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`THE
`
`MERCK INDEX
`
`AN ENCYCLOPEDIA OF
`
`CHEMICALS, DRUGS, AND BIOLOGICALS
`
`TWELPTH EDITION
`
`Susan Budavari, Editor
`
`Maryadele J. O’Neil, Senior Associate Editor
`Ann Smith, Associate Editor
`Patricia E. Heckelman, Assistant Editor
`
`Joanne F. Kinneary, Assistant Editor
`
`Published by
`Merck Research Laboratories
`
`Division of
`
`MERCK & C0., INC.
`
`Whitehouse Station, NJ
`
`I996
`
`AstraZeneca Exhibit 2101 p. 1
`InnoPharma Licensing LLC V. AstraZeneca AB
`IPR2017-00905
`
`Fresenius-Kabi USA LLC V. AstraZeneca AB
`
`IPR2017-01912
`
`
`
`MERCK & CO., INC.
`Whitehouse Station, NJ.
`USA.
`
`lst Edition—4889
`2nd Edition—1896
`3rd Edition—1907
`4th Edition—1930
`5th Edition—4940
`6th Edition—«1952
`7th Edition—1960
`8th Edition—4968
`9th Edition—I976
`10th Edition—1983
`11th Edition~——1989
`
`Library of Congress Catalog
`Card Number 89—6000]
`ISBN Number 0911910-12-3
`
`Copyright © 1996 by MERCK & CO., INC.
`All rights reserved. Copyright under the Universal Copyright Convention
`and the International Copyright Convention.
`Copyright reserved under the Pan-American Copyright Convention
`
`Primed in the U.S.A,
`
`AstraZeneca Exhibit 2101 p. 2
`
`
`
`EDITOR’S PREFACE
`
`With the Twelfth Edition, The Merck Index marks the beginning of its second
`century of publication. A comparison of this one—volume, 2600~page, multidis—
`ciplinary encyclopedia with the thin catalog of Merck products that was pub-
`lished in 1889, underscores the vast changes that have occurred in this publi—
`cation over twelve editions, and in the realm of scientific information. Although
`, the text continues to be designed primarily to serve the needs of chemists,
`biochemists, pharmacists, and those in allied professions, it contains informa—
`tion of interest to a broad spectrum of scientists and others in a large number
`of disciplines. The material is assembled with today’s quick reference needs in
`mind, but the commitment to enhanced scientific communication and to excel—
`
`lence in scientific scholarship remains paramount.
`This edition contains a diverse collection of over 10,000 monographs of
`which more than 4,000 are devoted to a wide variety of drugs and pharmaceu-
`ticals, over 2,000 describe common organic chemicals and laboratory reagents,
`and another 2,000 cover naturally occurring substances and plants. An addi—
`tional 1,000 monographs focus on the elements and on inorganic chemicals,
`almost 1,000 pertain to compounds of agricultural significance, and several
`hundred describe endogenous substances and biological agents.
`A number of changes have been made since the Eleventh Edition was pub-
`lished in 1989. The monograph section has been extensively revised. The
`chemical structures have been redrawn employing current conventions for
`chemical depictions. Nomenclature has been reviewed and stereochemical de-
`scriptors have been added, where pertinent. In response to requests from our
`readership, the section on Organic Name Reactions, which last appeared in
`1983 in the Tenth Edition, has been updated and reintroduced. The compilation
`of Chemical Abstracts Service Registry Numbers has been significantly ex—
`panded. Several new tables have been added including a glossary emphasizing
`some of the newer terminology employed in the fields of molecular biology
`and immunology.
`In recognition of the growing utilization of electronic versions of traditional
`reference works, THE MERCK INDEX ONLINE is made available through
`major online database vendors. A CD-ROM version of the Twelfth Edition,
`which is both'text and structure searchable, will also be published in 1996.
`Compared with their counterparts of earlier eras, scientists of the 1990s have
`unparalleled access to information from a multitude of sources. In this envi-
`ronment, it is especially gratifying that so many readers inform us that they
`refer to The Merck Index on a daily basis. We hope that this edition, published
`by Merck & Co., Inc., as a service to the scientific community, will continue
`the tradition and prove to be an indispensable reference to all who consult it.
`
`Susan Budavari, Editor
`Merck Research Laboratories
`
`Rahway, New Jersey 07065
`
`AstraZeneca Exhibit 2101 p. 3
`
`
`
`ACKNOWLEDGMENTS
`
`The creation process for each edition of The Merck Index involves the efforts
`of many dedicated people with special talents and varied expertise. The suc-
`cessful publication is a tribute to all involved.
