UNITED STATES PATENT AND TRADEMARK OFFICE
`____________
`
`BEFORE THE PATENT TRIAL AND APPEAL BOARD
`____________
`
`PFIZER, INC.,
`Petitioner,
`
`v.
`
`GENENTECH, INC.,
`Patent Owner.
`____________
`
`Case IPR2017-01488
`Patent 6,407,213 B2
`____________
`
`
`
`PETITIONER’S FIRST AMENDED APPENDIX OF EXHIBITS
`
`
`
`
`
`
`
`
`
`
`
`____________
`
`BEFORE THE PATENT TRIAL AND APPEAL BOARD
`____________
`
`PFIZER, INC.,
`Petitioner,
`
`v.
`
`GENENTECH, INC.,
`Patent Owner.
`____________
`
`Case IPR2017-01488
`Patent 6,407,213 B2
`____________
`
`
`
`PETITIONER’S FIRST AMENDED APPENDIX OF EXHIBITS
`
`
`
`
`
`
`
`
`
`
`
`
`IPR2017-01488
`Petitioner’s First Amended Appendix of Exhibits
`
`PETITIONER’S EXHIBIT LIST
`Description
`U.S. Patent No. 6,407,213, Method for making humanized
`antibodies (filed July 17, 1993) (issued June 18, 2002)
`File History for U.S. Patent No. 6,407,213
`
`Exhibit No.
`1001
`
`1002
`Vols. 1–10
`1003
`
`Declaration of Dr. Foote in Support of Petition for Inter Partes
`Review of Patent No. 6,407,213
`Curriculum Vitae of Dr. Foote
`1003A
`1003B Materials Reviewed by Dr. Foote
`1003C–Q Exhibits C–Q of Dr. Foote’s Declaration
`Declaration of Mr. Buss in Support of Petition for Inter Partes
`1004
`Review of Patent No. 6,407,213
`Curriculum Vitae of Mr. Buss
`1004A
`1004B Materials Reviewed by Mr. Buss
`1005
`Reserved
`1006
`Reserved
`1007
`Reserved
`1008
`Reserved
`1009
`Reserved
`1010
`Reserved
`1011
`Reserved
`1012
`Reserved
`1013
`Reserved
`1014
`Reserved
`1015
`Reserved
`1016
`Reserved
`1017
`Reserved
`1018
`Reserved
`1019
`Reserved
`1020
`Reserved
`
`
`
`
`2
`
`
`
`IPR2017-01488
`Petitioner’s First Amended Appendix of Exhibits
`
`Exhibit No.
`1021
`
`1022
`
`1023
`
`1024
`
`1025
`
`1026
`
`1027
`
`1028
`
`1029
`
`1030
`
`PETITIONER’S EXHIBIT LIST
`Description
`Hudziak et al., p185HER2 Monoclonal Antibody Has
`Antiproliferative Effects In Vitro and Sensitizes Human Breast
`Tumor Cells to Tumor Necrosis Factor, 9(3) MOLECULAR
`CELLULAR BIOLOLGY 1165–72 (1989) (“Hudziak”)
`Köhler et al., Continuous Cultures of Fused Cells Secreting
`Antibody of Predefined Specificity, 256(5517) NATURE 495–97
`(1975)
`Prabakaran, The Quest for a Magic Bullet, 349(6246) SCIENCE 389
`(2015)
`Marks, The Story of Cesar Milstein and Monoclonal Antibodies: A
`Healthcare Revolution in the Making,
`http://www.whatisbiotechnology.org/exhibitions/milstein (last
`accessed March 23, 2017)
`Cosimi et al., Treatment of Acute Renal Allograft Rejection with
`OKT3 Monoclonal Antibody, 32(6) TRANSPLANTATION 535−39
`(1981) (“Cosimi ‘81”)
`Ortho Multicenter Transplant Study Group, A Randomized
`Clinical Trial of OKT3 Monoclonal Antibody for Acute Rejection
`of Cadveric Renal Transplants, 313(6) NEW ENG. J. MED. 337–42
`(1985) (“OMTSG ‘85”)
`Jaffers et al., Monoclonal Antibody Therapy: Anti-Idiotypic and
`Non-Anti-Idiotypic Antibodies to OKT3 Arising Despite Intense
`Immunosuppression, 41(5) TRANSPLANTATION 572–78 (1986)
`(“Jaffers ‘86”)
`Sears et al., Phase-I Clinical Trial of Monoclonal Antibody in
`Treatment of Gastrointestinal Tumours, 1 LANCET 762–65 (1982)
`Sikora, Monoclonal Antibodies in Oncology, 35(4) J. CLINICAL
`PATHOLOGY 369–75 (1982)
`Protein Data Bank - Chronology, National Science Foundation,
`https://www.nsf.gov/news/news_summ.jsp?cntn_id=100689 (last
`accessed April 12, 2017)
`
`
`
`
`3
`
`
`
`IPR2017-01488
`Petitioner’s First Amended Appendix of Exhibits
`
`Exhibit No.
