throbber
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY l PCT)
`
`(19) World Intellectual Property Organization -
`International Bureau
`'
`
`(43) International Publication Date
`1 November 2007 (01.11.2007)
`
`
`
`||||l|||l||||t|||||||l||l|||||||l||||||l||||||||||l||||||l|||||||||ll||||t||ll||l||||||||||||
`
`(10) International Publication Number
`
`W0 2007/ 12237 5 A2
`
`(51) International Patent Classification:
`AME Sill-£55 (2W601)
`A618 5’08 (2006.01)
`A613 5.3024 (2006.0l)
`
`(74) Agent: CHARIG, Raymond; liric Potter (Ilarkson 1.].1’.
`Park View House. 58 The Ropcwalk. Nottingham NS]
`SDD (GB).
`
`(21)
`
`IllTvemaTvim'laj APPHWlion Nun‘beri V _
`PLUGBBOD-Hm I 355
`11 Apfil2007t|1.04.2007)
`[ingfish
`
`(22) International Filing Date:
`(35) Filing Language:
`
`English
`
`t81) Designated States (titties: otherwise indicated. for every
`kind of national protection available}: AE. AG. AL. AM.
`
`Fl. GB. GD. GE. Gll. GM, GT. ll'N. IIR. IlU. ID, IL, IN.
`IS, JP, KE. KG. KM. KN, KP, KR.
`LA. LC, LK. LR.
`LS. LT. LU. LY. MA. MD. MG. MK. MN. MW. MX. MY.
`MZ, NA, NG, N1, NO, NZ, OM. PG, PH, PL, PT, Rt), RS,
`RU, so, St), SE. so, SK, 31., SM, SV. SY, '1'], TM, TN,
`TR. T1". TZ. UA, UG, us. UZ, vc. VN, ZA, ZM, zw.
`_
`.
`I
`I
`1
`{84) Diningnatcd' states (unless otherwise indicated. for every
`kind nfmgimirit protection available): ARl'PO (BW. Gll,
`GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM,
`KW). Eurasian (AM. AZ. BY. KG. KZ. MD. RU. TJ. TM).
`liuropean (AT. Bli, BG, CH, CY, CZ, DE, DK, lili, 155. 1‘1,
`FR. GB, GR. IIU, 115, IS. 1T. LT. LU. LV. MC. MT, NL, PL,
`PT, RO. SE. SI, SK, TR). OAPI (BF, BJ, CF, CG, Cl. CM,
`GA. GN, GQ, GW. ML. MR. NE. SN. TD. TG).
`
`(26) Publication Language:
`I
`.
`_
`‘3") Pr'"“‘-" "3”"
`“3
`11 AW" 300“ U "0430“)
`“5073705
`(71) Applicant [for all designated States except US}: THE
`UNIVERSITY OF NOTTINGHAI“ [GBIGBR Univcp
`my Park‘ leingham NG? 2RD (GBI
`[72) Inventors; and
`[75)
`lnventorst'Applicants (for US only): CROWE, John
`[(33033]; School of Electrical and Electronic Engineer
`ing. The University of Nottingham. University Park,
`Nottingham NG7 2RD (GB). GRUBB. Mark lGBKiBI;
`School of Electrical and lilectronic Engineering. The
`University of Nottingham. University Park, Nottingham Published:
`NG? 2RD (GB). HAYESflfliL, Barrie [GBJ'GB]; School
`without international scrim}! report and to be republished
`of Electrical and Electronic Engineering. The University
`upon receipt of that report
`of Nottingham, University Park, Nottingham NUT 2RD
`(GB). MILES. Nicolas lGBt’GB]: School ot'lilectrical and
`Electronic Engineering, The University of Nottingham,
`Universin Park. Nottingham NG't' 2RD (GB).
`
`For terJetter codes and other abbreviations. refer to the "Guide
`mice Notes on Codes and Abbreviations " appearing tit the begin-
`ning ofeach regular issue ofthe PCT Gazette.
`
`(54) Title: PHO’t‘om.n't'HstOGRAPHv
`
`100
`
`101
`
`102
`
`105
`
`10?
`
`
`
`
`
`7/122375A2|||||||||||||||||||||||||||||||||ll||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
`
`(57) Abstract: A photoplethysmograph device includes a light source for illuminating a target object. A modulator drives the light
`source such that the output intensityr varies as a function of a modulation signal at a modulation frequency. A detector receives light
`from the target object and generates an electrical output as a function of the intensity of received light. A demodulator with a local
`: oscillator receives the detector outth and produces a demodulated output representative of the modulation signal. The demodulator
`c is insensitive to any phase difference between the modulation signal and the oscillator of the demodulator.
`lirom the demodulated
`N output. a signal indicative of blood volume as a function of time and for blood composition is generated. A number ol'dcmodulators
`may be provided to derive signals from multiple light sources of different wavelengths, or from an array ofdelectors. The plethys-
`mograph may operate in a transmission mode or a reflectance mode. When in a reflectance mode, the device may use the green part
`of the optical spectnim and may use pelarising filters.
`
`0001
`
`Apple Inc.
`APL 1049
`
`US. Patent No. 8,923,941
`FITBIT, Ex. 1049
`
`Apple Inc.
`APL1049
`U.S. Patent No. 8,923,941
`
`0001
`
`FITBIT, Ex. 1049
`
`

