfiumhwfimcooAll.=33”.meEmEme.
`
`
`
`
`
`
`
`meEmE.mESE.5.—..muficooVmwummAll333550;...Al5.53m...Ea...xmE.
`
`
`
`
`0::m.3.3.“...200.mhomwwmo.Ecosfinm.3350.96.5.3>E3uwn£3
`
`
`
`
`
`
`
`
`
`
`
`528%“..oEEwfiEowE.3893E.Econ.5.33.558...Emmi9052.5.5”..3...an3.8.9053.6252......Emmmuo:3E...EmEEmE.meEIE
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`.05.8.369....mw.Em...EmEEmE.meE.9...2EwEEmbm...3.3.653.29..go:3E...EmEEmE.meE.9..28.9.66
`
`
`
`
`
`66...BmEEmE.mEmE.m52Ewanan.2.85.E53.533.350.558m..E99......398_.mc.va.._SB2:059.56...29.53....5..m_mo.ouco
`
`
`
`
`
`
`
`
`339.38%2.385%m.awnBEE253m63SEE3“EmmaEmEfimh9....3.3.5506.3wwc:EmEEmE.mEmE.9..B:35mm.Esocw.62.3.5.0Emwmnoc35>.BmEEmE.meE..:.5329..6mmm.63m5.86m.9.59.«0.5.65:236m...E.w.2m:BmEEmEREE...9..9355C.
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`.uumfiaoucw3.5.033m.23.;30.5.0c.cc..un.u.tmait....37....“mc.m.32—3.3502.5+0EuEummcuE“was3.::2:33:2.zuuzunfit...30.5.0
`
`
`
`
`
`
`
`
`
`
`
`
`
`.3333.3.3..«5032::35Eombov.5acozwucmfiEnnw.:<“$02
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 16
`
`
`
`

`

`
`
`,xmncmmwczmusw
`
`
`
`
`
`OOH$0chHmmmgm,
`$9283»?Ec.Em
`
`
`
`3%canEmcuofiwzu
`
`
`
`252$Ewgmwfl
`
`
`
`ukuutwwomhnwwm
`
`
`
`
`
`
`mam$33322W:
`
` :52"...
`
`
`
`
`
`
`35:32£53mwLE£55mcam
`
`
`
`wcszswEvans.535353qu
`
`3:355yowfiflr
`
`
`
`.3335503.23333.5«Nbomgma2wacazmucwEEooQ.E“E3:
`
`
`
`
`
`
`
`60353:»3.33anmm“3.:ESE—uEcozgfifg.EEREE—ow5a.:5"ku32.3men3«:qu?sz$32:3533:32002unfit...E356
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 17
`
`
`
`
`
`
`
`mn>2_m“232B5.3.53:35;Ban!»2:Sofia.53>5Ev83an3.2.hassavanna:35on»wac=w33m32:,32$!£8:.23.£232.3chgwcmfiasno.233288@mama»?.moomeSENS
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`

`

`
`
`xmusmmémuiw
`
`
`
`
`
`
`
`wwwwwowhEm0:50.235m>_mm>:_
`
`88.E.z.8285c.
`
`
`
`35.3.3.93.33....
`
`
`
`
`
`$05.33.5:023:30.0.55.0.3
`
`
`
`33.03H82zmono:EmEEnE
`
`33.2.2.0...H383.050....
`
`
`
`wu:w...¢2:w.TEm...an.c£.onB
`
`552.3..m5.
`
`wwwEm3.3.33.5
`
`
`
`.moEmu.«:2.»5.$2.saw"...uwmmnéEfiaquE...
`
`
`.wizwoavan5meo.h...+5533.“.EmExm=EmmimE..w>m_+>EouuwnEz.32mg".
`
`
`Stuart...Al.0All$533.
`
`
`
`.aEwE.2:...mafia:1.3333353
`
`
`.02:mmuo:EmEEmE
`
`
`
`
`
`35.......S.32+>EBuSme.53
`
`
`
`3:...:9...520o..5.+5.33m...
`
`
`
`
`
`BEE...2:...mafia:5.3.5.35...»
`
`
`
`
`
`amazes...hmdmmm.m>.m<>2_
`
`
`
`nmuz<>n<fining.mo".
`
`
`
`
`
`u.E£m>m.2053...$33.50
`
`w:..wu.:wEu:
`away—MD“—:51;me
`
`
`
`macwchU.«Dw—QWIP
`
`.3533.
`
`$983.02
`
`
`
`3:533...8.3.539.2.3sz9All.3:0..meoz
`
`
`
`
`
`5.3%.»...
`
`
`
`
`
`.3533.owing...$2.5<wbogs...mammansuucwEEooE:4.202
`
`
`
`5:533......zms..=<mm...Adzofimxniuo.>n§m1h05mzom.>....<~.mn.0mm..
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`033.3253.3.02.3w.En...28.5.0z.seamsuiun..m...33......nc.w.Ewan...30:33.53.caEwmwan.3».w...«a...$23.33200:int...325.0
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`9r525.23....o53.5...5......83982..35...;Eu..55333...:3.2..3.=§3=g...a;35.8.3:8...£3893.......2as$03.»...5883355238.30.“:SS@$.83..88.5.3..
`
`
`
`
`
`
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 18
`
`
`
`

