`
`Curriculum Vitae
`
`Christopher J. Roberts, Ph.D
`
`Professor, Chemical and Biomolecular Engineering
`University of Delaware, Newark, DE 19716
`Email: cjr@udel.adu
`
`Positions l Appointments
`
`Faculty Member, Center for Molecular and Engineering Thermodynamics. University
`of Delaware
`Faculty Member, UD Chemistry-Biology Interface Program, University of Delaware
`Visiting investigator, GlaxoSmithKline
`Associate Professor (affiliated), Biomedical Engineering, University of Delaware
`Associate Professor, Department of Chemical and Biomolecular Engineering,
`University of Delaware
`Graduate Program Co-Director, Department of Chemical and Biomolecular
`Engineering, University of Delaware
`Faculty Member, UD IGERT Biotechnology Program
`Assistant Professor,'Department of Chemical Engineering, University of Delaware
`Senior Research Scientist, Department of Pharmaceutical R&D. Pfizer Global
`Research and Development
`Research Scientist, Department of Pharmaceutical R&D. Pfizer Central Research
`Graduate Research Associate, Department of Chemical Engineering, Princeton
`University
`Visiting Research Associate, Pafra Biopreservation. Ltd.
`
`
`
`Visiting Professor. School of Chemical Engineering and Analytical Sciences,
`University of Manchester
`Director, Center for Biomanufacturing Science and Technology, University of
`Delaware
`Professor. Department of Chemical and Biomolecular Engineering. University of
`Delaware
`Director, Biomolecular Interaction Technologies Center
`Guest Researcher. National Institute of Standards and Technology, Center for
`Neutron Research
`
`2016 -
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`2015 -
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`2015 -
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`2014 -
`2010 -
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`2009 -
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`2003 -
`2010
`2010 - 2014
`2009 - 2015
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`2008 - 2014
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`2006 - 2008
`2002 - 2009
`2000 - 2002
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`1999 - 2000
`1994 - 1999
`
`1995
`
`Education
`
`Princeton University
`University of Delaware
`
`Chemical Engineering, Ph.D.
`Chemical Engineering, BChE summa cum laude
`
`1999
`1994
`
`Selected Honors
`
`Research & Scholarship
`o Inaugural John Finlayson Lecture. US Food & Drug Administration (2016)
`AAPS Chapter Pharmaceutics Lecturer, University of Kansas (2006)
`AAPS New Investigator Award (Pharmaceutics and Pharmaceutical Technology) (2005)
`Merck Faculty Fellow, University of Delaware (2004-2007)
`Ebert Prize. American Pharmaceutical Association & American Pharmaceutical Research Society (2004)
`Wallace Memorial Fellowship, Princeton University (1998)
`National Science Foundation Graduate Fellowship (1994-1998)
`Barry M. Goldwater Scholarship (1992-1994)
`
`CSL EXHIBIT 1018
`CSL v. Shire
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`Teaching and Service
`Editorial Advisory Board. J. Pharm. Sci. (2017-present)
`Scientific Advisory Board. PIPPI consortium (2016-present)
`College of Engineering. Excellence-in-Teaching Award. University of Delaware (2008)
`Nominated. University Excellence-in-Teaching Award. University of Delaware (2004, 2006. 2009)
`Journal of Pharmaceutical Sciences Service Award (2007, 2008. 2012, 2015). Biophysical Chemistry
`Service Award (2014)
`
`Peer-Reviewed Publications (h-lndex = 29, for multi-author publications, asterisk denotes corresponding
`author(s))
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`Roberts CJ, Franks F” Crystalline and amorphous phases in the binary system water — (3,0 trehalose. J.
`Chem. Soc. Faraday Trans. 92:1337-1343 (1996).
`Roberts CJ, Debenedetti PG‘ Polyamorphism and density anomalies in network-fom'ring fluids: Zeroth- and
`first-order approximations. J. Chem. Phys. 105:658~672(1996).
`Roberts CJ. Panagiotopoulos AZ, Debenedetti PG“ Liquid-liquid immiscibility in pure fluids: Polyamorphism
`in simulations of a network-fonning fluid. Phys. Rev. Lett. 77:4386-4389 (1996).
`Roberts CJ. Karayiannakis GA. Debenedetti PG‘ Pure-fluid liquid-liquid equilibrium In a model of network-
`forrning fluids. and implications for polyamorphism in water. Ind. & Eng. Chem. Res. 37:3012-3020 (1998).
`Roberts CJ. Debenedetti PG‘ Structure and dynamics in concentrated amorphous carbohydrate-water
`systems by molecular dynamics simulation. J. Phys. Chem. B 103:7308—7318 (1999).
`Debenedetti PG". Stillinger FH. Truskett TM, Roberts CJ. The equation of state of an energy landscape. J.
`Phys. Chem. B 103:7390-7397 (1999).
`Roberts CJ. Stillinger FH. Debenedetti PG' Equation of state of the energy landscape of SPC/E water. J.
`Phys. Chem. B 103:10258-10265 (1999).