`

`W0 2007I'122375
`
`PCT/G 82007/001355
`
`PHOTOPLETHYSMOGRAPHY
`
`The present invention relates photoplethysrnography and in particular to a method and
`
`apparatus for measuring pulse rate, breathing rate and blood constituents in the human
`
`or animal body.
`
`The word plethysrnography is a combination of the Greek words Piethysmos,
`
`meaning increase, and graph, meaning write. A plethysmograph is an instrument,
`method or apparatus used to measure the variations in blood volume in the body.
`Photoplethysmography (hereinafter also referred to as 'PPG') refers to the use of light
`
`10
`
`to measure these changes in volume, and therefore a photoplethysmograph is an
`
`instrument, method or apparatus that uses light to perform these measurements.
`
`Although the human or animal body is generally assumed to he opaque to light, most
`
`15
`
`soft
`
`tissue will
`
`transmit and reflect both visible and near-infrared radiation.
`
`Therefore, if light is projected onto an area of skin and the emergent light is detected
`
`after its interaction with the slcin, blood and other tissue, time varying changes of light
`
`intensity havhig a relation with blood volume, known as the plethysmogram, can be
`
`observed. This time varying light intensity signal will depend on a number of factors
`
`including the optical properties of the tissues and biood at the measurement site, and
`
`the wavelength of the light source. The signal results because blood absorbs light and
`
`the amount of light absorbed, and hence the intensity of remaining light detected,
`
`varies in relation with the volume of blood illuminated.
`
`Variation in the
`
`plethysmogram is caused by the variation in blood volume flowing in the tissue.
`
`This technique was introduced in 1937 by Hertzman. He was the first to use the term
`
`photoplethysmcgraphy and suggested that the resultant piethysmograrn represented
`
`volumetric changes of blood in the skin's vessels.
`
`The plethysmogram is usually described with respect to its AC and DC components.
`
`The absorption of light by uon—pulsatile blood, bone and tissue is assumed to be
`
`constant and giVes rise to the DC component. The DC component represents the
`
`volume of non-pulsatile blood below the sensor, plus light reflected and scattered off
`
`20
`
`25
`
`30
`
`1
`
`0002
`
`FITBIT, EX. 1049
`
`0002
`
`FITBIT, Ex. 1049
`
`