`1031
`
`1032
`
`1033
`
`1034
`
`1035
`
`1036
`
`1037
`
`1038
`
`1039
`
`1040
`
`1041
`
`PETITIONER’S EXHIBIT LIST
`Description
`Morrison et al., Chimeric Human Antibody Molecules: Mouse
`Antigen-Binding Domains With Human Constant Region
`Domains, 81(21) PROC. NAT’L ACAD. SCI. USA 6851–55 (1984)
`(“Morrison ‘84”)
`Liu et al., Chimeric Mouse-Human IgG1 Antibody that can
`Mediate Lysis of Cancer Cells, 84(10) PROC. NAT’L ACAD. SCI.
`USA 3439– 43 (1987) (“Liu ‘87”)
`Jones et al., Replacing the Complementarity-Determining Regions
`in a Human Antibody With Those From a Mouse, 321(6069)
`NATURE 522–25 (1986) (“Jones ‘86”)
`Queen et al., A Humanized Antibody That Binds to the Interleukin
`2 Receptor, 86(24) PROC. NAT’L ACAD. SCI. USA 10029–33
`(1989) (“Queen 1989”)
`Kirkman et al., Early Experience with Anti-Tac in Clinical Renal
`Transplantation, 21(1) TRANSPLANTATION PROC. 1766–68 (1989)
`(“Kirkman ‘89”)
`Waldmann et al., The Interleukin-2 Receptor: A Target for
`Monoclonal Antibody Treatment of Human T-Cell Lymphotrophic
`Virus I-Induced Adult T-Cell Leukemia, 82(6) BLOOD 1701–12
`(1993) (“Waldman ‘93”)
`Hakimi et al., Reduced Immunogenicity and Improved
`Pharmacokinetics of Humanized ANTI-Tac in Cynomolgus
`Monkeys, 147(4) J. IMMUNOLOGY 1352–59 (1991) (“Hakimi ‘91”)
`Vincenti et al., Interleukin 2-Receptor Blockade with Daclizumab
`to Prevent Acute Rejection in Renal Transplantation, 338(3) NEW
`ENG. J. MED. 161–65 (1998) (“Vincenti ‘98”)
`SEER Stat Fact Sheets: Breast Cancer, National Cancer Institute,
`http://seer.cancer.gov/statfacts/html/breast.html (last accessed
`March 17, 2017)
`Harris et al., Medical Progress: Breast Cancer, 327(5) NEW ENG.
`J. MED. 319–28 (1992) (“Harris ‘92”)
`King et al., Amplification of a Novel v-erbB-Related Gene in a
`Human Mammary Carcinoma, 229(4717) SCIENCE 974–76 (1985)
`(“King ‘85”)
`
`
`
`
`4
`
`
`
`IPR2017-01488
`Petitioner’s First Amended Appendix of Exhibits
`
`Exhibit No.