`Roberts CJ‘, Ji 0. Zhang L. Darrington RT. Dissolution behavior of porcine somatotropin with simultaneous
`gel-formation and lysine Schiff-base hydrolysis. J. Controlled Release, 77:107-116 (2001).
`Waterman KC‘. Adaml RC, Alsante KM. Hong J. Landis MS, Lombardo F, Roberts CJ. Stabilization of
`pharmaceuticals to oxidative degradation. Pharm. Dev. Tech. 7:1-32 (2002).
`Roberts CJ, Debenedetti PG’ Engineering pharmaceutical stability with am0rphous solids.
`48:1 140-1144 (2002).
`Roberts CJ. Kinetics of irreversible protein aggregation: analysis of extended Lumry-Eyring models and
`implications for shelf life prediction J. Phys. Chem. B 107:1194-1207 (2003).
`Roberts CJ‘. Darrington RT, Whitley MB. Irreversible aggregation of recombinant bovine granulocyte-colony
`stimulating factor (bG-CSF) and implications for predicting protein shelf life. J. Pharm. Sci.. 92:1095-1111
`(2003).
`Roberts CJ. Improved quasi-chemical equation of state based on energy and density fluctuations in the
`small system grand canonical ensemble, J. Phys. Chem. B 108:19843-19851 (2004).
`Shah PP. Roberts CJ' Molecular salvation in water-methanol and water-sorbitol mixtures: the roles of
`preferential hydration. hydrophobicity. and the equation of state. J. Phys. Chem. B 111:4467-4476 (2007).
`Andrews JM. Roberts CJ' Non-native aggregation of u-chymotrypsinogen occurs through nucleation and
`growth with competing nucleus sizes and negative activation energies, Biochemistry 46:7558-7571 (2007).
`Andrews JM. Roberts CJ' A Lumry-Eyring nucleated-polymerization model of protein aggregation kinetics:
`1. Aggregation with pre-equilibrated unfolding. J. Phys. Chem. B 111:7897-7913 (2007).
`Roberts CJ [134] Nonnative protein aggregation kinetics. Biotechnol. Bioeng. 98:927-938 (2007).
`Young TM, Roberts CJ' A quasichemical approach for protein~cluster free energies in dilute solution. J.
`Chem. Phys. 127:165101/1-10 (2007).
`Weiss WF IV, Hodgdon TK, Kaler EW. Lenhoff AM, Roberts CJ‘ Normative protein polymers: structure,
`morphology. and relation to nucleation and growth. Biophys. J. 93:4392-4403 (2007).
`Shah PP. Roberts CJ” Salvation in mixed-aqueous solvents from a thermodynamic cycle approach. J. Phys.
`Chem. B 112:1049-1052 (2008).
`Andrews JM. Weiss WF IV, Roberts CJ" Nucleation. growth. and activation energies for seeded and
`unseeded aggregation of a-chymotrypsinogen A. Biochemistry 47:2397-2403 (2008).
`Top A, Kiick KL'. Roberts CJ* Modulation of self-association and subsequent fibril formation in an alanine-
`rich helical polypeptide. Biomacromolecu/es 9:1595-1603 (2008).
`Weiss WF IV. Young TM. Roberts CJ' Principles. approaches, and challenges for prediction of protein
`aggregation kinetics and shelf life J. Pharm. Sci. 98:1246-1277 (2009).
`
`AlChE J.
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`Li Y. Weiss WF IV, Roberts CJ“ Characterization of high molecular-weight nonnative aggregates and
`aggregation kinetics by size exclusion chromatography with inline multi-angle laser light scattering.
`J.
`Pharm. Sci. 98:3997-4016 (2009).
`Spatara ML. Roberts CJ, Robinson AS" Kinetic folding studies of the P22 tailspike beta-helix domain reveal
`multiple unfolded states. Biophys. Chem. 141:214-221 (2009).
`Li Y. Roberts CJ‘ A Lumry-Eyring nucleated-noiymerization (LENP) model of protein aggregation kinetics 2.
`Competing growth via condensation- and chain-polymerization. J. Phys. Chem. B 113:7020—7032 (2009).
`Young TM, Roberts 0.1“ Structure and thermodynamics of colloidal protein cluster formation: comparison of
`square-well and simple dipolar models. J. Chem. Phys. 131 :125104/1-9 (2009).
`Li Y, Ogunnaike BA, Roberts CJ‘ Multi—variate approach to global protein aggregation behavior and kinetics:
`effects of pH, NaCI. and temperature for a-chymotrypsinogen A. J. Pharm. Sci. 99:645662 (2010).
`Sahin E, Grillo A0, Perkins MD. Roberts CJ’ Comparative effects of pH and ionic strength on protein-
`protein interactions. unfolding. and aggregation for lgGl antibodies. J. Pharm. Sci. 99:4830-4848 (2010).
`Zhang A. Jordan JL. Ivanova MA. Weiss WF. Roberts CJ, Fernandez EJ’ Molecular-level insights into
`thermally-induced a-chymotrypsinogen A amyloid aggregation mechanism and semi-flexible protofibril
`morphology. Biochemistry 49:10553-10564 (2010).