`The Merck Index Editorial staff wishes to especially thank our coworkers
`for their untiring efforts and cooperation: Jo Ann Gallipeau for assistance in
`researching and preparing various portions of the manuscript; Mary Ann
`D’Arecca for organizing the data entry of the tabular material and for procuring
`research materials; Edward Hendrzak for preparing tabular material and skill-
`fully drawing the chemical structures; and Mariann E. Lucas for diligent edi-
`torial assistance in evaluating various topics and standardizing the structures.
`We also wish to thank Dr. Norman Penix for providing computer expertise,
`custom programming and technical guidance at critical times; Debra Shelinsky
`Greene, Susan C. Manson and Jon Filderman, for advice and counsel on
`
`intellectual property and contractual issues; and especially, Gary Zelko, our
`Publisher, for facilitating all business aSpects of this edition and for providing
`needed support.
`We would like to express our gratitude to Professor David A. Evans of
`Harvard University and Professor Barry M. Trost of Stanford University who
`reviewed various portions of the manuscript for the Organic Name Reactions
`section and provided salient comments and valuable suggestions.
`Finally, we wish to mention and thank the numerous Merck scientists, past
`and present, who contributed in varying degrees to this book, as well as the
`many readers who took the time to contact us with comments, suggestions, and
`corrections.
`
`vi
`
`AstraZeneca Exhibit 2101 p. 4
`
`
`
`TABLE OF CONTENTS
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`Periodic chart
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`inside front cover
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`. viii
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`. xiii
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`.l—1741
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`. MISC-l—MISC-107
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`.MISC-l
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`.MISC—2
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`.MISC—7
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`.MIsc~8
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`Editor’s preface
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`Acknowledgments
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`Explanatory notes.
`. ..... .
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`Abbreviations
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`MONOGRAPHS .
`MISCELLANEOUS TABLES .
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`Alphabeticallistoftables.
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`Glossary
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`Common Heterocyclic Ring Systems .
`.
`Abbreviated terms used by the U.S. Adopted Names (USAN)
`Councfl for Radicals and Adducts
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`International non--proprietary names for radicals and groups
`.MISC—8
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`proposed by the World Health Organization (WHO)
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`. MISC—10
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`Cancer chemotherapy drug regimens
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`. MISC—12
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`Code letters used by companies for experimental substances.
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`. MISC—l6
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`Company register.
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`. MISC-3O
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`Numerical prefixes commonly used1n forming chemical names
`. MISC—30
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`Alchemical symbols used1n biology and botany
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`. MISC—30
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`Prescription notation
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`Latinterms...
`.................,Mrsc—31
`Greek and Russian alphabets
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`. MISC-33
`Roman Numerals.
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`l
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`. MISC-33
`Chemical Terms Translator.
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`. MISC—34
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`. MISC-36
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`. MISC-42
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`. MISC-46
`.
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`...MISC—47
`.
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`. M18058
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`. MISC~60
`.
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`. MISC-61
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`Boiling points of solvents
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`Density of liquids.
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`Percentage solution tables
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`Isotonicsolutions.
`.
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`..... .
`Indicato1s .
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`Amino Acid Abbreviations and pKa Values
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`Saturated solutions
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`Cooling mixtures .
`. ..... .
`Thermometric equivalents
`International system of units (SI)
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`Universal conversion factors
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`Table of rad1oact1ve isotopes
`Radioactive isotopes used1n medical therapy and diagnosis .
`Table of Minerals
`.
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`..... .
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`ORGANIC NAME REACTIONS .
`.
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`CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBERS
`Alphabetic order by compound name .
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`CAS Registry Number o1der
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`THERAPEUTIC CATEGORY AND BIOLOGICAL
`ACTIVITY INDEX .
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`FORMULA INDEX.
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`NAME INDEX.
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`. MISC-66
`. MISC-66
`. MISC-67
`. MISC-68
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`. MISC-78
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`. MISC—93
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`.MISC—lOO
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`. ONR-1—-ONR-107
`
`.REG~l——REG~59
`.
`.REG-60-REG—124
`
`.THER-l—THER-28
`.
`.
`.
`FI—l—FI-76
`.
`.
`.NI—l—N1-36O
`
`inside back cover
`
`Atomic weights
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`vii
`
`AstraZeneca Exhibit 2101 p. 5
`
`
`
`EXPLANATORY NOTES
`
`The Twelfth edition of The Merck Index contains 10,330 monographs de—
`scribing significant chemicals, drugs, and biological substances. The entries are
`not a listing of Merck & Co., Inc. products, but rather cover a wide range of
`compounds which have been selected on the basis of present, or historic,
`importance and interest. Since the publication of the Eleventh Edition in 1989,
`over 5000 monographs have been significantly revised and updated, while
`several hundred monographs have either been condensed, or deleted from the
`manuscript to make room for hundreds of new monographs.