`

`W0 2007f122375
`
`PCT/G32007/001355
`
`the skin, bone and other tissues. The AC component is caused by the time varying
`
`absorption of light caused by temporal changes in blood volume below the sensor.
`
`Changes in the blood volume can be caused by cardiovascular regulation, blood
`
`pressure regulation, fliermoregulation and respiration. Thus the ple’diysmogram can
`
`be analysed to determine mforrnation on such parameters as pulse rate, breathing rate,
`
`blood pressure, perfusion, cardiac stroke volume and respiratory tidal volume. These
`
`can be observed as periodic and non-periodic changes in the amplitude of AC and DC
`
`components in the plethysmogram. This has been described in more detail in Kamal
`
`et at:
`
`'Skz'n Phoroplerhysmography — a review’, Computer Methods and Programs in
`
`Biomedicine, 28 (1989) 257-269).
`
`The plethysmogram can also he analysed to
`
`determine blood constituents.
`
`One such technique is pulse oximetry, which
`
`determines the relative amount of oxygen in the blood. Other blood constituents can
`
`also be measured by using photoplethysmography.
`
`There are two modes of photoplethysmography, the transmission mode and the
`
`reflection mode. In transmission mode the light source is on one side of the tissue and
`
`the photodetector is placed on the other side, opposite the light source. The use of
`
`transmission mode is limited to areas where the tissue is thin enough to allow light to
`
`propagate, for example the fingers, toes and earlobes of a human subject.
`
`In reflection mode the light source and photodetector are place side-by—side. Light
`
`entering the tissue is reflected and a proportion of this is detected at the photodetector.
`
`This source—detector configuration is more versatile and allows measurements to be
`
`performed on almost any area of tissue. However, the use of reflectance mode is
`
`much harder to design than transmission because the signal level is significantly lower
`
`at the most effective wavelengths. Thus, considerable attention must be given to
`
`maximising signal-to-noise ratio. As a result, the most common PPG sensors use
`
`transmission mode and hence are restricted to positions where light can pass through
`
`10
`
`15
`
`20
`
`25
`
`30
`
`tissue.
`
`As a photodetector is used to measure light from the source, the photoplethysmograph
`
`can also respond to interfering signals from other sources of light, for' example
`
`2
`
`0003
`
`FITBIT, EX. 1049
`
`0003
`
`FITBIT, Ex. 1049
`
`

`

`W0 2007;122:375
`
`PCT/GBZOU'l/OGISSS
`
`fluorescent lighting and computer monitors. The sensor must also respond to changes
`
`in the light propagating through tissue, i.e. the plethysmo gram. These physiological
`
`changes contain frequency components between DC and 25 Hz. However, it is
`
`desirable for the sensor not to respond to ambient light noise. Accordingly, the
`
`phot0plethysmograph should reject ambient
`plethysmogram in the bandwidth ofinterest.
`
`light noise while detecting the
`
`A second source of interference is other electrical apparatus. Other electrical devices
`
`can generate radio frequency signals that a photoplethysmograph can detect.
`
`It is
`
`desirable to minimise the Sensitivity of the system to interfering sources of this nature.
`
`A third source of
`
`interference
`
`is
`
`the
`
`electrical noise generated by the
`
`photoplethysmo graph itself. Such noise can be generated by electronic components,
`
`and can include thermal noise, flicker noise, shot noise, as Well as noise spikes, for
`
`example, harmonics generated by missing codes in an analogue-to-digital converter.
`
`It is also desirable to minimise the sensitivity of the system to interference from these
`SOUICB$
`
`A known technique for reducing the noise generated by these three sources of
`
`interference is to drive the sensor's light source with a carrier modulated at a
`
`frequency that is not present, or dominant,
`
`in the ambient
`
`light, electrical radio
`
`frequency signals, 'or photoplethysmograph system noise. This can be done by
`
`modulating the sensor’s light source with a square wave, by pulsing it on and off. The
`
`detected signals are then band pass filtered to attenuate interference outside the
`
`fiequency range of
`
`interest.
`
`Subsequent demodulation will
`
`recover
`
`the
`
`plethysmogram.
`
`In general, any periodic signal such as a sine wave may be used to
`
`modulate the light source.
`
`Though modulated light photoplethysmography exists in the prior art, there are still
`
`critical limitations in how it has been applied, especially in terms of suitable signal
`
`conditioning circuits for attenuating or removing noise, and demodulation. For
`
`example, EP0335357, EPG314324, W00144780 and W09846125 disclose modulated
`
`light phot0plethysmography. However,
`
`they use a demodulation method. and
`
`10
`
`15
`
`20
`
`25
`
`30
`
`3
`
`0004
`
`FITBIT, EX. 1049
`
`0004
`
`FITBIT, Ex. 1049
`
`

