`
`
`
`
`
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`____________
`
`BEFORE THE PATENT TRIAL AND APPEAL BOARD
`____________
`
`PFIZER, INC. and
`SAMSUNG BIOEPIS CO., LTD.,1
`
`Petitioner,
`
`v.
`
`GENENTECH, INC.,
`Patent Owner.
`____________
`
`Case IPR2017-01489
`Patent 6,407,213
`____________
`
`
`PETITIONERS’ UPDATED EXHIBIT LIST
`
`
`1 Samsung Bioepis Co. Ltd.’s IPR2017-02140 has been joined with this proceeding.
`
`(IPR2017-02140, Paper 40.)
`
`
`
`
`
`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`
`PETITIONER’S EXHIBIT LIST
`Description
`U.S. Patent No. 6,407,213, Method for making humanized
`antibodies (filed July 17, 1993) (issued June 18, 2002)
`File History for U.S. Patent No. 6,407,213
`
`Exhibit No.
`1501
`
`1502
`Vols. 1–10
`1503
`
`Declaration of Dr. Foote in Support of Petition for Inter Partes
`Review of Patent No. 6,407,213
`Curriculum Vitae of Dr. Foote
`1503A
`1503B Materials Reviewed by Dr. Foote
`1503C–Q Exhibits C–Q of Dr. Foote’s Declaration
`Declaration of Mr. Buss in Support of Petition for Inter Partes
`1504
`Review of Patent No. 6,407,213
`Curriculum Vitae of Mr. Buss
`1504A
`1504B Materials Reviewed by Mr. Buss
`1505
`Reserved
`1506
`Reserved
`1507
`Reserved
`1508
`Reserved
`1509
`Reserved
`1510
`Reserved
`1511
`Reserved
`1512
`Reserved
`1513
`Reserved
`1514
`Reserved
`1515
`Reserved
`1516
`Reserved
`1517
`Reserved
`1518
`Reserved
`1519
`Reserved
`1520
`Reserved
`
`
`
`
`1
`
`
`
`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`
`Exhibit No.
`1521
`
`1522
`
`1523
`
`1524
`
`1525
`
`1526
`
`1527
`
`1528
`
`1529
`
`1530
`
`PETITIONER’S EXHIBIT LIST
`Description
`Hudziak et al., p185HER2 Monoclonal Antibody Has
`Antiproliferative Effects In Vitro and Sensitizes Human Breast
`Tumor Cells to Tumor Necrosis Factor, 9(3) MOLECULAR
`CELLULAR BIOLOLGY 1165–72 (1989) (“Hudziak”)
`Köhler et al., Continuous Cultures of Fused Cells Secreting
`Antibody of Predefined Specificity, 256(5517) NATURE 495–97
`(1975)
`Prabakaran, The Quest for a Magic Bullet, 349(6246) SCIENCE 389
`(2015)
`Marks, The Story of Cesar Milstein and Monoclonal Antibodies: A
`Healthcare Revolution in the Making,
`http://www.whatisbiotechnology.org/exhibitions/milstein (last
`accessed March 23, 2017)
`Cosimi et al., Treatment of Acute Renal Allograft Rejection with
`OKT3 Monoclonal Antibody, 32(6) TRANSPLANTATION 535−39
`(1981) (“Cosimi ‘81”)
`Ortho Multicenter Transplant Study Group, A Randomized
`Clinical Trial of OKT3 Monoclonal Antibody for Acute Rejection
`of Cadveric Renal Transplants, 313(6) NEW ENG. J. MED. 337–42
`(1985) (“OMTSG ‘85”)
`Jaffers et al., Monoclonal Antibody Therapy: Anti-Idiotypic and
`Non-Anti-Idiotypic Antibodies to OKT3 Arising Despite Intense
`Immunosuppression, 41(5) TRANSPLANTATION 572–78 (1986)
`(“Jaffers ‘86”)
`Sears et al., Phase-I Clinical Trial of Monoclonal Antibody in
`Treatment of Gastrointestinal Tumours, 1 LANCET 762–65 (1982)
`Sikora, Monoclonal Antibodies in Oncology, 35(4) J. CLINICAL
`PATHOLOGY 369–75 (1982)
`Protein Data Bank - Chronology, National Science Foundation,
`https://www.nsf.gov/news/news_summ.jsp?cntn_id=100689 (last
`accessed April 12, 2017)
`
`
`
`
`2
`
`
`
`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`
`Exhibit No.