`Entries are generally limited to single substances and related compounds
`(isomers, salts, etc.). While multi—component drugs are, for the most part,
`excluded, there are a number of monographs devoted to families of natural
`products or biological substances. Monographs vary greatly in length. The
`length of a monograph, however, is not necessarily indicative of the importance
`of a compound, but rather may simply be an indication of the amount of relevant
`published information available for the compound.
`For the purpose of illustrating the general monograph format, a typical drug
`monograph is depicted and the components are identified. While all the possible
`categories of information in a monograph are described below, it must be
`emphasized that not all categories are present in every monograph.
`Monograph Number. Sequential accession numbers are assigned to mono-
`graphs which are alphabetized by title. Entries in the indices are referenced to
`these numbers, not to page numbers. (Note: Monograph numbers in the Twelfth
`Edition do not correspond to Eleventh Edition monograph numbers.)
`Monograph Title. Titles are usually generic (United States Adopted Names
`(USAN) or International Nonproprietary Names (INN), in the case of drugs),
`trivial, or simple chemical names. Trademarks, designated by ®, are used for
`a small number of entry titles, primarily when nonproprietary terms are not
`available.
`
`Chemical Abstracts Name(s). Synonyms in boldface italic following the
`title are uninverted forms of Chemical Abstracts Service (CAS) Index names.
`
`When a specific isomer is being discussed, stereochemical descriptors have
`been included, when possible, to more clearly delineate that isomer. The Chem-
`ical Abstracts Names (and CAS Registry Numbers starting on page REG-l)
`are provided as aids for further searching of the compound of interest in
`Chemical Abstracts and elsewhere.
`
`Alternate Name(s). Other chemical names which identify the entry, trivial
`names, experimental drug codes, and current (and former) trademarks are listed.
`Listing of trademarks is for information purposes only and it should not be
`assumed that the trademarks are in current use. The first letter of each trademark
`
`is capitalized; absence of capitalization, however, does not preclude that a name
`may either currently be a proprietary name, or may once have been the subject
`of proprietary rights. In those cases where it has come to our attention that a
`trademark is obsolete, we have indicated that fact. If known, the company
`associated with a particular trademark (as a manufacturer, distributor or trade-
`mark owner), is listed alongside the trademark in the Name Index. Names
`
`viii
`
`AstraZeneca Exhibit 2101 p. 6
`
`
`
`
`
`
`[1(IS,2R),5(S)]-2,3,5-T192166xy-N-(23-
`Indinavir.
`,. 4979.
`{’"‘;';2;;;;2;2;;2222;2;;;>
`W dilzydr0~2~hydroxy-IH~inden~I-yl)-5-[2~[[(l,1-dimethylethyl)-
`aminojcarbonyl] ~ 4 - (3 -pyr1'dinylmethy1) - 1 -piperazinyl] - 2 -
`”MM___________
`(phenylmethyl)-D-erythro~pent0namide; (aR,'yS,ZS)-a—benzyl-”\,
`
`
`21/ Percentage
`2—(tert-butylcarbamoyl)-y—hydroxy—N—[(lS,2R)-2—hydroxy—1-
`\‘3
`a
`. \ indany1]- 4- (3—pyridy1methyl) — 1 — piperazinevaleramide; N— 2:14 names (22 htface)
`\§2(R)- hydroxy- 1(S)- indanyl) 2(R)- (phenylm6thyl)———4(S) hy—E \...............
`y— 5— [l- [4- (3— pyridylmethyl)2(S)- (N- tert butylcarba~3
`moy )\ piperazinylfl
`pentanamide. C36H47N504; mol wt
`>——————————I613.803°C 7045%, H 7.72%, N 11.41% 0 10.43%.Member
`
`{of the novel hydroxyaminopentane amide class of HIV— 1
`3protease inhibitors. Prepn:
`J. P. Vacca 21511., Eur. pat?
`2Appl. 541,168; eidem, U..S pat 5,413999 (1993 1995 both
`3to Merck & Co.;) B. D Dorsey ex 111., J. Med Chem 37
`33443 (1994). Diastereoselective synthesis: D. Askin et (11.,
`3“Tetmhed10n Letters 35, 673 (1994); P. E. Maligres et a1.
