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`CSL EXHIBIT 1009
`CSL V. Shire
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`Page 1 of 16
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`CSL EXHIBIT 1009
`CSL v. Shire
`
`

`

`THE JOURNAL OF
`Allergy... Clinical
`Immunology
`VOLUME ll7 0 NUMBER 4
`
`Contents
`
`5A
`
`The front coverofthis issue ol'the Joumal pays tribute to the progress in
`primary immunodeficiency that has been made in the past 80 years. The
`artist presents the world of primary immunodeficiency that appears in all
`populations of people in every country with representative images of
`patients. one Ilefl) with ataxia telangicctasia first described in l926. and
`another today (right) with X-linked severe combined immunodeficiency
`(SCID). Shown also are the healing hands ofniedicine that provide patient
`care. education. and research support for patients with primary immuno-
`deficiency (see also Fig l
`in the Editorial in this issue by Shearer and
`Fischer. pp 748-52). In the span of 80 years we have come from the time
`when only the clinical phenotype of immuntxlcticiency could be de-
`scribed. to the present when not only detennination of the genotype of
`immune diseases can be accomplished but the correction of faulty genes
`as well. Thus. formerly. the patient with ataxia telangiectasia received
`only supportive care. whereas today the patient with X-linkecl SClD is receiving an infusion of his own bone
`man‘ow—dcrivcd stem cells into which the nonnal gene for the ll,-ZR",/ chain gene has been inserted (courtesy of
`Drs Harry Malech and Jennifer Puck. National Institutes of Health. Bethesda. Md). Considering the spectacular
`jouniey ol‘the past 8 decades. one must ask. "Where will the next 80 years take us?"
`The update on primary imtnunodeticiency featured in this issue is presented in several reviews. features. and
`original articles that are noted in the Table of Contents by a red starhurst beside their titles. We thank Associate
`Editor William T. Shearer. MD. PhD. for developing this excellent theme issue.
`Carer design by JD]. LLC.
`
`
`AMERICAN AcADhMt' or ALLERGY
`ASTHMA s IMMUNOtha‘
`
`OFFICIAL JOURNAL or m: AMERICAN ACADEMY or ALLERGY, ASTHMA AND IMMUNOLOGY
`
`
`
`* This month's theme: Update on primary immunodeficiency
`
`About the cover
`
`This month in Beyond Our Pages
`
`The distribution in the peripheral airways of inhaled [i-agonists of various paniele sizes was compared with the
`bronchodilating effects of such preparations. 0 Encouraging findings in large studies of 2 new rotavirus vaccines
`have been reported. O A large epidemiologic study compared the association of endotoxin exposure and asthtna
`prevalence. I Another study explored mechanisms involved in the recruitment of eosinophils to the area of airway
`nerves. 0 An investigation showed that missense mutations might lead to altered function of peItoriII. a protein
`involved in cytotoxic defense mechanisms. leading to certain diseases. 0 Studies in a murinc transgenic model
`support the view that basophils have an imponant primary role in chronic allergic inflammation.
`
`© 2006 American At‘m/wut of Allergy.
`
`.‘1.\'{/llll(l um! IIIIIIIIHIo/ogi'
`
`T’k’JUltl'lidl (Ifxl/lcrg)‘ and ('lI'Iu'r'u/ [alumna/oer t [Ssh- (KWIWOTJQI Is published monthly 1 l2 issues per yth by L‘lsm Ier lnt‘.. 300 Park Avenue South. New
`York. NY lflfilfl-l't‘lfl. Business and Editorial Utltccs
`tom John l-. Kennedy llIIIIlesard. Suite IKtltl. Philadelphia. PA “Niki-28‘)”. Accounting and
`Ctrculatinn Offices 6277 Sea Harbor Dnve, Orlando. H. RIM-\‘T-JKIKJ, PcIILIdIcals postage paid .II Orlando. Fl. fess: and additional mailing offices.
`PUS'I'MAS'I'ER Send address changes In The Jnuuml ul' :ilft‘ltlt tnul ('Iinr't HI lumtttlnrlug}. L‘lwvlct' Pt'riotht tll\ ('tIsIIIIncI Sen ice. 0277 Sea Haer Drise.
`Orlando. lL .t2tts7-4xno
`
`J ALLERGY CLlN IMMUNOL
`
`April 2006
`
`Page 2 of 16
`
`

