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`CASE RECORDS OF THE MASSACHUSET TS GENERAL HOSPITAL
`
`Case Records of the Massachusetts General Hospital
`
`Weekly Clinicopathological Exercises
`F O U N D E D B Y R I C H A R D C . C A B O T
`
`, M.D.,
` E. S
`R
` Editor
`C U L L Y
`O B E R T
` J. M
`, M.D.,
` Associate Editor
`A R K
`U G E N E
`
`E
`
`W
`
`, M.D.,
`N
` F. M
` Associate Editor
`E E L Y
`C
`I L L I A M
`S
` H. E
`,
` Assistant Editor
`B E L I N G
`A L L Y
`
`NORMAL REFERENCE LABORATORY VALUES
`
`P
`REPARED
`
`
`
`BY
`
` A
`LEXANDER
`
` K
`RATZ
`
`, M.D., P
`H
`
`.D.,
`
`AND
`
` K
`ENT
`
` B. L
`EWANDROWSKI
`
`, M.D.
`
`The following is a table of reference values, meth-
`ods, and conversion factors for tests commonly or-
`dered at the Massachusetts General Hospital (MGH)
`and recorded in the Case Records. The table revises
`the most recently published data (Normal Reference
`Laboratory Values. N Engl J Med 1992;327:718-
`24). Laboratory values are expressed in the units
`used at MGH (MGH units) and the units of the
`Système International d’Unités (SI units), with a
`factor to convert MGH units to SI units by multi-
`plication. This table is not intended to provide a
`comprehensive review of reference values, since this
`information is widely available in standard text-
`books. Detailed information on specific methods
`and instruments is not provided, in order to avoid
`
`suggesting an endorsement of commercial products
`by the hospital or the
`
`Journal. Because reference val-
`ues are affected by many variables, the ranges used
`at MGH may not be appropriate for other insti-
`tutions. Furthermore, the methods and units report-
`ed should not be interpreted as a judgment about
`the optimal way to perform or report a given labo-
`ratory test.
`The table was compiled with the aid of Dr. Mi-
`chael Laposata, Dr. James Flood, Dr. Neal Smith,
`Dr. Kathryn Ruoff, Dr. Mary Jane Ferraro, Dr. Eliz-
`abeth Van Cott, William Young, Catherine Tuttle,
`Patricia Puopolo, Linda Ardisson, Ela Dhanak, Ed-
`ward Masley, Fu-Mei Huang, Stephen Johnson, Lin-
`da Jennings, Jeanne Casey, and Debera Grzybek.
`
`CHEMISTRY
`
`
`
`ANALYTE
`
`
`
`SPECIMEN
`
`
`
`* MGH UNIT
`
`
`
`SI UNIT
`
`
`
`METHOD
`
`
`
`OR
`
`
`
` INSTRUMENT
`
`6.0–76.0 pg/ml
`
`1.3–16.7 pmol/liter
`
`kat/liter
`0.12–0.50
`m
`0.17–0.92
`kat/liter
`m
`31–43 g/liter
`
`0–7 U/liter
`
`55–250 pmol/liter
`
`Immunoassay
`Kinetic method
`
`Colorimetry (bromo-
`cresol purple)
`Kinetic method
`Immunoassay
`
`Adrenocorticotropin (ACTH)
`Alanine aminotransferase (ALT, SGPT)
`Female
`Male
`Albumin
`
`Aldolase
`Aldosterone (adult)
`Supine, normal-sodium diet
`Upright, normal-sodium diet
`
`Supine, low-sodium diet
`
`Urine, normal-sodium diet
`Alkaline phosphatase (adult)
`Female
`Male
`Alkaline phosphatase, heat fractionated
`
`P
`S
`
`S
`
`S
`
`S, P
`S, P
`
`S, P
`
`U
`S
`
`S
`
`7–30 U/liter
`10–55 U/liter
`3.1–4.3 g/dl
`
`0–7 U/liter
`
`2–9 ng/dl
`2–5 times supine value with
`normal-sodium diet
`2–5 times supine value with
`normal-sodium diet
`2.3–21.0
`g/24 hr
`m
`
`30–100 U/liter
`45–115 U/liter
`20–35%
`
`
`FACTOR
`
`FOR
`
`CONVERSION
`
` SI UNIT
`TO
`
`0.2202
`0.01667
`
`10
`
`1
`
`27.74
`
`6.38–58.25 nmol/24 hr
`
`0.5–1.67
`kat/liter
`m
`0.75–1.92
`kat/liter
`m
`0.20–0.35
`
`Kinetic method
`
`2.774
`0.01667
`
`Kinetic method
`
`0.01
`
`Volume 339 Number 15
`
`·
`
`1063
`
`The New England Journal of Medicine
`Downloaded from nejm.org at INFOTRIEVE on February 15, 2017. For personal use only. No other uses without permission.
` Copyright © 1998 Massachusetts Medical Society. All rights reserved.
`
`
`1 of 10
`
`Taro Pharmaceuticals, Ltd.
`Exhibit 1032
`
`