`,3 ibid 36, 2195 (1995). C1ysta1 structure of HIVII protease,3
`‘complex. 2 Chen et al J. Biol. Chem. 269, 26344 (1994)
`
`gAntiviral activity and pharmacokinetics: J. P Vacca et (11.,
`EProc. Nat Acad. Sc1. USA 91, 4096 (1994). HPLC determn ;\/
`gin plasma and urine. E. Woolf et (11., J. Chromatog. A. 692,3
`245 (1995). Metabolism in humans. S. K Balani et (11., Drug,3
`EMetab.D1‘spos 23, 266 (1995)
`
`,.........\
`“gamma
`\-.f.fii‘ii‘ffi/
`
`
`
` .........2\
`{€359,399
`2‘
`
`\
`
`N/W OH
`K/
`
`oH
`=
`
`2
`
`
`
`aao‘
`
`........................../
`{title compound
`2
`
`/,.
`Occurs as monohydrate, crystals from wet ethyl or iso—
`2
`,.
`3‘p1opyl acetate, loss of water below 100° followed by recrys—
`
`
`/tallization of anhydrous form with mp 153- 154°; second,/'”‘\.
`3anhydrous form mp 167—5168". Soly in wate1 (mg/ml):
`
`0.015 (unbuffered), > 1.5 (pH 4.0) [01]?)2 +/241° (c =
`0.01331n chloroform).
`29/"
`
`Sulfate C36H47N504.H2804, MK-639, Crixivan. Occurs as
`2
`
`the monoethanolate, crystals from absolute 601%); softens
`Etiflffffflgéfint/l\3 at 135° mp 150— 153° (dec). Converts to hydrate
`pon loss 22222222222222222222222222222222222222222222222
`
`
`E20f ethanol and exposure to moist air33\\
`2
`r/Trademarks (capitalized) \
`
`for derivative
`\derivative (boldface italic);
`WWWW'“ MMWTHERAP CAT: Antivi1‘.a1
`,
`1’2Physicaldam ‘2
`1 and/orsynonymsof
`//Therap6utic category =,,/
`1(in humans)
`
`
`
`ix
`
`AstraZeneca Exhibit 2101 p. 7
`
`
`
`appearing elsewhere in the monograph in boldface italic, also appear in the
`Name Index.
`
`Molecular Formula, Molecular Weight, % Composition. Elements in the
`molecular formula are listed according to the Hill convention (C, H, then other
`
`elements in alphabetical order). Formula and molecular weight are provided
`for all title compounds having a specific known structure. The 1993 IUPAC
`Standard Atomic Weights have been used to calculate all molecular weights.
`Literature References. A concise reference history of each compound is
`provided. Frequently, there is a brief description or capsule statement, although
`in some monographs, particularly those on significant biological substances, a
`lengthier description is given. References to isolation, preparation or synthesis,
`patent information, and structural studies are cited. While reference is made to
`various methods of synthesis, the intent is to give a representative, but by no
`means, exhaustive list. Patent numbers are provided merely as a source of
`preparative information. However, whenever possible, the United States prod
`uct patent has been cited in monographs which were newly added for the
`Eleventh and Twelfth Editions. References to pharmacology or biological ac—
`tivity, clinical trials, and toxicity studies may be included, where appropriate.
`Review articles, where available, are usually cited at the end of the references.
`Reviews pertaining to a group of closely related compounds or to a family of
`natural substances, are generally listed only in the monograph for the parent
`element or compound. Literature references are cited in the conventional man-
`ner; journal abbreviations (with notable exceptions listed in the Table of Ab-
`breviations) generally correspond to those in Chemical Abstracts Service
`Source Index (CASSI). The number of the first page of the reference is given;
`first and last page numbers are listed for reviews.
`Structure. For this edition, all structures have been drawn according to
`current conventions using CambridgeSoft’s ChemDrawTM software package.
`Structural depictions, including stereochemistry, if relevant, are included in
`over 6500 monographs. Structures which do not correspond precisely to the
`monograph title, have been labeled to identify the specific form depicted.
`Standard conventions of heavy wedges and dotted lines to show bonds directed
`above, or below the plane of the paper are used where appropriate; whenever
`possible, double bond geometry has been defined within the structure. Amino
`acid residues are assumed to be L unless specified otherwise. In addition, more
`than 2000 monographs contain line formulae showing molecular arrangements.
`Physical Data. Data are cited as found in the literature. When several alter—
`nate data values appear in the literature, the data is evaluated and representative
`selections are made. The values are then reported with the corresponding
`source. Whenever possible, the color of a substance is stated, but the absence
`of color (white or colorless) is often omitted. Temperatures are given in degrees
`Celsius (centigrade), unless otherwise noted. When solubilities are determined
`at room temperature (about 25°C), the temperature is generally omitted. When
`optical rotations are measured in water, the solvent is usually not specified. For
`ultraviolet absorption measurements, the solvent is given within parentheses.