`

`W0 2007;122:375
`
`PCT/GBZOU'l/OGISSS
`
`apparatus that requires
`
`the modulating and demodulating carrier phase to be
`
`synchronised. Error in the synchronisation timing will add noise to the demodulated
`
`signal (timing jitter or phase noise). The prior art also fails to make full use of band
`
`pass filter characteristics to remove ambient interfering light, by still relying on a
`
`separate channel to measure ambient light, and later subtracting it fi'om the signal,
`
`which adds
`
`filrther complexity and is arguably less efficient at attenuating
`
`interference. These limitations reduce immunity to broadband and narrowband noise
`
`from sources such as fluorescent lighting, computer monitors, sunlight, incandescent
`
`light, electrical RF interference, thermal noise, flicker noise, and shot noise.
`
`A further limitation in the prior art is the choice of wavelength for reflectance mode
`
`sensors. Both reflection mode and transmission mode sensors use light sources in the
`
`red andfor infrared part of the spectrum, wavelengths between 600nm and lOOOnrn
`
`being typical. However, red l infrared reflectance sensors do not function well
`
`because light at red and infrared wavelengths is poorly absorbed by blood. This
`
`results in low modulation of the reflected signal and therefore a small AC component.
`
`Therefore red / infrared reflectance probes give poor results when compared to
`
`transmittance probes. It has been shown in Weija Cui er al: “In Vivo Reflectance of
`
`Blood and Tissue as a Function of Light Wavelength”,
`
`IEEE Transactions on
`
`Biomedical Engineering, Volume 37, No 6, June 1996), that a larger plethysmogram
`
`AC component amplitude can be recorded if a reflectance mode sensor uses light of
`
`wavelengths between 500nm and 600nm (green light).
`
`A continuous non-modulated green light photoplethysmograph was described in W0
`
`9822018Al. HUWever, the objective of this invention was reflectance pulse oximetry,
`
`and the patent does not explain the steps necessary to produce a reliable
`
`photoplethysmograph suitable for measuring the plethysmogram AC and DC
`
`component. Such a green light sensor would be necessary to reliably detect the AC
`
`component, for example heart rate, but moreover the breathing signal, which is
`
`extremely small and was not detected by this system.
`
`In Benton er al: “Integrated synchronous receiver channelfor optical instrumentation
`
`applications” Proceedings of SPIE — The International Society for Optics]
`
`10
`
`15
`
`20
`
`25
`
`30
`
`4
`
`0005
`
`FITBIT, EX. 1049
`
`0005
`
`FITBIT, Ex. 1049
`
`

`

`W0 2007;122:375
`
`PCT/GBZOU'l/OGISSS
`
`Engineering,
`
`Volume
`
`3100,
`
`75—88,
`
`1997),
`
`3. modulated
`
`light
`
`reflectance
`
`photcplethysmograph is described that uses a switching multiplier to systematically
`
`change‘the gain of the signal path between +1 and —1. This is the equivalent of
`
`mixing the modulated signal with a square wave to recover the plethysmogram.
`
`However, similar to the other prior art described previously, this method needs the
`
`modulating carrier and demodulating local oscillator signals to be iii-phase.
`
`It is an object of the present invention to provide an improved plethysmograph.
`
`According to one aspect,
`
`the present
`
`invention provides a photoplethysmograph
`
`device comprising:
`
`a light source for illuminating a target object;
`
`a modulator for driving the light source such that the output intensity varies as
`
`a function of a modulation signal at a modulation frequency;
`
`a detector for receiving light from the target object and generating an electrical
`
`output as a function of the intensity of received light;
`
`a demodulator for receiving the detector output, having a local oscillator and
`
`producing a demodulated output representative of the modulation signal and any
`
`sidebands thereof, in which the demodulator is insensitive to any phase difference
`
`between the modulation signal and the oscillator of the demodulator; and
`
`means for generating, from the demodulated output, a signal indicative of
`
`blood volume as a function of time and f or blood composition.
`
`According to another aspect, the present invention provides a method of generating a
`
`plethysmograrn, comprising the steps of:
`
`illuminating a target object with a light source;
`
`driving the light source with a modulator such that the output intensity varies
`
`as a fimction of a modulation signal at a modulation frequency;
`
`receiving light from the target object with a detector and generating an
`
`electrical output as a function of the intensity of received light;
`
`receiving the detector output in a demodulator having a local oscillator and
`
`producing a demodulated output representative of the modulation signal and any
`
`10
`
`15
`
`20
`
`25
`
`30
`
`0006
`
`FITBIT, EX. 1049
`
`0006
`
`FITBIT, Ex. 1049
`
`