`

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`
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`
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`
`
`
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`
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`
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`
`
`The New England Journal of Medicine
`
`CHEMISTRY (Continued)
`
`
`FACTOR
`
`FOR
`
`CONVERSION
`
` SI UNIT
`TO
`
`0.775
`1
`0.01667
`
`
`
`ANALYTE
`
`
`
`SPECIMEN
`
`
`
`* MGH UNIT
`
`
`
`SI UNIT
`
`
`
`METHOD
`
`
`
`OR
`
`
`
` INSTRUMENT
`
`Immunoassay
`Enzymatic analysis
`Kinetic method
`
`S
`P
`
`SPU
`
`Alpha-fetoprotein (nonmaternal)
`Ammonia
`Amylase
`
`0.0349
`1
`
`0.01
`0.01
`1
`0.01667
`
`1
`
`1
`17.1
`17.1
`0.33
`1
`1
`1
`1
`1
`1
`
`0.25
`0.025
`1
`1
`0.1333
`
`0.01
`
`1
`
`5.458
`5.911
`6.53
`5.458
`(as normet-
`anephrine)
`
`0.01
`1¬10
`6
`
`10
`
`.05551
`0.01
`
`1 0
`
`.01
`
`Immunoassay
`Kinetic method
`
`Nephelometry
`
`Kinetic method
`
`Immunoassay
`
`Calculation
`Colorimetry
`Colorimetry
`Immunoassay
`Nephelometry
`Immunoassay
`Immunoassay
`Immunoassay
`Immunoassay
`Immunoassay
`
`Colorimetry
`Colorimetry
`Ion-selective electrode
`Carbon dioxide electrode
`Carbon dioxide electrode
`
`Co-oximetry
`
`Immunoassay
`High-pressure liquid
`chromatography
`
`Nephelometry
`Manual count
`Coulometry
`Enzymatic analysis
`Nephelometry
`Manual measurement
`
`Turbidometry
`
`Nephelometry
`Coulometry
`
`Colorimetry
`
`10
`1
`
`0.02586
`
`Immunoassay
`
`27.59
`
`Immunoassay
`
`2.759
`
`<12.8 IU/ml
`12–48 μmol/liter
`53–123 U/liter
`43–115 U/liter
`4–400 U/liter
`50–250 ng/dl
`
`19–95 U/liter
`19–79 U/liter
`
`119–240 mg/dl
`52–163 mg/dl
`0.35–0.98
`
`9–25 U/liter
`10–40 U/liter
`1.2–2.8 mg/liter
`<200 μg/liter
`22–26 meq/liter
`0.0–0.4 mg/dl
`0.0–1.0 mg/dl
`0.5–2.0 ng/ml
`0.0–12.0 mg/liter
`0–30 U/ml
`0–37 U/ml
`0–32 U/ml
`0–35 U/ml
`
`3–26 pg/ml
`2–17 pg/ml
`8.5–10.5 mg/dl
`0–300 mg/24 hr
`1.14–1.30 mmol/liter
`24–30 mmol/liter
`35–45 mm Hg
`
`g/liter
`<9.92
`m
`12–48
`mol/liter
`m
`0.88–2.05 nkat/liter
`0.72–1.92 nkat/liter
`0.07–6.67 nkat/liter
`1.75–8.73 nmol/liter
`
`19–95 U/liter
`19–79 U/liter
`
`1.19–2.4 g/liter
`0.52–1.63 g/liter
`0.35–0.98
`
`kat/liter
`0.15–0.42
`m
`0.17–0.67
`kat/liter
`m
`1.2–2.8 mg/liter
`<200
`g/liter
`m
`22–26 mmol/liter
`0–7
`mol/liter
`m
`0–17 μmol/liter
`0.17–0.66 nmol/liter
`0–12 mg/liter
`0–30 kU/liter
`0–37 kU/liter
`0–32 kU/liter
`0–35 kU/liter
`
`3–26 ng/liter
`2–17 ng/liter
`2.1–2.6 mmol/liter
`0.0–7.5 mmol/24 hr
`1.14–1.30 mmol/liter
`24–30 mmol/liter
`4.7–6.0 kPa
`
`<5% of total hemoglobin
`
`0.0–3.4 ng/ml
`
`<0.05 fraction of total
`hemoglobin saturation
`0.0–3.4
`g/liter
`m
`
`g/24 hr
`2–24
`m
`g/24 hr
`15–100
`m
`52–480
`g/24 hr
`m
`26–121
`g/24 hr
`m
`
`11–131 nmol/24 hr
`89–591 nmol/24 hr
`340–3134 nmol/24 hr
`142–660 nmol/24 hr
`
`11–48 mg/dl
`0–5 mononuclear cells/
`l
`m
`120–130 mmol/liter
`50–75 mg/dl
`8.0–8.6 mg/dl
`70–180 mm of water
`
`0.11–0.48 g/liter
` cells/liter
`0–5¬10
`6
`120–130 mmol/liter
`2.8–4.2 mmol/liter
`0.08–0.086 g/liter
`70–180 arbitrary units
`
`15–45 mg/dl
`15–25 mg/dl
`5–15 mg/dl
`27–50 mg/dl
`100–108 mmol/liter
`Depends on diet
`
`<200 mg/dl
`200–239 mg/dl
`>239 mg/dl
`
`5–25
`g/dl
`m
`5–15
`g/dl
`m
`0–10
`g/dl
`m
`g/24 hr
`20–70
`m
`
`0.15–0.45 g/liter
`0.15–0.25 g/liter
`0.05–0.15 g/liter
`270–500 mg/liter
`100–108 mmol/liter
`Depends on diet
`
`<5.17 mmol/liter
`5.17–6.18 mmol/liter
`>6.18 mmol/liter
`
`138–690 nmol/liter
`138–414 nmol/liter
`0–276 nmol/liter
`55–193 nmol/24 hr
`
`S
`S
`
`S
`
`S
`
`S, P
`U
`WB, S
`S
`S
`S, P
`S
`S
`S
`S
`S
`S
`
`SU
`
`WB
`P
`WB
`
`WB
`
`P, S
`U
`
`CSF
`
`S
`
`PU
`
`S
`
`S
`
`U
`
`Androstenedione (adult)
`Angiotensin-converting enzyme
`Male
`Female
`Apolipoprotein
`Apolipoprotein A-1
`Apolipoprotein B
`Apolipoprotein B:apolipoprotein A-1 ratio
`Aspartate aminotransferase (AST, SGOT)
`Female
`Male
`-microglobulin
`Beta
`2
`
`¡
`
`)
`
`Bicarbonate (HCO
`3
`Bilirubin, direct
`Bilirubin, total
`C peptide (adult)
`C-reactive protein
`CA 15-3
`CA 19-9
`CA 27,29
`CA-125
`Calcitonin
`Male
`Female
`Calcium
`
`Calcium, ionized
`Carbon dioxide content, total
`Carbon dioxide, partial pressure, arterial
`)
`(PaCO
`2
`Carboxyhemoglobin
`
`Carcinoembryonic antigen (CEA)
`Catecholamines (adult)
`
`Epinephrine
`Norepinephrine
`Dopamine
`Total (epinephrine + norepinephrine)
`
`Cerebrospinal fluid (adult)
`Albumin
`Cell count
`Chloride
`Glucose
`IgG
`Pressure
`Protein
`Lumbar
`Cisternal
`Ventricular
`Ceruloplasmin
`Chloride
`
`Cholesterol
`Desirable
`Borderline high
`High
`Cortisol
`Fasting, 8 a.m.–noon
`Noon–8 p.m.
`8 p.m.–8 a.m.
`Cortisol, free
`
`1064
`
`·
`
`October 8, 1998
`
`The New England Journal of Medicine
`Downloaded from nejm.org at INFOTRIEVE on February 15, 2017. For personal use only. No other uses without permission.
` Copyright © 1998 Massachusetts Medical Society. All rights reserved.
`
`
`2 of 10
`
`Taro Pharmaceuticals, Ltd.
`Exhibit 1032
`
`