`

`CONTENTS
`
`The editors’ choice
`
`723
`
`Donald Y. M. Leung. MD. PhD. Harold S. Nelmn. MD. and Stanley ]. Sufler. MD
`
`Reviews and feature articles
`
`Current reviews of allergy and clinical immunology
`
`The Wiskott—Aldrich syndrome
`Han: D. ()eln. MI), and Adrian j. Tarot/Jar. MD, PM). Seattle. Wax/1. and London. United Kingdom
`
`725
`
`Continuing Medical Education examination: The Wiskott-Aldrich syndrome
`
`739
`
`Molecular mechanisms in allergy and clinical immunology
`
`Molecular basis of common variable immunodeficiency
`Emanuele (hing/i. BSA and
`Celia. MI). Barton. Man
`
`740
`
`Continuing Medical Education examination: Molecular basis of common
`variable immunodeficiency
`
`Editorials
`
`The last 80 years in primary immunodeficiency: How far have we come,
`how far need we go?
`William T. Shearer. MD. PhD. and Alain Pitcher. MD, PhD. Holman. Tex. and Pam. France
`
`Navigating today's success to prepare for tomorrow’s exploration
`Donald Y, M. Lmng, MD. PhD. Namy T. Hopper. 35. MA. and Terrie DuHaduuy. Dem/n. Cob. and S! Lam}. Ala
`
`Clinicalpearls
`
`Primary immunodeficiency or not? Making the correct diagnosis
`Relm‘m H. Barkley. MI). Dar/ram. NC
`
`756
`
`
`
`Continued on page 9.4
`
`Contents
`
`The Journal of Allergy and Clinical Immunology posts in-press articles online in advance of their appearance
`in the print edition of the Journal. They are available at the JACl Web site at www.jacionline.org at the “Articles in
`Press" link. as well as at Elsevier‘s ScienceDiiect Web site. WWw.sciencedirect.com. Each print article will
`acknowledge the e-publication date (the date when the article first appeared online). As soon as an wide is
`published online. it is fully citable through use of its Digital Object Identifier (DOI). Please visit the JACI Web site
`and view our hot—off-the—wire articles through the “Articles in Press" link.
`
`a Editors' Choice (p 723)
`
`@ ()nline Repository material
`* Theme issue
`* CME examination article available online at www.jacionline.org
`
`J ALLERGY CLIN IMMUNOL
`
`April 2006 7A
`
`Page 3 of 16
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`

`

`CONTENTS
`
`CONTINUED
`
`Asthma diagnosis and treatment
`
`Original article:
`
`Contents
`
`a Accuracy of US Food and Drug Administration—cleared lgE antibody assays
`in the presence of anti-IgE (omalizumab)
`Rabat! G. Hamilton, PM), DAIIMIJ. lid/Irma". Md
`
`759
`
`in serum
`the presence of omalizumab (Xolair: anti—human lgE)
`This study finds that
`degrades the accuracy of most US Food and Drug Administration—cleared total and
`allergen-specific lgE assays used in clinical
`immunology laboratories; however.
`the
`lmmunoCAP is designed to accurately quantify levels of total and allergen—specific IgE
`in human serum containing therapeutic levels oft)malizun1ab.
`
`767
`
`Bronchial challenges in athletes applying to inhale a BZ—agonist at the 2004
`Summer Olympics
`Sum/rd I). Anderson. PhD. DSr, Malta/m Subeu. 1W3 C/IB. PhD. Clare P. Perry, 354', Dip Ell. C/Ir‘iuirw
`(Int/2w". MD. PhD. I’amlle Kip/"1m. I’IJD. Don C. McKenzie, AID, PhD, Km C. Bet/z, PhD. and Ken D. Firth.
`MIME. MI), (famprnllm/u um] Nrrllundr. Australia, Trend/trim. Norway. Athens. (inert. Varmint/(r. British
`(Mum/7m, Gourde. andS! l’aul. Mimi
`
`April 2006 9A
`
`This study is a summary of the objective evidence submitted on athletes for the Summer
`Olympic Games to justify the use ofan inhaled [ll—agonist prior to an event.
`It is of clinical
`importance that athletes with lung function well within the healthy range have such marked
`bronchial hyperresponsivencss and suggests that many athletes with asthma are being
`undertrcated.
`
`Mechanisms of asthma and allergic inflammation
`
`Association between genetic variations of vascular endothelial growth factor
`receptor 2 and atopy in the Korean population
`qung- Wm: l’urle. AID, fling-Fm: Let. I’III). [5:41:50an Shin. I’M). lur Young In. Ml). Imm— W00 Balm. MI). I[tung-
`Ilum 0/). MI).
`.S'un- Young U/r, I’M). Sung-Ham (film. AID, Her—Bum Moan. Ml). Kyung—Up Aim. Ml), jack A.
`Elms. MD.
`l’au- Young Kim. MI). and You" Km" Kim. A”). Seoul and Kyunggidu. Korea. and
`Nrw Huwu. Calm
`
`774
`
`This is the first report demonstrating that genetic variations of vascular endothelial growth
`factor (VEGF) receptor 2 are significantly associated with atopy in the gene-ml population
`and also among asthma patients. This result
`implies that VEGF signaling pathways are
`involved in the genetic predisposition to atopy.
`
`Reduced airway hyperrcsponsiveness and tracheal responses during allergic
`asthma in mice lacking tyrosine kinase inducible T—cell kinase
`[mum /. I‘rmim. MS. (gym/rm Mull/(r. MS. Nisrbim Sit/m. MS.
`.‘lbdtllaziz Bm-Irbrid. 1M". and
`Artery August.
`I’IJD. Unil'rrnly I’url', Pu
`
`This article provides evidence for a prominent role for T-cell-expressed Tec family tyrosine
`kinasc inducible T-cell kinase (lTK)
`in the modulation and development of airway
`hyperresponsiveness.
`tracheal responses. and lung T..2 cytokine production in a routine
`model of allergic airway disease. The results in this article suggest that efforts to target lTK
`phatmaceutically might be beneficial in reducing allergic airway responses.
`
`.l ALLERGY CLIN IMMUNOL
`
`Continued on page I IA
`
`Page 4 of 16
`
`