`

`W0 2007f122375
`
`PCT/G32007/001355
`
`sidebands thereof, in which the demodulator is insensitive to any phase difference
`
`between the modulation signal and the oscillator of the demodulator; and
`
`generating, from the demodulated output, a signal indicative of blood volume
`
`as a function of time and / or blood composition.
`
`According to another aspect, the present invention provides a photoplethysmograph
`
`device comprising:
`
`one or more light sources each for illuminating a portion of a target object;
`
`one or more modulators for driving the light sources such that the output
`
`intensity of each light source varies as a function of a modulation signal at a
`
`modulation frequency;
`one or more detectors for receiving light from the target object and generating
`
`one or more electrical outputs as a function of the intensity of received light;
`
`a plurality of demodulators each for receiving one or more of the electrical
`
`outputs and producing a demodulated output representative of the modulation signal
`
`of one of the modulated light sources and any sidebands thereof, to thereby produce a
`
`plurality of demodulated outputs corresponding to the plurality of light sources and!or
`
`plurality of detectors; and
`
`means for generating, from the demodulated outputs, plethysmogram signals
`
`indicative of blood volume as a function of time and f or blood composition for each
`
`of the demodulator outputs.
`
`According to another aspect, the present invention provides a method of generating a
`
`plethysmogram, comprising the steps of:
`
`illuminating a portion of a target object with one or more light sources;
`
`driving the light sources with one or more modulators such that the output
`
`intensity of each light source varies as a function of a modulation signal at a
`
`modulation frequency;
`
`receiving light from the target object with one or more detectors and
`
`generating one or more electrical outputs as a fimction of the intensity of received
`
`light;
`
`receiving one or more of the electrical outputs with a plurality of
`
`demodulators, each producing a demodulated output representative of the modulation
`
`10
`
`15
`
`20
`
`25
`
`30
`
`6
`
`0007
`
`FITBIT, EX. 1049
`
`0007
`
`FITBIT, Ex. 1049
`
`

`

`W0 2007f122375
`
`PCT/GBIOEJ’l/OGISSS
`
`signal of one of the modulated light sources and any sidebands thereof, to thereby
`
`produce a plurality of demodulated outputs corresponding to the plurality of light
`
`sources; and
`
`generating, from the demodulated outputs, plethysmogram signals indicative
`
`of blood volume as a function of time and X or blood composition for each of the
`
`demodulator outputs of the pixel array.
`
`According to another aspect, the present invention provides a photoplethysmograph
`
`device for non—contact use, comprising:
`
`alight source for illuminating a target object via a first polarising filter;
`
`a modulator for driving the light source such that the output intensity varies as
`
`a function of a modulation signal at amodulation frequency;
`
`a detector for receiving light from the target object via a second polarising
`
`filter having a different polarisation state than the first polarising filter, the detector
`
`adapted to generate an electrical output as a function of the intensity of received light;
`
`a demodulator for receiving the detector output and producing a demodulated
`
`output representative of the modulation signal and any sidebands thereof; and
`
`means for generating, from the demodulated output, a signal indicative of
`
`blood volume as a function of time and f or blood composition.
`
`According to another aspect, the present invention provides a method of generating a
`
`photoplethysmogram, comprising the steps of:
`
`illuminating a target object with a light source via a first polarising filter;
`
`driving the light source with a modulator such that the output intensity varies
`
`as a function of a modulation signal at a modulation frequency;
`
`receiving light from the target object with a detector via a second polarising
`
`filter having a different polarisation state than the first polarising filter, the detector
`
`generating an electrical output as a function of the intensity of received light;
`
`receiving the detector output with a demodulator and producing a demodulated
`
`output representative of the modulation signal and any sidebands thereof; and
`
`generating, from the demodulated output, a signal indicative of blood volume
`
`as a function of time and f or blood composition.
`
`10
`
`15
`
`20
`
`25
`
`30
`
`0008
`
`FITBIT, EX. 1049
`
`0008
`
`FITBIT, Ex. 1049
`
`