`1042
`
`1043
`
`1044
`
`1045
`
`1046
`
`1047
`
`1048
`
`1049
`
`1050
`
`PETITIONER’S EXHIBIT LIST
`Description
`Semba et al., A v-erbB-Related Protooncogene, c-erbB-2, is
`Distinct from the c-erbB-1 / Epidermal Growth Factor-Receptor
`Gene and is Amplified in a Human Salivary Gland
`Adenocarcinoma, 82(19) PROC. NAT’L ACAD. SCI. USA 6497–01
`(1985) (“Semba ‘85”)
`Coussens et al., Tyrosine Kinase Receptor with Extensive
`Homology to EGF Receptor Shares Chromosomal Location with
`neu Oncogene, 230(4730) SCIENCE 1132–39 (1985) (“Coussens
`‘85”)
`Fukushige et al., Localization of a Novel v-erbB-Related Gene, c-
`erbB-2, on Human Chromosome 17 and its Amplification in a
`Gastric Cancer Cell Line, 6(3) MOLECULAR CELLULAR BIOLOGY
`955–58 (1986)
`Slamon et al., Human Breast Cancer: Correlation of Relapse and
`Survival with Amplification of the HER-2/neu Oncogene,
`235(4785) SCIENCE 177–82 (1987) (“Slamon ‘87”)
`Kraus et al., Overexpression of the EGF Receptor-Related Proto-
`Oncogene erbB-2 in Human Mammary Tumor Cell Lines by
`Different Molecular Mechanisms, 6(3) The EMBO J. 605– 10
`(1987)
`Hudziak et al., Increased Expression of the Putative Growth
`Factor Receptor p185HER2 Causes Transformation and
`Tumorigenesis of NIH 3T3 Cells., 84(20) PROC. NAT’L ACAD. SCI.
`USA 7159–163 (1987) (“Hudziak ‘87”)
`Shepard et al., Monoclonal Antibody Therapy of Human Cancer:
`Taking the HER2 Protooncogene to the Clinic, 11(3) J. CLINICAL
`IMMUNOLOGY, 117–27 (1991)
`Chothia et al., Conformations of Immunoglobulin Hypervariable
`Regions, 342(21) NATURE 877–83 (1989) (“Chothia ‘89”)
`Queen, International Publication No. WO 1990/07861 (published
`July 26, 1990) (“Queen 1990”)
`
`
`
`
`5
`
`
`
`IPR2017-01488
`Petitioner’s First Amended Appendix of Exhibits
`
`Exhibit No.
`1051
`
`1052
`
`1053
`1054
`1055
`
`1056
`1057
`1058
`
`1059
`
`1060
`1061
`
`PETITIONER’S EXHIBIT LIST
`Description
`Tramontano et al., Framework Residue 71 is a Major Determinant
`of the Position and Conformation of the Second Hypervariable
`Region in the VH Domains of Immunoglobulins, 215(1) J.
`MOLECULAR BIOLOGY 175–82 (1990) (“Tramontano”)
`Kabat et al., SEQUENCES OF PROTEINS OF IMMUNOLOGICAL
`INTEREST: TABULATION AND ANALYSIS OF AMINO ACID AND
`NUCLEIC ACID SEQUENCES OF PRECURSORS, V-REGIONS, C-
`REGIONS, J-CHAIN, T-CELL RECEPTOR FOR ANTIGEN, T-CELL
`SURFACE ANTIGENS, β2-MICROGLUBINS, MAJOR
`HISTOCOMPATIBILITY ANTIGENS, THY-1 COMPLEMENT, C-
`REACTIVE PROTEIN, THYMOPOIETIN, POST-GAMMA GLOBULIN, AND
`α2-MACROGLOBULIN 41–175 (4th ed. 1987) (“Kabat 1987”)
`Reserved
`Reserved
`Kabat et al., 1 SEQUENCES OF PROTEINS OF IMMUNOLOGICAL
`INTEREST: TABULATION AND ANALYSIS OF AMINO ACID AND
`NUCLEIC ACID SEQUENCES OF PRECURSORS, V-REGIONS, C-
`REGIONS, J-CHAIN, T-CELL RECEPTOR FOR ANTIGEN, T-CELL
`SURFACE ANTIGENS, β2-MICROGLUBINS, MAJOR
`HISTOCOMPATIBILITY ANTIGENS, THY-1 COMPLEMENT, C-
`REACTIVE PROTEIN, THYMOPOIETIN, POST-GAMMA GLOBULIN, α2-
`MACROGLOBULINS, AND OTHER RELATED PROTEINS 103–338 (5th
`ed. 1991) (“Kabat 1991”)
`Reserved
`Reserved
`Davies & Metzger, Structural Basics of Antibody Function, 1
`ANN. REV. IMMUNOLOGY 87–117 (1983) (“Davies & Metzger”)
`Amit et al., Three-Dimensional Structure of an Antigen-Antibody
`Complex at 2.8 Å Resolution, 233(4765) SCIENCE 747–53 (1986)
`(“Amit ‘86”)
`Reserved
`Reserved
`
`
`
`
`6
`
`
`
`IPR2017-01488
`Petitioner’s First Amended Appendix of Exhibits
`
`Exhibit No.