`

`
`CONTENTS
`
`CONTINUED
`
`
`
`
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`
`
`
`
`
`Airway epithelial cells produce neurotrophins and promote the survival of
`
`
`
`
`
`eosinophils during allergic airway inflammation
`Christian Hahn. PhD. Art'yan Pimyesb [tlammm Harald anz, MD. and Wofigang Arm'th Norah”, MD. MSr,
`
`
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`
`
`Mitrburg. Germany
`
`
`
`
`
`
`787
`
`Contents
`
`Neurotrophins contribute to eosinophil—epithelial cell interactions during allergic airway
`
`
`
`
`
`
`
`
`inflammation through upregulation of epithelial neutotrophin production and pro-
`
`
`
`
`
`
`
`
`longation of tissue eosinophil survival. Inhibition of increased epithelial neurotrophin
`
`
`
`
`
`
`
`
`
`production might be an important target to control the allergic airway eosinophilia.
`
`
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`
`
`April 2006 11A
`
`
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`
`
`@ Prenatal farm exposure is related to the expression of receptors of the innate
`
`
`
`
`
`
`
`
`® immunity and to atopic sensitization in school-age children
`Markus fall/1mm lzlgr. MD. Christian Bieli, MD, era Fffl. MSr, Ruben Theodonr van Sty-I'm. PhD, jamflt’irdlzr,
`
`
`
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`
`
`MD. Ellen Ublaggrr, MD, Divider .S‘t'hram—Bijkerll’. MSr. Herr Bmiztlererfi PhD. Marianne mm Huge, MD. PhD.
`
`
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`
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`rlimikn b't'lre‘vniut. MD. MID. Gb'mn PrrJlmgen. fill). P111). Marcus R. Benz, MD, Roger Layman MD, Erika 21m:
`
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`
`
`Marius. MD. Churlam Hmumfabrkz‘nder, MI). and the l’ARSIFAL Study ream. Munirlv, Grmumy. Basel and
`
`
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`lurid]. Srtdtzrrlrma’,
`.S‘r-hwarzarl) and bkizlmrg. Amm'zz. Utrerht, The Netbarlana‘r. and Stockholm. Sweden
`
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`Maternal exposure to environments rich in microbial compounds is inversely associated
`
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`with the risk of atopy and increases gene expression of receptors of the innate immune
`
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`system in the offspring. This article highlights the importance of prenatal environmental
`
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`exposures for the development of allergic diseases.
`
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`lL—17F sequence variant (HislélArg) is associated with protection against
`
`
`
`
`
`
`
`asthma and antagonizes wild—type IL—17F activity
`.Mia Kawagm‘fri, MD. Dm'jukr Tinktzlarrtbi. MD. Nabuyuki Himwtz, MD. Slainmra Suzuki, MD. Sarashr'
`
`
`
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`
`
`1Wdl5mlmrtl, MD, Fumla Kml’ubn. MD. Yukika Mrreda, MI).
`l’aslu'rmlm le’m'. Ml). Saws/)1 Karma. MD, Shun-Ki:
`
`
`
`
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`
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`
`
`l’bD. Mambnm Nnhimum. MD. and Mitmm Admin, MD.
`limbo and Sapporo, japan. and Hdln'marr, Md
`Huang.
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`is inversely associated with
`lL—l7l: variant. which antagonizes wild—type l[.—17F activity.
`
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`
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`asthma. suggesting a role For lL—17F in the pathogenesis of asthma, and a therapeutic utility
`
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`of targeting IL—l7F activity.
`
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`Rhinitis, sinusitis, and ocular diseases
`
`
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`
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`@ Sublingual immunotherapy with once—daily grass allergen tablets: A random—
`
`
`
`
`
`
`
`ized controlled trial in seasonal allergic rhinoconjunctivitis
`Stephen R. Durham, MD. William H. Yang. Ml), Martin R. Prrlrrrm, MSr-lerm, Nielrjalmmm. MSr-C/er Eng. and
`
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`saline Rails MD. London. United Kingdom. Ottawa. Ontario. (,‘anatfiz. Hers/Mm, Denmrk. and Gb‘relmg. Sweden
`
`
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`802
`
`Specific immunotherapy For allergic disease, although eficctive, might be associated with
`
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`serious side effects as a result of being delivered by injection. Suhlingual immunotherapy
`
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`
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`represents an alternative treatment that can relieve symptoms with an improved safety profile.
`
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`Double—blind, placebo-controlled study with a modified therapeutic vaccine of
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`Salmla kali (Russian thistle) administered through use of a cluster schedule
`Carlos Cain's. MD. PhD. Susana Ail-9112.6". MU.
`l‘r'JD. Ma'nir'tr thurini, MD. and Apalinar 11212101, MD. PhD.
`
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`Zamgaza. Spain
`
`
`that
`report
`immunotherapy with a depigmented and glutaraldehyde—
`The authors
`
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`
`
`polymerized extract of Salmlrt kali pollen is safe and effective in the treatment of patients
`
`
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`clinically sensitive to this pollen.
`
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`
`
`810
`
`
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`Environmental and occupational respiratory disorders
`
`
`
`817
`
`J ALLERGY CLlN IMMUNOL
`
`
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`
`
`Continued on page 13A
`
`
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`Page 5 of 16
`
`