`

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`
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`
`
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`
`
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`
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`
`
`
`
`
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`
`
`
`
`
`
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`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
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`
`
`CASE RECORDS OF THE MASSACHUSET TS GENERAL HOSPITAL
`
`CHEMISTRY (Continued)
`
`
`
`ANALYTE
`
`
`
`SPECIMEN
`
`
`
`* MGH UNIT
`
`
`
`SI UNIT
`
`
`
`METHOD
`
`
`
`OR
`
`
`
` INSTRUMENT
`
`Creatine kinase (CK)
`Male
`Female
`Creatine kinase isoenzyme index
`
`Creatine kinase isoenzymes, MB fraction
`Creatinine
`
`S
`
`S
`
`S
`
`60–400 U/liter
`40–150 U/liter
`0–2.5% relative index
`
`1.00–6.67
`0.67–2.50
`None
`
`kat/liter
`m
`kat/liter
`m
`
`Kinetic method
`
`ng/ml
`Total CK(U/liter) ¬100
`Immunoassay
`Colorimetry
`
`
`FACTOR
`
`FOR
`
`CONVERSION
`
` SI UNIT
`TO
`
`0.01667
`
`None
`
`Immunoassay
`
`1
`88.4
`0.0884
`0.03467
`
`Immunoassay
`
`10
`
`Immunoassay
`Immunoassay
`Immunoassay
`Immunoassay
`
`30.3
`0.02886
`2.4
`3.671
`
`Spectrophotometry
`Immunoassay
`
`Immunoassay
`Calculation: total pro-
`tein¡albumin
`Immunoassay
`Enzymatic analysis
`Enzymatic analysis
`Spectrophotometry
`
`Immunoassay
`Liquid chromatography
`Colorimetry
`
`High-pressure liquid
`chromatography
`Immunoassay
`
`1
`1
`
`1
`10
`
`1
`0.05551
`0.05551
`1
`
`1
`0.01
`0.02586
`
`1
`
`5.23
`
`0.03
`
`Immunoassay
`Immunoassay
`Colorimetry (nitro-
`prusside)
`Modified Zimmerman
`reaction
`
`2.496
`7.175
`
`3.467
`
`Enzymatic analysis
`Kinetic method
`
`1
`0.01667
`
`<5 IU/liter
`
`Immunoassay
`
`0–5 ng/ml
`0.6–1.5 mg/dl
`15–25 mg/kg/day
`
`180–1250 ng/dl
`130–980 ng/dl
`
`10–619
`
`m
`
`g/dl
`
`g/dl
`12–535
`m
`g/dl
`30–260
`m
`2–19 ng/dl
`12–158 ng/dl
`18–62 pg/ml
`
`μg/liter
`
`0–5
`53–133
`mol/liter
`m
`0.13–0.22 mmol/kg/day
`
`6.24–43.3 nmol/liter
`4.5–34.0 nmol/liter
`
`100–6190
`
`g/liter
`m
`
`g/liter
`120–5350
`m
`g/liter
`300–2600
`m
`61–576 nmol/liter
`0.35–4.56 nmol/liter
`43.2–148.8 pmol/liter
`
`50–145 pg/ml
`112–443 pg/ml
`50–241 pg/ml
`<59 pg/ml
`<50 pg/ml
`0.17–0.95 mmol/liter
`
`184–532 pmol/liter
`411–1626 pmol/liter
`184–885 pmol/liter
`<217 pmol/liter
`<184 pmol/liter
`0.17–0.95 mmol/liter
`
`3.0–20.0 U/liter
`9.0–26.0 U/liter
`1.0–12.0 U/liter
`18.0–153.0 U/liter
`1.0–12.0 U/liter
`<100 ng/liter
`2.6–4.1 g/dl
`
`20–100 pg/ml
`<0.05 g/dl
`70–110 mg/dl
`
`1–94 U/liter
`1–70 U/liter
`2–5 ng/ml
`3.8–6.4%
`<35 mg/dl
`
`<5 mIU/ml
`
`3.0–20.0 U/liter
`9.0–26.0 U/liter
`1.0–12.0 U/liter
`18.0–153.0 U/liter
`1.0–12.0 U/liter
`<100 ng/liter
`26–41 g/liter
`
`20–100 ng/liter
`<0.003 mmol/liter
`3.9–6.1 mmol/liter
`
`1–94 U/liter
`1–70 U/liter
`2–5 μg/liter
`0.038–0.064
`<0.91 mmol/liter
`
`«6 mg/24 hr
`
`«31.4 μmol/day
`
`5–250 ng/dl
`
`20–100 ng/dl
`100–250 ng/dl
`100–500 ng/dl
`«70 ng/dl
`8–42 ng/ml
`2–20 μU/ml
`Negative
`
`0.15–7.5 nmol/liter
`
`0.6–3.0 nmol/liter
`3–7.5 nmol/liter
`3–15 nmol/liter
`«2.1 nmol/liter
`20–105 nmol/liter
`14.35–143.5 pmol/liter
`Negative
`
`7–20 mg/24 hr
`5–15 mg/24 hr
`0.5–2.2 mmol/liter
`110–210 U/liter
`
`24.3–69.3 μmol/24 hr
`17.3–52.0 μmol/24 hr
`0.5–2.2 mmol/liter
`1.83–3.50 μkat/liter
`
`PU
`
`S
`
`S
`
`S
`S
`S
`S, P
`
`S
`S, P
`
`S
`S
`
`P
`U
`P
`S
`
`S
`WB
`S
`
`S
`
`U
`
`S
`
`S
`S, P
`S, U
`
`U
`
`P
`S
`
`Dehydroepiandrosterone (DHEA) (adult)
`Male
`Female
`Dehydroepiandrosterone (DHEA)
`sulfate (adult)
`
`Male
`Female
`Premenopausal
`Postmenopausal
`Deoxycorticosterone (DOC) (adult)
`11-Deoxycortisol (adult) (8 a.m. sample)
`1,25-Dihydroxyvitamin D
`Estradiol
`Female
`Menstruating
`Follicular phase
`Midcycle peak
`Luteal phase
`Postmenopausal
`Male
`Fatty acids, free (adult)
`Follicle-stimulating hormone (FSH)
`Female
`Menstruating
`Follicular phase
`Ovulatory phase
`Luteal phase
`Postmenopausal
`Male
`Gastrin
`Globulin
`
`Glucagon
`Glucose
`Glucose, fasting
`-Glutamyltransferase (GGT)
`g
`Male
`Female
`Growth hormone (resting)
`Hemoglobin A
`1C
`High-density lipoprotein cholesterol, as
`major risk factor
`Human chorionic gonadotropin (hCG)
`(nonpregnant women)
`5-Hydroxyindoleacetic acid (5-HIAA)
`
`17-Hydroxyprogesterone (adult)
`Male
`Female
`Follicular phase
`Midcycle peak
`Luteal phase
`Postmenopausal
`25-Hydroxyvitamin D
`Insulin
`Ketone (acetone)
`
`17-Ketosteroids
`Male
`Female
`Lactic acid
`Lactate dehydrogenase (LDH)
`
`The New England Journal of Medicine
`Downloaded from nejm.org at INFOTRIEVE on February 15, 2017. For personal use only. No other uses without permission.
` Copyright © 1998 Massachusetts Medical Society. All rights reserved.
`
`Volume 339 Number 15
`
`·
`
`1065
`
`
`3 of 10
`
`Taro Pharmaceuticals, Ltd.
`Exhibit 1032
`
`