`An effort has been made to provide toxicity data (e.g. LDSO, LC50, etc.) and
`to identify the source of this information. Caution and/or Note statements are
`
`AstraZeneca Exhibit 2101 p. 8
`
`
`
`also provided in a number of monographs. Specific statements are given for
`compounds on the US. Government’s Schedules of Controlled Substances in
`Title 21 of the 1995 Code of Federal Regulations, for compounds listed as
`suspected or confirmed carcinogens in the Seventh Annual Report on Carcin—
`ogens issued in 1994 by the US. Department of Health and Human Services
`(USDHHS), and for chemicals considered potential occupational hazards as
`described in sources such as the NIOSH Pocket Guide to Chemical Hazards
`
`(USDHHS). Note: Absence of toxicity data or specific cautions does not imply
`that toxic effects do not exist.
`
`Derivatives. When derivatives (isomers, salts, etc.) of the title compound are
`described in a monograph, the information appears in the paragraph(s) directly
`following the physical data. Data for derivatives are presented in the same
`format as for the parent compound. Molecular formulae for parent substances
`appear in the Formula Index. Molecular formulae for derivatives other than
`acid addition salts or simple hydrates, are listed in the Formula Index if there
`are names associated with them.
`
`Derivative paragraphs may also be used to describe specific members of a
`large family of natural substances. Literature references pertaining to these
`specific substances may be included here.
`Use. Descriptions of specific uses, which are not medical or veterinary ther—
`apeutic applications, are summarized under this heading.
`In most
`Therapeutic Category and Therapeutic Category (Veterinary).
`cases,
`therapeutic categories correspond to those published in the USP
`Dictionary of USAN and International Drug Names. However, in instances
`where there is no listing, or where the USAN Council has listed a mechanism
`of action, a therapeutic category has been assigned which most closely describes
`the indication claimed by the manufacturer, or reported in the clinical literature.
`When available, mode of action information is included in the literature refer—
`
`ences section of the monograph. Monographs for human drugs have been
`indexed by both therapeutic category and biological activity beginning on page
`THER-l.
`-
`
`Indices. More than 60,000 synonyms, including titles, CAS names, alternate
`names, trademarks and derivative names, are contained in the Name Index, and
`
`more than 11,500 entries appear in the Formula Index. Each entry directs the
`reader to the number of the monograph in which the substance of interest is
`described. The effort to match trademarks with associated companies has been
`continued for this edition. In the Name Index an abbreviated form of the
`
`company name appears in brackets following the trademark. The complete
`company name and location is listed in an updated and expanded Company
`Register in the TABLES section of the book. Company names are provided as
`a source of additional information and do not necessarily imply trademark
`ownership. Due to reorganizations or mergers, some company names may have
`changed since the original matching process was completed.
`In the Therapeutic Category and Biological Activity Index, monographs
`describing human drugs have been listed by one or more therapeutic indica~
`tions and/or mechanisms of action. Cross references to closely related categories
`and mechanisms have been included. Whenever appropriate, subclassifications
`
`xi
`
`AstraZeneca Exhibit 2101 p. 9
`
`
`
`have been developed by grouping compounds according to structural similari—
`ties.
`
`Two CAS Registry Number indices are also provided: one arranged alpha~
`betically by substance name, the second by ascending Registry Number order.
`Registry Numbers are provided for title substances and for selected derivatives.
`Where appropriate, Registry Numbers are provided for isomeric and unspecified
`forms.
`
`The Merck Index is not intended as an official therapeutic guide. Inclusion
`of a drug, or any other compound in this book, is not an endorsement, but
`merely a statement of the fact that such a substance exists. THERAPEUTIC
`CATEGORY and THERAPEUTIC CATEGORY (VETERINARY) paragraphs
`are intended only as summary statements of major pharmacological properties
`or indications for the individual compounds. For additional information on
`uses, dosage, side effects and adverse reactions, readers are directed to consult
`pertinent scientific and professional publications, product circulars, information
`sheets or material safety data sheets prepared, or published, by the respective
`manufacturers.
`
`Organic Name Reactions. This section, which has been significantly updated
`since it was last published in 1983, is comprised of 425 named reactions, each
`containing a concise reference history and reaction scheme, and an index.
`Tables. A compilation of over 100 pages of tables including a glossary, is
`provided to supplement the material presented in the monographs.
