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`v Copyright © 1999 and published by Medical Economics Company, Inc. at Montvale, NJ 07645-1742. All rights reserved. None ofthe content of this publication
`-Imay be reproduced, storedIn a retrieval system, resold, redistributed, or transmitted”In any form or by any means (electronic, mechanical, photocopying, record-
`ing, or otherwise) without the prior written permission of the publisher. PHYSICIANS' DESK REFERENCE“, PDR“ PDR For Nonprescription Drugs“ PDFI For
`‘ Ophthalmology“, Pocket PDR“, and The PDFI“ Family Guide to Prescription Drugs® are registered trademarks used herein under license. PDR Companion GuideTM,
`_ PDR“ for Herbal Medicines'M, PDR“ MedicalDictionaryTM, PDR“ Nurse's HandbookTM, PDR“ Nurse's DictionaryTM, ThePDR“ Family Guide Encyclopedia of Medical
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`ISBN: 1563632888
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`AstraZeneca Exhibit 2169 p. 7
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`

`
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`
`AstraZeneca Exhibit 2169 p. 8
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`
`
`CONTENTS
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` .Manufacturers’ Index(White Pages) I ‘ . " ‘ _ H II L 1
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`' Section 1 .,
`Lists all pharmaceutical manufacturers partibipating in PHYSIClANS' DESK REFERENCE.
`Includes addresses, phone numbers, and emergency contacts. Shows each manufacturer'5
`products and the page number of those described in PDR.
`
`
`
`
`
`‘Brand and Generic NaIne Index (Pink Pages) o 101 I ..
`
`
`
`
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`Section 2
`
`I Gives the page number of each product by brand and generic name.
`
`
` Product‘categoryvlndex.(BlueiPages) I ‘ V d ,. I I “ 7 201‘, H
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`Section 3 I
`Lists all fIIlly described products by prescribing category. An overview of the headings A
`appears on pages 201 and 202.
`
`
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`
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`Product Identification Guide e... Pages) (301 -' I v .'
`section 4
`Presents fullcolor,actual--size photos of tablets and capsules, plus pictures of ‘a variety of other
`dosageforms andpackages. Arranged alphabetically by manufacturer.
`
`
`
` Product InformatIon (White Pages) ,- I “ _’ .. ‘ . . ‘401’
`
`
`
`
`- Section 5
`The main section of the book Includes entries for over 2,200 pharmaceuticals. Listings are
`
`
`'arranged alphabetically by manufactUrer. -
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`
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`
`
`
`Diagnostic Product Information 733467 ’ 2‘ V V _ ‘
`_ Gives usage gaidelines for a varietyof common diagnOstic agents. Arrangedalphabetically bymanufacturer
`
`.
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`I
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`.
`
`I
`
`section 6
`
`I
`
`DruglnformatIonCenters .................... '. .....~............‘
`.....
`................................‘. ...... 220
`A national directory ofinstitutions that ansWer. queries regarding drugs. Arranged alphabetically by state and city.
`Key to Controlled Substances Categories.....
`........................................... ....-...347
`Gives the definition of each category and the prescribing limitations that apply.
`Keyto FDA Use-in-Pregnancy Ratings .....
`.............347
`Provides the exact interpretation of each risk/benefit rating.
`U.5. Foodand DrugAdministration Telephone Directory........‘.............................-.......................................348
`Gives numbers of key reporting programs and information services.
`’POiSonControlCenters..... ‘.' ...................................................
`A nationaldirectOry arranged alphabetically by state and city.
`
`..........v ...... ............‘.'......3478
`
`......
`
`AstraZeneca Exhibit 2169 p. 10
`
`

`

`
`
` ZUET lttlFQEtMA‘Fllil'N= ‘
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`id. The usual maintenance dosage-£2120 mg to=240
`day.Insome‘mstanwsadosageofGMmgadaymay
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`ztoagive‘ndosage iswaiiableand may range froma
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`price-dailydosingiseil‘ective'and citumaintain a re-
`i in blood pressure throughout the day, so'me pa-
`especially when lower doses aroused, mayexperi-
`modestrise‘in bloodpressm‘towardthe end-ofthe
`"r?dosing"interval. This (an be évaludte’dby measur:
`oilpressureneartheendofthedomngmtervalto de-
`e whether satisfactory control‘isbeingmaintained
`huut‘the diiy.Ifcufiel‘is not adequate, a largerdose,
`hes-dailytherapy may achieve bettercontroli';
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`r,Pecturis—‘Dosage riiust be individualized.
`lailydoses of80mgto320mg,whenadministeied
`tmceadaythieetimesadaygorfuurtimesaday,
`eenshuwntomcreaseexemsetoleranceandtore-
`'ehemic‘cban'gesintheECG Iftreati'nentis tube dis-
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`(SeeWARNINGS!)
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`rdial infarction—The recommendeddailydosage is
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`reness and safety ofdaily dosages greaterthan,240
`preventionofcardiacinortahty havenot.beenestab-
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`itlaloraldoseIsSOmgInderaldailymdivrdeddoses
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`sage maybe increased 9adually to achieveoptimum
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`£21m fourto six-weeks afierreaching the maximum
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`ctr) withdrawthe drug graduallyover a period-of.sev-
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`ialTremor—Dosage must be individualized.
`A
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`ion ofessential tremoris usuallyachieved with adose
`mg per day. Occasionally, itmay be nw‘essaryto ads.
`e‘r240mgto320mgiperdayw
`rophic Subaunic sunfish—20 mg to 40 mg‘ threeor
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`doses forthree daysprior to surgery concomitantly
`ii alpha-adrenergic blocking agent.“ ~'-
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`1 Pediatric Patienu. Intravenous. administration of ‘
`lis not recommendedin pediatric patients. Oral dos-
`treatinghypertension requires individual titration,
`ungmthalOmgperkgMdywelghtnerdaydos-
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`rualpediatncdosagerangeIsngto4mgperkgper
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`{per kg b.i.d.). Pediatric dosage calculamd by weight
`mended) generally produces pmpranololplasma lev-
`atherapeutic range similar to thatin adults. On the
`bahd, pediatricdoses calculated on the basis of body
`9.area (not recommended) usually_resultin plasma
`abovethemean adult therapeutic range. Doses above
`perkgper day should notbeusedinpediatric pa-
`If.treatment with Inderal,‘is to be discontinued a
`illydecreasing ddse titration over a 7- to14—day pe~
`necessary
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`:eral drug products should be inspected visually for
`flats matter and discoloration prior to administra-
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`enous administrationis reserved for life-threatening
`hmias or those occurringunder anesthesia. The usual
`from 1 mgt03 mgadmi'nisteredundercarefiilmou-
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`we. of administration should not exceed 1 mg (1 mL)
`inute to diminish the possibility of lowering blood
`we andcausing cardiac standstill. Suflicient time
`be allowed for the drug to reach the site of action
`When a slow circulation ispresent. Ifnecessary, a sec-
`se may be given alter two minutes. Thereafter, addi-
`drug should not begi