`

`CONTENTS
`
`CONTINUED
`
`Effects of ultrafine carbon partide inhalation on allergie inflammation
`of the lung
`Francesca Alessandrini, PhD, Holger Schulz, MD, Shinji Takenaka, DVM, PhD, Bernd lentner, BSc,
`Erwin Karg, MSc, Heidmn Behrendt, MD, and Thilo Jakob, MD, Neuherberg and Munich, Cermany
`
`This article evaluates the effects of inhalation of elemental carbon ultrafine particles
`(EC-UF P) on the allergen-induced inAammation of the lung. EC-UFP inhalation prior
`co allergen challenge dramatically augments the allergie inflam macory response (as
`documented by increased bronchoaleveolar lavage cellular infiltrate, bronchoalveolar lavage
`fluid cytoki nes, and airway hyperreactivi ty), whereas EC-UFP inhalation during an ongoing
`allergie inflammation does not. AJlergic sensitization might chus represent a susceptibility
`factor for rhe efîects of UFP on allergen-induced inflammation of the Jung.
`
`Effect of codeine on objective measurement of cough in chronic obstructive
`pulmonary disease
`Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD, and Ashley Woodcock, MD, Manchester and
`Liverpool, United Kingdom
`
`831
`
`Codeine is the standard anti tussive agent co which nove! treatments are compared. ln chis
`double-blind, randomized co ntrol trial, codeine had no significa nt effect over placebo in
`patients with chronic obstructive pulmonary disease with chronic cough.
`
`Food allergy, dermatologie diseases, and anaphylaxis
`
`Cathelicidin deficiency predisposes ro eczema herpeticum
`Michael D. Howell, PhD, Andreas Wollenberg, MD, Richard l. Gallo, MD, PhD, Michael Flaig, M D, Joanne E.
`Streib, BA, Cathy Wong, BS, Tatjana Pavicic, MD, Mark Boguniewicz, MD, and Donald Y. M. leung, MD, PhD,
`Denver, Colo, Munich, Cermany, and San Diego, Ca/if
`
`This srudy demonstrared chat the narurally occurring antimicrobial peptide LL-37 kills
`herpes simplex vi rus. Furrhermore, a deficiency of LL-37 might predispose this population
`of patients ro eczema herpeticum and this might correlate with serum IgE.
`
`Skin prick test ro egg white provides additional diagnostic utility to serum egg
`white-specific IgE antibody concentration in children
`Adina Kay Knight, MD, Wayne C. Shrejfler, MD, PhD, Hugh A. Sampson, MD, Scott H. Sicherer, MD,
`Sally Noone, RN, MSN, Shideh Mofidi, MS, RD, CSP, and Anna Nowak-Wegrzyn, MD, New York, NY
`
`T he size of egg white skin prick test wheal might provide the clinician with additional
`information to determine the timing of egg oral food challenge in children with low egg
`white- specific IgE antibody level.
`
`Molecular doning and expression in insect cells of honeybee venom allergen
`acid phosphatase (Api m 3)
`Thomas Grunwald, PhD, Benjamin Bockisch, PhD, Edzard Spillner, PhD, Johannes Ring, M D, PhD,
`Reinhard Bredehorst, MD, and Markus W O!lert, MD, Hamburg and Munich, Germany
`
`The authors' findings suggest that a new tool might be available to facilitate the
`develop ment of improved diagnostic resrs as well as the design of safer and more effective
`immunotherapies for honeybee venom allergy.
`
`836
`
`842
`
`848
`
`J ALLERGY CLIN IMMUNOL
`
`Continued on page 14A
`
`April 2006 13A
`
`Page 6 of 16
`
`

