Genentech Exhibit 2001
`
`Pfizer v. Genentech
`Pfizer v. Genentech
`IPR2017-01488
`|PR2017-01488
`Genentech Exhibit 2001
`
`Page 1
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`

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`MICROFILMED
`To maintain documenmilm
`integrity, do not add or
`detete notewmateriala
`to this notebook.
`Document
`Imaging Do 1.
`Gananttefl,
`Inc. 0:30:35an...—
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`NOTEBOOK no.M
`ISSUED 10W—
`“ >3
`191;
`00:1“:er
`
`RETURNED_—_19____
`
`--SCIENT]FIC NOTEBOOK CO.—
`2831 LAWRENCE AVE.
`P.O. BOX 238
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`616-429-8285
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`Page 3
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`Page 3
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`Genentech Laboratory Notebook Procedures
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`Important steps for maintenance of your notebooks:
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`1)
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`2)
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`out any unused portion of a page at the end of each experiment.
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`4)
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`9)
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`Have a witness who understands and is aware of your work, but who is not directly involved in your
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`Table of Contents
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`SCIENTIFIC NOTEBOOK C0.
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`Page 5
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`SCIENTIFIC NOTEBOOK CO.
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`— P
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`age 7
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`Page 7
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`SCIENTIFIC NOTEBOOK CO.
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`age 9
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`IIIIIIIIIIIIIIIIIIIIIIIIIIIII-I----I.I------------"
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`Table of Contents
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`Page
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`SCIENTIFIC NOTEBOOK C0.
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`— P
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`Page 13
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`Project No.
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`Project No
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`ta*ktkflt‘ktifizrntnamttkrnfitfififitkaktflkflntfitn’tIntii§*tiifitttit*tttfifiitfi*ixfikfiti
`ZHCP, 1FBJ AND ZHFL are kappa-type
`11734 and SFAB are lambda—type
`a—strand residue:
`() denotes be
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`To Page No.
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`Page 15
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`Page 15
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`

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`GAP IN SEQUENCE:
`51-
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`GAP IN SEQUENCE:
`62— 67 in fileleBLPDBASALA
`GAP IN SEQUENCE:
`72— 76 in file:lFB4.PDBASALA
`C.” IN SEQUENCE:
`83-
`92 in file: lFB4.PDBASALA
`W IN SEQUENCE:
`98- 107 in file: IFBL PDBASALA
`O” IN SEQUENCE:
`62 residues and
`1m.PDBASALA
`0-
`3
`in file: lFBJ.PDBASALA
`Gfl’
`IN SEQUENCE:
`17 in file:lE-‘BJ.PDBA5ALA
`B—
`GSA?
`IN SEQUENCE:
`23-
`33 in file-.1FBJ.PDBASALA
`W IN SEQUENCE:
`41-
`45 in file:lFBJ.PDBASALA
`GAP IN SEQUENCE:
`51— 58 in file:lFBJ.PDBASALA
`GAP IN SEQUENCE:
`62-
`67 in file:lFBJ.PDBASALA
`GI! IN SEQUENCE:
`72»
`76 in file:lFBJ.PDBASALA
`GAP IN SEQUENCE:
`83— 92 in file: lF‘BJ.PDBASALA
`GAP IN SEQUENCE:
`98— 107 in file: 1m]. PDBASALA
`cu IN SEQUENCE:
`62 residues and
`ZULPDBASALA
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`3 in file: 2HFL.PDBASALA
`an IN SEQUENCE:
`a— 17 in file:2HI-‘L.PDBASALA
`an IN SEQUENCE:
`23-
`33 in file:2HFL.PDBASALA
`._ GI? IN SEQUENCE:
`41— 45 in file:2HI‘L.PDBASALA
`61.? IN SEQUENCE:
`51— 55 in file:2HFL.PDBASALA
`an IN SEQUENCE:
`52~
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`cu IN SEQUENCE:
`72— 76 in Eile:2HF’L.PDBASALA
`an IN SEQUENCE:
`83-
`92 in file:2HFL.PDBASALA
`Gk!
`IN SEQUENCE:
`98— 105 in file:2HFL. PDBASALA
`GAP IN SEQUENCE:
`62 residues and
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`- GU IN SEQUENCE:
`17 in {neancrxpnmsm
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`23-
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`41-
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`633 IN SEQUENCE:
`51— 60 in file:2MCP.PDBASALA
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`64— 69 in file:2MCP.PDBASAL.A
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`74— 78 in file:
`:cpynmsm
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`85— 94 in file: 2MCP.pDEASALA
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`17 in file:3FAB.PDBASALA
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`23— 33 in file:3FAB.PDBASALA
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`5.20
`0.119
`0.221
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`0.364
`0.423
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`4
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`0.372
`0.417
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`14.80 - 18.00
`0.391
`0.455
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`13.00 — 21.20
`0.434
`0.490
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`0.533
`0.752
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`0.730
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`0.000 7
`1.440
`620
`0.037 —
`1.306
`145
`0.021 —
`1.474 +.
`192
`0.035 —
`1.016
`235
`0.044 —
`1.439
`177
`0.055 ~
`1.505
`104
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`2.033
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`Page16
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`Page 16
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`