`Sahin E. Jordan JL, Zhang A, Naranjo A, Costanzo JA. Weiss WF IV. Spatara ML. Robinson AS. Fernandez
`EJ*, Roberts CJ‘ Computational design and biophysical characterization of point mutations for gamma-D-
`crystallin illustrate a balance of conformational stability and intrinsic aggregation propensity. Biochemistry
`50:628-639 (2011).
`Brummitt RK. Nesta DP, Chang L. Chase SF. Laue TM, Roberts CJ" Non-native aggregation of an lgG1
`antibody in acidic conditions:
`1. Unfolding. colloidal
`interactions. and formation of amyloid-like high
`molecular weight aggregates. J Pharm Sci 100:2087-2103 (201 1).
`Brummitt RK. Nesta DP, Chang L, Kroetsch AM, Roberts CJ” Non-native aggregation of an lgG1 antibody in
`acidic conditions:
`2. Nucleation-and-growth kinetics with competing growth mechanisms. J Pharm Sci
`100:2104-2119 (2011).
`Top A, Roberts CJ", Kiick KL' Conformational and aggregation properties of a PEGyIated alanine-rich
`polypeptide Biomacromo/ecules 12:2184—2192 (201 1).
`Blanco MA. Sahin E, Li Y, Roberts CJ' Reexamining Protein-Protein and Protein-Solvent interactions from
`Kirkwood-Buff Analysis of Light Scattering in Multi-Component Solutions. J Chem Phys 134:225103/1-12
`(2011).
`Brummitt. RK. Nesta DP, Roberts, CJ' Predicting accelerated and low-temperature aggregation rates for
`monoclonal antibody formulations. J Pharm Sci 100:4234-4243 (2011).
`Roberts CJ'. Das TK. Sahin E. Predicting Aggregation Rates for Therapeutic Proteins: Approaches and
`Challenges. Int J Pharm 418:318-333 (2011).
`Top A, Zhong S, Yan C. Roberts CJ". Pochan DJ‘. Kiick KL' Controlling assembly of helical polypeptides
`via PEGyIation strategies. Soft Matter 729758-9766 (2011).
`Sahin E. Weiss WF IV, Kroetsch AM. King KR. Kessler RK. Das TK. Roberts CJ" Non-native aggregation
`and pH—temperature phase behavior of aggregates for an lgGZ antibody J Pharm Sci 101:1678—1687
`(2012).
`Siderius DW', Krekelberg WP, Roberts CJ, Shen VK. Osmotic virial coefficients for model protein and
`colloidal solutions: Importance of ensemble constraints. J Chem Phys, 136(17) 175102I1-9 (2012).
`Brummitt RK. Andrews JM, Jordan JL. Fernandez EJ, Roberts CJ" Thermodynamics of amyloid dissociation
`provide insights into aggregate stability regimes Biophys Chem, 168-169: 10-18 (2012).
`Kroetsch AM. Sahin E, Wang H-Y, Krizman S, Roberts CJ‘ Relating particle formation to sait— and pH-
`dependent phase separation of non-native aggregates of alpha-chymotrypsinogen A. J Pharm Sci,
`101:3651-3660 (2012).
`Sahin E, Roberts CJ’ Size-Exclusion Chromatography with Multi-Angle Light Scattering (SEC-MALS) for
`Elucidating Protein Aggregation Mechanisms. Methods Mol Biol 899:403-423 (2012).
`Grfinberger A. Lai P-K, Blanco MA, Roberts CJ" Coarse-grained modeling of protein second osmotic virial
`coefficients: sterics and non-specific attractions. J Phys Chem B, 117:763—770 (2013).
`Kim N, Remmele RL, Liu D. Razinkhov V. Fernandez EJ, Roberts CJ‘ Aggregation of Anti-Streptavidin
`lmmunoglobulin Gamma-1 Mediated by Fab Unfolding and Competing Growth Pathways. Biophys Chem,
`172:26-36 (2013).
`Wang W'. Roberts CJ' Non-Arrhenius Protein Aggregation. AAPS J, (online only) doi: 10.1208/512248-013-
`9485-3 (2013).
`Roberts CJ’, Nesta DP, Kim N. Effects of temperature and osmolytes on parallel degradation routes for an
`lgG1 antibody. J Pharm Sci 102:3556-3566 (2013).
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`Murphy RM‘. Roberts CJ. Protein misfoiding and aggregation research: some thoughts on improving quality
`and utility. Biotechnol Prog 29:1109-111 5 (2013).
`Maurer RW. Hunter AK, Wang X. Wang WK. Robinson AS“, Roberts CJ* Folding and aggregation of a
`mulii-domain engineered immunotoxin. Blochem Eng J. 8128-14 (2013).
`Blanco MA, Sahin E, Robinson AS, Roberts CJ' Coarse-grained model of protein-protein interactions. 822.
`and protein cluster formation. J Phys Chem B 117: 16013-16028 (2013).