`

`CONTENTS
`
`CONTINUED
`
`Basic and clinical immunology
`
`Current perspectives
`
`Defects of class-switch recombination
`
`Luigi D. Notarangelo, MD, Gaerana Lanzi, PhD, Sophie l'eron, and Anne Durandy, MD, PhD,
`Brescia, !ta/y, and Paris, France
`
`Gene therapy for immune disorders: Good news tempered by bad news
`Jmniftr M. Puck, MD, and Harry L. Malech, MD, Berhesda, Md
`Case studies
`TAC I mutation with invasive polyclonal cos+ T-cell lymphoproliferation in
`a patient with common variable immunodeficiency
`
`Lucinda}. Berg/und, MBBS, Graham}. Jones, BSc, PhD, Rajmohan Mura li, MBBS, and David A. Fu/cher, MBBS,
`PhD, Sydney, Ausrralia
`
`Etanercept treatment of cutaneous granulomas in common variable
`immunodeficiency
`Joan11 H. Lin, MD, Myron Liebhaber, MD, Robert L. Roberts, MD. l'hD, Zeb Dyer, PA. and
`E. Richard Sriehm, MD, Los Angeles and Sa111a Barbara, Ca/if
`
`Workshop summary
`
`Primary immunodeficiency diseases: An update from the International Union
`oflmmunological Societies Primary lmmunodeficiency D iseases Classification
`Committee Meeting in Budapest, 2005
`Luigi Norarangelo, MD, Jean-Laurent Casanova, MD, Mary Elle11 Cordey, MD, Helen Chape/, MD, Alain Fischer,
`MD, }m11iftr Puck, MD, Chaim Roifman, MD, Reinhard Seger, MD. and RaifS. Geha, MD, for the International
`U11io11 of lmmu110/ogical Societies Primary lmmu11odejiciency Diseases Classification Commiuu, Brescia, lraly, Paris,
`France, Memphis, Tmn, Oxford, United Ki11gtÛJm, Bethesda, Md, Toromo, Omario, Canada, Zurich, Swùzerl111d,
`and Boston, Mass
`
`Original articles
`
`Mutations in the RNA component of RNase mitochondrial RNA processing
`might cause Omenn syndrome
`Chaim M. Roifman, MD, FRCl'C, Yiping Gu, BSc, a11d Amos Cohen, l'hD, Toronto, Omario, Canada
`
`T his report shows fo r the first time that mutations in the RMRP RNA gene, which are
`known ro be associaced wirh carrilage-hair hypoplasia, mighr cause Omenn syndrome.
`
`Self-administration of C l-inhibicor concencrace in patients with hereditary
`or acquired angioedema caused by C l-inhibitor deficiency
`Marcel Levi, MD, Goda Choi, MD, Charles l'icavet, MA, a11d C. Erik Hack, MD, Amsttrdam, The Ne1herla11tls
`
`Self-admi nistration of C l -inhibi ror concenrrare, as reporred in this article, saves valuable
`rime and resulrs in early relief and complere resolution of angioedema symproms and in
`prevenrion of angioedema arcades in patients using the co ncenrrare as prophylaxis.
`
`855
`
`865
`
`870
`
`878
`
`883
`
`897
`
`904
`
`14A April 2006
`
`Continued on page 16A
`
`J ALLERGY CLIN IMMUNOL
`
`Page 7 of 16
`
`

`

`CONTENTS
`
`CONTINUED
`
`Associatio n of C D 4+ T -lymphocyte counts and new thymie emigram s
`in HIV-infected children during successful highly active antiretroviral
`therapy
`Akihiko Saitoh, MD, K11mud K. Singh. f'hD, Sharsti Sand,,//, BS. Christine A. Powell, MA, Trrrenu Femon, &ID,
`Courtney V. Fletcher, f'harmD, Karen Hsia, PhD, and Suphen A. Spector, MD, La fol/a, Cali[. Boston, Mass, and
`Dmver, Co/,J
`
`T-cell recepcor excisio n circle (TREC) levels co rrelarc with HTV- 1 intracellular DNA lcvels
`and C D 4• T -lym phocyre counts in HJV-1-infected children receiving highly active
`antiretroviral therapy with sustained viral suppressio n.
`
`Decreased C D4+ lymphocytes and innate immune respo nses in adults with
`previous extrapul monary ruberculosis
`f'a11lo R. Z. Amas, PhD, li Ding, M D, Judith Hackma11, RN, Linda Ruvts-Hammock, RN, Ayumi K Shima11i,
`PhD, MPH, joshua Schi.ffer, MD, Steven M. Ho/land, MD, and Timothy R. Sterling, MD, N11shvill.r, Tenn, and
`Bethesda and Baltimore, Md
`
`Compared to perso ns with cured pul monary tubcrculosis or Mycobacterium tubermlosis
`infection, HI V-seronegative adules with cured extrapul monary tuberculosis had lower CD4•
`lym phocytes and unstimu laced cytokine production, suggescing abnormal innace immune
`fu nccion.
`
`Leuko triene 0 4 enhances imm unoglobulin production in C D 40-activated
`human B lymphocytes
`}osée Lamoureux, PhD, Jana Stankov11, PhD, t1nd Marek Rola-1'/rszczynski, MD, Sherbrooke, Q11ebN, Cant1d11
`
`Sti mulation of human B lymphocytes wid1 C D40 ligand in conju nction with IL-4 enhances
`cheir expression ofCysLT 1 and this is associated with incrcased responsiveness of the cells ro
`L TD4 in terms of calcium mobilizatio n and lg p rod uction.
`
`Associations of cord b lood fatty acids wich lymphocyte prol ife ration,
`IL- 13, and IFN-y
`Diane R. Gold, MD, MPH, Ben M. Willwmh, MD, MSr, Kelan G. Tamisira, MD. Patricia W'. Finn, MD. Bitmca
`Schaub, MD, David l. Perkins, MD, PhD, Arthur Tzianabos, PhD, Ngoc P. Ly, MD. Christian Sthroeur, MD,
`Fiona Gibbons, MD, Hmmia Campos, MD, Emily Olun, MD, MP/-1, Mauhew W'. Ci/Iman, MD, SM,
`Lyle j. Palmer. PhD, Louise M. Ryan, PhD, and Srou T Weiss, MD. Boston, Man
`
`In cord blood , elevated levels o f n-3 eicosapenraeno ic acid and n-6 arachidonic acid were
`associated with arrenuation of lymphocyte proliferation and IFN-y production. Implica(cid:173)
`tions of these fi ndings for allergy or asth ma d evelopment are not yet known.
`
`909
`
`916
`
`924
`
`931
`
`IgE memory: Persistence of antigen-specific IgE responses years after trearment
`of human filarial infectio ns
`
`939
`
`Edward Mitre, MD, t1nd Thomas B. Nutm1111, MD. Btthesda, Md
`
`This stud y demonstrates long-term persistcnce of parasite-specific lgE responses in hum ans
`in the absence of reexposure to pathogen. Clinically, these find ings suggest that absoluce
`allergen avoidance might not result in the Joss of all ergy, and parasire-spccific lgE- ind uci ng
`vacci nes, if effective, could potenrially induce longstandi ng protection.
`
`16A April 2006
`
`Continued on page J 8A
`
`J A LLERGY CLIN IMMUNOL
`
`Page 8 of 16
`
`