`

`
`
`.2w5&3sz30mm *0wcwEU—wwt.@ww
`
`Hafiz—m“
`
`val
`
`mzzwuiw$0ch$35353mm
`
`
`
`
`mycmwcoo*0£an
`
`
`
`xmnE$5.356
`
`00...$38wamkm
`
`ucmzflmm92
`
`EHm
`
`0ch535w>_mm>c_
`
`83.Ea523:0535.0335moan—2m
`
`
`
`
`
`maimcgmozmw—mzumm
`
`LO
`
`
`
`mOmmDQ—mOg1.5....2.
`
`ww<mm5>_mw<hw
`
`329%.03.
`
`new:.
`
`mozfidm>m3w
`
`n.3450440m
`
`
`
`
`
`memo“Sauce.353..
`
`
`
`canmwconumeofiEhmhE35.x..
`
`
`
`3ch9:32.29»?new9.0.
`
`5%ace::o.5820an
`
`canamwnuEE:.6.5323.50_.
`
`WEB:ozficmfizuou>305..
`
`
`
`“umEStmn333.;an3:t.
`
`«353....:£39509.
`
`”KENSE:*0cowaEEEwwu
`
`cwEounm
`
`
`
`39.x50:0.
`
`cauwmcom.
`
`:9:Eam.5—0Emé:35ESE
`
`53.5:.E.fionon.w5:32:Nw395EEmaEEmE.
`33.350
`
`£23“cmzonfi:o5525.
`
`“mm33353
`
`
`
`mafiau:9.:NF33m.583.
`
`OEMrE?»
`
`:5me
`
`
`
`
`
`EBQEQ“an332:323:.-
`
`
`
`
`
`umzafiw«.mm:new
`
`
`
`EN3333:3533:53«an.
`
`
`
`
`
`230%+NE:390T:Ea.ImELoxncmOI.mEm:mconmnEzonw9.:meWEE...»
`
`9:03DEEESvan9:comBmauE3285;:20m25533E$306?me
`
`.IwE382.5503
`
`
`
`:95up2.8%ccmEmEazm“Em“mficoEmm$223umfimaxm“EmmaflwfiwflmeanonUs>329:Range;6EmhmfioEwcoB5526EC30353
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`.vfiwflufi$3,35032::(w£38395acozuucwEEouE:6."£02
`
`JEmEQmvmcEzmmb
`
`
`
`
`
`
`
`
`
`.uamwfiouco2.50333mi..._3_==uE:Euunfiwtam.35_3_:=umEm.Egan.5053a...“3EmewncuEEmaas...3535:32002“with.5256
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Frl>2—m.20”:.5.unsung—ht::ifit?genxw05~30££359*Mr."C.wgnsunflb3«0:hurtcomm—gag:£5EEG“252031503F"..3339REE.—=J~US.szLSEWUmemcmnmL—QEDU35..anWSW@NQmNBw68W#4Exam»)
`
`
`
`
`
`
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 19
`
`
`