`Weiss WF IV, Zhang A, Jordan JL. lvanova MA, Sahin E. Fernandez EJ. Roberts CJ" Reduction of the
`0191-0220 disulfide of a-chymotrypsinogen A accelerates amyloid formation via reduced nucleation
`barriers. Biophys Chem 185:79-87 (2014).
`Maurer RW, Hunter AK, Robinson AS'. Roberts CJ* Aggregates of a-chymotrypsinogen anneal to access
`more stable aggregate states. Biotechnol Bioeng 111: 782-791 (2014).
`Wu H, Kroe-Barrett R, Singh 8, Robinson AS. Roberts CJ’ Competing aggregation pathways for
`monoclonal antibodies. FEBS Letters 588: 936-941(2014).
`. Costanzo JA, O'Brien CJ. Tiller K, Tamargo E, Robinson AS. Roberts CJ', Fernandez EJ" Computational
`Design to Control Protein Aggregation Rates Through Conformational Stability. Protein Engineering Design
`& Selection 27: 157-167 (2014).
`Blanco MA. Martorana E. Manno M, Perevozchikova T. Roberts CJ" Protein-protein interactions in dilute to
`concentrated solutions: alpha-chymotrypsinogen at acidic pH. J Phys Chem B 118: 5817-5831 (2014).
`Roberts CJ. Therapeutic protein aggregation: mechanisms. design, and control. Trends Biotech. 32: 372-
`380 (2014).
`Roberts CJ. Protein Aggregation and Its Impact on Product Quality. Curr Opin Biotech 301211-217 (2014).
`Roberts CJ.’ Bianco MA. Role of anisotropic interactions for proteins and patchy nanoparticles. J Phys
`Chem B 118:12599—12611 (2014).
`Amin S.’ Barnett GV, Pathak J.‘ Roberts CJ, Sarangapani PS. Protein aggregation, particle formation,
`characterization. and rheology. Curr Opin Coll Int Sci 19:439-449 (2014).
`Paik B. Blanco MA. Roberts CJ,‘ Jia X. Kiick KL‘ Aggregation of poly(acryiic acid)-containing elastin
`copolymers. Soft Matter 1 1:1839-1850 (2015).
`Barnett GV, Razinkov V, Kenlvin BA. Laue TM, Woodka A. Butler PD, Perevozchikova T, Roberts CJ'
`Specific ion effects on the aggregation mechanisms and protein-protein interactions for anti-streptavidin
`lmmunoglobulin gamma 1. J Phys Chem B 119:5793-5804 (2015).
`Perevozchikova T, Nanda H, Nesta DP. Roberts CJ‘ Protein adsorption. desorption, and aggregation
`mediated by solid-liquid interfaces. J Pharm Sci 104:1946-1959 (2015).
`Barnett GV, Qi W, Amin S. Lewis EN, Roberts CJ‘ Aggregate structure. morphology and the effect of
`aggregation mechanisms on viscosity at elevated protein concentrations. Biophys Chem 207:21-29 (2015).
`Wu H, Truncali K, Ritchie J, Kroe-Barrett R, Singh S, Robinson AS. Roberts CJ‘ Weak protein interactions
`and pH- and temperature-dependent aggregation of human Fc1. mAbs 7:1—12 (2015).
`Bamett GV, Qi W. Amin S. Lewis EN. Razinkov V, KenNin BA. Liu Y. Roberts CJ‘ Sthctural Changes and
`Aggregation Mechanisms for Anti-streptavidin lgG1 at Elevated Concentration. J Phys Chem B 119:15150—
`15163 (2015).
`Barnett GV, Razinkov V. Kerwin BA, Hillsley A, Roberts CJ‘ Acetate and Citrate Specific-lon~Effects on
`Temperature-Dependent Aggregation Rates of Anti-Streptavidin lgG1. J Pharm Sci 105:1066-1073 (2016).
`Ghosh R, Calero-Rubio C. Saluja A. Roberts CJ’ Relating protein-protein interactions and aggregation
`rates from low to high concentrations. J Pharm Sci 105:1086-1096 (2016).
`Barnett GV, Razinkov V, Kerwin BA, Blake 3, Qi W. Curtis RA, Roberts CJ' Osmolyte Effects on
`Monoclonal Antibody Stability and Concentration-Dependent Protein Interactions with Water and Common
`Osmolytes J Phys Chem B 120:3318—3330 (2016).
`O'Brien CJ. Blanco MA. Robinson AS,‘ Roberts CJ‘ Modulating Non-Native Aggregation and Electrostatic
`Protein-Protein Interactions with Computationally Designed Single Point Mutations, Protein Engineering
`Design & Selection 29:231-243 (2016).
`Calero-Rubio C, Saluja A, Roberts CJ* Coarse-grained antibody models for “weak” protein-protein
`interactions from low to high concentrations J Phys Chem B 120:6592-6605 (2016).
`Calero—Rubio C. Paik BA, Jia X. Kiick KL’. Roberts CJ‘ Predicting unfolding thermodynamics and stable
`intermediates for alanine-rich helical peptides with the aid of coarse-grained molecular simulation. Biophys
`Chem 217:8-19 (2016).