`

`CONTENTS
`
`CONTINUED
`
`Letters to the Editor
`
`Quantitative assessment of che compliance with a once-daily sublingual
`immunocherapy regimen in real life (EASY Project: Evaluation of A nove!
`SUT formulation during a Year)
`
`946
`
`Giovanni Passalacq1111, MD, Amonino Mufllrrn, MD, Silvin Pecora, MD, Snverio Amoroso, MD, leonnr@
`Antonicelli, MD, Gitwni Cadario, MD, Mario Di Gioncchino, MD, Carlo l ombnrdi, MD, Erminin Ridolo, MD,
`Gui@ Sacerdoti, MD, Domenico Schiavino, MD, and Gianenrico Smna, MD, Gmoa, Milan, Ancona, Turin,
`Chieti, Bmcia, Naples, Rome, and Verona, Ira/y
`
`A survey co nducced by the auchors found thac a simplified sublingual immunotherapy
`(S UT) sched ule self-managed by t he patient was characterized by a satisfacrory
`compliance rare.
`
`Aiiway inflammation in occupational asthma caused by styrene
`Mar Femtindez-Nieto, MD, Santiago Quirce, MD, PhD, Juan Fraj, MD, Victoria del Pozo, PhD, Carmen Seoane,
`BSc, Beatriz Sasrre, BSc, Carlos Lahoz. MD, PhD, and joaquîn Same, MD, PhD, Madrid and Zaragoza,
`Spain
`
`948
`
`An autobod y shop worker developed occupacional asthma due to sryrene exposurc
`as confirmed by specific inhalation challenge and inAammatory changes in induced
`sputum.
`
`Prolonged elevation of serum tryptase in idiopathie anaphylaxis
`Ganesh Shanmugam, MD, Lawrence B. Schwartz. MD, PhD, and David A. Khan, MD, Dallas, Tex, and Richmond, Va
`
`950
`
`Serum tryptase can be used to help diagnose idiopathie anaphylaxis even several hours after
`the onser of symptoms.
`
`Deep inhalation bronchoprocection in asthma: Correlarion with airway
`respons1veness
`Donald W Cockcroft, MD, FRCP(C), and Beth E. Davis, BSc, Saskatoon, Saskatchewan, C1111ada
`
`The deep inhalation protection of bronchoconstricrio n induced by methacholine in mild
`asthma correlares with rhe underlying airway responsiveness, occurring o nly in rhose with
`methacholine PC20 > 2mg/mL.
`
`Correspondence
`
`Cost-effectiveness of home-based interventions should also cake into account
`nonrespiratory indoor health hazards
`Denis André Charpin, MD, MPH, Marseille, France
`
`Reply
`Meyer Kattan, MD, Sally Stearm, PhD, Ellen Crain, MD, Cindy Vimm, MA. MPH, and Herman Mitchell, PhD,
`for the lnner-City Asthma Srudy, New York and Bronx, NY. and Chape/ Hill, NC
`
`Nutritional supplements and pediatric upper respiratory tract illnesses
`
`Linda A. linday, MD, New York, NY
`
`951
`
`953
`
`953
`
`953
`
`18A April 2006
`
`Continued on page 22A
`
`J ALLERGY CLIN IMMUNOL
`
`Page 9 of 16
`
`