`

`
`
`mm=8..an“.3396
`
`
`
`.Ewmmam_mm.wm.wE0.5..t.332..wcoEB:Loim..m£o:.m:oo.5:632.Cbomwfio.
`
`
`
`
`
`
`
`
`
`
`
`:35mpEnocmficwEmiazmQ:asoSEESnew9.:comBubsEagmo£33Bum0.5.3.3.6EmceEEmma
`
`
`
`rm....3umELccoumg2225+N.6:89OI.Ea.IwE.0..ow0....9.2..«can.9...2:95m:..mm.m-w.m1m
`
`
`
`
`
`
`
`anc.$55320
`
`00.18ch335
`
`
`
`$05..3”.ms.ESm
`
`
`
`.50ch$35m>.mm>:_moom¢gmu_=%fl%fi
`
`..is
`
`FIE].
`
`
`
`>_mwfirwamuzmmmaommLOhzmfibfimm...
`
`
`
`59533.3toSrA.:wmowaEd.553.522...5...”.92
`
`Marga..5
`
`
`
`
`www.333...mmfimEEmQuillfimswaccm—Ewon.nhmum?EEEOEEfim
`
`.$9956.52.62:0mamm:#3323
`
`..6$.38.E55
`
`$533.5
`
`950w>..m.=mn.mNman.»
`
`
`
`
`
`
`.3350amn..5gamma:Estam33:33..02.EmomSoszofiEhma:.2955A!.8gas—50..3:20.333..xnnhwfioEmzo«ocnwimz333..me0:055....52x893".
`«Emu
`
`.35sHn..hmwém:
`..33woEmn.was":mu.ummm._3.5.3
`
`
`
`2002www3556thwoom.33353-35
`
`
`
`
`
`
`
`.55..358«cachea....:30.5..55.3aE.n..umcwmo..mw=:w
`
`
`
`
`
`umfiEcucEéOC3.5m.35..quo.n¢E=~3m§.05036.8m...3.53%m.nm__m>mm.E...wagons“...m.m:_m<m«5.3.3.335»....w“3332..229.6.n
`
`
`
`
`
`
`
`.u..>z.m
`
`
`
`429:Qmv8.5.3.6cam65.5.:
`
`
`
`cgfigmso533.......h
`
`525505nokzmzbmx...
`
`
`
`
`
`
`
`
`
`3.2.8.8.2.82:2.35.03%m.0<5...:EsznEoo:.:9».nmEzquflb
`
`
`
`ammo».IE...a53.5254+1]$380552...“Ema...“
`Enema
`
`
`
`
`aEwcouAl.w.n.mwon..5c2539..35....»E30322:5.u.H.a..a...33
`$350>Eofi£mw§.5.+>EfiomnEa.5.?E953...3......2:0
`
`
`
`35.32.E.5.+a2..5:.mm.a.E“V.
`
`wwwmmi
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`.80$59.56cm:mm3“watmcwum_nu.:..u“3.33.5.ufiaafizzguxubofiecL..._Iwn.mmmww.8352...rad.mnflwzuoEuzu.5..ng.569.3.3...535m
`
`
`
`
`
`
`
`
`
`
`
`
`
`9.3.3:“.3233“.@5335..w$33.....mquEEan..u
`
`
`
`
`
`
`
`
`
`
`
`Escumaucw653.305}Exmfiueumm35%:03wecozfiumm...35.03%$5“..sz9m.Emu5.323838.35.3..».23....w.naESNEmwh5.3coszQEGU.6«an»..323533.3.9....3no???.3935“..m:.mnczanou
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`.,,,,,,,,,,,$93.9aawufiég20.3233053:5..w
`
`
`
`
`
`€35.353.335033.2:<N309.395mcosmucwEEouw..3."802
`
`
`
`
`
`
`
`
`
`
`
`6325353.23%»m.£3....33....:.5:33.thit..3.c..umc.m.EEK».30:32.5B52:333..3".2.»3533.2.3200253......ESE—U
`
`
`
`
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 20
`
`
`
`
`
`
`
`
`
`Nquiz—minn:.6$3383..cant?$233up:2.55.2..58>5z.30:325..2.S:.685.333...£5.25waging—am32....33$»:£3...._<6:..fiaémzEacwuo>ficwn€n€835%....83®megw.83r8.2%.
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`