`Barnett GV, Drenski MC. Razinkov V, Reed WF'. Roberts CJ“ Protein aggregation mechanisms and
`kinetics from combined monomer depletion rates and continuous scattering Analytical Biochem 511:80-91
`(2016).
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`73.
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`Barnett GV. Razinkov V, Kerwin BA, Blake S, Qi W, Curtis RA, Roberts CJ" Reply to Comment on
`Osmolyte Effects on Monoclonal Antibody Stability and Concentration-Dependent Protein Interactions with
`Water and Common Osmolytes. J Phys Chem B 120:11333-11334 (2016).
`Bain DL, Brenowitz M, Roberts CJ. Commentary on higher education and next-generation researchers:
`Biophysical characterization. higher-order structure. and industrial/academic opportunities. J Pharm Sci.
`105:3483-3486 (2016).
`Meric UG, Robinson AS'. Roberts CJ" Driving forces for non-native protein aggregation and approaches for
`predicting aggregation-prone regions. Ann Rev Chem Biomol Eng 8 (2017), DOI: 10.1146lannurev-
`chembioeng-060816-101404
`Mazzer A, Nanda T, Butler P, Roberts CJ. Clifton L, Bracewell DG‘ Neutron reflectivity measurement of
`protein A — antibody complex at the solid-liquid interface. J ChromatographyA (in press)
`Rosa MF, Roberts CJ, Rodriguez MA" Connecting High-Temperature and Low-Temperature Protein
`Stability and Aggregation. PLOS One (online only) DOI: 10/1371ljoumal.pone.0176748 (2017)
`Woldeyes MA,“ Calero-Rubio C," Furst EM‘, Roberts CJ" Predicting protein interactions in concentrated
`globular protein solutions using colloidal models J Phys Chem B 121:4756-4767 (2017).
`
`Under Review
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`79.
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`80.
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`Calero-Rubio C, Strab C, Barnett GV. Roberts CJ" Protein partial molar volumes in multi-component
`solutions from the perspective of inverse Kirkwood-Buff theory.
`Yang D. Kroe-Barrett R, Singh S, Roberts CJ, Laue TM' igG cooperativity - is there allostery? Implications
`In therapeutic antibody development.
`
`Book Chapters
`
`1. Roberts CJ. Non-native protein aggregation: pathways, kinetics, and shelf-life prediction, in Misbehaving
`Proteins: Protein (Mis)Folding, Aggregatlon. and Stability. Murphy. R. M. & Tsal. A. M. Eds., Springer-
`Vedag: New York, NY 2006.
`Roberts CJ.
`Irreversible protein aggregation: principles and rationale for common stabilization strategies, in
`Encyclopedia of Agricultural, Food. and Biological Engineering, Heldman, 0., Ed., Taylor and Francis, 2006.
`(http://www.dekker.com/sdekfissues~db=enc~content=t713172957)
`in Aggregation of
`Li Y, Roberts CJ' Protein Aggregation Pathways, Kinetics, and Thermodynamics.
`Therapeutic Proteins. Wang, W & Roberts, CJ. Eds., John Wiley & Sons: New York, NY 2010.
`Roberts, CJ Nucleation. Aggregation, and Conformational Distortion, Ch. 5 in Biophysical Methods for
`Biotherapeutics: Discovery and Development Applications. Das, TK (Ed.), John Wiley & Sons. Hoboken, NJ,
`2014.
`
`S. Ewing, A. Hussain, G. Collins, C. Roberts. E. Shalaev. Low-Temperature Mobility of Water in Sugar
`Glasses: Insights from Thermally Stimulated Current Studies,
`in Water Stress in Biological. Chemical,
`Pharmaceutical, and Food Systems. G. F. Gutierrez-Lopez, L. AlamilIa-Beltran, M. del Pilar Buera, J. Welti-
`Chanes, E. Parade-Arias. G. V. Barbosa-Canovas (Eds.), Springer, New York (2015).
`
`Books
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`Aggregation of Therapeutic Proteins, Eds. W. Wang and C. J. Roberts. John Wiley & Sons: New York, NY
`(2010).
`
`Protein Solutions: From a Molecular to a Thermodynamic Perspective. R. A. Curtis, L. Lue. C. J. Roberts (in
`preparation).
`
`Research Presentations and Lectures
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`Plenary / Keynote / Named Lectures
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`1.
`2.
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`3.
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`Inaugural John Finlayson Lecture, US Food and Drug Administration, Silver Spring. MD (2016).
`Symposium for the Relevance of Protein Aggregation in Biologics and Vaccines Development, Merck 8. Co.,
`Kenilworth, NJ (2016).
`Advanced Biomanufacturing Centre, University of Sheffield, Sheffield, United Kingdom (2015).
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`4. Protein Engineering Summit. Boston, MA (2015).
`5.
`International Symposium on Polymer Analysis and Characterization. New Orleans. LA (2013).
`6.
`International Light Scattering Conference, Santa Barbara. CA (2012).
`7. 2012 Biomolecular Interaction Technologies Conference. Durham. NH (2012).