`

`CONTENTS
`
`CONTINUED
`
`Reply
`Craha111 Devereux, MD, m1d Antho11y Sraton, MD, Aberdeen, United Kingdom
`
`The d ifference berween groups and in d ividuals
`
`Sejal Sagiani, MB, ChB, A11drew Husl>, MD. 11nd Don11ld Payne, MD, London, U11ited Ki11gdam
`
`Reply
`Jacqu es de Blic, MD, Isabelle Ti/lie-/ eblo11d, MD, Pl,[), and l'trrrr Schm1mam1, MD. Paris 1111d Li/Ir. Fr1111re
`
`V iral specim en co llection by parents increases response rate in
`population-based virus scudies
`Marukr M. ,,,w drr Zal,11, MD, Cu110 S. P. M. Uirerwa,,I, MD, Pl,D, Brita M. dr Jang, MD, Herry Wilbrink, PhD.
`and Comelis K. 1>1111 drr l:'111, MD, PhD, Utrecht and Bdrhor•rn, The Nrthrrla11ds
`
`Rep ly
`Robert F. Lr111amke, Jr, MD, Jm11rs E. Cern. MD, a11d Ro11a!tl /:. C11ng11or1, PhD. Madiso11, Wis
`
`Environm ent-induced reactivicy against autoallergens: Possible raie
`of latex
`Fabrizio Cuarnrri. MD. Claudio Guarneri, MD, 1111d Salvatore Benvmga, MD. Mmiw1, /111/y
`
`The allergy archives: Pioneers and milestones
`
`H enry C laman in profile
`
`Stephrn C. Dmkin, MD, PhD, Drnver Colo
`
`Identification of cellular cooperation in antibody production
`
`Charles H. Kirkpatrirk. MD, Denver, Cola
`
`T hymocytes and bo ne marrow cells in 1966: W here d id we go
`fro m there?
`
`Philippa Marrack, PhD. Dmvrr. Cola
`
`Beyond our pages
`
`Burton Zwri111an, MD. and Marc E. Rothmbrrg, MD, PhD. Editors
`
`Corrections
`
`Response to inhaled albucerol duri ng noccurnal asrhma
`(Hmdelrs L, Beaty R, Ahrrm R. Stevem C. a11d Hanna,, ti\1. 2004:l /3:1058-62)
`
`Innate immuni ry for biodefense: A scracegy whose rime has come
`
`(Amlie-lefond C, Paz DA, Co1111elly Ml'. H1iff,111gle CH, Du1111 KS. Whe/1111 NT. a11d \'(ll,r/a11 IIT
`2005; 116: 1334-42)
`
`954
`
`955
`
`955
`
`955
`
`956
`
`957
`
`959
`
`960
`
`962
`
`965
`
`773
`
`923
`
`22A April 2006
`
`Continued on page 23A
`
`J ALLERGY CLI N IMM UNOL
`
`Page 10 of 16
`
`

`

`CONTENTS
`
`CONTINUED
`
`Reader services
`
`Instructions fo r aurhors
`Information for readers
`Newsview- American Academy of Al lergy, Asrhma and l mmunology
`C ME calendar- American Academy of Allergy, Asth ma and lmmuno logy
`C ME activiries informatio n
`Professio nal opporruniries
`C hange of add ress
`
`www.jacionline.org and January 2006, pages 23A-30A
`30A
`33A
`38A
`40A
`41A
`758
`
`Continuing Medical Educatio n (CM E) cred it is available 10 readers who s uccessfull y complete examinations
`accom panying the anicles in the monthly series Currellf Re,·iews of Allergy and Cli11ical lmmunology and Molern/ar
`Mechanisms in Allergy and Clinicat /11111111110/ogy. This C ME oppo rtunity furthers the jo int educational goal of the
`Jo urnal and it, sponsori ng foundalion. the American Academy of Allergy. Asthma and lmmu nology (AAAA I).
`Leam ing objectives, examination q uestions, and full detai ls appear in each review art icle in the print and online Journal.
`The sclf-directcd examinatio ns can be taken at the JAC I website (www.jac ionlinc.org). Cred it is admin istered by the
`AAAAI.
`
`Complimenlary 1-ycar subscriplions lo The Jaumal of Allergy and Cli11ica/ /11111111110/ogy are available
`nited
`tales through an unrestricted educational grant from Alcon
`to AAAAI member FITs in the
`Laboratories, Inc.
`
`Stateme n1, and opini<>n, expre,...,d 1n the a111clcs and communica11on, he re111 are tho>e of the au1hor(,) and 1101 nece, ~anl) tho..e of the Eduor. pubh,her. or 1he
`American Academy of Allergy. A,thma and lmmunology. The Editor. pubh, hcr. and the American Academ) of Allergy. A,1hma and lmmunology d1scla1m
`any respon"b1hty or hab1lil) for ,uch matcnal and do not guarantee. " ammt. or endon.e an) product or senice ad, en,~
`1n th" publication. nor do the)
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`
`J ALLERGY CLIN IMMUNOL
`
`April 2006 23A
`
`Page 11 of 16
`
`