`

`W0 2007f122375
`
`PCT/G32007/001355
`
`According to another aspect, the present invention provides a photoplethysmograph
`
`devicc for non-contact use, comprising:
`
`a light source for illuminating a target object with optical
`
`radiation of
`
`wavelength less than 600 nm;
`
`a modulator for driving the light source such that the output intensity varies as
`
`a function of a modulation signal at a modulation frequency;
`
`a detector for receiving light from the target object and adapted to generate an
`
`electrical output as a function of the intensity of received light, the light source and
`
`detector being disposed laterally adjacent to one another on a substrate such that the
`
`active surfaces thereof can be directed towards substantially the same point on a
`
`surface of the target body;
`
`a demodulator for receiving the detector output and producing a demodulated
`
`output represtative of the modulation signal and any sidebands thereof; and
`
`means for generating, from the demodulated output, a signal indicative of
`
`blood volume as a function of time and/ or blood composition.
`
`10
`
`15
`
`According to another aspect, the present invention provides a method of generating a
`
`photoplethysmogram, comprising the steps of:
`
`illuminating a target object with optical radiation of wavelength less than 600
`
`20
`
`nm fi'om a light source;
`
`driving the light source with a modulator such that the output intensity varies
`
`as a function of a modulation signal at a modulation fi‘equency;
`
`receiving light from the target object with a detector to generate an electrical
`
`output as a function of the intensity of received light, the light source and detector
`
`being disposed laterally adjacent to one another on a substrate such that the active
`
`surfaces thereof can be directed towards substantially the same point on a surface of
`
`the target body;
`
`receiving the detector output with a demodulator and producing a demodulated
`
`output representative of the modulation signal and any sidehands thereof; and
`
`generating, from the demodulated output, a signal indicative of blood volume
`
`as a fitnetion of time and f or blood composition.
`
`25
`
`30
`
`0009
`
`FITBIT, EX. 1049
`
`0009
`
`FITBIT, Ex. 1049
`
`

`

`W0 2007f122375
`
`PCT/G32007/001355
`
`The invention provides a modulated light photoplethysmograph device.
`
`In selected
`
`embodiments, it combines the features of modulated light, band pass filtering, and IQ
`
`demodulation to give a plethysmogram of perfuse tissue. When used in reflectance
`
`mode, light in the blue and/or green portion of the optical spectrum is used which
`
`gives a larger pulsatiie signal and improved signal to noise ratio.
`
`Selected embodiments of the invention provide improved reliability through the
`
`reduction of noise when the photoplethysmograph device is used in transmission
`
`mode.
`
`In addition, the choice of light in the blue K green portion of the optical
`
`spectrum (i.e. wavelengths of between 400 nm and 600nm) gives improved reliability
`
`through the reduction of noise and the increase in AC component signal amplitude,
`
`when the photoplethysmograph device is used in reflection mode.
`
`Selected embodiments can be applied to different photoplethysmography techniques
`
`including
`
`single wavelength
`
`photoplethysmography, multiple wavelength
`
`photoplethysmography,
`
`pixel
`
`array
`
`photoplethysmography,
`
`and
`
`non-contact
`
`photoplethysmography.
`
`Embodiments of the present invention will now be desoribed by way of example and
`
`with reference to the accompanying drawings in which:
`
`Figure
`
`1
`
`is
`
`a
`
`fiinctional block diagram of
`
`a
`
`single wavelength
`
`photoplethysmograph device;
`
`Figure 2 is a functional block diagram of a demodulator suitable for use in the
`
`photoplethysmograph device of figure 1;
`
`Figure 3
`
`is
`
`a
`
`functional block diagram of a multiple wavelength
`
`photoplethysmograph device;
`
`Figure 4 is a schematic plan view of a pixel array photoplethysmograph
`
`device;
`
`10
`
`15
`
`20
`
`25
`
`Figure 5a is a schematic side view of a non—contact photoplethysmograph
`
`30
`
`device with polarising filters;
`
`Figure 5b is a plan view of a polarisng filter for use with the reflectance mode
`
`photoplethysmo graph device of figure 7;
`
`0010
`
`FITBIT, EX. 1049
`
`0010
`
`FITBIT, Ex. 1049
`
`