`1531
`
`1532
`
`1533
`
`1534
`
`1535
`
`1536
`
`1537
`
`1538
`
`1539
`
`1540
`
`PETITIONER’S EXHIBIT LIST
`Description
`Morrison et al., Chimeric Human Antibody Molecules: Mouse
`Antigen-Binding Domains With Human Constant Region
`Domains, 81(21) PROC. NAT’L ACAD. SCI. USA 6851–55 (1984)
`(“Morrison ‘84”)
`Liu et al., Chimeric Mouse-Human IgG1 Antibody that can
`Mediate Lysis of Cancer Cells, 84(10) PROC. NAT’L ACAD. SCI.
`USA 3439– 43 (1987) (“Liu ‘87”)
`Jones et al., Replacing the Complementarity-Determining Regions
`in a Human Antibody With Those From a Mouse, 321(6069)
`NATURE 522–25 (1986) (“Jones ‘86”)
`Queen et al., A Humanized Antibody That Binds to the Interleukin
`2 Receptor, 86(24) PROC. NAT’L ACAD. SCI. USA 10029–33
`(1989) (“Queen 1989”)
`Kirkman et al., Early Experience with Anti-Tac in Clinical Renal
`Transplantation, 21(1) TRANSPLANTATION PROC. 1766–68 (1989)
`(“Kirkman ‘89”)
`Waldmann et al., The Interleukin-2 Receptor: A Target for
`Monoclonal Antibody Treatment of Human T-Cell Lymphotrophic
`Virus I-Induced Adult T-Cell Leukemia, 82(6) BLOOD 1701–12
`(1993) (“Waldman ‘93”)
`Hakimi et al., Reduced Immunogenicity and Improved
`Pharmacokinetics of Humanized ANTI-Tac in Cynomolgus
`Monkeys, 147(4) J. IMMUNOLOGY 1352–59 (1991) (“Hakimi ‘91”)
`Vincenti et al., Interleukin 2-Receptor Blockade with Daclizumab
`to Prevent Acute Rejection in Renal Transplantation, 338(3) NEW
`ENG. J. MED. 161–65 (1998) (“Vincenti ‘98”)
`SEER Stat Fact Sheets: Breast Cancer, National Cancer Institute,
`http://seer.cancer.gov/statfacts/html/breast.html (last accessed
`March 17, 2017)
`Harris et al., Medical Progress: Breast Cancer, 327(5) NEW ENG.
`J. MED. 319–28 (1992) (“Harris ‘92”)
`
`
`
`
`3
`
`
`
`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`
`Exhibit No.
`1541
`
`1542
`
`1543
`
`1544
`
`1545
`
`1546
`
`1547
`
`1548
`
`1549
`
`PETITIONER’S EXHIBIT LIST
`Description
`King et al., Amplification of a Novel v-erbB-Related Gene in a
`Human Mammary Carcinoma, 229(4717) SCIENCE 974–76 (1985)
`(“King ‘85”)
`Semba et al., A v-erbB-Related Protooncogene, c-erbB-2, is
`Distinct from the c-erbB-1 / Epidermal Growth Factor-Receptor
`Gene and is Amplified in a Human Salivary Gland
`Adenocarcinoma, 82(19) PROC. NAT’L ACAD. SCI. USA 6497–01
`(1985) (“Semba ‘85”)
`Coussens et al., Tyrosine Kinase Receptor with Extensive
`Homology to EGF Receptor Shares Chromosomal Location with
`neu Oncogene, 230(4730) SCIENCE 1132–39 (1985) (“Coussens
`‘85”)
`Fukushige et al., Localization of a Novel v-erbB-Related Gene, c-
`erbB-2, on Human Chromosome 17 and its Amplification in a
`Gastric Cancer Cell Line, 6(3) MOLECULAR CELLULAR BIOLOGY
`955–58 (1986)
`Slamon et al., Human Breast Cancer: Correlation of Relapse and
`Survival with Amplification of the HER-2/neu Oncogene,
`235(4785) SCIENCE 177–82 (1987) (“Slamon ‘87”)
`Kraus et al., Overexpression of the EGF Receptor-Related Proto-
`Oncogene erbB-2 in Human Mammary Tumor Cell Lines by
`Different Molecular Mechanisms, 6(3) The EMBO J. 605– 10
`(1987)
`Hudziak et al., Increased Expression of the Putative Growth
`Factor Receptor p185HER2 Causes Transformation and
`Tumorigenesis of NIH 3T3 Cells., 84(20) PROC. NAT’L ACAD. SCI.