`

`Self-administration of C1-inhibitor concentrate
`in patients with hereditary or acquired
`angioedema caused by C1-inhibitor deficiency
`
`Marcel Levi, MD.a Goda Choi, MD.a Charles Picavet, MA,b and C. Erik Hack, MDc*
`A111sterda111. Tlie Netherlands
`
`Background: Administration or C l-inhibitor conccntrate i,
`cfTecth c for proph)' laxis and treatment or severe angiocdema
`a llacks cat15ed by C 1-inh ibitor deficienq. The concentra te
`should be administered intr3\ c nous ly a nd hence nccd5 to be
`i1dministercd by he:1lth carc prorcs.~ionals, which might cause
`considcrahle delay in trea tment a nd inconveniencc for patients.
`Objecthe: The aim or this study " as to im estigate the
`rcasibility, cfficacy, and sarety or on-dernand and prophylactic
`self-administration or C 1-inhibitor concentrate in patients \1 ith
`frequ cnt atlacks of angioedema.
`l\lethods: Patients \1ith hcreditary or acquircd C l -inhibitor
`deficiency who had \'Cry frequent angioedema attacks werc
`trained to self-lldminister C 1-inhibitor concentratc. T he study
`consisted or 3 1 patients us ing on-demand treatment a nd 12
`patients us ing prophylaxis \\ith C l -inhibitor conccntrate.
`Mean follow-up wos 3.5 years.
`Resulls: Ali patienL, were ca pa ble or self-administering the
`concentrate, with tcchnical fuilure rate, or self-injection being
`less than 2%. Times beh•ccn the onset or the attack and the
`initiation of relier or complete resolution of symptoms in the
`on-dcma nd group n ere significantly shortencd t2.2 hours a nd
`7.9 hours. r espcclh cly) compared \\ith the ~itua tion before
`the start of self-administration. ln the 1>rophylaxis group
`self-administration or C l -inhihitor concent rate decrea5ed the
`a ngioedema attack rate from 4.0 to 0.3 uttacks (>er month.
`Co nclusion: lnt ra, cnous self-administration or C l -inhibitor
`conccntrate is a reusiblc and sare option and results in more
`rapid and more effective treatmcnt or prevcntion or scverc
`a ngiocdema a ttacks in patients nith C l -inhibitor deficiencJ .
`Clinical implications: Self-administration or Cl -inhibito r
`concentrat e could he a valuable and convenient treatment
`modalitJ to pre,·ent or treat angioedenm attacks in patient..
`"ilh C l -inhibito r dcficiency. (J Allergy Clin lmmunol
`2006: 117: 904-8.)
`
`Frorn "the Dcpanmcnt ni Internai Medicine. Acallcmic Medirnl Ccntcr. l1111vcr(cid:173)
`s11) of Amsterdam. "The -..:ctberland, Patiem A"ocia t,on ol l lered1taf}
`Ani10-cc.lcma and Ouinc~c ·, Ldcma: and ' the Land,temer Labomltlf}.
`Ac,Klcmll \led,cal Center. L0 nl\tl'oll) ol Am,terù.un. and the Dcpanment
`ofCli111c:il Chcmi, tr). Free Uni,cl'oily Mcdical Ccmcr. Am,tcrd:1111.
`• o r llac~ " currcntly afti hated "1th Crucell Hnll:md BV. u:1den. The
`l'.'etherlands.
`Dhclo,ure of po1cnta.tl 1.:onf11c1 ol mtcre,1 . The ,1uthOI"\ have de1.:larcd th~~ ha\.l.'
`no confüu ol 111tere,1.
`Recc,ved for publicat,on l'-ovemhcr 26. 2005: l'i!\ 1,ed Jami,tr) 1. 20()6;
`accepted for pubhcatmn JanuaJ) 4. 2(M)6.
`Availablc nnline Fcbruaf) 14. 2006.
`Repnnt rc4ue,1s: Marcel Levi. ~1D. Depanment of \lcdic111c (F-41. Acadcmll
`Mcdical Center. llniver,ity ol AnNcrdam. Mc,bergdreel 9. I IOSA/
`AnNerdam. The 1'ctherland,. 1 mail: m.m.lc,,(a,unc.u,a.nl
`0091 -6749/$31.tXI
`<: 2(K)6 Amcrican Acac.lcm) of Allcrg). A,lhma ,md lmmunolog)
`doi: I0. 10 16/j.jaci.2(Xl6 OI .(Ml1
`
`904
`
`Key words: C l-111/11huor d1j111r11, ·'. C l -111hih11or umu•,urarc. hl'I, d(cid:173)
`itarv an~ioedcma. acq11ired a11~ù1ede111a
`
`Deliciency of C 1-inhibitor leads to n.:current ang.10-
`edema attacks and can be an irn.:apacitating disorder that
`might even rewlt in life-threatening '>ituation\. 1 4 The dd1-
`ciency might be due to an inherited (auto\omal dominant)
`or spontaneow,ly occurring genctic defect. lt also might
`be caused by an acquired condition. \ uch a\ the formation
`of autoantibodies toward C 1-inhibitor or the fom1ation of
`anti-id iotype antibodies in patients with lymphoproli fera(cid:173)
`tive disease. leading to consumption of C 1-inhibitor. 1 he
`angiocdema attach might occur at various sites of the
`body (often the extremities). but in particular. angioedema
`attad.s in the orof