`

`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`The New England Journal of Medicine
`
`CHEMISTRY (Continued)
`
`
`
`ANALYTE
`
`
`
`SPECIMEN
`
`
`
`* MGH UNIT
`
`
`
`SI UNIT
`
`
`
`METHOD
`
`
`
`OR
`
`
`
` INSTRUMENT
`
`
`FACTOR
`
`FOR
`
`CONVERSION
`
` SI UNIT
`TO
`
`0.01
`0.01
`0.01
`0.01
`0.01
`0.01667
`
`0.1667
`10
`0.02586
`
`Electrophoresis
`Electrophoresis
`Electrophoresis
`Electrophoresis
`Electrophoresis
`Kinetic method
`
`Kinetic method
`Nephelometry
`Calculation
`
`Lactate dehydrogenase isoenzymes
`LD
`1
`LD
`2
`LD
`3
`LD
`LD
`5
`Total LDH (when isoenzymes deter-
`mined)
`
`4
`
`S
`
`S
`S
`S
`
`S, P
`
`16–29%
`30–41%
`15–24%
`6–13%
`5–29%
`90–250 U/liter
`
`3–19 U/dl
`0–30 mg/dl
`
`<130 mg/dl
`130–159 mg/dl
`»160 mg/dl
`
`0.16–0.29
`0.30–0.41
`0.15–0.24
`0.06–0.13
`0.05–0.29
`1.5–4.17 μkat/liter
`
`0.5–3.17 μkat/liter
`0–300 mg/liter
`
`<3.36 mmol/liter
`3.36–4.11 mmol/liter
`»4.13 mmol/liter
`
`2.0–15.0 U/liter
`22.0–105.0 U/liter
`0.6–19.0 U/liter
`16.0–64.0 U/liter
`2.0–12.0 U/liter
`0.7–1.0 mmol/liter
`
`Immunoassay
`
`1
`
`0.5
`
`2.0–15.0 U/liter
`22.0–105.0 U/liter
`0.6–19.0 U/liter
`16.0–64.0 U/liter
`2.0–12.0 U/liter
`1.4–2.0 meq/liter
`
`45–290 μg/24 hr
`82–500 μg/24 hr
`120–700 μg/24 hr
`0.4–1.5% of total hemo-
`globin
`<20 μg/ml
`0–11 U/liter
`280–296 mOsm/kg of
`water
`80–100 mm Hg
`
`10–60 pg/ml
`<1.3 pmol/liter
`7.35–7.45 pH units
`2.6–4.5 mg/dl
`average, 1 g/day
`3.4–4.8 mmol/liter
`3.5–5.0 mmol/liter
`Depends on diet
`19.5–35.8 mg/dl
`
`<1.0 ng/ml
`3–20 ng/ml
`<1.0 ng/ml
`
`0–20 ng/ml
`0–15 ng/ml
`0–15 ng/ml
`
`<0.5 ng/ml
`
`0.0–2.0 ng/ml
`0.0–4.0 ng/ml
`>25% associated with benign
`prostatic hyperplasia
`
`6.0–8.0 g/dl
`<165 mg/day
`
`0.3–3.0 ng/ml/hr
`1.0–9.0 mg/ml/hr
`55–260 ng/ml
`
`245–1583 nmol/24 hr
`448–2730 nmol/24 hr
`655–3821 nmol/24 hr
`0.004–0.015
`
`<20 mg/liter
`0.02–0.18 μkat/liter
`280–296 mmol/kg of
`water
`10.7–13.3 kPa
`
`10–60 ng/liter
`<1.3 pmol/liter
`7.35–7.45 pH units
`0.84–1.45 mmol/liter
`average, 32 mmol/day
`3.4–4.8 mmol/liter
`3.5–5.0 mmol/liter
`Depends on diet
`195–358 mg/liter
`
`<3.18 nmol/liter
`9.54–63.6 nmol/liter
`<3.18 nmol/liter
`
`0–20 μg/liter
`0–15 μg/liter
`0–15 μg/liter
`
`<0.5 μg/liter
`
`0.0–2.0 μg/liter
`0.0–4.0 μg/liter
`>0.25 associated with
`benign prostatic hyper-
`plasia
`60–80 g/dl
`<0.165 g/day
`
`0.08–0.83 ng/(liter . sec)
`0.28–2.5 ng/(liter . sec)
`0.31–1.48 μmol/liter
`
`6–44 mmol/liter
`8–85 mmol/liter
`
`6–44 mmol/liter
`8–85 mmol/liter
`
`Colorimetry
`Chromatography
`
`Co-oximetry
`
`Nephelometry
`Kinetic method
`Freezing-point
`depression
`Oxygen electrode
`
`Immunoassay
`Immunoassay
`pH electrode
`Spectrophotometry
`
`Ion-selective electrode
`
`Nephelometry
`Immunoassay
`
`Immunoassay
`
`Immunoassay
`
`5.458
`5.46
`5.458
`0.01
`
`1
`0.01667
`1
`
`0.1333
`
`1
`1
`1
`0.3229
`32.29
`1
`
`10
`3.18
`
`1
`
`1
`
`Immunoassay, calculation
`
`0.01
`
`Colorimetry
`Turbidometry
`Immunoassay
`
`High-pressure liquid
`chromatography
`Immunoassay
`
`10
`0.001
`0.2778
`
`0.00568
`
`1
`
`S
`U
`
`P
`
`U
`S
`S, P
`
`WB
`
`S
`P
`WB
`
`SU
`
`PSU
`
`S
`S,P
`
`S
`
`S
`
`S
`
`SU
`
`P
`
`WB
`
`S
`
`Lipase
`Lipoprotein(a)
`Low-density lipoprotein cholesterol
`Desirable
`Borderline high risk
`High risk
`Luteinizing hormone (LH)
`Female
`Menstruating
`Follicular phase
`Ovulatory phase
`Luteal phase
`Postmenopausal
`Male
`Magnesium
`Metanephrines
`Metanephrine
`Normetanephrine
`Total
`Methemoglobin
`
`Microalbumin, random urine
`5'-Nucleotidase
`Osmolality
`
`)
`
`Oxygen, partial pressure, arterial (PaO
`2
`(room air, age dependent)
`Parathyroid hormone
`Parathyroid hormone–related protein
`pH, arterial
`Phosphorus, inorganic (adult)
`
`Potassium
`
`Prealbumin (adult)
`Progesterone
`Female
`Follicular phase
`Midluteal phase
`Male
`Prolactin
`Female
`Premenopausal
`Postmenopausal
`Male
`Prostate-specific antigen (PSA)
`Female
`Male
`<40 yr old
`»40 yr old
`Prostate-specific antigen (PSA), free, in
`males 45–75 yr old, with PSA values
`between 4 and 20 ng/ml
`Protein, total
`
`Renin (adult, normal-sodium diet)
`Supine
`Upright
`Serotonin
`
`Sex hormone–binding globulin (adult)
`Male
`Female
`
`1066
`
`·
`
`October 8, 1998
`
`The New England Journal of Medicine
`Downloaded from nejm.org at INFOTRIEVE on February 15, 2017. For personal use only. No other uses without permission.
` Copyright © 1998 Massachusetts Medical Society. All rights reserved.
`
`
`4 of 10
`
`Taro Pharmaceuticals, Ltd.
`Exhibit 1032
`
`