`USA 7159–163 (1987) (“Hudziak ‘87”)
`Shepard et al., Monoclonal Antibody Therapy of Human Cancer:
`Taking the HER2 Protooncogene to the Clinic, 11(3) J. CLINICAL
`IMMUNOLOGY, 117–27 (1991)
`Chothia et al., Conformations of Immunoglobulin Hypervariable
`Regions, 342(21) NATURE 877–83 (1989) (“Chothia ‘89”)
`
`
`
`
`4
`
`
`
`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`
`Exhibit No.
`1550
`
`1551
`
`1552
`
`1553
`1554
`1555
`
`1556
`1557
`1558
`
`1559
`
`1560
`
`PETITIONER’S EXHIBIT LIST
`Description
`Queen, International Publication No. WO 1990/07861 (published
`July 26, 1990) (“Queen 1990”)
`Tramontano et al., Framework Residue 71 is a Major Determinant
`of the Position and Conformation of the Second Hypervariable
`Region in the VH Domains of Immunoglobulins, 215(1) J.
`MOLECULAR BIOLOGY 175–82 (1990) (“Tramontano”)
`Kabat et al., SEQUENCES OF PROTEINS OF IMMUNOLOGICAL
`INTEREST: TABULATION AND ANALYSIS OF AMINO ACID AND
`NUCLEIC ACID SEQUENCES OF PRECURSORS, V-REGIONS, C-
`REGIONS, J-CHAIN, T-CELL RECEPTOR FOR ANTIGEN, T-CELL
`SURFACE ANTIGENS, β2-MICROGLUBINS, MAJOR
`HISTOCOMPATIBILITY ANTIGENS, THY-1 COMPLEMENT, C-
`REACTIVE PROTEIN, THYMOPOIETIN, POST-GAMMA GLOBULIN, AND
`α2-MACROGLOBULIN 41–175 (4th ed. 1987) (“Kabat 1987”)
`Reserved
`Reserved
`Kabat et al., 1 SEQUENCES OF PROTEINS OF IMMUNOLOGICAL
`INTEREST: TABULATION AND ANALYSIS OF AMINO ACID AND
`NUCLEIC ACID SEQUENCES OF PRECURSORS, V-REGIONS, C-
`REGIONS, J-CHAIN, T-CELL RECEPTOR FOR ANTIGEN, T-CELL
`SURFACE ANTIGENS, β2-MICROGLUBINS, MAJOR
`HISTOCOMPATIBILITY ANTIGENS, THY-1 COMPLEMENT, C-
`REACTIVE PROTEIN, THYMOPOIETIN, POST-GAMMA GLOBULIN, α2-
`MACROGLOBULINS, AND OTHER RELATED PROTEINS 103–338 (5th
`ed. 1991) (“Kabat 1991”)
`Reserved
`Reserved
`Davies & Metzger, Structural Basics of Antibody Function, 1
`ANN. REV. IMMUNOLOGY 87–117 (1983) (“Davies & Metzger”)
`Amit et al., Three-Dimensional Structure of an Antigen-Antibody
`Complex at 2.8 Å Resolution, 233(4765) SCIENCE 747–53 (1986)
`(“Amit ‘86”)
`Reserved
`
`
`
`
`5
`
`
`
`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`
`Exhibit No.
`1561
`1562
`
`1563
`
`1564
`1565
`1566
`1567
`1568
`
`1569
`
`1570
`1571
`
`1572
`1573
`
`1574
`1575
`1576
`1577
`1578
`
`PETITIONER’S EXHIBIT LIST
`Description
`
`Reserved
`Chothia & Lesk, Canonical Structures for the Hypervariable
`Regions of Immunoglobulins, 196(4) J. MOLECULAR BIOLOGY
`901–17 (1987) (“Chothia & Lesk”)
`Chothia et al., Domain Association in Immunoglobulin Molecules:
`The Packing of Variable Domains, 186 J. MOLECULAR BIOLOGY
`651–63 (1985)
`Reserved
`Reserved
`Reserved
`Reserved
`Verhoeyen et al., Reshaping Human Antibodies: Grafting an
`Antilysozyme Activity, 239(4847) SCIENCE 1534–36 (1988)
`(“Verhoeyen ‘88”)
`Riechmann et al., Reshaping Human Antibodies for Therapy,
`332(6162) NATURE 323–27 (1988) (“Riechmann ‘88”)
`Reserved
`Kurrle et al., EP Publication Number 0403156, Improved
`Monoclonal Antibodies Against the Human Alphabeta T-Cell
`Receptor, Their Production and Use (published December 19,
`1990) (“Kurrle”)
`Reserved
`Winter et al., EP Publication Number 0239400, Recombinant
`Antibodies and Methods for Their Productions (published
`September 30, 1987)
`Reserved
`Reserved
`Reserved
`Reserved
`Reserved
`
`
`
`
`6
`
`
`
`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`
`Exhibit No.
