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`(JP). ~’~ IE (ARIKA, Tadashi) [JP/JP]; ~565-0802
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`(21) I~ [~ hq. J~-:
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`DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL,
`IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU,
`LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL,
`PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ,
`UA, UG, US, UZ, VN, YU, ZA, ZW.
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`
`(54) Title: METHOD FOR DETECTING PATHOGENIC MICROORGANISM AND ANTIMICROBIAL AGENT, METHOD
`FOR EVALUATING THE DRUG EFFECT OF ANTIMICROBIAL AGENT, AND ANTIMICROBIAL AGENTS
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`(54) ~l~,q dg:~ ~ti: ~~ d~ ~X~tJ~D~;’-~, :J~~J(D~~#d G ~17_~’~tJ
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`(57) Abstract: A novel method for evaluating the drug effect of an antimicrobial agent which comprises eliminating the antimicro-
`bial agent remaining in a biological sample, etc. to thereby accurately evaluate the drug effect of the antimierobiai agent without
`being affected by the remaining antimicrobial agent. Remedies for nail mycosis which can be obtained by the drug effect evaluation
`-- method as described above.
`
`(57) ~,~J:
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`ARGENTUM EX1010
`
`Page 1
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`7+ [] 7 / ~ X (Trichophyton mentagrophytes) i ~, ~ !
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`;~3 ;~t ~- I~ ~ (Antimicrobial Agents and Chemotherapy,
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`36:2523--2525, 1992, 39:2353--2355, 1995)o ~_J, ~ ,
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`g
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`Conference on Antimicrobia] Agents and Chemotherapy,
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`New Or|eans, Louisiana, 1996, Abstr. F80)o
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`Onychomycoses, Drugs, 58’ 283-296 1999)
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`
`
`INTERNATIONAL SEARCH REPORT
`
`International application No.
`
`PCT/JP00/04617
`
`m.
`
`CLASSIFICATION OF SUBJECT MATTER
`Int. Clv C12QI/18, A61K31/454, A61P31/10,
`
`G01N33/15, G01N33/50
`
`According to International Patent Classification (IPC) or to both national classification and IPC
`
`B. FIELDS SEARCHED
`Minimum documentation searched (classification system followed by classification symbols)
`Int. Cl7 C12QI/18, A61K31/454, A61P31/10, G01N33/15, G01N33/50
`
`Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched
`
`Electronic data base consulted during the international search (name of data base and, where practicable, search terms used)
`JICST FILE(JOIS)
`
`C.
`
`DOCUMENTSCONSIDEREDTO BE RELEVANT
`
`Category*
`
`x/Y
`
`Citationofdocument, withindication, whereappropfi~e, oftherelevantpassages
`JP, 8-i03291, A (Pola Chemical Industries Inc.),
`23 April, 1996 (23.04.96) (Family: none)
`
`JP, 10-28597, A (Gunze Limited),
`03 February, 1998 (03.02.98) (Family: none)
`
`Relevanttoclaim No.
`II,16/I-9,15
`
`1-9,15
`
`Y
`
`x
`
`WO, 94/26734, A1 (KAKEN PHARMACEUTICAL CO.,
`24 November, 1994 (24.11.94)
`& US, 5620994, A
`& EP, 698606, A1
`& US, 5962476, A
`& US, 5716969, A
`
`LTD.),
`
`i0,12-14,17
`
`[]
`
`Further documents are listed in the continuation of Box C. [] See patent family annex.
`
`*
`"A"
`
`"E"
`
`"L"
`
`"O"
`
`"P"
`
`Special categories of cited documents:
`document defining the general state of the art which is not
`considered to be of particular relevance
`earlier document but published on or after the international filing
`date
`document which may throw doubts on priority claim(s) or which is
`cited to establish the publication date of another citation or other
`special reason (as specified)
`document referring to an oral disclosure, use, exhibition or other
`means
`document published prior to the international filing date but later
`than the priority date claimed
`
`"T’
`
`"X"
`
`later document published after the international filing date or
`priority date and not in conflict with the application but cited to
`understand the principle or theory underlying the invention
`document of particular relevance; the claimed invention cannot be
`considered novel or cannot be considered to involve an inventive
`step when the document is taken alone
`document of particular relevance; the claimed invention cannot be
`considered to involve an inventive step when the document is
`combined with one or more other such documents, such
`combination being obvious to a person skilled in the art
`"&" document member of the same patent family
`
`"Y"
`
`Date of the actual completion of the international search
`14 September, 2000 (14.09.00)
`
`Date of mailing of the international search report
`
`03 October, 2000 (03.10.00)
`
`Name and mailing address of the ISA/
`Japanese Patent Office
`
`Facsimile No.
`
`Form PCT/ISA/210 (second sheet) (July 1992)
`
`Authorized officer
`
`Telephone No.
`
`Page 39
`
`
`
`INTERNATIONAL SEA