`

`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`CASE RECORDS OF THE MASSACHUSET TS GENERAL HOSPITAL
`
`CHEMISTRY (Continued)
`
`
`FACTOR
`
`FOR
`
`CONVERSION
`
` SI UNIT
`TO
`
`1
`
`1
`
`
`
`SPECIMEN
`
`
`
`* MGH UNIT
`
`
`
`SI UNIT
`
`
`
`METHOD
`
`
`
`OR
`
`
`
` INSTRUMENT
`
`135–145 mmol/liter
`Depends on diet
`
`135–145 mmol/liter
`Depends on diet
`
`Ion-selective electrode
`
`PU
`
`S
`
`
`
`ANALYTE
`
`Sodium
`
`Immunoassay
`
`Immunoassay
`
`0.03467
`
`Immunoassay
`
`34.67
`
`1
`1
`
`1
`12.87
`0.01
`0.01129
`0.01536
`1
`
`0.357
`1
`59.48
`
`11
`
`11
`
`1
`
`1
`
`Immunoassay
`Immunoassay
`
`Immunoassay
`Immunoassay
`Nephelometry
`Spectrophotometry
`Immunoassay
`Immunoassay
`
`Conductivity
`Conductivity
`Colorimetry
`
`Reflectance
`Spectrophotometry
`
`Manual method
`
`Immunoassay
`Colorimetric
`
`182–780 ng/ml
`114–492 ng/ml
`90–360 ng/ml
`71–290 ng/ml
`
`6–86 ng/dl
`270–1070 ng/dl
`
`0.6–3.1 pg/ml
`0.4–2.5 pg/ml
`0.2–2.0 pg/ml
`
`15.0–40.0 pg/ml
`13.0–35.0 pg/ml
`12.0–28.0 pg/ml
`0–60 ng/ml
`0.77–1.23
`
`0.5–5.0 μU/ml
`4.5–10.9 μg/dl
`191–365 mg/dl
`40–150 mg/dl
`60–181 ng/dl
`<0.6 ng/ml
`>1.5 ng/ml consistent with
`acute myocardial infarct
`8–25 mg/dl
`6–17 g/day
`
`3.6–8.5 mg/dl
`2.3–6.6 mg/dl
`
`5.0–9.0
`1.001–1.035
`Negative
`
`182–780 μg/liter
`114–492 μg/liter
`90–360 μg/liter
`71–290 μg/liter
`
`0.21–2.98 nmol/liter
`9.36–37.10 nmol/liter
`
`20.8–107.5 pmol/liter
`13.9–86.7 pmol/liter
`6.9–69.3 pmol/liter
`
`520–1387 pmol/liter
`451–1213 pmol/liter
`416–971 pmol/liter
`0–60 μg/liter
`0.77–1.23
`
`0.5–5.0 μU/ml
`58–140 nmol/liter
`1.91–3.65 g/liter
`0.45–1.69 mmol/liter
`0.92–2.78 nmol/liter
`<0.6 μg/liter
`>1.5 μg/liter
`
`2.9–8.9 mmol/liter
`6–17 g/day
`
`214–506 μmol/liter
`137–393 μmol/liter
`
`5.0–9.0
`1.001–1.035
`Negative
`
`0–2/high-power field
`0–2/high-power field
`<75 pg/ml
`
`0–2/high-power field
`0–2/high-power field
`<75 ng/liter
`
`S
`
`S
`
`S
`S
`
`S
`S
`S
`S
`S
`S
`
`P
`U
`S
`
`U
`
`U
`
`P
`
`4–9 g/5 hr
`None detected
`
`4–9 g/5 hr
`None detected
`
`US
`
`
`(fasting)
`
`Somatomedin C (insulin-like growth factor I)
`16–24 yr
`25–39 yr
`40–54 yr
`>54 yr
`Testosterone, total (morning sample)
`Female
`Male
`Testosterone, unbound (morning sample)
`Female
`20–40 yr
`41–60 yr
`61–80 yr
`Male
`20–40 yr
`41–60 yr
`61–80 yr
`Thyroglobulin
`Thyroid hormone–binding index
`RU)
`(THBI; T
`3
`Thyroid-stimulating hormone
`)
`Thyroxine, total (T
`4
`Transferrin
`Triglycerides (fasting)
`Triiodothyronine, total (T
`3
`Troponin I
`
`)
`
`Urea nitrogen (BUN) (adult)
`Urea nitrogen, urine
`Uric acid
`Male
`Female
`Urinalysis
`pH
`Specific gravity
`Chemical screens
`Urine sediment
`White cells
`Red cells
`Vasoactive intestinal polypeptide (VIP)
`Xylose
`
`The New England Journal of Medicine
`Downloaded from nejm.org at INFOTRIEVE on February 15, 2017. For personal use only. No other uses without permission.
` Copyright © 1998 Massachusetts Medical Society. All rights reserved.
`
`Volume 339 Number 15
`
`·
`
`1067
`
`
`5 of 10
`
`Taro Pharmaceuticals, Ltd.
`Exhibit 1032
`
`