`Great care has been taken to assure the accuracy of the information contained
`in The Merck Index. However, the Editorial-Staff and the Publisher cannot be
`
`responsible for errors incurred in publication or for any consequences arising
`from use of the information published in The Merck Index. Accordingly, ref-
`erence to original sources is strongly encouraged, as is reporting of errors and
`omissions in order to assure that appropriate changes may be made in the next
`edition.
`
`xii
`
`AstraZeneca Exhibit 2101 p. 10
`
`
`
`Abbreviations and Selected Definitions
`
`Please consult the Glossary (Misc. Tables Section) for additional definitions.
`A.S.T.M.
`
`American Society for Testing
`Materials
`asymmetrical, unsymmetrical
`atomic
`American Type Culture Collection
`atmosphere(s), atmospheric
`atomic number
`adenosine triphosphate
`adenosine triphosphatase
`atomic weight
`British Approved Name
`bone marrow or bursa of Fabricius
`derived cell
`Bacillus Calmette—Guerin
`Baumé (a specific gravity scale)
`Beilstein’s Handbuch der
`Organischen Chemie
`Belgian patent
`Chemische Berichte (Berichte der
`Deutschen Chemischen
`Gesellschaft)
`bovine gamma globulin
`biological
`British Intelligence Objectives
`Subcommittee
`tert--butoxycarbonyl
`biochemical oxygen demand
`boiling
`basepair; boiling point; boils at;
`boiling at Example.bp7048°
`means boils at 48°C if the pressure
`is 70 mm Hg
`British Pharmacopeia
`British Pharmaceutical Codex
`British patent
`biological response modifier
`bovine serum albumin
`British thermal units
`butyl
`benzoyl CfiHsCO—
`benzaldehyde
`benzoic acid
`concentration by volume (g/ 100ml)
`after optical rotations only
`cytosine; cytidine; complement
`Centigrade degrees; Celsius
`degrees
`heat capacity (constant pressure)
`(circa) about
`Chemical Abstracts
`calorie(s)
`calculate, calculated
`Canadian patent
`carbobenzoxy
`complete blood count
`cubic centimeter(s) (milliliter)
`cholecystokinin
`ciicular dichroism
`cytidine diphosphate
`carcinoembryonic antigen
`(confer) compare
`comglete Freund’s adjuvant (same as
`complement fixation test
`coronary heart disease
`congestive heart failure
`chemical
`Journal of the Chemical Society,
`Chemical Communications.
`curie
`Colour Index (British)
`stereodescriptor see Glossary
`centimeter(s)
`
`as-, asym~
`at.
`ATCC
`atm, atmos
`at. no.
`ATP
`ATPase
`at. wt.
`BAN
`B cell
`
`BCG
`Be
`Beilstein
`
`Belg. pat.
`Ber.
`
`BGG
`biol
`B.I.O.S.
`
`BOC
`B‘O.D.
`boil.
`bp
`
`B.P.
`B.P. C.
`Brit. pat
`BRM
`BSA
`Btu
`Bu
`Bz
`BzH
`BzOH
`
`c C°
`
`C
`
`Crc .
`CA.
`cal
`calc(d)
`Can. pat
`Cbz
`cbc
`cc
`CCK
`CD
`CDP
`CEA
`Cf-
`CFA
`
`CFT
`CHD
`CHF
`chem
`Chem. Commun.
`
`Ci
`C.I.
`cis—
`cm
`
`
`
`
`
`adenine; adenosine; absorbance
`(extinction)
`Angstrom units
`ot,-antitrypsin
`antibody
`absolute; absorption
`absolute configuration
`abstract
`cx—aminobutyric acid
`acetyl CH3CO—
`according
`angiotensin converting enzyme
`acetyl coenzyme A
`acetic anhydride
`ethyl acetate
`acetic acid
`acyl carrier protein
`American Chemical Society
`adrenocorticotropic hormone
`acyl coenzyme A
`antibody—dependent cellular
`cytotoxicity
`adding, addition
`adenine
`alcohol dehydrogenase
`adenosine diphosphate
`(United States) Atomic Energy
`Commission
`antigen, silver
`anaphylotoxin inhibitor
`acqui1ed immunodeficiency
`synd10me
`alanine
`alcohol(ic); ethanol; ethyl alcohol
`anti-lymphocyte globulin
`alkali(ne)
`specific optical rotation at 25° C for
`D (sodium) line; absence of
`brackets indicates optical rotation
`of a liquid in a l decimeter cell,
`neat
`anti—lymphocyte serum amyotrophic
`lateral sclerosis
`molai absorptivity (concn1n
`g-moles/l)
`amorphous
`adenosine 5’-m0nophosphate
`(adenylic acid)
`cyclic AMP
`ampules
`amount(s)
`anti—nuclear factor; atrial natriuretic
`factor
`anhydrous
`stereodescriptor, see Glossary
`Justus Licbig’s Annalen der Chemie
`American Pharmaceutical
`Association
`approximatefly)
`alum precipitated toxoid
`aqueous
`aryl
`analytical reagent
`AIDS related complex
`Naunyn Schmiedebergs Archivfiir
`Experimentelle Pathologie und
`Pharmakologie
`aromatic acyl radical
`arginine
`[3-carboxyaspartic acid
`asparagine
`aspartic acid
`association; associated
`
`. A
`
`AA
`
`AT
`Ab
`abs
`abs config
`abstr
`Abu
`Ac
`acc
`ACE
`Acetyl CoA
`ACZO
`AcOEt
`AcOH
`ACP
`A.C.S.