`

`$0555..5.meow.S...I323:0c.
`
`
`
`
`
`
`
`08.8ch$3....hfiUF—MU«mmwhm¢>_wm>:—35.39.363.3.2.“.
`
`
`
`xmuc.mmc..musw
`
`
`
`
`
`
`
`
`
`
`
`.2mw<hwmuzmmmaumm“.0szibawm...MZDEKOIm0”.>m<mm1h£3.26...qu
`
`
`
`
`
`.Emszssazua...»n.3...£23..83.».oz
`
`
`
`
`
`
`w...>z.m:.m....2289:92:33:00.2252.«25:90
`
`w:mE.mm...89855.32355::ENE...
`
`
`
`
`.0.ocofimmfiEn
`
`
`538mg.—mcoEBLoz33»...
`
`
`
`
`26:heEFF.9533usanEEg3.0.x...2250.393:
`
`
`
`
`
`
`
`
`
`
`
`Emsh.mcoEBIEm:mwnawwmwcmuzmmxnommno5......»de
`
`.2523sz033:83..oz
`N...>z.mEm<I.2259.
`
`1899.:
`
`:.“EmEmafioEmcoBwmcuamm.m932:»...3.2.339:.2ucm.EmBQEm.$32...$2.?ncm.899:2:62.3amwwmMfiufifl”waauowwwwwmnoflflmfl”Mwcogo;
`
`
`
`
`
`
`
`
`
`9.2.3....9.ucoumm.8956.£3st:.ESE.mcoEac55......2:36m5ymEcozmagmcoon3.323.....232:...
`
`
`
`“3:5..me.3.:..u3»..qu.2“28......nugmwaufiue.
`
`
`
`
`
`
`
`
`
`.§=.EE.rm...hgflESEozu3.5.99.660:33..3:95
`
`
`
`
`
`
`
`
`
`
`
`inmEEoEwcumacscoowfia.mum...w_55.9%.2...Eon...5.32%»...use.25.2.....93...z.
`
`
`
`
`
`
`
`3:55...55.3%3.23%...m82%...$33.?»5.63.3“.22.5a52.9.3.2.3
`
`
`
`
`
`
`
`
`
`
`
`
`
`.u83.uc.3.33:532...:«Rbows—3m...»mcozuucuEEoou.:6..302
`
`
`
`
`
`
`
`
`
`
`
`
`
`.uomfisauzu3.5.033a.23.:32......:.:ozwn.u_twn..5....32...»mc.w.$35..32.3mcwt...EuEmmncmEER.9:“a...$33.32002“with.335
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`AstraZeneca Exhibit 2074 p. 21
`
`
`
`
`
`
`
`
`
`
`
`
`
`MFx>z_m.2002E5.325»...53......gas:3.:Esau;5.3«an53333.3.on..8:am...5:33...2....2...35.3.333:.‘3...memfg..3.us.€ng.3chwzmcwnEquo.wccuwzmama@SEQ?doomacoma»...
`
`
`
`
`
`
`
`
`
`
`
`
`
`