`1062
`
`1063
`
`1064
`1065
`1066
`1067
`1068
`
`1069
`
`1070
`1071
`
`1072
`1073
`
`1074
`1075
`1076
`1077
`1078
`
`PETITIONER’S EXHIBIT LIST
`Description
`Chothia & Lesk, Canonical Structures for the Hypervariable
`Regions of Immunoglobulins, 196(4) J. MOLECULAR BIOLOGY
`901–17 (1987) (“Chothia & Lesk”)
`Chothia et al., Domain Association in Immunoglobulin Molecules:
`The Packing of Variable Domains, 186 J. MOLECULAR BIOLOGY
`651–63 (1985)
`Reserved
`Reserved
`Reserved
`Reserved
`Verhoeyen et al., Reshaping Human Antibodies: Grafting an
`Antilysozyme Activity, 239(4847) SCIENCE 1534–36 (1988)
`(“Verhoeyen ‘88”)
`Riechmann et al., Reshaping Human Antibodies for Therapy,
`332(6162) NATURE 323–27 (1988) (“Riechmann ‘88”)
`Reserved
`Kurrle et al., EP Publication Number 0403156, Improved
`Monoclonal Antibodies Against the Human Alphabeta T-Cell
`Receptor, Their Production and Use (published December 19,
`1990) (“Kurrle”)
`Reserved
`Winter et al., EP Publication Number 0239400, Recombinant
`Antibodies and Methods for Their Productions (published
`September 30, 1987)
`Reserved
`Reserved
`Reserved
`Reserved
`Reserved
`
`
`
`
`7
`
`
`
`IPR2017-01488
`Petitioner’s First Amended Appendix of Exhibits
`
`Exhibit No.
`1079
`
`1080
`
`1081
`
`1082
`
`1083
`
`1084
`1085
`
`1086
`
`1087
`
`1088
`
`PETITIONER’S EXHIBIT LIST
`Description
`Kabat et al., SEQUENCES OF PROTEINS OF IMMUNOLOGICAL
`INTEREST: TABULATION AND ANALYSIS OF AMINO ACID AND
`NUCLEIC ACID SEQUENCES OF PRECURSORS, V-REGIONS, C-
`REGIONS, J-CHAIN, β2 MICROGLOBULINS, MAJOR
`HISTOCOMPATIBILITY ANTIGENS, THY-1, COMPLEMENT, C-
`REACTIVE PROTEIN, THYMOPOIETIN, POST-GAMMA GLOBULIN, AND
`α2-MACROGLOBULIN (1983)
`Bernstein et al., The Protein Data Bank: A Computer-based
`Archival File for Macromolecular Structures, 112(3) J.
`MOLECULAR BIOLOGY 535–42 (1977)
`Sheriff et al., Three-Dimensional Structure of an Antibody-
`Antigen Complex, 84(22) PROC. NAT’L ACAD. SCI. USA. 8075–79
`(1987) (“Sheriff ‘87”)
`Marquart et al., The Three-Dimensional Structure of Antibodies,
`3(6) IMMUNOLOGY TODAY 160–66 (1982)
`Saul et al., Preliminary Refinement and Structural Analysis of the
`Fab Fragment from Human Immunoglobulin New at 2.0 Å
`Resolution*, 253(2) J. BIOLOGICAL CHEMISTRY 585–95 (1978)
`(“Saul ‘78”)
`Reserved
`Satow et al., Phosphocholine Binding Immunogloubulin Fab
`McPC306 An X-ray Diffraction Study at 2•7 Å, 190(4) J.
`MOLECULAR BIOLOGY 593–604 (1986)
`Herron et al., Three-Dimensional Structure of a Fluorescein-Fab
`Complex Crystallized in 2-Methyl-2,4-Pentanediol, 5(4) PROTEINS
`271–80 (1989)
`Padlan et al., Structure of an Antibody-Antigen Complex: Crystal
`Structure of the HyHEL-10 Fab-Lysozyme Complex, 86(15) PROC.
