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`4/13/04 CANCERWK 19
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`NewsRoom
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`4/13/04 Cancer Wkly. Plus 19
`2004 WLNR 542429
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`Cancer Weekly
`Copyright 2004 Cancer Weekly via NewsRx.com & NewsRx.net
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`April 13, 2004
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`Section: Expanded Reporting
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`European launchof Faslodex reported
`Breast Cancer
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`AstraZeneca announcedthe first Europeanlaunchesofits new breast cancer drug Faslodex ( fulvestrant) in Germany
`and Sweden, with Austria following imminently.
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`The novel drug - an estrogenreceptor antagonist with no agonist effects - is for the treatment of advanced breast cancer
`in postmenopausal women whose cancer has progressed on previous anti-estrogen treatments such as tamoxifen.
`Fulvestrant has been launched in the U.S. since May 2002, and more recently in Brazil in July 2003.
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`Fulvestrant was approved for launch in the European Union (E.U.) on 12 March 2004, makingit the first new type of
`hormonaltreatment for estrogen receptor-positive breast cancer to be approvedin the E.U. since 1995. The launch of
`the drug in Germany, Sweden, and Austria therefore provides new hope to the thousands of women suffering from
`advanced disease in these countries. Further launches throughout Europe are expected during the course of this year.
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`Commenting on the launch, professor Kurt Possinger, head of the oncology department at Humboldt University of
`Berlin, Germany, explains, "The availability of 'Faslodex' in these countries is very exciting as women who have
`progressed on prior tamoxifen therapy now have a new additional and effective treatment option which may help
`extend the window of endocrine therapy and delay the use of cytotoxic chemotherapies withtheir well-recognized and
`unwantedside-effects.
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`In addition, unlike other endocrine therapies used in postmenopausal women, 'Faslodex' is a once-monthly injection
`which enablesclinicians to have greater contact with their patients to review progress and free womenof the worry of
`remembering to take a daily tablet, allowing them to focus on their life and not their illness."
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`Breast cancer affects one in nine women at somepoint in their lives and although many tumors are detected early and
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`© 2015 ThomsonReuters. No Claim to Orig. US Gov. Works.
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`AstraZeneca Exhibit 2067 p. 1
`InnoPharma Licensing LLC v. AstraZeneca AB IPR2017-00904
`Fresenius-Kabi USA LLC v. AstraZeneca AB IPR2017-01910
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`treated successfully, a large number of womenstill go on to be diagnosed with advanced breast cancer. The goal of
`treatment for these womenis to achieve an effective disease response and to enable the patient to maintain good
`quality of life for as long as is feasibly possible.
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`Hormonal agents such as aromatase inhibitors and tamoxifen are standard therapy in postmenopausal women with
`advanced breast cancer, providing an effective and well-tolerated treatment option. However, in time tumourcells can
`grow resistant to treatment with these hormonaltherapies and as a result there is a need for new agents to which tumors
`are not resistant. Fulvestrant is an exciting new type of therapy, which brings new choices for women with advanced
`disease, extending the sequence of'patient-friendly' hormonal therapies that can be used to control the disease.
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`Fulvestrant works differently to any other treatment available, althoughlike the other hormonal therapies it interferes
`with the effect of the hormone'estrogen' on tumour growth. Many breast cancers are dependent onthe presence of
`estrogen to grow. Of the current therapies, aromatase inhibitors (e.g. Arimidex (anastrozole)) work by reducing the
`amount of estrogen in a woman's body, and tamoxifen (an anti-estrogen) blocks estrogen receptors. However, ta-
`moxifen also mimics someofthe actions of estrogen, which can result in unwantedside effects. In contrast, fulvestrant
`works by blocking and removing the estrogen receptors in the breast cancer cells and, unlike tamoxifen, does not
`mimic the actions of estrogen.
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`Fulvestrant offers durable responses and has tolerability benefits compared with aromatase inhibitors and tamoxifen.
`Fulvestrantis effective following disease progression on prior anti-estrogen and aromatase inhibitor therapy in addi-
`tion both therapies are effective following fulvestrant therapy. Fulvestrant therefore meets a key unmet need for
`women with advanced breast cancer, since it can be addedinto the sequence of well-tolerated hormonal therapies and
`may delay the need to resort to cytotoxic chemotherapies with their well-recognized side effects.
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`This article was prepared by Cancer Weekly editors from staff and other reports. Copyright 2004, Cancer Weekly via
`NewsRx.com & NewsRx.net.
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`Copyright © 2004 Cancer Weekly via NewsRx.com & NewsRx.net
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`---- INDEX REFERENCES---
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`COMPANY: ASTRAZENECA PLC
`
`NEWSSUBJECT: (Health & Family (1HE30); World Organizations (1IN77); European Union (1EU94))
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`INDUSTRY: (Pharmaceuticals & Biotechnology (1PH13); Healthcare (1HE06); Endocrinology & Metabolism
`(1EN72); Internal Medicine (1IN54); Healthcare Practice Specialties (1HE49); Cancer Drugs (1CA21); Oncology &
`Hematology (LON95))
`
`REGION: (Western Europe (1WE41); Austria (1AU39); Scandinavia (1SC27); Germany (1GE16); Europe (1EU83);
`Northern Europe (1NO01); Central Europe (1CE50))
`
`© 2015 ThomsonReuters. No Claim to Orig. US Gov. Works.
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`AstraZeneca Exhibit 2067 p. 2
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`Language: EN
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`OTHER INDEXING: (ASTRAZENECA; EUROPEAN UNION; HUMBOLDT UNIVERSITY) (Arimidex; Breast
`Cancer; Cancer Weekly; Commenting; Faslodex; Kurt Possinger)
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`KEYWORDS: AstraZeneca; Therapy; Women's Health; All News; Consumer News; Oncology
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`Word Count: 841
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`4/13/04 CANCERWK 19
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`END OF DOCUMENT
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`© 2015 Thomson Reuters. No Claim to Orig. US Gov. Works.
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`AstraZeneca Exhibit 2067 p. 3
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