`

`W0 2007f122375
`
`PCT/G32007/001355
`
`Figure
`
`6
`
`is
`
`a
`
`functional
`
`block diagram of a
`
`single wavelength
`
`photoplethysmograph device;
`
`Figure 7 is a schematic plan View, side view and end View of a reflectance
`
`mode photopiethysmograph device;
`
`Figure 8 is a circuit diagram of a transimpedance amplifier suitable for use in
`
`the photoplcthysmograph devices described herein;
`
`Figure 9 is a circuit diagram of a band pass filter circuit suitable for use in the
`
`photoplethysmograph devices described herein;
`
`Figure 10 is a circuit diagram of a light source driver circuit suitable for use in
`
`10
`
`15
`
`the photoplethysmograph devices described herein;
`
`Figure 11 is a process flow diagram illustrating a demodulation algorithm
`
`suitable for use in the photoplethysmograph devices described herein;
`
`Figure 12 is a functional block diagram of a light source brightness control
`
`loop suitable for use in the photoplethysrnograph devices described herein;
`
`Figure 13a is a photoplethysrnogram showing a combined AC and DC output
`
`of a photoplethysmograph device;
`
`Figure 13b is a photoplethysmogram showing the magnified AC component
`
`from figure 13a;
`
`Figure 14a is a photoplethysmogram showing combined pulsatiie and
`
`20
`
`breathing signal;
`
`Figure 14b is a photoplethysmogram showing the breathing signal of figure
`
`14a only;
`
`Figure 15a. is a photoPIethysmogram showing a breathing signal only;
`
`Figure 15b is a corresponding breathing signal as measured by an oral
`
`25
`
`thermistor;
`
`Figure 16 is a photoplethysmogram recorded using a green light source of
`
`wavelength 510 nm;
`
`Figure 17 is a photoplethysmogram recorded using a red light source of
`
`wavelength 644 nm;
`
`30
`
`Figure 18 is a fimctiona] block diagram of an alternative demodulator suitable
`
`for use in the photoplethysrnograph device of figure 1;
`
`Figure 19 is a functional block diagram of an alternative demodulator suitable
`
`for use in the photoplethysmograph device of figure 1;
`
`10
`
`0011
`
`FITBIT, EX. 1049
`
`0011
`
`FITBIT, Ex. 1049
`
`

`

`W0 2007;122:375
`
`PCT/G32007/001355
`
`Figure 20 is a functional block diagram of an alternative demodulator suitable
`
`for use in the photoplethysmo graph device of figure 1.
`
`Single wavelength photoplethysmogmph device
`
`With reference to figure I, a photoplethysmograph device 100 comprises a driver
`circuit 101 which is coupled to energise a light source 102 with modulated drive
`
`signal such that the output intensity of the light source varies as a function of a
`
`modulation signal having a specific modulation frequency (fm) and modulation
`
`amplitude (Ml(t)). The waveform driving the light source is therefore a modulating
`
`carrier characterised by its frequency and amplitude.
`
`The light source 102 is configured to illuminate a. target object 103 such as an area of
`
`tissue of the human or animal body. The light source 102 preferably comprises one or
`
`more light emitting devices each of a given wavelength or range of wavelengths.
`
`A photodetector 104 is configured to receive light from the target object 103 after its
`
`interaction therewith. Depending on the relative positioning of the light source 102,
`
`the target object 103 and the photodetector 104, this_received light may be one or
`
`more of light that has been transmitted through the target object, light that has been
`
`reflected from the surface of the target object, and light that has been scattered by and
`
`f or reflected from structures or fluids within the target object. The photodetector will
`
`generate an electrical current that is a function of, eg. proportional to, the amount of
`
`light incident to its active area.
`
`10
`
`15
`
`20
`
`25
`
`A detector 105 may be provided to convert
`
`the electrical current
`
`from the
`
`photodetector 104 to a voltage that is proportional to the current. The detector 105
`
`may incorporate an amplifier (not shown). The gain of that amplifier can be rolled off
`
`at a frequency greater than the modulation frequency. The detector 105 and amplifier
`
`can, with careful design, minimise the noise at the input to a band pass filter 106
`
`30
`
`coupled thereto.
`
`In a general sense, the photodetector 104 and detector 105 functions
`
`may be provided by any detector capable of receiving light from the target object and
`
`generating an electrical output that is a_ function of the intensity ofthe received light.
`
`11
`
`0012
`
`FITBIT, EX. 1049
`
`0012
`
`FITBIT, Ex. 1049
`
`