`1579
`
`1580
`
`1581
`
`1582
`
`1583
`
`1584
`1585
`
`1586
`
`1587
`
`1588
`
`PETITIONER’S EXHIBIT LIST
`Description
`Kabat et al., SEQUENCES OF PROTEINS OF IMMUNOLOGICAL
`INTEREST: TABULATION AND ANALYSIS OF AMINO ACID AND
`NUCLEIC ACID SEQUENCES OF PRECURSORS, V-REGIONS, C-
`REGIONS, J-CHAIN, β2 MICROGLOBULINS, MAJOR
`HISTOCOMPATIBILITY ANTIGENS, THY-1, COMPLEMENT, C-
`REACTIVE PROTEIN, THYMOPOIETIN, POST-GAMMA GLOBULIN, AND
`α2-MACROGLOBULIN (1983)
`Bernstein et al., The Protein Data Bank: A Computer-based
`Archival File for Macromolecular Structures, 112(3) J.
`MOLECULAR BIOLOGY 535–42 (1977)
`Sheriff et al., Three-Dimensional Structure of an Antibody-
`Antigen Complex, 84(22) PROC. NAT’L ACAD. SCI. USA. 8075–79
`(1987) (“Sheriff ‘87”)
`Marquart et al., The Three-Dimensional Structure of Antibodies,
`3(6) IMMUNOLOGY TODAY 160–66 (1982)
`Saul et al., Preliminary Refinement and Structural Analysis of the
`Fab Fragment from Human Immunoglobulin New at 2.0 Å
`Resolution*, 253(2) J. BIOLOGICAL CHEMISTRY 585–95 (1978)
`(“Saul ‘78”)
`Reserved
`Satow et al., Phosphocholine Binding Immunogloubulin Fab
`McPC306 An X-ray Diffraction Study at 2•7 Å, 190(4) J.
`MOLECULAR BIOLOGY 593–604 (1986)
`Herron et al., Three-Dimensional Structure of a Fluorescein-Fab
`Complex Crystallized in 2-Methyl-2,4-Pentanediol, 5(4) PROTEINS
`271–80 (1989)
`Padlan et al., Structure of an Antibody-Antigen Complex: Crystal
`Structure of the HyHEL-10 Fab-Lysozyme Complex, 86(15) PROC.
`NAT’L ACAD. SCI. USA 5938–42 (1989) (“Padlan ‘89”)
`Kumar et al., Regulation of Phosphorylation of the c-erbB-
`2/HER2 Gene Product by Monoclonal Antibody and Serum
`Growth Factor(s) in Human Mammary Carcinoma Cells, 11(2)
`MOLECULAR CELLULAR BIOLOGY 979–86 (1991)
`
`
`
`
`7
`
`
`
`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`
`Exhibit No.
`1589
`
`1590
`
`1591
`
`1592
`
`1593
`
`1594
`1595 Vols.
`1–15
`
`1596
`
`1597
`
`1598
`1599
`1600
`
`1601
`
`PETITIONER’S EXHIBIT LIST
`Description
`Soomro et al., C-erbB-2 Expression in Different Histological
`Types of Invasive Breast Carcinoma, 44(3) J. CLINICAL
`PATHOLOGY 211–14 (1991)
`Wilson & Goulding, A BIOLOGIST‘S GUIDE TO PRINCIPLES AND
`TECHNIQUES OF PRACTICAL BIOCHEMISTRY, §Protein Sequencing,
`170–73 (3d ed. 1986)
`Edelman et al., The Covalent Structure of an Entire γG
`Immunoglobulin Molecule*, 63(1) PROC. NAT’L ACAD. SCI. USA
`78–85 (1969)
`Capra & Kehoe, Variable Region Sequences of Five Human
`Immunoglobulin Heavy Chains of the VHIII Subgroup: Definitive
`Identification of Four Heavy Chain Hypervariable Regions, 71(3)
`PROC. NAT’L ACAD. SCI. USA 845–48 (1974)
`Morin, From Oncogene to Drug: Development of Small Molecule
`Tyrosine Kinase Inhibitors as Anti-Tumor and Anti-Angiogenic
`Agents, 19(56) ONCOGENE 6574– 83 (2000)
`Reserved
`Patent Interference No. 105,744 (Senior party Application No.