`NAT’L ACAD. SCI. USA 5938–42 (1989) (“Padlan ‘89”)
`Kumar et al., Regulation of Phosphorylation of the c-erbB-
`2/HER2 Gene Product by Monoclonal Antibody and Serum
`Growth Factor(s) in Human Mammary Carcinoma Cells, 11(2)
`MOLECULAR CELLULAR BIOLOGY 979–86 (1991)
`
`
`
`
`8
`
`
`
`IPR2017-01488
`Petitioner’s First Amended Appendix of Exhibits
`
`Exhibit No.
`1089
`
`1090
`
`1091
`
`1092
`
`1093
`
`1094
`1095 Vols.
`1–15
`
`1096
`
`1097
`
`1098
`1099
`1100
`
`1101
`
`PETITIONER’S EXHIBIT LIST
`Description
`Soomro et al., C-erbB-2 Expression in Different Histological
`Types of Invasive Breast Carcinoma, 44(3) J. CLINICAL
`PATHOLOGY 211–14 (1991)
`Wilson & Goulding, A BIOLOGIST‘S GUIDE TO PRINCIPLES AND
`TECHNIQUES OF PRACTICAL BIOCHEMISTRY, §Protein Sequencing,
`170–73 (3d ed. 1986)
`Edelman et al., The Covalent Structure of an Entire γG
`Immunoglobulin Molecule*, 63(1) PROC. NAT’L ACAD. SCI. USA
`78–85 (1969)
`Capra & Kehoe, Variable Region Sequences of Five Human
`Immunoglobulin Heavy Chains of the VHIII Subgroup: Definitive
`Identification of Four Heavy Chain Hypervariable Regions, 71(3)
`PROC. NAT’L ACAD. SCI. USA 845–48 (1974)
`Morin, From Oncogene to Drug: Development of Small Molecule
`Tyrosine Kinase Inhibitors as Anti-Tumor and Anti-Angiogenic
`Agents, 19(56) ONCOGENE 6574– 83 (2000)
`Reserved
`Patent Interference No. 105,744 (Senior party Application No.
`11/284,261, Inventors John Robert Adair et al., Junior Party, U.S.
`Patent 6,407,213, Inventors Paul J. Carter and Leonard G. Presta)
`(“Adair”)
`U.S. Patent No. 5,677,171, Monoclonal Antibodies Directed to the
`HER2 Receptor (filed August 5, 1994) (issued October 14, 1997)
`Sambrook et al., MOLECULAR CLONING: A LABORATORY MANUAL
`(Cold Spring Harbor Laboratory Press, 2d ed. 1989)
`Reserved
`Reserved
`Colman et al., Three-Dimensional Structure of a Complex of
`Antibody with Influenza Virus Neuraminidase, 326(6111) NATURE
`358–63 (1987) (“Colman ‘87”)
`Reserved
`
`
`
`
`9
`
`
`
`IPR2017-01488
`Petitioner’s First Amended Appendix of Exhibits
`
`Exhibit No.
`1102
`
`1103
`
`1104
`
`1105
`
`1106
`
`1107
`
`1108
`1109
`1110
`1111
`1112
`1113
`
`1114
`
`PETITIONER’S EXHIBIT LIST
`Description
`Bender et al., Immunogenicity, Efficacy and Adverse Events of
`Adalimumab in RA Patients, 27(3) RHEUMATOLOGY INT’L 269–74
`(2007)
`Brient & Nisonoff, Quantitative Investigations of Idiotypic
`Antibodies. IV. Inhibition by Specific Haptens of the Reaction of
`Anti-Hapten Antibody with Its Anti-Idiotypic Antibody, 132 J.
`EXPERIMENTAL MED. 951–61 (1970)
`Koprowski et al., Human Anti-Idiotype Antibodies in Cancer
`Patients: Is the Modulation of the Immune Response Beneficial for
`the Patient?, 81(1) PROC. NAT’L. ACAD. SCI. USA 216–19 (1984)
`(“Koprowski ‘84”)
`Chanh et al., Monoclonal Anti-Idiotypic Antibody Mimics the CD4
`Receptor and Binds Human Immunodeficiency Virus, 84 PROC.