`

`W0 2007f122375
`
`PCT/G32007/001355
`
`The band pass filter 106 may be provided for attenuating signals outside a bandwidth
`
`of interest. The filter bandwidth is preferably centred on the modulation frequency fin
`
`and is sufficiently wide to pass the modulating carrier and sidebauds caused by
`
`plethysmogram amplitude modulation, but narrow enough to attenuate frequency
`
`components of interference and noise. To reduce noise, the bandwidth of the band
`
`pass filter 106 should be as narrow as possible.
`
`It need only be wide enough to pass
`
`the upper and lower sidebands of the plethysmograrn, typically but not limited to 50
`
`Hz. The band pass filter 106 may incorporate an amplifier (not shown) to provide
`
`additional gain. The band pass filter 106 and amplifier are preferably designed to
`
`10
`
`minimise noise at the input of the following stage, namely a demodulator 107. It will
`
`be appreciated that the provision of a band pass filter 106 is not always necessary but,
`
`if employed, an increase in signal—to-noise ratio (SNR) may result.
`
`A preferred arrangement of demodulator 107 is shown in more detail in figure 2. The
`
`15
`
`demodulator 107 is adapted to demodulate the output of the band pass filter 106 and
`
`hence recover a plethysmogram from the detected light received from the target
`
`object. The preferred demodulator 107 uses a method that is insensitive to the phase
`
`difference between the modulation carrier and a demodulation carrier. In other words,
`
`the demodulator is insensitive to any phase difference between the modulation signal
`
`20
`
`and an oscillator in the demodulator, as will be explained later.
`
`Thus,
`
`it
`
`is
`
`unnecessary to maintain a predetermined phase relationship between the modulation
`
`and demodulation process.
`
`The demodulator 107 may comprise a multiplexer 210 for splitting the modulated
`
`25
`
`30
`
`signal M16) into two channels. A first channel processes a first modulated input
`
`signal Ml(t)a and a second channel processes a second modulated input signal
`
`M1(t)b. The first modulated input signal Ml(t)a is provided as input to a first
`
`multiplier 201 together with an Output of a first demodulator local oscillator (LO)
`
`signal 204, D1(t). The frequency of the local oscillator signal 204 is preferably
`
`substantially equal to the frequency of the modulation signal and therefore equal to
`
`the modulating carrier
`
`frequency of input signal M16).
`
`The result of the
`
`multiplication of Ml(t)a with the first LO signal 204 is mil (‘in phase’) signal. In the
`
`second channel, the second modulated input signal is multiplied, using a multiplier
`
`12
`
`0013
`
`FITBIT, EX. 1049
`
`0013
`
`FITBIT, Ex. 1049
`
`

`

`W0 2007f122375
`
`PCT/G32007/001355
`
`206, with a second demodulator local oscillator (LO) signal that also has a frequency
`
`preferably substantially equal to the fi'equency of the modulation signal. However,
`
`the second demodulator LO signal is phase shifted by phase shifter 205 with respect
`
`to the first demodulator LO signs].
`
`The phase difference between the first
`
`demodulator L0 and second demodulator L0 is preferably 90 degrees. The result of
`
`the multiplication of M1(t)b with the second demodulator LO signal
`
`is the Q
`
`(‘quadrature phase') signal.
`
`It will he understood that the local oscillator, although
`
`shown as a producing a sine wave output, could produce other waveforms of the
`
`required frequency.
`
`10
`
`The separate I and Q signals are preferably separately low pass filtered in filter
`
`elements 202 and 207 respectively to remove unwanted harmonics and products of the
`
`multiplication process. Optionally,
`
`the resulting signals may be decimated in
`
`decimators 203 and 208 respectively to reduce the sample rate. The results of this are
`
`15
`
`the I’ and Q’ signals.
`
`The I’ and Q’ sig

This document is available on Docket Alarm but you must sign up to view it.


Or .

Accessing this document will incur an additional charge of $.

After purchase, you can access this document again without charge.

Accept $ Charge
throbber

Still Working On It

This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.

Give it another minute or two to complete, and then try the refresh button.

throbber

A few More Minutes ... Still Working

It can take up to 5 minutes for us to download a document if the court servers are running slowly.

Thank you for your continued patience.

This document could not be displayed.

We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.

Your account does not support viewing this document.

You need a Paid Account to view this document. Click here to change your account type.

Your account does not support viewing this document.

Set your membership status to view this document.

With a Docket Alarm membership, you'll get a whole lot more, including:

  • Up-to-date information for this case.
  • Email alerts whenever there is an update.
  • Full text search for other cases.
  • Get email alerts whenever a new case matches your search.

Become a Member

One Moment Please

The filing “” is large (MB) and is being downloaded.

Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.

Your document is on its way!

If you do not receive the document in five minutes, contact support at support@docketalarm.com.

Sealed Document

We are unable to display this document, it may be under a court ordered seal.

If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.


Access Government Site

We are redirecting you
to a mobile optimized page.





Document Unreadable or Corrupt

Refresh this Document
Go to the Docket

We are unable to display this document.

Refresh this Document
Go to the Docket