`11/284,261, Inventors John Robert Adair et al., Junior Party, U.S.
`Patent 6,407,213, Inventors Paul J. Carter and Leonard G. Presta)
`(“Adair”)
`U.S. Patent No. 5,677,171, Monoclonal Antibodies Directed to the
`HER2 Receptor (filed August 5, 1994) (issued October 14, 1997)
`Sambrook et al., MOLECULAR CLONING: A LABORATORY MANUAL
`(Cold Spring Harbor Laboratory Press, 2d ed. 1989)
`Reserved
`Reserved
`Colman et al., Three-Dimensional Structure of a Complex of
`Antibody with Influenza Virus Neuraminidase, 326(6111) NATURE
`358–63 (1987) (“Colman ‘87”)
`Reserved
`
`
`
`
`8
`
`
`
`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`
`Exhibit No.
`1602
`
`1603
`
`1604
`
`1605
`
`1606
`
`1607
`
`1608
`1609
`1610
`1611
`1612
`1613
`
`1614
`
`PETITIONER’S EXHIBIT LIST
`Description
`Bender et al., Immunogenicity, Efficacy and Adverse Events of
`Adalimumab in RA Patients, 27(3) RHEUMATOLOGY INT’L 269–74
`(2007)
`Brient & Nisonoff, Quantitative Investigations of Idiotypic
`Antibodies. IV. Inhibition by Specific Haptens of the Reaction of
`Anti-Hapten Antibody with Its Anti-Idiotypic Antibody, 132 J.
`EXPERIMENTAL MED. 951–61 (1970)
`Koprowski et al., Human Anti-Idiotype Antibodies in Cancer
`Patients: Is the Modulation of the Immune Response Beneficial for
`the Patient?, 81(1) PROC. NAT’L. ACAD. SCI. USA 216–19 (1984)
`(“Koprowski ‘84”)
`Chanh et al., Monoclonal Anti-Idiotypic Antibody Mimics the CD4
`Receptor and Binds Human Immunodeficiency Virus, 84 PROC.
`NAT’L. ACAD. SCI. USA 3891–95 (1987) (“Chanh ‘87”)
`Schroff et al., Human Anti-Murine Immunoglobulin Responses in
`Patients Receiving Monoclonal Antibody Therapy, 45(2) CANCER
`RES. 879–85 (1985) (“Schroff ‘85”)
`Abdou et al., Network Theory in Autoimmunity. In Vitro
`Suppression of Serum Anti-DNA by Anti-idiotypic Antibody in
`Systemic Lupus Erythematosus, 67(5) J. CLINICAL INVESTIGATION
`1297–1304 (1981)
`Reserved
`Reserved
`Reserved
`Reserved
`Reserved
`Epp et al., The Molecular Structure of a Dimer Composed of the
`Variable Portions of the Bence-Jones Protein REI Refined at 2.0-
`Å Resolution, 14(22) BIOCHEMISTRY 4943–52 (1975)
`Mian, Structure, Function and Properties of Antibody Binding
`Sites, 217(1) J. MOLECULAR BIOLOGY 133–51 (1991)
`
`
`
`
`9
`
`
`
`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`
`Exhibit No.
`1615
`
`1616
`
`1617
`1618
`1619
`1620
`1621
`
`1622
`1623
`1624
`1625
`
`1626
`
`1627
`
`1628
`
`1629
`
`PETITIONER’S EXHIBIT LIST
`Description
`Poljak et al., The Three-Dimensional Structure of the Fab
`Fragment of A Human Myeloma Immunoglobulin at 2.0-Å
`Resolution, 71(9) PROC. NAT’L ACAD. SCI. USA. 3440–44 (1974)
`Padlan et al., Model Building Studies of Antigen-binding Sites: the
`Hapten Binding Site of MOPC-315, 41 COLD SPRING HARBOR
`SYMP. QUANTITATIVE BIOLOGY 627–37 (1977)
`Reserved
`Reserved
`Reserved
`Reserved
`Suh et al., The Galactan-Binding Immunoglobulin Fab J539: An
`X-Ray Diffraction Study at 2.6-Å Resolution, 1(1) PROTEINS 74–80
`(1986) (“Suh ‘86”)
`Reserved
`Reserved
`Reserved
`Furey et al., Structure of A Novel Bence-Jones Protein (Rhe)
`Fragment at 1.6Å Resolution, 167(3) J. MOLECULAR BIOLOGY
`661–92 (1983) (“Furey”)
`Segal et al., The Three-Dimensional Structure of a
`Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the
`Nature of the Antigen Binding Site, 71(11) PROC. NAT’L ACAD.