`

`The New England Journal of Medicine
`
`TOXICOLOGY AND THERAPEUTIC DRUG MONITORING
`
`
`
`ANALYTE
`
`
`
`SPECIMEN
`
`
`
`* MGH UNIT
`
`
`
`SI UNIT
`
`
`
`METHOD
`
`
`
`OR
`
`
`
` INSTRUMENT
`
`>794 μmol/liter at 2–4 hr Liquid chromatography
`Immunoassay
`
`1.7–12 μmol/liter
`26–43 μmol/liter
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`FACTOR
`
`FOR
`
`CONVERSION
`
` SI UNIT
`TO
`
`6.62
`1.71
`
`S
`S
`
`>120 μg/ml at 2–4 hr
`
`1–7 μg/ml
`15–25 μg/ml
`
`Liquid chromatography
`
`3.61
`
`Acetaminophen, toxicity
`Amikacin
`Trough
`Peak
`Amitriptyline
`Amitriptyline
`Nortriptyline
`Barbiturate screen
`Basic drug screen
`Benzodiazepine screen
`Carbamazepine (adult)
`Chlordiazepoxide
`Clomipramine
`Clonazepam
`Clozapine
`Clozapine
`Norclozapine
`Desipramine
`Diazepam
`Digoxin
`Doxepin
`Ethanol
`
`Fluoxetine
`Fluoxetine
`Norfluoxetine
`Fluvoxamine
`Gentamicin
`Trough
`Peak
`Imipramine
`Imipramine
`Desipramine
`Lithium
`Methadone
`Methotrexate
`24 hr after high-dose infusion
`48 hr after high-dose infusion
`72 hr after high-dose infusion
`Nordiazepam
`Paroxetine
`Phenobarbital
`Phenytoin
`Quinidine
`Salicylate intoxication
`Sertraline
`Sulfamethoxazole
`Theophylline
`For apnea control
`Thiocyanate, toxic range
`Tobramycin
`Trough
`Peak
`Trazodone
`Valproic acid
`Vancomycin
`Trough
`Peak (2 hr after infusion)
`
`S
`
`S
`S
`S
`S
`S
`S
`S
`S
`
`S
`S
`S
`S
`S
`
`S
`
`S
`S
`
`S
`
`S, P
`S
`S
`
`S
`S
`S
`S
`S
`
`S
`S
`S
`
`S
`S
`
`S
`S
`S
`
`120–250 μg/liter
`50–150 μg/liter
`Negative
`Negative
`Negative
`4–12 μg/ml
`1.0–3.0 mg/liter
`150–450 μg/liter
`10–70 μg/liter
`
`150–500 μg/liter
`100–450 μg/liter
`150–300 μg/liter
`100–1000 μg/liter
`0.9–2.0 ng/ml
`150–250 μg/liter
`Clinical intoxication:
`>1000 mg/liter
`
`50–450 μg/liter
`50–450 μg/liter
`12–240 μg/liter
`
`<2.1 μg/ml
`4–8 μg/ml
`
`150–250 μg/liter
`150–300 μg/liter
`0.5–1.5 mmol/liter
`50–800 μg/liter
`
`<10 μmol/liter
`<1 μmol/liter
`<0.4 μmol/liter
`100–800 μg/liter
`20–190 μg/liter
`15–50 μg/ml
`5–20 μg/ml
`1.2–4.0 μg/ml
`>500 mg/liter
`40–160 μg/liter
`5–15 mg/dl
`10–20 μg/ml
`5–15 μg/ml
`>100 mg/liter
`
`<2.0 μg/ml
`4.0–8.0 μg/ml
`800–1600 μg/liter
`50–100 μg/ml
`
`<10.1 μg/ml
`18–26 μg/ml
`
`433–903 nmol/liter
`181–542 nmol/liter
`Negative
`Negative
`Negative
`17–51 μmol/liter
`3.3–10 μmol/liter
`476–1427 nmol/liter
`32–222 nmol/liter
`
`459–1530 nmol/liter
`320–1440 nmol/liter
`563–1125 nmol/liter
`0.35–3.50 μmol/liter
`1.2–2.6 nmol/liter
`537–895 nmol/liter
`Clinical intoxication:
`>1 g/liter
`
`162–1454 nmol/liter
`169–1521 nmol/liter
`38–756 nmol/liter
`
`<4.4 μmol/liter
`8.4–16.7 μmol/liter
`
`536–893 nmol/liter
`563–1125 nmol/liter
`0.5–1.5 mmol/liter
`0.16–2.58 μmol/liter
`
`<10 μmol/liter
`<1 μmol/liter
`<0.4 μmol/liter
`0.37–2.95 μmol/liter
`61–576 nmol/liter
`65–216 μmol/liter
`20–79 μmol/liter
`3.7–12.3 μmol/liter
`>3.62 mmol/liter
`130–522 nmol/liter
`19.8–59.2 nmol/liter
`56–111 μmol/liter
`28–83 μmol/liter
`>1720 μmol/liter
`
`<4.3 μmol/liter
`8.6–17.1 μmol/liter
`2152–4304 nmol/liter
`347–693 μmol/liter
`
`<7.0 μmol/liter
`12–18 μmol/liter
`
`Liquid chromatography
`Liquid chromatography
`Liquid chromatography
`Immunoassay
`Liquid chromatography
`Liquid chromatography
`Liquid chromatography
`Liquid chromatography
`
`Liquid chromatography
`Liquid chromatography
`Immunoassay
`Liquid chromatography
`Gas chromatography
`
`Liquid chromatography
`
`Liquid chromatography
`Immunoassay
`
`Liquid chromatography
`
`Ion-selective electrode
`Liquid chromatography
`Immunoassay
`
`Liquid chromatography
`Liquid chromatography
`Immunoassay
`Immunoassay
`Liquid chromatography
`
`Liquid chromatography
`Liquid chromatography
`Immunoassay
`
`4.23
`3.336
`3.17
`3.17
`
`3.06
`3.20
`3.75
`0.0035
`1.28
`3.58
`0.001
`
`3.23
`3.38
`3.15
`
`2.09
`2.09
`
`3.57
`3.75
`1
`0.00323
`1
`
`0.00369
`3.03
`4.31
`3.96
`3.08
`0.00724
`3.26
`3.95
`5.55
`
`Spectrophotometry
`Immunoassay
`
`17.2
`2.14
`
`Liquid chromatography
`Immunoassay
`Immunoassay
`
`2.69
`6.93
`0.690
`
`1068
`
`·
`
`October 8, 1998
`
`The New England Journal of Medicine
`Downloaded from nejm.org at INFOTRIEVE on February 15, 2017. For personal use only. No other uses without permission.
` Copyright © 1998 Massachusetts Medical Society. All rights reserved.
`
`
`6 of 10
`
`Taro Pharmaceuticals, Ltd.
`Exhibit 1032
`
`