`NAT’L. ACAD. SCI. USA 3891–95 (1987) (“Chanh ‘87”)
`Schroff et al., Human Anti-Murine Immunoglobulin Responses in
`Patients Receiving Monoclonal Antibody Therapy, 45(2) CANCER
`RES. 879–85 (1985) (“Schroff ‘85”)
`Abdou et al., Network Theory in Autoimmunity. In Vitro
`Suppression of Serum Anti-DNA by Anti-idiotypic Antibody in
`Systemic Lupus Erythematosus, 67(5) J. CLINICAL INVESTIGATION
`1297–1304 (1981)
`Reserved
`Reserved
`Reserved
`Reserved
`Reserved
`Epp et al., The Molecular Structure of a Dimer Composed of the
`Variable Portions of the Bence-Jones Protein REI Refined at 2.0-
`Å Resolution, 14(22) BIOCHEMISTRY 4943–52 (1975)
`Mian, Structure, Function and Properties of Antibody Binding
`Sites, 217(1) J. MOLECULAR BIOLOGY 133–51 (1991)
`
`
`
`
`10
`
`
`
`IPR2017-01488
`Petitioner’s First Amended Appendix of Exhibits
`
`Exhibit No.
`1115
`
`1116
`
`1117
`1118
`1119
`1120
`1121
`
`1122
`1123
`1124
`1125
`
`1126
`
`1127
`
`1128
`
`1129
`
`PETITIONER’S EXHIBIT LIST
`Description
`Poljak et al., The Three-Dimensional Structure of the Fab
`Fragment of A Human Myeloma Immunoglobulin at 2.0-Å
`Resolution, 71(9) PROC. NAT’L ACAD. SCI. USA. 3440–44 (1974)
`Padlan et al., Model Building Studies of Antigen-binding Sites: the
`Hapten Binding Site of MOPC-315, 41 COLD SPRING HARBOR
`SYMP. QUANTITATIVE BIOLOGY 627–37 (1977)
`Reserved
`Reserved
`Reserved
`Reserved
`Suh et al., The Galactan-Binding Immunoglobulin Fab J539: An
`X-Ray Diffraction Study at 2.6-Å Resolution, 1(1) PROTEINS 74–80
`(1986) (“Suh ‘86”)
`Reserved
`Reserved
`Reserved
`Furey et al., Structure of A Novel Bence-Jones Protein (Rhe)
`Fragment at 1.6Å Resolution, 167(3) J. MOLECULAR BIOLOGY
`661–92 (1983) (“Furey”)
`Segal et al., The Three-Dimensional Structure of a
`Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the
`Nature of the Antigen Binding Site, 71(11) PROC. NAT’L ACAD.
`SCI. USA 4298 (1974)
`Jones, Diffraction Methods for Biological Macromolecules.
`Interactive Computer Graphics: FRODO, 115 METHODS
`ENZYMOLOGY 157–71 (1985) (“Jones ‘85”)
`Co et al., Humanized Antibodies for Antiviral Therapy, 88(7)
`PROC. NAT’L ACAD. SCI. USA 2869–73 (1991) (“Co ‘91”)
`Excel Trick, History of Microsoft Excel 1978–2013,
`http://www.exceltrick.com/others/history-of-excel/ (last accessed
`April 13, 2017)
`
`
`
`
`11
`
`
`
`IPR2017-01488
`Petitioner’s First Amended Appendix of Exhibits
`
`Exhibit No.