`ACTH
`AcylSCoA
`ADCC
`
`add(n)
`Ade
`ADH
`ADP
`AEC
`
`Ag
`AI
`AIDS
`
`Ala
`alc, alcoh
`ALG
`alk
`[alias
`
`ALS
`
`(1M
`
`amorph
`AMP
`
`CAMP
`amps
`amt(s)
`ANF
`
`anhydr
`anti
`Ann.
`APhA
`
`approx
`APT
`aq
`Ar
`A.R.
`ARC
`Archiv Exp.
`Pathol.
`Pharmakol.
`ArCO-
`Arg
`Asa
`Asn
`Asp
`assoc(d)
`
`xiii
`
`AstraZeneca Exhibit 2101 p. 11
`
`
`
`CM—cellulose
`CMI
`CML
`CMP
`
`CNS
`CoA or CoASH
`coll. vol.
`compd
`compn
`Con A
`conc(d)
`concn
`config
`constit
`contd
`contg
`CoQ
`cor(r)
`corresp
`CP
`C.P.
`cpd
`crit press
`crit temp
`cryst
`crystn
`CSF
`
`CTFA
`
`CTP
`Cys
`Cyt
`
`DEAE cellulose
`dec, decomp
`decompn
`deg
`deliquesc
`A (delta)
`deriv
`determn
`DFP, DIFP, DIPF
`
`Dha
`Dhb
`
`diff
`di1(d), (n)
`distln
`d1-
`DI;
`
`dm
`DMA
`DMARD
`DMF
`DMSO
`DNA
`cDNA
`mtDNA
`DNAase
`DNFB
`DNP
`
`Dopa
`dp, DP
`
`0-(carboxymethy1) cellulose
`cell-mediated immunity
`cell—mediated lymphocytotoxicity
`cytidine 5'-monophosphate (cytidylic
`acid)
`central nervous system
`coenzyme A
`collective volume
`compound
`composition
`concanavalin A
`concentrated
`concentration
`configuration
`constituent
`continued
`containing
`coenzyme Q (ubiquinone)
`corrected
`corresponding, corresponds
`centipoise
`chemically pure
`compound
`critical pressure
`critical temperature
`crystalline crystals
`crystallization
`colony stimulating factor; cerebral
`spinal fluid
`Cosmetic, Toiletry and Fragrance
`Assoc.
`cytidine triphosphate
`cysteine
`cytosine
`density; specific gravity ((149 specific
`gravity at 19° referred to water at
`°)
`dextro(rotatory), the Opposite of l
`dextro (in configurational sense
`only), the opposite of L
`daltons
`0-(diethylaminoethyl)cellulose
`decompose(s), decomposition
`decomposition
`degree
`deliquescent
`indicates the locant of the double
`bond
`derivative
`determination
`diiSOpropyl fluorophosphate or
`diisopropyl phosphofluoridate
`dihydroalanine
`dehydrobutyrine,
`B‘methyldehydroalanine
`difference
`dilute, diluted, dilution
`distillation
`racemic
`optically inactive by external
`compensation as contrasted with
`meso~
`decimeter(s)
`dimethylacetamide
`disease modifying antirheumatic drug
`dimethylformamide
`dimethylsulfoxide
`deoxyribonucleic acid
`complementary DNA
`mitochondrial DNA
`deoxyribonuclease
`2,4-dinitro- 1fluorobenzene
`2,4--_dinitrophenyl or 24-
`dinitrophenol
`dihydroxyphenylalanine
`degree of polymerization (number of
`monomeric units in the polymer)
`
`D.R.P.
`
`DTT
`dyn
`
`1%
`Elem
`
`EM
`EAA
`EAC
`
`EAE
`
`EC
`ECF—A
`
`ECG
`EC. No.
`ed.
`ED
`Ed(s).
