`
`Celltrion v. Genentech
`Celltrion V. Genentech
`IPR2017-01374
`IPR2017-01374
`Genentech Exhibit 2005
`Genentech Exhibit 2005
`
`Page 1 of 108
`
`Page 1 of 108
`
`

`

`(
`
`MICHOFILMED
`To maintain documenUfilm
`integrity, do not add or
`delete notes/materials
`to this notebook.
`
`Document
`Genentech,
`
`imaging Dart
`Inc. Date 1-
`
`Page 2 of 108
`
`Page 2 of 108
`
`

`

`
`
`uomoox Io._,fl4_o__
`Issumro ' an
`364%
`
`0"
`December ‘Z_
`19
`if?
`09““er
`
`RETURNED_ _____ 19
`
`MJWL%Z/ chmégau/Jyé
`m hianLL/ /€€/}oaflzw “be/'74
`
`—SClENTlFIC NOTEBOOK CO.—
`2831 LAWRENCE AVE.
`R0. BOX 238
`STEVENSVILLE, Ml 49127
`616-429-8285
`
`_—#
`
`Page 3 of 108
`
`Page 3 of 108
`
`

`

`Genentech Laboratory Notebook Procedures
`
`important steps for maintenance of your notebooks:
`
`1)
`
`2)
`
`3i
`
`4)
`
`5i
`
`5)
`
`8)
`
`9i
`
`Use dark permanent ink to record all of your work in your notebook on a daily basis. Sign and date
`each day’s entries.
`
`Permanently affix all attachments without covering any other entries. Please attach copies of any
`computer data entered into your computer files. These data are considered part of your experimen-
`tal record.
`
`Make any changes in data in dark permanent ink and. it appropriate, initial and date in the margin.
`Ensure that the original entry remains visible. Leave no open areas. When the book ls completed line
`out any unused portion of a page at the end of each experiment.
`
`Have a witness who understands and is aware of your work, but who is not directly involved in your
`project, sign and date your notebook entries (not later than one month after you do the work).
`
`Don’t hold book data for later entry and don't keep a "rough draft“ notebook.
`
`Report the quantitative or qualitative results oniy. Avoid over broad and potentially inflammatory
`comments like "failed experiment“, “doesn't work", or "toxic compound."
`
`The source and character of starting materiais should be described. Preferably. refer to the notebook
`pages describing the starting material and its method of preparation.
`
`Be sure your notebook record is understandable. Omit abbreviations or slang that would not be
`understood by others working in your field.
`it is helpful to introduce each experiment with a state-
`ment of purpose, and make liberal use of cross-references to related experiments. While sufficient
`detail should be included to enable reproduction of experiments, it is acceptable to refer to conven-
`tional or published procedures. However, record any changes you may make to such procedures.
`
`Record your ideas too, not )ust experimental data. This is important to demonstrate when an inven-
`tion or thought occurred to you, and is an important part of establishing priority in inventorship
`contests. Don‘t hesitate to broaden the scope of your ideas;
`there is no reason to limit them to
`specific experiments planned for the next few days. although you should include as much detail as
`possible. Your notebook will not be published and there is no penalty for guessing wrong on note—
`book ldea entries. so don't hesitate to let your imagination run.
`
`10!
`
`Try to keep a different notebook for each product and/or protect. Please complete the table of con-
`tents Indicating which product and/or protect this work concerns.
`
`Genentcch's success. and with it your own prosperity and research support, depends upon the quality
`and timing of your work. This may require that WI: prove what you did and when you did it in the face
`of a contrary challenge. Such challenges have and wilt continue to arise in judicial proceedings. in patent
`validity or infringement or challenge, lnventorship priority contests and product liability actions. The
`key to winning in such cases is the ability to supply appropriate evidence.
`
`
`
`____".'_..
`
`Page 4 of 108
`
`Page 4 of 108
`
`

`

`
`
`Table of Contents
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`SCIENTIFIC NOTEBOOK C0.
`
`Page 5 of 108
`
`Page 5 of 108
`
`

`

`.......:...__u
`
`l'
`
`Page 6 of 108
`
`Page 6 of 108
`
`
`
`

`

`Ta ble of Contents
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`SCIENTIFIC NOTEBOOK C0.
`
`Page 7 of 108
`
`Page 7 of 108
`
`