`

`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`FACTOR FOR
`CONVERSION
`TO SI UNIT
`
`0.01
`
`1
`
`1
`
`1
`
`1
`
`0.01
`0.01
`
`0.01
`
`0.01
`0.01
`
`10
`
`.01
`
`76–189 mg/dl
`
`0.76–1.89 g/liter
`
`Nephelometry
`
`Negative
`<5 U/ml
`
`Negative
`<2.8 U/ml
`
`Negative
`<5 kU/liter
`
`Western blot assay
`ELISA
`
`Negative
`<2.8 kU/liter
`
`Indirect immunofluorescence
`ELISA
`
`Negative
`<1.4 U/ml
`
`Negative
`<1.4 kU/liter
`
`Indirect immunofluorescence
`ELISA
`
`Negative at 1:10 dilution
`Negative at 1:10 dilution
`Negative
`Negative
`Negative
`Negative
`Negative at 1:40 dilution
`Negative at 1:20 dilution
`Negative
`Negative
`Negative
`Negative
`Negative at 1:20 dilution
`Negative
`<0.3 IU/ml
`None detected
`None detected in a
`50-fold concentration
`
`Not applicable
`Not applicable
`Not applicable
`Not applicable
`Not applicable
`Not applicable
`Not applicable
`Not applicable
`Not applicable
`Not applicable
`Not applicable
`Not applicable
`Not applicable
`Not applicable
`<0.3 kIU/liter
`Not applicable
`Not applicable
`
`<2.5 mg/dl
`<5.0 mg/dl
`
`12.4–24.5 mg/dl
`Present
`
`86–184 mg/dl
`20–58 mg/dl
`63–145 U/ml
`17–42 mg/dl
`None detected
`None detected
`None detected
`
`<0.03 g/liter
`<0.05 g/liter
`
`0.12–0.25 g/liter
`Present
`
`0.86–1.84 g/liter
`0.20–0.58 g/liter
`63–145 kU/liter
`0.17–0.42 g/liter
`Not applicable
`Not applicable
`Not applicable
`
`Indirect immunofluorescence
`Indirect immunofluorescence
`ELISA
`ELISA
`ELISA
`Indirect immunofluorescence
`Indirect immunofluorescence
`Indirect immunofluorescence
`ELISA
`ELISA
`ELISA
`ELISA
`Indirect immunofluorescence
`Immunoassay
`Immunoassay
`Immunoelectrophoresis
`Immunoelectrophoresis
`
`Nephelometry
`
`Nephelometry
`Immunodiffusion
`
`Nephelometry
`Nephelometry
`Immunoassay
`Nephelometry
`Manual method
`Manual method
`Immunodiffusion
`
`CASE RECORDS OF THE MASSACHUSET TS GENERAL HOSPITAL
`
`IMMUNOLOGY
`
`
`
`ANALYTE
`
`
`
`SPECIMEN* MGH UNIT
`
`SI UNIT
`
`METHOD OR INSTRUMENT†
`
`S
`S
`
`S
`
`S
`
`SSSSSSSSSSSSSSS
`
`SU U
`
`S
`
`SSSS
`
`S
`S
`S
`CSF
`
`S
`S
`
`SSSS
`
`JF
`JF
`
`S, JF
`S
`S
`
`Alpha1-antitrypsin (adult)
`Anti–glomerular basement membrane
`antibodies
`Qualitative
`Quantitative
`Antineutrophil cytoplasmic autoanti-
`bodies, cytoplasmic (C-ANCA)
`Qualitative
`Quantitative (antibodies to
`proteinase 3)
`Antineutrophil cytoplasmic autoanti-
`bodies, perinuclear (P-ANCA)
`Qualitative
`Quantitative (antibodies to myeloper-
`oxidase)
`Autoantibodies
`Antiadrenal antibody
`Anti–double-stranded (native) DNA
`Antigranulocyte antibody
`Anti–Jo-1 antibody
`Anti-La antibody
`Antimitochondrial antibody
`Antinuclear antibody
`Anti–parietal-cell antibody
`Anti-Ro antibody
`Anti-RNP antibody
`Anti–Scl-70 antibody
`Anti-Smith antibody
`Anti–smooth-muscle antibody
`Antithyroglobulin antibody
`Antithyroid antibody
`Bence Jones protein
`Qualitative
`
`Quantitative
`Kappa
`Lambda
`C1-esterase–inhibitor protein
`Antigenic
`Functional
`Complement
`C3 (adult)
`C4 (adult)
`Total complement (adult)
`Factor B
`Cryocrit
`Cryoproteins
`Cryoprotein identification
`CSF
`Agarose electrophoresis
`
`Quantitation of albumin (adult)
`Quantitation of IgG (adult)
`Haptoglobin
`Immunofixation
`Immunoglobulin (adult)
`IgA
`IgE
`IgG
`IgM
`Joint fluid crystal
`Joint fluid mucin
`
`Rheumatoid factor
`Serum protein electrophoresis
`Viscosity
`
`No banding seen in an
`80-fold concentration
`11.0–50.9 mg/dl
`0.0–8.0 mg/dl
`16–199 mg/dl
`None detected
`
`60–309 mg/dl
`10–179 IU/ml
`614–1295 mg/dl
`53–334 mg/dl
`No crystals seen
`Only type I mucin
`present
`<30 IU/ml
`Normal pattern
`1.4–1.8 relative viscosity
`units, as compared with
`water
`
`Not applicable
`
`Agarose electrophoresis
`
`0.11–0.51 g/liter
`0.0–0.08 g/liter
`0.16–1.99 g/liter
`Not applicable
`
`0.60–3.09 g/liter
`24–430 μg/liter
`6.14–12.95 g/liter
`0.53–3.34 g/liter
`Not applicable
`Not applicable
`
`Nephelometry
`Nephelometry
`Nephelometry
`Agarose electrophoresis
`
`Nephelometry
`Immunoassay
`Nephelometry
`Nephelometry
`Microscopy
`Manual method
`
`<30 kIU/liter
`Not applicable
`1.4–1.8 relative viscosity
`units, as compared with
`water
`
`Nephelometry
`Agarose electrophoresis
`Ostwald viscosimetry
`
`0.01
`0.01
`0.01
`
`0.01
`2.4
`0.01
`0.01
`
`1
`
`1
`
`The New England Journal of Medicine
`Downloaded from nejm.org at INFOTRIEVE on February 15, 2017. For personal use only. No other uses without permission.
` Copyright © 1998 Massachusetts Medical Society. All rights reserved.
`
`Volume 339 Number 15
`
`·
`
`1069
`
`
`7 of 10
`
`Taro Pharmaceuticals, Ltd.
`Exhibit 1032
`
`