`

`xvammEEosw
`
`$956“memi
`00%$0ch$35.
`
`9505.8.50232:
`
`88.E,..328:0:_
`
`32:33303202.“.
`
`m:E5.5.._«mam.35%32.33295
`
`
`oz"ESE“.359:805“8
`44¢953:.25233
`
`
`
`“Eumv2325.05E3.....
`
`
`
`“moan".chqu:..
`
`
`
`
`
`wuo:i=5.Eczcww
`
`wemE:am25:35.
`
`
`
`23:>=moE=U
`
`Emocmflu
`
`
`
`.35553:950:Ln.
`
`D2<
`
`E832:5:8:93:E:o_m_uxm.25093oz.
`
`5.83%32.3
`
`E..96.
`
`“ENEown:5523
`
`
`
`
`«5563“En
`
`.52::«amagma:
`wan:>=mu_:__u
`
`
`
`mfiozmfiuyo
`
`
`
`
`
`mm>EEEwwkucwtgxm
`
`:53one:
`
`
`25550sz052.5a:.EuwA.
`
`umfim.335.0E.
`
`
`
`
`
`
`
`68.9%$335E35.50ch535Emzm£5,mocwtmaxmnflcmEzocugm:“szEwEwcoc55”.:me
`
`
`
`
`
`
`
`
`
`:osmfifivcm$28.:52>cofimzumfiStaucmEma—05mm“$553“;mEEumE32oz:5552062
`
`
`
`
`
`
`
`
`
`
`
`.m:o_m_um_oEmEfiwzE».30:.mEEmm3mm::oEmagooco
`
`
`
`
`
`
`
`
`
`
`
`.8EommfimuvwwnocBmEEmE
`
`
`
`
`
`REES33E:wmmEEU:Ecozao>805mun:EcucmmEmEEmEEEEEmwmwmo=w5$33$9.EczcmwEm=_x<w
`
`
`
`
`
`«CwEu—mePE—L—Om9.000.."Ow":5qu
`
`Ami
`
`053336:3ch33$3anm
`
`
`
`
`£23on3£33.
`
`
`
`
`
`
`
`($25.52..B539:2.5%;$2532:33.?.53a.»53039.9.38:an...8:332:E...2535.33%89:.3232an?.2E.6%:388upmzmsensoo65%:33a$3?.38F:23;
`
`
`
`
`
`
`
`
`
`
`
`
`
`.ummflagcw25333a£3:$25.".5533.9%?.3....noizoaE3«5:350:3*53EuEwmucuE«man«5$5wu>w=wn2002“23:..325
`
`
`
`
`
`
`
`
`
`
`
`
`
`wccmvE01,.EEExoSv«saga.de:0wwwmo300333By.gm:3ENEAID:EiEmcufiwfcczEE—czEEQSU
`
`.Am333mg_m_w.m>§:oom_EwEmagEmac:
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`‘mEEEmEwom“EmESmeEw:5:3@5539»was:_w>m__=:E.3umczmvEmEmzoE.mus:.mczcmmm
`
`
`
`
`
`
`
`
`
`.ufiwofifi3.385032::(a3338EnacosnucwEEauE=<"302
`
`
`
`AstraZeneca Exhibit 2074 p. 22
`
`
`
`

`

`
`
`xmnE$56330
`
`
`
`00FLmucmu#mwmhm
`
`mmucwgéwmEEEm
`
`
`
`
`
`6ch“mafiam>_wm>:_Sawmggsmmfluomfi
`
`-.I>m
`
`
`
`
`
`ZO_._.Ommw_n_>m<.._.=x<
`
`
`
`
`
`:9:.5335BtwnammctmbmcoEmuEmu03:53.”.ho933%9::—
`
`
`
`
`
`
`
`
`
`
`
`ESE»—>_._w_=u_tmngm:on?£533£0333?ave:59:2>._£__xm
`
`
`
`
`
`
`
`
`
`.tm0n.323:5.2>335£53m?Em>=.€mS:03023miEon?
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`ucflxwan.230$553$?bflzxmon...._m:o_un_o352233BE:_33:5““—0moan—50:39:“29:55.3Earn—:8302$55,wmofi
`
`
`
`
`
`
`
`3:3an:3ch$35353mm
`
`$5330”3293.
`
`
`
`$3.35533.55032::«NbomflmuEamzozmucwEEge=<“362
`
`
`
`.Ad.>z_mmam.«EB—9:3
`
`
`
`wane:=S_5.5.9:E“:95an3.“..me395m_955u=Ecomwuo:
`
`
`
`
`
`:ounocmquEmcooan>9:>303£3::nEeEEEwm:mm$523..ancum_20:3«5vanEmma2.0:.mczcmmnoucwtwnxow309.33
`
`
`
`
`
`
`
`
`
`
`
`
`
`53233:»3.33302£33.322».:mcasmsfltwn..55.836mEEp.52332.3>53EmEommcwE$32.:3535:3zoo:unfit...30.5.0
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`mu>2_m.2823223?.2.cant;$293on»33335:33:»E“Saga!33...$5c3233.:£5E.»3532.632:.,vmimmw.Ham:"2as.$33239:3mzwcmzwanu3...ngmeow@333:.33F:32?
`
`
`
`
`
`
`
`
`
`
`
`
`
`g
`
`
`AstraZeneca Exhibit 2074 p. 23
`
`
`