`EDTA
`EEG
`e.g.
`EGF
`eidem
`EINECS
`
`EKG
`ELISA
`emf
`en
`endo—
`
`EPA
`EPO
`
`e (epsilon)
`
`eq
`equilib
`equiv
`esp
`esu
`Et
`n (eta)
`et al.
`etc.
`EtZO
`EtOH
`Eur. pat. App].
`ev
`evac
`evapn
`exo-
`
`expt(ly)
`ext(d)
`extern
`°F
`F— 1 —P
`F—6-P
`FA
`FAB
`FAD (FADHZ)
`FCA
`
`
`
`Fd
`F.D.A.
`
`FD&C
`
`xiv
`
`(Deutsches Reichs-Patent)—German
`patent
`double stranded
`dithiothreitol
`dynes
`entgegen, stereodescriptor, see
`Glossary
`the absorbance of a solution
`containing one gram per 100 m1
`containedin a cell having an
`absorption path of one cm
`molar extinction coefficient (concn1n
`g--moles/l)
`excitatory amino acid
`erythrocyte coated by antibody and
`complement
`experimental allergic
`encephalomyelitis
`electron capture
`eosinophil chemotactic factor of
`anaphylaxis
`electrocardiogram
`Enzyme Commission Number
`edition
`effective dose
`editor(s)
`ethylenediaminetetraacetic acid
`electroencephalogram
`(exempli gratia) for example
`epidermal growth factor
`the same (authors), plural of idem
`European Inventory of Existing
`Chemical Substances
`electrocardiogram
`enzyme—linked immunosorbent assay
`electromotive force
`ethylenediamine (in formulas)
`stereochemical descriptor, see
`Glossary
`Environmental Protection Agency
`erythropoietin; European Patent
`Office
`molar extinction coefficient (concn in
`g-moles/l); dielectric constant
`equation
`equilibrium
`equivalent
`especially
`electrostatic units of electrical charge
`ethyl C2115“-
`viscosity
`(et alii) and others
`et cetera
`ether
`ethyl alcohol
`European patent application
`electron volt
`evacuated
`evaporation
`stereochemical descriptor, see
`Glossary
`experimental(ly)
`extract, extracted
`externally
`Fahrenheit degrees; also Fourneau
`fructose l-phosphate
`fructose 6-phosphate
`fatty acid
`fast atom bombardment
`flavin adenine dinucleotide (reduced
`form)
`Freund’s complete adjuvant (same as
`CFA)
`ferredoxin
`Food and Drug Administration
`(U.S.A.)
`Food, Drug and Cosmetic (U.S.A).
`
`AstraZeneca Exhibit 2101 p. 12
`
`
`
`FDNB
`FDP
`ff
`FFA
`FFC
`FIA
`
`FIAT
`
`FMN (FMNHZ)
`
`Fmoc
`Forz‘schr. Chem.
`Org. Naturst.
`
`Glc
`GLC
`Gch
`GlcN
`GlcNAc
`GlcUA
`Gln
`Glu
`GluA
`Gly
`Glycerol-3-P
`Gmelin 's
`
`GMP
`
`cGMP
`GM-CSF
`
`gov’t
`GP
`GRF, GHRF
`GSH
`GSSG
`GTP
`GU
`Gua
`
`1-fluoro—2,4-dinitrobenzene
`fructose 1,6-diphosphate
`following
`free fatty acid
`free from chlorine
`Freund’s incomplete adjuvant (same
`as ICFA)
`Field Information Agency, Technical
`(U.S. reports)
`flavin mononucleotide (reduced
`form); same as riboflavin
`phosphate
`9-fluorenylmethoxycarb0nyl
`Forlschritte der Chemie Organischer
`Natttrstofle (Progress in the
`Chemistry of Organic Natural
`Products)
`freezing point
`flavoprotein
`fast protein liquid chromatography
`French patent
`P. Friedlander Fortschritte der Teer-
`farbenfabrikation, a collection of
`patents
`fructose
`follicle~stimulating hormone
`Fourier transform
`gram(s)
`guanine; guanosine
`glucose 1-phosphate
`glyceraldehydep3-phosphate
`glucose 6-phosphate
`'y—aminobutyric acid
`gallon(s)
`galactose
`N—acetyl-D-galactosamine
`microgram(s)
`gas chromatography
`glutamate dehydrogenase
`guanosine diphosphate
`geminal, stereodescriptor see
`Glossary
`geological
`German patent
`growth hormone
`gastrointestinal
`grams per liter
`y-carboxyglutamic acid
`glucose
`gas-liquid chromatography
`gluconic acid
`glucosamine
`N—acety