`8. XV International Congress on Rheology, Lisbon, Portugal (2012).
`9. CHI Bioprocessing Summit, Boston. MA (2012).
`10. Symposium on Biopharmaceutical and Pharmaceutical Applications, CALCON, Oahu, HI (2011).
`11. AAPS Chapter Annual Pharmaceutics Lecture. Department of Pharmaceutical Chemistry. University of
`Kansas. Lawrence. KS (2006).
`
`Invited
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`12. Protein Engineering Summit, Boston, MA (2017)
`13. Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS (2017)
`14. Janssen Pharmaceuticals. Spring House Station, PA (2017)
`15. Workshop on Recent Breakthroughs and New Perspectives on Protein Aggregation, University of
`Manchester, UK (2017)
`16. Mid-Atlantic Soft Matter Conference, Newark. DE (2017)
`17. Advances in Biophysical Methods for Protein Characterisation. Palermo, Italy (2016)
`18. Merck Research Laboratories, West Point. PA (2016)
`19. Dept. of Biochemistry and Molecular Biology, University of Kansas Medical Center. Kansas City. KS (2016)
`20. Protein Engineering Summit. Boston. MA (2016)
`21. Eli Lilly, Indianapolis, IN (2016)
`22. Amgen, Thousand Oaks, CA (2016)
`23. Department of Pharmaceutical Sciences. University of Connecticut, Storrs, CT (2015).
`24. IABS, Progress and Challenges for Particle Formation and lmmunogenicity of Biotherapeutics 2015.
`Rockville, MD (2015).
`'
`25. Bristol-Myers Squibb Biologics Development Organization. Pennington. NJ (2015)
`26. AAPS Annual Meeting, Orlando. FL (2015).
`27. Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY (2015).
`28. Higher Order Structure Conference. Boston, MA (2015).
`29. PepTalk, Cambridge Healthtech Institute, San Diego. CA (2015).
`30. Abeie. Worcester, MA (2014).
`31. Merck Research Laboratories, Kenilworth. NJ (2014).
`32. Neutron Characterisation in Fundamental and Applied Biotechnology. Abingdon, UK (2014).
`33. Bioprocessing Summit, Boston, MA (2014).
`34. Biological and Pharmaceutical Complex Fluids ll. Durham. NC (2014).
`35. Teva Pharmaceuticals, Rockville, MD (2014).
`36. Department of Chemical Engineering, University of Caiifomia, Santa Barbara, CA (2014).
`37. institute for Bioscience and Biotechnology Research, University of Maryland. Rockville. MD (2014).
`38. Colorado Protein Stability Meeting. Breckenridge. CO (2013)
`39. Malvern Instruments, Columbia, MD (2013).
`40. Departmental Seminar, Preclinical Development. Regeneron Pharmaceuticals. Tarrytown, NY (2013).
`41. Department of Chemical and Biological Engineering. Princeton University, Princeton. NJ (2013).
`42. Department of Chemical Engineering, University of Texas. Austin, TX (2012).
`43. Department of Chemical Engineering, University of Virginia. Charlottesvilie, VA (2012).
`44. American Association of Pharmaceutical Sciences Annual Meeting, Chicago, IL (2012).
`45. Peck Symposium. College of Pharmacy. Purdue University, West Lafayette, IN (2012).
`46. Department of Pharmaceutical Sciences. University of Kentucky. Lexington, KY (2012).
`47. ECI, Biological and Pharmaceutical Complex Fluids: New Trends in Characterizing Microstructure.
`Interactions & Properties. Tomar, Portugal (2012).
`48. American Conference on Neutron Scattering, Washington, D.C. (2012).
`49. Process Development Department. Genentech, South San Francisco. CA (2012).
`50. University of Manchester Interdisciplinary Biosciences. Manchester. United Kingdom (2012).
`51. Bioprocess International Annual Conference, Prague. Czech Republic (2012).
`52. Formulation Sciences. Allergan. Inc., Irvine, CA (2012).
`53. Department of Chemical Engineering, Lehigh University. Bethlehem, PA (2012).
`54. Department of Chemical and Biomolecular Engineering. Univ. of Maryland. College Park. MD (2011).
`
`Page 6 of 9
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`Page 6 of 9
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`

`

`55.
`56.
`57.
`58.
`
`59.
`60.
`61.
`62.
`63.
`64.
`
`65.
`66.
`67.
`68.
`69.
`70.
`71.
`
`Departmental seminar. Drug Product Development, Amgen. Seattle. WA (2011).
`Department of Biotherapeutics R&D, Boehringer—Ingelheim Pharmaceuticals. Ridgefieid. CT (2011).
`World Pre-Filled Syringes Summit. Tyson's Comer, VA (2011).
`Laboratory of Biochemistry and Genetics. National Institute of Diabetes, Digestive, and Kidney Disorders.
`Bethesda. MD (2011).
`1st International Symposium on Higher-Order Structure of Protein Therapeutics, Rockville, MD (2011).
`Drug Product Science & Technology R&D Seminar. Bristol Myers Squibb. New Brunswick. NJ (2011).