`

`anEmmc__mn_:w
`
`
`
`
`
`Ont.5“.chammmhm
`
`$055thwEEEm
`
`
`
`
`
`>n<mm1k20:3.deGEE—30mm
`
`050Emmim>_mm>:_
`
`
`83.3,,a828:05mm==wE=w3:95.".
`
`
`
`
`
`.1...02_>mmw200.._.w<mmmO...w20_._.<0_02_§._.200
`
`
`
`
`
`5.3».9:33..29.9.:m:_>._ow:oo.umwm.5.8mcozmufifimbcao
`
`
`
`
`
`:3»“was“..553.5053kmhorn.
`
`“320mm?
`
`
`
`
`
`>053anacts“..E.
`
`
`
`
`
`0335:2323”:mctmmnnm“cm—.525:.5.33233$.55.
`
`35meutEonss.
`
`
`
`
`
`
`
`
`
`”635$“
`
`mEEuSQ$0chEmmiB533”.
`
`
`
`
`macaw—SD5.0$33
`
`ENEgan—mo.EumA”SEQ...
`
`
`3:3:ucmmESvaBm
`
`
`
`
`
`£33.35wfiszfi32:...4w3033Enacozwucvfifiouw.:4"302
`
`
`
`
`
`
`
`.umwflugnw2:233»w.an?5&5.»Ecozwnfifum.3:.823mEE33330:3man“5«5.209sz33m5:2:353:32002“with.3320
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`“Hafiz—M.2823Egg...“gas...»333»2.:Eons;EsE533333B8:.3533%;...as.35$5.83332:.32323%:.38.£222*8ch3335.38.55328%@Noam?98FEmmi
`
`
`
`
`
`
`
`
`
`
`
`gownmmvExmQ:@5235wmwmmzumamm:3:03:00938d.__339$3.23%SE:.823mctSafi353:0.woozzzi.
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`g
`
`AstraZeneca Exhibit 2074 p. 24
`
`
`
`

`

`
`
`anc.wwémniw
`
`
`
`
`
`00;.$0chwwmwum
`
`mmucmhwfim92EEm
`
`
`
`
`
`>n_<mm_.._._.A<ZOEEOIhz<>2wn<
`
`05033.5m>_mm>:_
`
`
`88.EI328.553:23.303:9an
`
`>m.3;29:onEng—:5...-
`
`
`
`
`
`w_ouohmm:<.
`
`
`
`.0uwflfioucm....u:__n.m_n=ou69m.655mmEn...”—mucw2>m25m5,6».EmEr
`
`
`
`
`
`owmomfiEtonam325......203.33.”35mflmbmcoEwu.2:anginamm5:35.“;Broan—:82:9535:8“m_n_m..o>£a$9:
`
`
`
`
`
`
`
`
`
`3.1.5an3%E58505353:33.853?
`
`
`
`
`
`_w>_u_::mu9.333.253..m_mocmtwnxw353%?can.:2:£5
`
`
`
`
`
`
`
`
`
`cmmm332233.>9:239.55%6E:Ewtzum53.wumE
`
`
`
`
`
`Em55533.2::memnSan.2225.32:*o5333:”.harm
`
`
`
`
`
`2305cwtonfi:9252.50$an3523mmmhvum5:cug.3:>355EmtnoanmE:m_flanohmmcd‘.mBNobmmcmU.
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`3:336Sudan.553m355mm;
`
`War—Qw—
`
`00he$.93.
`
`
`
`6835533:3333::(NE3332»303355532E»"392
`
`
`
`
`
`wmwflsgcm>__n_uunwwflwiE3253E:ozun_n._tmu.353256mEw_Susanhung».a...»SEmewmcmE339.:3533:3zuozEat...325.0
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`01>2—m.2092B532.53cast;384x:95505:5.52h_.._n2.33352on.S...hascoax/sag:3...»v535.23%33:...dog».3ch.32.$953230chw>_m:wszEoo.30me83@woxmmavdeem«SEE,
`
`
`
`
`
`
`
`
`
`
`
`w
`
`AstraZeneca Exhibit 2074 p. 25
`
`
`
`