`1130
`
`1131
`
`1132
`1133
`1134
`1135
`1136
`1137
`1138
`1139
`1140
`1141
`1142
`1143
`1144
`1145
`1146
`1147
`1148
`1149
`1150
`1151
`1152
`1153
`1154
`
`PETITIONER’S EXHIBIT LIST
`Description
`U.S. Patent No. 4,891,762, Method and Apparatus for Tracking,
`Mapping and Recognition of Spatial Patterns (filed February 9,
`1988) (issued January 2, 1990)
`Wallick et al., Glycosylation of A VH Residue of a Monoclonal
`Antibody Against α(L-6) Dextran Increases its Affinity for
`Antigen, 168(3) J. EXPERIMENTAL MED. 1099–109 (1988)
`(“Wallick ‘88”)
`Reserved
`Reserved
`Reserved
`Reserved
`Reserved
`Reserved
`Reserved
`Reserved
`Reserved
`Library of Congress Copyright Record for Cosimi ‘81
`Library of Congress Copyright Record for OMTSG ‘85
`Library of Congress Copyright Record for Jaffers ‘86
`Library of Congress Copyright Record for Morrison ‘84
`Library of Congress Copyright Record for Liu ‘87
`Library of Congress Copyright Record for Jones ‘86
`Library of Congress Copyright Record for Queen 1989
`Library of Congress Copyright Record for Kirkman ‘89
`Library of Congress Copyright Record for Waldamnn ‘93
`Library of Congress Copyright Record for Hakimi ‘91
`Library of Congress Copyright Record for Vincenti ‘98
`Library of Congress Copyright Record for Harris ‘92
`Library of Congress Copyright Record for King ‘85
`Library of Congress Copyright Record for Semba ‘85
`
`
`
`
`12
`
`
`
`IPR2017-01488
`Petitioner’s First Amended Appendix of Exhibits
`
`Exhibit No.
`1155
`1156
`1157
`1158
`1159
`1160
`1161
`1162
`1163
`1164
`1165
`1166
`1167
`1168
`1169
`1170
`1171
`1172
`1173
`1174
`1175
`1176
`1177
`1178
`1179
`1180
`1181
`1182
`
`PETITIONER’S EXHIBIT LIST
`Description
`Library of Congress Copyright Record for Coussens ‘85
`Library of Congress Copyright Record for Slamon ‘87
`Library of Congress Copyright Record for Hudziak ‘87
`Library of Congress Copyright Record for Chothia ‘89
`Library of Congress Copyright Record for Davies & Metzger
`Library of Congress Copyright Record for Amit ‘86
`Reserved
`Reserved
`Library of Congress Copyright Record for Verhoeyen ‘88
`Library of Congress Copyright Record for Riechmann ‘88
`Reserved
`Reserved
`Library of Congress Copyright Record for Sheriff ‘87
`Library of Congress Copyright Record for Saul ‘78
`Reserved
`Library of Congress Copyright Record for Padlan ‘89
`Library of Congress Copyright Record for Colman ‘87
`Library of Congress Copyright Record for Koprowski ‘84
`Library of Congress Copyright Record for Chanh ‘87
`Library of Congress Copyright Record for Schroff ‘85
`Reserved
`Reserved
`Reserved
`Library of Congress Copyright Record for Suh ‘86
`Library of Congress Copyright Record for Jones ‘85
`Library of Congress Copyright Record for Co ‘91
`Library of Congress Copyright Record for Wallick ‘88
`Bodmer, International Publication No. WO 1989/01783 (published
`March 9, 1989)
`
`
`
`
`13
`
`
`
`IPR2017-01488
`Petitioner’s First Amended Appendix of Exhibits
`
`Exhibit No.
`1183
`
`1184
`1184A
`
`1184B
`
`1184C
`
`1184D
`
`1184E
`
`1184F
`
`PETITIONER’S EXHIBIT LIST
`Description
`Gorman, International Publication No. WO 1992/05274
`(published April 2, 1992)
`Declaration of Karen Younkins
`Three-Dimensional Structure of an Antibody-Antigen Complex,
`RCSB Protein Data Bank,
`http://www.rcsb.org/pdb/explore/obsolete.do?obsoleteId=2HFL&e
`vtc=Suggest&evta=PDBID&evtl=autosearch_SearchBar_querySu
`ggest (last accessed April 25, 2017)
`The Three-Dimensional Structure of Antibodies, RCSB Protein
`Data Bank,