`Colorado Protein Stability Conference. Breckenridge. CO (2011).
`Symposium on Databases. Global Analysis, Modeling. and Simulations, CALCON, Oahu, HI (2011).
`CHI Protein Engineering Summit, Boston. MA (2011).
`Institute of Biophysics. National Research Council of Italy (Consiglio Nazionale della Ricerche). Palermo.
`Italy (2011).
`Novo Nordisk Biophysics Symposium, Copenhagen. Denmark (2011).
`Department of Chemical and Biomolecular Engineering. Tulane University, New Orleans (2011).
`XV School of Pure and Applied Biophysics. Venice, Italy (2011).
`Protein Sciences. Inc., Meridan. CT (2010).
`New Cell, New Vaccines Conference. Wilmington, DE (2010).
`Department of Biochemical Engineering. University College London, London UK (2010).
`Chemical Science & Technology Laboratories. Departmental Seminar. National Institute of Standards and
`Technology. Gaithersburg, MD (2010).
`72.
`Bioproduct R&D Departmental Seminar. Eli Lilly 8. 00.. Indianapolis, IN (2010).
`73.
`Food and Drug Administration, Bethesda. MD (2010).
`74.
`SANS Seminar Series. National Institute of Standards and Technology. Gaithersburg, MD (2010).
`75.
`Cambridge Health Institute. Protein Aggregation Conference. San Diego, CA (2010).
`76.
`Wyeth Vaccine Research, Pearl River. NY (2009).
`77.
`ED Sensitive Drug Initiative 2009 Science and Technology Forum. San Francisco. CA (2009).
`78.
`IIR BioProduction Conference, Barcelona. Spain (2009).
`79.
`Colorado Protein Stability Conference. Breckenridge. CO (2009).
`80.
`National Institute of Standards and Technology. Gaithersburg, MD (2009).
`81.
`CALCON, Santa Fe. NM (2009).
`82.
`AAPS National Biotechnology Conference. Seattle, WA (2009).
`83.
`Fraunhofer, Inc., Newark, DE (2009)
`84.
`ARO Enzyme Stability Workshop. Key West. FL (2008).
`85.
`Dept. of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY (2008).
`86.
`EMD Chemicals Inc., Gibbstown. NJ (2008).
`87.
`Biomolecular Interaction Technologies Conference, Durham. NH (2008)
`88.
`Recovery of Biological Products Xlll, Quebec City. Québec (2008).
`89.
`AAPS National Biotechnology Conference. Toronto. Ontario (2008).
`90.
`RISE seminar series, College of Natural Sciences. University of Puerto Rico — Rio Piedras (2008).
`91.
`Symposium on Biophysics and Multiscale Modeling. ACS Spring Meeting, New Orleans, LA (2008)
`92.
`IIR 5h Annual Formulation & Forced Degradation Strategies for Biomolecules, San Diego. CA (2008)
`93.
`Computational Biology Seminar Series, Washington University at St. Louis, St. Louis, MO (2007).
`94.
`Department of Chemical Engineering. Purdue University, West Lafayette. lN (2007).
`95.
`Parenteral Center of Emphasis. Pfizer Global R&D, Groton. CT (2007).
`96.
`Department of Chemical and Biological Engineering, University of Colorado - Boulder (2007).
`97.
`Merck Bioprocess R&D. Rahway, NJ (2007)
`98.
`Bristol-Myers Squibb, New Brunswick, NJ (2007)
`99
`Biochemical Engineering XV, Québec City. Quebec (2007)
`100.
`AAPS National Biotechnology Conference, San Diego, CA (2007).
`101.
`Dept. of Chemical and Biochemical Engineering, University of Maryland - Baltimore County (2007).
`102.
`Department of Pharmaceutical Sciences, Univarsity of Kentucky (2007).
`103.
`Department of Pharmaceutical Sciences. University of Connecticut (2007).
`104.
`Society of Biological Engineering Meeting. Coronado. CA (2007).
`105.
`Department of Chemical and Biological Engineering. University of Wisconsin (2007).
`106.
`Pfizer Global R&D, St. Louis. MO (2006).
`107.
`Glaxo—Smith Kline. King of Prussia, PA (2006).
`108.
`Amgen. Inc., Thousand Oaks, CA (2005).
`109.
`Centocor, Inc., Malvern, PA (2005).
`
`Page 7 of 9
`
`Page 7 of 9
`
`

`

`110. American Association of Pharmaceutical Scientists Annual Meeting. Nashville. TN (2005).
`111. 5“1 Annual IBC Formulation Strategies for Protein Therapeutics, Boston. MA (2005).
`112. Colorado Protein Stability Conference, Breckenridge. CO (2005).
`113. Midwest Thermodynamics and Statistical Mechanics Conference, Purdue University (2005).
`114. Bristol-Meyers Squibb. Pennington. NJ (2005).
`115. DuPont Experimental Station. Wilmington. DE (2004 ).
`116. 4'" Annual IBC Formulation Strategies for Protein Therapeutics. Boston. MA (2004).