`

`
`
`
`
`rlfihil.ah.II...Sliver-IIII:-
`
`mu.
`
`-._
`
`Page 8 of 108
`
`Page 8 of 108
`
`
`
`

`

`Table of Contents
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`SCIENTIFIC NOTEBOOK C0.
`
`
`
`
`
`
`
`
`
`
`
`
`Page 9 of 108
`
`Page 9 of 108
`
`

`

`Page 10 of 108
`
`Page 10 of 108
`
`
`

`

`
`
`Table of Contents
`
`
`
`
`
`
`
`
`
`
`
`
`
`SCIENTIFIC NOTEBOOK C0.
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Page 11 of 108
`
`Page 11 of 108
`
`

`

`
`
` ..l.H.....__.....i..r_5i!”1..
`
`..ti‘1.........I.EFu:laiif.-$\
`
`i.l..||.’l.l.fln1u...n"IdI.
`
`Page 12 of 108
`
`Page 12 of 108
`
`
`

`

`
`
`Witnessed & Understood by me,
`_
`E": 3M
`
`
`
`Date M???'y
`9:4 /90
`e 0'2,“ by
`
`‘
`
`Page 13 of 108
`
`Page 13 of 108
`
`

`

`Witnessed & Understood by me,
`
`Page 14 of 108
`
`

`

`Witnessed a. Understood by me.
`
`Page 15 of 108
`
`

`

`5%.: 90
`
`Witnessed & Understood by me.
`_ Hi;
`
`Date
`
`Page 16 of 108
`
`

`

`v
`
`Page 17 of 108
`
`

`

`Recorded by
`
`Witnessed & Understood y me,
`7qu
`kt) 44W”
`
`Date
`(916’! A
`
`99
`
`Invented by
`
`Date
`
`Page 18 of 108
`
`

`

`I.-"
`
`am“ 922.90 @3177
`
`.w 1‘
`
`R :". rded by
`
`Page 19 of 108
`
`

`

`figfiurdad hy-
`
`Witnessed & Understoofiy me.
`,7.
`QMRJM v
`
`_ -'
`
`.
`
`x
`
`Date016,490
`
`Page 20 of 108
`
`

`

`Recorded by
`
`Witnessed a. Understood by me.
`
`Invented by
`
`0819
`
`Page 21 of 108
`
`

`

`R forded by
`
`[Ste ) 9‘) ”FmDalje
`
`Witnessed & Understood b 1
`C) Mfrmfl/Wyzfi
`
`'
`
`e.
`
`6
`
`.
`
`Page 22 of 108
`
`

`

`6/90
`
`Witnessed & Understood by me,
`
`Date
`
`Page 23 of 108
`
`

`

`\,
`
`Witnessed & Understqod by me,
`41
`9W
`
`Dane
`I
`
`Date WEE
`agJ-90
`,,
`.1
`R» aided by
`
`._
`
`Page 24 of 108
`
`

`

`r Witnessed 8. Understood by me,
`
`Page 25 of 108
`
`

`

`Recorded by
`
`Witnessed & Understood by me.
`
`To Page No.
`
`._.
`
`Invented by
`
`Date
`
`Page 26 of 108
`
`

`

`
`
`Page 27 of 108
`
`

`

`Recorded by
`
`WIInessed & Understood by me.
`
`Invented by
`
`Page 28 of 108
`
`

`

`Witnessed 81 UnderstooE by me.
`
`Page 29 of 108
`
`

`

`_ Icorded by
`
`(3.684 90WM 072 L/fi
`
`Witnel:ed & {Jude-latent: mm.
`
`I
`
`.-.-_1
`
`If 5'” ME" -.
`
`.
`
`o
`
`Page 30 of 108
`
`

`

`-
`
`Witnessed a. Understood by
`
`Page 31 of 108
`
`

`

`ch . “1/!KW
`
`Witnessed & Understood byyze,
`
`Page 32 of 108
`
`

`

`I a!
`
`of“ 90mm 2/2 1/49.?
`Witrlwessedenderstood by "1°!
`Wynn/W 0‘6 f'
`a -- hi I"
`-'
`
`Page 33 of 108
`
`