`

`FIT—é.
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`4
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`Page17
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`Page 17
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`

`

`Project No.
`Book No.
`
`
`
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`

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`8
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`Page 20
`
`

`

` '
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`
`TITLE WW 9 Book No._._.
`
`'
`
`Project No.
`
`
`
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`had Lengths & Angles for AVERAGE after 200 cycles minimization (.COR3)
`Ji-Ca
`Ca—C
`C-O C-N CA-Cb C-N-Ca N-Ca-C Ca—C-O Ca-CcN O-C-N N-Ca-Cb
`1.454 1.526 1.230 1.337 1.530 124.2
`109.7
`120.2
`116.6
`123.3
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`land Lengths a. Angles for AVERAGE
`(.COR4)
`after 300 cycles minimization (100 Ca released)
`I-Ca
`Ca—C
`C30 C-N Ca-Cb C-N’Ca N-Ca-C Ca-C-O Ca-C-N O-C-N
`1.454 1.528 1.231 1.338 1.531 124.2
`109.9
`120.4
`116.5
`123.1
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`0.9
`0.4
`0.4
`0.2
`64
`64
`64
`55
`60
`55
`64
`64
`55
`55
`land Lengths 5 Angles for AVERAGE
`(.CORS)
`after 600 cycles minimization (400 Ca released)
`I-Ca Ca-C
`C-O C—N
`(Ia-Cb C-N-Ca were Ca-C-O Ca‘C~N O-C-N N-Ca-Cb
`1.454 1.528 1.230 1.338 1.531 124.1
`110.0
`120.5
`116.5
`123.1
`109.6
`0.002 0.002 0.001 0.001 0.001
`0.6
`0.8
`0.4
`0.4
`0.2
`0.4
`64
`64
`64
`55
`60
`55
`64
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`55
`60
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`1.451l.5071.1601.2821.499 125.3
`110.3
`120.9
`117.6
`122.2
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`62
`62
`62
`53
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`Bond Lengths E. Angles for AVERAGE after 50 cycles minimization (.COR)
`l-Ca Ca-C
`C-O C-N Ca-Cb C-N-Ca NACd’C Ca-C‘O Ca-C'N O-C~N N-Ca'Cb
`1.450 1.522 1.230 1.334 1.528 123.6
`109.4
`120.1
`116.6
`123.3
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`1.2
`64
`64
`64
`55
`60
`55
`64
`64
`55
`55
`60
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`load Lengths & Angles for AVERAGE after 100 cycles minimization (.CORZ)
`l-Ca Ca-C
`C-O C-N Ca-Cb CeNcCa N-Ca-C Ca-C-O Ca-C-N O-C-N N-Ca-Cb
`1.452 1.524 1.231 1.335 1.530 124.0
`109.5
`120.1
`116.6
`123.3
`109.8
`0.004 0.005 0.003 0.004 0.002
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`1.6
`0.7
`1.0
`0.5
`0.9
`64
`64
`64
`55
`60
`55
`64
`64
`55
`55
`60
`
`land Lengths 5 Angles for AVERAGE after 200 cycles minimization with Ca
`(.COR3c)
`50 cycles with C; at 10
`100 cycles with Ca at 2.5
`100 cycles with Ca at 0.5
`C’O CnN Ca-Cb C—N-Ca N—Ca-C Ca-C-O Oa-C-N O-C—N N—Ca-Cb CbcCa-C
`N—Ca Cd-C
`1.455 1.520 1.23]. 1.33. 1.531 124.2
`110.0
`120.4
`116.5
`123.1
`109.5
`111.2
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`
`11—1»-
`
`Page 21
`
`

`

`10
`
`Av
`
`‘ mm Page No.
`
`Preject No.
`Book No.___ TITLE
`
`X
`
`1
`
`7
`
`J11
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`
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`
`Dill-dill Angles for AVERAGE after 200 cyclu 11112111111251.1011
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`
`Rocardod by
`
`Page 22
`
`Page 22
`
`

`

`
`Project No.
`Book No.#_
`
`'
`
`I'ITLE
`
`11
`
`AVERAGE.PDBS
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`0-2307
`
`Page 23
`
`Rest Resfl Dist
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`From Page No.15
`
`Dihedrnl Angles for AVERAGE
`after 200 cycles minimization with Ca at 20.0
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`Page 24
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`

`

`'ITLE
`
`Projecl No.
`
`Book No.
`
`fiom Page No._
`
`Miflzmm_'
`
`Page 25
`
`

`

`Project No.
`Book No._________
`
`TITLE
`
`. ,--fi,..__
`
`14
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`9- tom Pay; No.—
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