`

`The New England Journal of Medicine
`
`HEMATOLOGY AND COAGULATION
`
`ANALYTE
`
`SPECIMEN* MGH UNIT‡
`
`SI UNIT
`
`METHOD OR INSTRUMENT†
`
`FACTOR FOR
`CONVERSION
`TO SI UNIT
`
`Ratio >2.0
`
`Not applicable
`
`Automated clotting assay
`
`80–130%
`
`Negative
`
`Negative
`
`0.80–1.30
`
`Negative
`
`Negative
`
`Chromogenic assay
`
`0.01
`
`Dilute phospholipid clotting
`assay
`Clotting assay
`
`11
`
`10
`0.01
`
`111
`
`1
`0.01
`1
`
`0.01
`0.01
`0.01
`0.01
`0.01
`0.01
`
`1¬106
`1¬106
`1
`
`0.01
`0.01
`0.01
`0.01
`0.01
`0.01
`0.01
`0.01
`
`1
`1
`
`1
`0.01
`2.266
`
`0.01
`0.01
`0.6206
`
`0.01
`0.01
`
`0.1791
`0.1791
`1¬106
`1
`
`0–15 GPL units
`0–15 MPL units
`
`0–15 arbitrary units
`0–15 arbitrary units
`
`ELISA
`ELISA
`
`22–39 mg/dl
`80–130%
`
`0.3–0.7 IU/ml
`0.5–1.0 IU/ml
`0.5–0.8 IU/ml
`2–9.5 min
`50–100%/2 hr
`<0.5 μg/ml
`
`45–75%
`0–5%
`16–46%
`4–11%
`0–8%
`0–3%
`
`220–390 mg/liter
`0.8–1.30 U/liter
`
`0.3–0.7 kIU/liter
`0.5–1.0 kIU/liter
`0.5–0.8 kIU/liter
`2–9.5 min
`0.50–1.00/2 hr
`<0.5 mg/liter
`
`0.45–0.75
`0.0–0.05
`0.16–0.46
`0.04–0.11
`0.0–0.8
`0.0–0.03
`
`4.50–5.30¬106/mm3
`4.10–5.10¬106/mm3
`
`4.50–5.30¬1012/liter
`4.10–5.10¬1012/liter
`
`1–25 mm/hr
`0–17 mm/hr
`60–140%
`60–140%
`60–140%
`50–200%
`60–140%
`60–140%
`60–140%
`60–140%
`No deficiency detected
`<0.5 Bethesda unit
`
`
`30–300 ng/mlg/
`30–300 ng/ml
`10–200 ng/ml
`10–200 ng/ml
`<2.5 μg/ml
`175–400 mg/dl
`
`3.1–17.5 ng/ml
`2.2–3.0 ng/ml
`<2.2 ng/ml
`>17.5 ng/ml
`No gross deficiency
`
`37.0–49.0
`36.0–46.0
`
`13.0–18.0 g/dl
`12.0–16.0 g/dl
`<3.5%
`<0.02%
`Negative
`
`1–25 mm/hr
`0–17 mm/hr
`0.60–1.40
`0.60–1.40
`0.60–1.40
`0.50–2.00
`0.60–1.40
`0.60–1.40
`0.60–1.40
`0.60–1.40
`Not applicable
`<0.5 Bethesda unit
`
`
`30–300 μg/literμg/
`30–300 μg/liter
`10–200 μg/liter
`10–200 μg/liter
`<2.5 mg/liter
`1.75–4.00 μmol/liter
`
`7.0–39.7 nmol/liter
`5.0–6.8 nmol/liter
`<5.0 nmol/liter
`>39.7 nmol/liter
`Not applicable
`
`0.37–0.49
`0.36–0.46
`
`8.1–11.2 mmol/liter
`7.4–9.9 mmol/liter
`<0.04
`<0.0002
`Negative
`
`Immunoassay
`Chromogenic assay
`Chromogenic assay
`
`Surgicutt
`Manual method
`Latex agglutination
`Automated cell counter or
`manual method
`
`Automated cell counter
`
`Automated erythrocyte-sedi-
`mentation-rate instrument
`
`Automated clotting assay
`Automated clotting assay
`Automated clotting assay
`Automated clotting assay
`Automated clotting assay
`Automated clotting assay
`Automated clotting assay
`Automated clotting assay
`Urea clot dissolution
`Automated clotting assay
`Immunoassay
`
`Latex agglutination
`Automated clotting assay
`Immunoassay
`
`Visual fluorescence screening
`
`Automated cell counter
`
`Automated cell counter
`
`Spectrophotometry
`Spectrophotometry
`ELISA
`
`30–160 μg/dl
`228–428 μg/dl
`4.5–11.0¬103/mm3
`25.0–35.0 pg/cell
`
`5.4–28.7 μmol/liter
`40.8–76.7 μmol/liter
`4.5–11.0¬109/liter
`25.0–35.0 pg/cell
`
`Colorimetry
`Colorimetry
`Automated cell counter
`Automated cell counter
`
`P
`
`P
`
`P PS
`
`P
`
`P
`
`WB
`P
`WB
`
`WB
`
`WB
`
`P
`P
`P
`P
`P
`P
`P
`P
`P
`P
`S
`S
`
`P
`P
`S, P
`
`WB
`
`WB
`
`WB
`
`WB
`WB
`P
`
`S
`S
`WB
`WB
`
`Activated protein C resistance (factor V
`Leiden)
`Alpha2-antiplasmin
`Antiphospholipid-antibody panel
`Partial-thromboplastin time–lupus
`anticoagulant screen
`Platelet-neutralization procedure
`Anticardiolipin antibody
`IgG
`IgM
`Antithrombin III
`Immunologic
`Functional
`Anti-Xa assay (heparin assay)
`Unfractionated heparin
`Low-molecular-weight heparin
`Danaparoid
`Bleeding time (adult)
`Clot retraction
`D-Dimer
`Differential blood count
`
`Neutrophils
`Bands
`Lymphocytes
`Monocytes
`Eosinophils
`Basophils
`Erythrocyte count (adult)
`Male
`Female
`Erythrocyte sedimentation rate
`
`Female
`Male
`Factor II, prothrombin
`Factor V
`Factor VII
`Factor VIII
`Factor IX
`Factor X
`Factor XI
`Factor XII
`Factor XIII screen
`Factor-inhibitor assay
`Ferritin
`Ferritin
`Male
`Male
`Female
`Female
`Fibrin(ogen)-degradation products
`Fibrinogen
`Folate (folic acid)
`Normal
`Borderline deficient
`Deficient
`Excessive
`Glucose-6-phosphate dehydrogenase
`(erythrocyte)
`Hematocrit (adult)
`Male
`Female
`Hemoglobin (adult)
`Male
`Female
`Hemoglobin A2
`Hemoglobin F
`Heparin-induced thrombocytopenia
`antibody
`
`Iron
`Iron-binding capacity
`Leukocyte count (WBC)
`Mean corpuscular hemoglobin (MCH)
`
`1070 · October 8, 1998
`
`The New England Journal of Medicine
`Downloaded from nejm.org at INFOTRIEVE on February 15, 2017. For personal use only. No other uses without permission.
` Copyright © 1998 Massachusetts Medical Society. All rights reserved.
`
`
`8 of 10
`
`Taro Pharmaceuticals, Ltd.
`Exhibit 1032
`
`

`

`CASE RECORDS OF THE MASSACHUSET TS GENERAL HOSPITAL
`
`HEMATOLOGY AND COAGULATION (Continued)
`
`ANALYTE
`
`SPECIMEN* MGH UNIT
`
`SI UNIT
`
`METHOD OR INSTRUMENT
`
`31.0–37.0 g/dl
`
`310–370 g/liter
`
`Automated cell counter
`
`Mean corpuscular hemoglobin concen-
`tration (MCHC)
`Mean corpuscular volume (MCV)
`(adult)
`Male
`Female
`Osmotic fragility of erythrocytes
`
`Partial-thromboplastin time, activated
`Plasminogen
`Antigen
`Functional
`Platelet aggregation
`
`Platelet count
`Platelet, mean volume
`Prekallikrein assay
`Prekallikrein screen
`Protein C
`Total antigen
`Functional
`Protein S
`Total antigen
`Functional
`Free antigen
`Prothrombin time
`Red-cell distribution width
`Reptilase time
`Reticulocyte count
`Ristocetin cofactor (functional
`von Willebrand factor)
`Blood group O
`Blood group A
`Blood group B
`Blood group AB
`Sucrose hemolysis
`Thrombin time
`Total eosinophils
`Vitamin B12
`Normal
`Borderline
`Deficient
`von Willebrand factor (vWF) antigen
`(factor VIII:R antigen)
`Blood group O
`Blood group A
`Blood group B
`Blood group AB
`von Willebrand factor multimers
`
`WB
`
`WB
`
`WB
`
`P
`P
`
`PRP
`
`WB
`WB
`P
`P
`P
`
`P
`
`P
`WB
`P
`WB
`P
`
`WB
`P
`WB
`S, P
`
`P
`
`P
`
`78–100 μm3
`78–102 μm3
`Increased hemolysis as
`compared with normal
`control
`22.1–34.1 sec
`
`8.4–14.0 mg/dl
`80–130%
`>65% aggregation in
`response to adenosine
`diphosphate, epineph-
`rine, collagen, ristoce-
`tin, and arachidonic
`acid
`150–350¬103/mm3
`6.4–11.0 μm3