`SCI. USA 4298 (1974)
`Jones, Diffraction Methods for Biological Macromolecules.
`Interactive Computer Graphics: FRODO, 115 METHODS
`ENZYMOLOGY 157–71 (1985) (“Jones ‘85”)
`Co et al., Humanized Antibodies for Antiviral Therapy, 88(7)
`PROC. NAT’L ACAD. SCI. USA 2869–73 (1991) (“Co ‘91”)
`Excel Trick, History of Microsoft Excel 1978–2013,
`http://www.exceltrick.com/others/history-of-excel/ (last accessed
`April 13, 2017)
`
`
`
`
`10
`
`
`
`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`
`Exhibit No.
`1630
`
`1631
`
`1632
`1633
`1634
`1635
`1636
`1637
`1638
`1639
`1640
`1641
`1642
`1643
`1644
`1645
`1646
`1647
`1648
`1649
`1650
`1651
`1652
`1653
`1654
`
`PETITIONER’S EXHIBIT LIST
`Description
`U.S. Patent No. 4,891,762, Method and Apparatus for Tracking,
`Mapping and Recognition of Spatial Patterns (filed February 9,
`1988) (issued January 2, 1990)
`Wallick et al., Glycosylation of A VH Residue of a Monoclonal
`Antibody Against α(L-6) Dextran Increases its Affinity for
`Antigen, 168(3) J. EXPERIMENTAL MED. 1099–109 (1988)
`(“Wallick ‘88”)
`Reserved
`Reserved
`Reserved
`Reserved
`Reserved
`Reserved
`Reserved
`Reserved
`Reserved
`Library of Congress Copyright Record for Cosimi ‘81
`Library of Congress Copyright Record for OMTSG ‘85
`Library of Congress Copyright Record for Jaffers ‘86
`Library of Congress Copyright Record for Morrison ‘84
`Library of Congress Copyright Record for Liu ‘87
`Library of Congress Copyright Record for Jones ‘86
`Library of Congress Copyright Record for Queen 1989
`Library of Congress Copyright Record for Kirkman ‘89
`Library of Congress Copyright Record for Waldamnn ‘93
`Library of Congress Copyright Record for Hakimi ‘91
`Library of Congress Copyright Record for Vincenti ‘98
`Library of Congress Copyright Record for Harris ‘92
`Library of Congress Copyright Record for King ‘85
`Library of Congress Copyright Record for Semba ‘85
`
`
`
`
`11
`
`
`
`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`
`Exhibit No.
`1655
`1656
`1657
`1658
`1659
`1660
`1661
`1662
`1663
`1664
`1665
`1666
`1667
`1668
`1669
`1670
`1671
`1672
`1673
`1674
`1675
`1676
`1677
`1678
`1679
`1680
`1681
`1682
`
`PETITIONER’S EXHIBIT LIST
`Description
`Library of Congress Copyright Record for Coussens ‘85
`Library of Congress Copyright Record for Slamon ‘87
`Library of Congress Copyright Record for Hudziak ‘87
`Library of Congress Copyright Record for Chothia ‘89
`Library of Congress Copyright Record for Davies & Metzger
`Library of Congress Copyright Record for Amit ‘86
`Reserved
`Reserved
`Library of Congress Copyright Record for Verhoeyen ‘88
`Library of Congress Copyright Record for Riechmann ‘88
`Reserved
`Reserved
`Library of Congress Copyright Record for Sheriff ‘87
`Library of Congress Copyright Record for Saul ‘78
`Reserved
`Library of Congress Copyright Record for Padlan ‘89
`Library of Congress Copyright Record for Colman ‘87
`Library of Congress Copyright Record for Koprowski ‘84
`Library of Congress Copyright Record for Chanh ‘87
`Library of Congress Copyright Record for Schroff ‘85
`Reserved
`Reserved
`Reserved
`Library of Congress Copyright Record for Suh ‘86
`Library of Congress Copyright Record for Jones ‘85
`Library of Congress Copyright Record for Co ‘91
`Library of Congress Copyright Record for Wallick ‘88
`Bodmer, International Publication No. WO 1989/01783 (published
`March 9, 1989)
`
`
`
`
`12
`
`
`
`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`
`Exhibit No.