`

`
`
`a35:23:253EEEwEEmcamcsnoB>£umo
`
`
`
`xmnEwmc=m03w
`
`
`
`
`
`
`
`wwmwmwemhEm.50ch«mmflmw>_mm>:_
`
`
`
`88.E,u328553582363:02....
`
`
`
`
`
`.5$2520.3:353:Bishoxogspseo:E£3520:5353:2353;5233333
`
`
`
`
`
`in";>Q§MIPOEMIU._.z<>:_..n_<
`
`$353252
`
`u<QU<m.
`
`
`
`933mm:252
`
`”EU.
`
`L<U~O<u.
`
`
`
`$32333H$253305203263:5on0.3.AQEEmanwacnc_u>2:_o_n=._oxou=83:203.:
`
`
`
`
`aAmEEmznwocnofigEfiEonoEExfimooE05..
`
`A_BE:ohanwumwaofimEBEEmzamocaggo5332.35053303.155A2?
`
`
`
`AwEEwanmoanoEEEEEEEQVom.
`
`mic.
`
`cBE:20:£33950fiaEEEEmsnwoznafi>£
`
`amxfifig
`
`
`
`A23Eanamesao_o>£:_o_ns._ox0304..
`
`
`
`
`
`
`
`EQEB£5;35:32wcwE_mm._vmmmnéfifiaoxouéocB8:33mg22:39:59EEmcEEwco339522230“.“mg“B383.8533$33397!me
`
`AmNbomflwuvOI.E$memEmeaxw.5>o
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`392569.9BE:353220cmwcwEEQfiEmfioEmcu559__<#552man39:miom56éEmtzocoo:23an3E399:cozwfiE“Em$3
`
`
`
`
`
`
`
`
`
`.53$256w.E953m552:0R535592%mm.gm:w:23%nmanawmfiw
`
`
`
`
`
`
`
`5:53:5;mocmvsm26m9.2mQ<9553man3:.33:63.3332$03mg“Emmmmsw.mE_mo._c__o$9.6mEst852$35%
`
`
`
`
`
`
`
`
`
`
`
`.uwtwfimaSmmcmE_m9EEQEOEEUmc_:_mEou.mE_o3m..Scm,Ecmzmam>:_won-muoc5%.
`
`
`
`
`
`
`
`
`
`.33:wazmoa90E55355.,BcwzmaB33?:mam”:20Al<mchaazwEm“.m5;
`
`
`
`
`
`
`
`
`
`.Ufi28:83.mg3:.39285.2005.$58mmmmzmRE@25629%
`
`
`
`6335533.55032::inbong—38nacasgcuEEoufl:4532
`
`
`
`
`
`
`
`3938520m:_39__o..cmzonfi£3...émzcgwwm53m323%39mg“Emazfimmm3mm...5:on395Mambarz

This document is available on Docket Alarm but you must sign up to view it.


Or .

Accessing this document will incur an additional charge of $.

After purchase, you can access this document again without charge.

Accept $ Charge
throbber

Still Working On It

This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.

Give it another minute or two to complete, and then try the refresh button.

throbber

A few More Minutes ... Still Working

It can take up to 5 minutes for us to download a document if the court servers are running slowly.

Thank you for your continued patience.

This document could not be displayed.

We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.

Your account does not support viewing this document.

You need a Paid Account to view this document. Click here to change your account type.

Your account does not support viewing this document.

Set your membership status to view this document.

With a Docket Alarm membership, you'll get a whole lot more, including:

  • Up-to-date information for this case.
  • Email alerts whenever there is an update.
  • Full text search for other cases.
  • Get email alerts whenever a new case matches your search.

Become a Member

One Moment Please

The filing “” is large (MB) and is being downloaded.

Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.

Your document is on its way!

If you do not receive the document in five minutes, contact support at support@docketalarm.com.

Sealed Document

We are unable to display this document, it may be under a court ordered seal.

If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.


Access Government Site

We are redirecting you
to a mobile optimized page.





Document Unreadable or Corrupt

Refresh this Document
Go to the Docket

We are unable to display this document.

Refresh this Document
Go to the Docket