`117. Barnett Protein Aggregation Conference. Phila., PA (2004).
`118. Protein Society Annual Meeting, San Diego, CA (2004).
`119. Freeze-Drying of Pharmaceuticals and Biologicals Conference. Breckenridge, CO (2004).
`120. Chemistry-Biology Interface Seminar, University of Delaware (2003).
`121. 3"I Annual IBC Conference on Protein Formulation and Stability. Philadelphia, PA (2003).
`122. International Workshop on Non-Equilibrium Thermodynamics and Complex Fluids, Princeton, NJ (2003).
`123. Merck Bioprocess Symposium, West Point, PA (2003).
`124. AAPS Short Course, Understanding Amorphous Pharmaceutical Systems. AAPS Annual Meeting, Toronto,
`Ontario (2002).
`
`Accepted from open submissions (underline indicates presenter)
`
`125. G. M. Ferreira, H. Sharma, R. Remmele Jr., C. J. Roberts. ACS Spring National Meeting, San Francisco.
`CA (2017)
`126. M. A. Woldeye . L. L. Josephson. W. Galush, C. J. Roberts, E. M. Furst. ACS Spring National Meeting,
`San Francisco, CA (2017)
`127. C. Calero-Rubio, A. Saluja. C. J. Roberts, ACS Spring National Meeting, San Diego. CA (2016).
`128. M. A. Wolde es, V. Razinkov. E. M. Furst. C. J. Roberts. ACS Spring National Meeting. San Diego, CA
`(2016)
`129. M. A. Woldeyes, C. J. Roberts. E. M. Furst. Society of Rheology Meeting (2015).
`130. G. V. Barnett, V. Razinkov, B. A. Kenn/in, C. J. Roberts. ACS Spring National Meeting, Denver, CO (2015).
`131 . R. Ghosh. C. Calero-Rubio. A. Saluja. C. J. Roberts, ACS Spring National Meeting, Denver, CO (2015).
`132. C. J. Roberts, G. V. Barnett. B. A. Kerwin. V. Razinkov. Amorph 2014, Cambridge, UK (2014).
`133. C. J. Roberts, V. K. Shen. ACS Spring National Meeting. Dallas. TX (2014).
`134. C. J. Roberts. M. A. Blanco. AlChE Annual Meeting, San Francisco. CA (2013).
`135. M. A. Blanco, T. Perevozchikova, E. Martorana, M. Manno, C. J. Roberts, ACS Spring National Meeting.
`New Orleans, LA (2013).
`136. C. J. O'Brien, M. A. Blanco, J. A. Costanzo. E. J. Fernandez. A. S. Robinson. C. J. Roberts. ACS Spring
`National Meeting, New Orleans, LA (2013).
`137. T. Perevozchikova. H, Nanda, R. L. Jones. C. J. Roberts, ACS Spring National Meeting, New Orleans. LA
`(2013).
`138. R. Jones. T. Perevozchikova. K. Weigandt. C. J. Roberts. Society of Rheology Meeting. Pasadena. CA
`(2013).
`139. J. Wiesbauer, R. Meier, C.J. Roberts. B. Nidetzky. 4th OGMBT Annual Meeting, Graz, Austria (2012).
`140. J. Wiesbauer, R. Meier, C. J. Roberts. B. Nidetzky, NAWI Graz Doctoral School of Molecular Biosciences
`and Biotechnology. Graz, Austria (2012).
`141. J. A. Costanzo. C. J. O'Brien. E. Sahin, E. Tamargo. K. Tiller, A. 8. Robinson, C. J. Roberts, E. J.
`Fernandez, ACS Spring Annual Meeting. San Diego, CA (2012).
`142. M. A. Blanco. J. Costanzo. C. J. O'Brien. E. J. Fernandez. A. 8. Robinson, C. J. Roberts. ACS Spring
`Annual Meeting, San Diego. CA (2012).
`143. C. J. Roberts, E. Sahin, M. Blanco, T. K. Das, AlChE Fall Meeting, Minneapolis. MN (2011)
`144. J. A. Costanzo. E. Sahin, C. O’Brien. E. Tamargo. K. Tiller, A. S. Robinson. C. J. Roberts. E. J. Fernandez.
`ACS Spring National Meeting. Anaheim, CA (2011).
`145. C. J. Roberts, D. P. Nesta, R. K. Brummitt. ACS Spring National Meeting. Anaheim. CA (2011).
`146. M. A. Blanco, E. Sahin, A. Gruenberger. C. J. Roberts. AlChE Annual Meeting, Salt Lake City, UT (2010).
`147. E. Sahin, A. O. Grillo. M. D. Perkins, C. J. Robfl. ACS Spring National Meeting, San Francisco, CA
`(2010).
`148. W. F. Weiss IV. A. Zhang, E. Sahin, E. J. Fernandez. C. J. Roberts, AlChE Fall Meeting, Nashville, TN
`(2009).
`149. R. K. Brummitt. L. Chang. D. P. Nesta, C. J. Roberts, ACS Annual Meeting, Washin