`1683
`
`1684
`1684A
`
`1684B
`
`1684C
`
`1684D
`
`1684E
`
`1684F
`
`PETITIONER’S EXHIBIT LIST
`Description
`Gorman, International Publication No. WO 1992/05274
`(published April 2, 1992)
`Declaration of Karen Younkins
`Three-Dimensional Structure of an Antibody-Antigen Complex,
`RCSB Protein Data Bank,
`http://www.rcsb.org/pdb/explore/obsolete.do?obsoleteId=2HFL&e
`vtc=Suggest&evta=PDBID&evtl=autosearch_SearchBar_querySu
`ggest (last accessed April 25, 2017)
`The Three-Dimensional Structure of Antibodies, RCSB Protein
`Data Bank,
`http://www.rcsb.org/pdb/explore/obsolete.do?obsoleteId=1FB4
`(last accessed April 25, 2017)
`Preliminary Refinement and Structural Analysis of the FAB
`Fragment from Human Immunoglobulin New at 2.0 Angstroms
`Resolution, RCSB Protein Data Bank,
`http://www.rcsb.org/pdb/explore/obsolete.do?obsoleteId=3FAB
`(last accessed April 25, 2017)
`Refined Crystal Structure of the Galactan-Binding
`Immunoglobulin Fab J539 at 1.95-Angstroms Resolution, RCSB
`Protein Data Bank,
`http://www.rcsb.org/pdb/explore/explore.do?structureId=2FBJ
`(last accessed May 4, 2017)
`Phosphocholine Binding Immunoglobulin Fab McPC603. An X-
`ray Diffraction Study at 2.7 A, RCSB Protein Data Bank,
`http://www.rcsb.org/pdb/explore/explore.do?structureId=1MCP
`(last accessed May 4, 2017)
`Three-dimensional Structure of a Fluorescein-Fab Complex
`Crystallized in 2-methyl-2,4-pentanediol, RCSB Protein Data
`Bank,
`http://www.rcsb.org/pdb/explore/explore.do?structureId=4FAB
`(last accessed May 4, 2017)
`
`
`
`
`13
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`
`
`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`
`Exhibit No.
`1684G
`
`1684H
`
`1684I
`
`1685
`
`1686
`1687
`1688
`1689
`
`1690
`
`1691
`
`1692
`
`1693
`
`1694
`
`1695
`
`PETITIONER’S EXHIBIT LIST
`Description
`Structure of an Antibody-Antigen Complex: Crystal Structure of
`the HyHEL-10 Fab-lysozyme Complex, RCSB Protein Data Bank,
`http://www.rcsb.org/pdb/explore/explore.do?structureId=3HFM
`(last accessed May 4, 2017)
`The Molecular Structure of a Dimer Composed of the Variable
`Portions of the Bence-Jones Protein REI Refined at 2.0-A
`Resolution, RCSB Protein Data Bank,
`http://www.rcsb.org/pdb/explore/explore.do?structureId=1REI
`(last accessed May 4, 2017)
`Structure of a Novel Bence-Jones Protein (Rhe) Fragment at 1.6 A
`Resolution, RCSB Protein Data Bank,
`http://www.rcsb.org/pdb/explore/explore.do?structureId=2RHE
`(last accessed May 4, 2017)
`Miller, To Build a Better Mousetrap, Use Human Parts, 90(1) J.
`NAT’L CANCER INST. 1416 (1998) (“Miller ‘98”)
`Library of Congress Copyright Record for Miller ‘98
`Declaration of Amanda Hollis
`Declaration of Christopher Lowden
`Declaration of Sarah K. Tsou in Support of Petitioner’s Motion for
`the Pro Hac Vice Admission
`Declaration of Benjamin A. Lasky in Support of Petitioner’s
`Motion for the Pro Hac Vice Admission
`Declaration of Mark C. McLennan in Support of Petitioner’s
`Motion for the Pro Hac Vice Admission
`Declaration of Christopher J. Citro in Support of Petitioner’s
`Motion for the Pro Hac Vice Admission
`Foote, Humanized Antibodies, 61(269) NOVA ACTA LEOPOLDINA
`103-110 (1989)
`Kolbinger, et al., Humunization of a Mouse Anti-Human IgE
`Antibody: A Potential Therapeutic for IgE-Mediated Allergies,
`6(8) PROTEIN ENGINEERING 971–980 (1993)
`DAVID J. KING, APPLICATIONS AND ENGINEERING OF MONOCLONAL
`ANTIBODIES (1998)
`
`
`
`
`14
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`
`
`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`
`Exhibit No.