`http://www.rcsb.org/pdb/explore/obsolete.do?obsoleteId=1FB4
`(last accessed April 25, 2017)
`Preliminary Refinement and Structural Analysis of the FAB
`Fragment from Human Immunoglobulin New at 2.0 Angstroms
`Resolution, RCSB Protein Data Bank,
`http://www.rcsb.org/pdb/explore/obsolete.do?obsoleteId=3FAB
`(last accessed April 25, 2017)
`Refined Crystal Structure of the Galactan-Binding
`Immunoglobulin Fab J539 at 1.95-Angstroms Resolution, RCSB
`Protein Data Bank,
`http://www.rcsb.org/pdb/explore/explore.do?structureId=2FBJ
`(last accessed May 4, 2017)
`Phosphocholine Binding Immunoglobulin Fab McPC603. An X-
`ray Diffraction Study at 2.7 A, RCSB Protein Data Bank,
`http://www.rcsb.org/pdb/explore/explore.do?structureId=1MCP
`(last accessed May 4, 2017)
`Three-dimensional Structure of a Fluorescein-Fab Complex
`Crystallized in 2-methyl-2,4-pentanediol, RCSB Protein Data
`Bank,
`http://www.rcsb.org/pdb/explore/explore.do?structureId=4FAB
`(last accessed May 4, 2017)
`
`
`
`
`14
`
`
`
`IPR2017-01488
`Petitioner’s First Amended Appendix of Exhibits
`
`PETITIONER’S EXHIBIT LIST
`Description
`Structure of an Antibody-Antigen Complex: Crystal Structure of
`the HyHEL-10 Fab-lysozyme Complex, RCSB Protein Data Bank,
`http://www.rcsb.org/pdb/explore/explore.do?structureId=3HFM
`(last accessed May 4, 2017)
`The Molecular Structure of a Dimer Composed of the Variable
`Portions of the Bence-Jones Protein REI Refined at 2.0-A
`Resolution, RCSB Protein Data Bank,
`http://www.rcsb.org/pdb/explore/explore.do?structureId=1REI
`(last accessed May 4, 2017)
`Structure of a Novel Bence-Jones Protein (Rhe) Fragment at 1.6 A
`Resolution, RCSB Protein Data Bank,
`http://www.rcsb.org/pdb/explore/explore.do?structureId=2RHE
`(last accessed May 4, 2017)
`Miller, To Build a Better Mousetrap, Use Human Parts, 90(1) J.
`NAT’L CANCER INST. 1416 (1998) (“Miller ‘98”)
`Library of Congress Copyright Record for Miller ‘98
`Declaration of Amanda Hollis
`Declaration of Christopher Lowden
`Declaration of Sarah K. Tsou in Support of Petitioner’s Motion for
`the Pro Hac Vice Admission
`Declaration of Benjamin A. Lasky in Support of Petitioner’s
`Motion for the Pro Hac Vice Admission
`Declaration of Mark C. McLennan in Support of Petitioner’s
`Motion for the Pro Hac Vice Admission
`Declaration of Christopher J. Citro in Support of Petitioner’s
`Motion for the Pro Hac Vice Admission
`
`
`
`15
`
`Exhibit No.
`1184G
`
`1184H
`
`1184I
`
`1185
`
`1186
`1187
`1188
`1189
`
`1190
`
`1191
`
`1192
`
`
`
`
`
`
`
`
`
`IPR2017-01488
`Petitioner’s First Amended Appendix of Exhibits
`
`Date: November 2, 2017
`
`Respectfully submitted,
`
`/s/ Amanda Hollis
`Amanda Hollis (Reg. No. 55,629)
`
`KIRKLAND & ELLIS LLP
`300 North LaSalle Street
`Chicago, Illinois 60654
`Telephone: (312) 862-2000
`Facsimile: (312) 862-2200
`Pfizer_Genentech_IPRs@kirkland.com
`
`Attorney For Petitioner
`
`16
`
`
`
`IPR2017-01488
`Petitioner’s First Amended Appendix of Exhibits
`CERTIFICATE OF SERVICE
`The undersigned hereby certifies that a copy of the foregoing Petitioner’s
`
`First Amended Appendix of Exhibits and Exhibits 1189–1192 were served
`
`on November 2, 2017, via electronic service on lead and back up counsel:
`
`David.Cavanaugh@wilmerhale.com
`
`Owen.Allen@wilmerhale.com
`Robert.Gunther@wilmerhale.com
`abrausa@durietangri.com
`ddurie@durietangri.com
`Andrew.Danford@wilmerhale.com
`Kevin.Pussia@wilmerhale.com
`Lisa.Pirozzolo@wilmerhale.com
`
` /Amanda Hollis/
`Amanda Hollis
`
`17
`
`
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