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`FOREWORDTOTHE FIFTY-THIRDEDITION
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`ciousclaims, warnsof conflicting conditions and drugs,
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` Manufacturers’ Index.(White© Pages) : | OO : . 4
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`. Section 1 -
`.
`Lists all pharmaceutical manufacturers participating in PHYSICIANS' DESK REFERENCE.
`Includes addresses, phone numbers, and emergency contacts. Shows each manufacturer’‘Ss
`
`products and.the page numberof those described in PDR. .
`
`
`Brand and Generic Name Index(PinkPages). - 201 as
`Section 2:
`Gives the page number ofeachh product bybrand andgeneric|name.
` Product Category Index (BluePages) | ee 201
`Lists. all fully described products by prescribingcategory. An overview ofthe. headings .
`
`appearson pages 201 and 202. :
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`Product IdentificationGuide(cayracs) =S=S*=*~<CS~*é‘=~*«S
`Section 4
`Presents full-color,actual-size photos oftablets and capsules, pluspictures ofa variety ofother
`dosage.forms andpackages. Arranged alphabetically by manufacturer.
` Product Information(White Pages) re a 401 |
`Section 5
`The main section ofthe‘book; Includes entriesfor over 2,200 pharmaceuticals. Listings are
`
`arranged alphabetically by manufacturer. ‘
`
`DiagnosticProduct Information 7 a | 3467
`. Gives usage guidelines fora1 varietyofcommon diagnostic agents. Arranged.alphabetically bymanufacturer.
`DrugInformation Centerspheaeeeanesanesevnesveneecteleeeserens"suadasueveonseseucecusduenssvustaassusaudasdeatessessanseseesauensneteasVeneer220
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`a.)national directoryofinstitutions that answer.queries regarding drugs. Arranged alphabeticallybystate and7 ety.
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`Key to ControlledSubstances Categories.........ccesccssssiessessentedecerspescneeenicertenebetes pueenensderenanees Leeserssuecevaeegee 4” ;
`_ Gives the definition of each category and the prescribing limitations that apply.
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`U.S. Food and Drug Administration TelephoneDirectory.......0..6c.scccecssssessessetecenssesseneneeeseasseeiareneneseenes 1.348)
`Gives numbers of key reporting programs. and, information services.
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`A nationalv dlrectory arranged alphabetically by state and city.
`
`Section 3
`
`.. Section 6
`
`.
`
`-
`
`.
`
`
`
`CONTENTS
`
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`7
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`AstraZeneca Exhibit 2046 p. 10
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` PRODUCT-INFORMATIONI::
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`AstraZeneca Exhibit 2046 p. 11
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`“NOVARTIS:PHARMACEUTICALS/2025
`
`HOWSUPPLIED:
`women need estrogen replaceniétit therapy’for né loiger
`| A stiff protective liner covers the adhesive side of:the
`Estraderti‘SStradiol transdermal system 0:05mg/day — |
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`Of 8 Systems oo...ccsceseeseessessteeegeaee‘1 NDC’‘0088-2310-08
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`ning of the bones makes the bones weakeranid‘ more Jikely
`adhesive.
`NDC 0083-2310-62
`to -break,; often. leading.-to fractures.of the spine,hip, and
`of 8 Systems’
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`wrist. Taking estrogens after the:menopause.slows,down:or
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`NDC: 0083-2310-24 -;
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`Estradefni‘estFadiol iranisdermal system0.1: mg}day each |
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`
`discontinued;, Eatingfoods that are high in calcium(such as
`20cm?‘systemcontains 8'mg oféstradiol USP’‘for norinal*
`milk products).or. taking calcium: supplements;and-certain
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`types of.exercise:may also help prevent. osteoporosis, Before
`Patient Calendar Pack|
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`a NDC:0088:2820.24
`osteoporosis should beconfined to women ho appearto be
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`Donot store ‘above 86°F (30°C).
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`1, ESTROGENS INCREASE THE RISK. OF.‘CANCER‘OF7
`>THE, UTERUS- IN--WOMEN. WHO: HAVE- HAD THEIR -
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`. MENOPAUSE.(”“CHANGE OFLIFE”),
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`may have an increasedrisk of developing abnormalitiesof
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`
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`an increased risk.of:developing’cancer of the vagina or’cer-
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`vix in her teens or twenties. Estrogenis not effective:in pre-"
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`
`having bitth: defects. Therisk of developing these. de=.;
`fects:is small;but.clearly. larger than the risk inchildren: |
`whose