`1696
`
`1697
`1698
`1699
`1700
`1701
`
`1702
`1703
`1704
`1705
`1706
`
`1707
`
`1708
`
`1709
`
`1710
`
`1711
`
`1712
`
`PETITIONER’S EXHIBIT LIST
`Description
`Presta, Humanized Monoclonal Antibodies, 29 Ann. Rep. in Med.
`Chemistry 317-24 (1994)
`Deposition Transcript of Ian A. Wilson, dated April 21, 2018
`Deposition Transcript of Paul J. Carter, dated April 27, 2018
`Deposition Transcript of Leonard G. Presta, dated May 1, 2018
`Deposition Transcript of Irene Loeffler, dated May 1, 2018
`Deposition Transcript of John B. Ridgway Brady, dated April 27,
`2018
`Reply Declaration of Jefferson Foote
`Reply Declaration of Christopher Lowden
`Reply Declaration of Benjamin Lasky
`Library of Congress Copyright Record for Presta ‘94
`Foote & Winter, Antibody Framework Residues Affecting the
`Conformation of the Hypervariable Loops, 224 J. MOLECULAR
`BIOLOGY 487-499 (1991).
`Hale et al., Remission Induction in Non-Hodgkin Lymphoma with
`Reshaped Human Monoclonal Antibody Campath-1H, 332
`LANCET 1394-1399 (1988).
`Mathieson et al., Monoclonal Antibody Therapy in Systemic
`Vasculitis, 323(4) NEW ENG. J. MED. 250-254 (1990).
`Kyle et al., Humanized Monoclonal Antibody Treatment in
`Rheumatoid Arthritis, 18(11) J. RHEUMATOLOGY 1737-1738
`(1991).
`Brown, Jr. et al., Anti-Tac-H, a Humanized Antibody to the
`Interleukin 2 Receptor Prolongs Primate Cardiac Allograft
`Survival, 88 PROC. NAT’L. ACAD. SCI. U.S. 2663-2667 (1991).
`Havrdova, et. al., Alemtuzumab in the Treatment of Multiple
`Sclerosis: Key Clinical Trial Results and Considerations for Use,
`8(1) THERAPEUTIC ADVANCES IN NEUROLOGICAL. DISORDERS
`31-45 (2015).
`Declaration of Sharick Naqi in Support of Petitioner’s Motion for
`the Pro Hac Vice Admission
`
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`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`
`
`Date: July 13, 2018
`
`Respectfully submitted,
`
`/s/ Amanda Hollis
`Amanda Hollis (Reg. No. 55,629)
`
`KIRKLAND & ELLIS LLP
`300 North LaSalle Street
`Chicago, Illinois 60654
`Telephone: (312) 862-2000
`Facsimile: (312) 862-2200
`Pfizer_Genentech_IPRs@kirkland.com
`
`Attorney For Petitioner Pfizer, Inc.
`
`
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`16
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`IPR2017-01489
`Petitioners’ Updated Exhibit List
`
`CERTIFICATE OF SERVICE
`The undersigned hereby certifies that a copy of the foregoing Exhibit List
`
`were served on July 13, 2018, via electronic service on lead and back up counsel:
`
`For Genentech, Inc.:
`david.cavanaugh@wilmerhale.com
`lauren.blakely@wilmerhale.com
`robert.gunther@wilmerhale.com
`abrausa@durietangri.com
`ddurie@durietangri.com
`andrew.danford@wilmerhale.com
`kevin.prussia@wilmerhale.com
`lisa.pirozzolo@wilmerhale.com
`
`For Samsung Bioepis Co. Ltd.:
`ddrivas@whitecase.com
`sweingaertner@whitecase.com
`eric.majchrzak@whitecase.com
`athakore@whitecase.com
`
` /Amanda Hollis/
`Amanda Hollis
`
`17
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