`

`Recorded by
`
`Witnessed & Understood by me.
`
`Invented by
`
`Date
`
`Page 34 of 108
`
`

`

`'
`
`Date W m D“
`_
`- L.
`’/27/?0
`Q6I /' 90
`r
`' 2 mad by
`
`Witnessed-a Understoggi py "18,
`0 max I'lfh-‘L_.f:L.-"'h-1:J'E\-¥1
`I
`
`I
`
`Page 35 of 108
`
`

`

`<9Mnmwm
`
`Witnessed 8: Understood by me,
`
`Page 36 of 108
`
`

`

`-rded by
`
`Date WM
`j
`w
`72 9/50
`0-.6'/''90
`
`:
`
`,
`
`/A"
`
`h
`
`Wimessed & Understood by me,
`.
`ill/(7y)Q/l(fix-5.4%
`
`Page 37 of 108
`
`

`

`
`
`Page 38 of 108
`
`

`

`n Faded by
`
`Date “W3“I7/v.’
`/ 3 Y X)
`
`I
`
`Witnessed‘Understoodbyme,
`r0 afflm m~ibflfl
`
`D
`
`(__/
`
`Page 39 of 108
`
`

`

`(i)CLJ /\M WAFfl
`
`Witnessed a. Understood by me.
`
`Page 40 of 108
`
`

`

`907%M4394
`
`Witnessed & Understood by me,
`f
`
`Page 41 of 108
`
`

`

`Witnessed 8: Understood by me.
`
`To Page No. .
`
`Page 42 of 108
`
`

`

`
`
`Page 43 of 108
`
`

`

`”“30
`
`goJ/VHMFA
`
`Wimoued I Understood by me,
`
`Date
`
`Page 44 of 108
`
`

`

`/3- 9- 9O
`
`WMnessed 8. Understood by me,
`I.
`-
`007m(EMA-J41}
`
`Date
`
`Page 45 of 108
`
`

`

`x.-
`
`Date WM Dal
`{awry
`-
`-
`‘ -
`:fgfip
`R. mama;
`.1
`
`TD Pa 93 Nn___
`
`\
`
`Witnessed & Understood by me,
`9“bl/w" M
`
`0'
`JV
`
`Page 46 of 108
`
`

`

`I:\/
`
`Date mu/D“.
`fi/[fl
`/3'L’ 90
`Rdenied by
`
`L
`
`‘
`
`Witnessed & Understood by me.
`SOT/WW4
`
`Page 47 of 108
`
`

`

`D a: [ma/VCNM
`
`Dan M: by
`..
`tub-«L
`/ ”:- 3" 90
`Re'gdrded by
`
`,
`
`Tn Pug. No.51 ' _.
`
`Date
`2 /§‘ /¢77
`
`.
`
`l
`
`.
`
`Witnessed a Understood by me,
`
`-
`
`.r'-J II
`n. l
`
`Page 48 of 108
`
`

`

`Oat?“M
`
`Witnessed & Understood by me.
`
`Page 49 of 108
`
`

`

`Récéuded by
`
`Date “Ham Da e
`:7 H95
`..
`-
`-
`2/7 079
`
`.1—’
`
`To Page No.__
`
`Witnessed 8: Understood by me,
`
`.J
`
`Page 50 of 108
`
`

`

`Recorded by
`
`Date MW/'7 ‘l 90
`)
`
`l ’
`
`‘-
`
`Witnessed & Understood by me,
`U may/$41M
`
`j
`
`_.
`
`,
`
`.
`
`_-.4
`
`Page 51 of 108
`
`

`

`Recorded by
`
`Witnessed & Understood by me.
`
`Date
`
`Invented by
`
`Tn Page Nu._.
`
`gut,
`
`Page 52 of 108
`
`

`

`'3'
`
`D WQ14 M /3 "/0
`
`ReC'd
`
`Witnessed 8. Understood by me.
`
`Date
`
`Page 53 of 108
`
`

`

`Backup ed by
`
`Dale “WM“ D e
`
`Witnessed 8: llJnderstood by me.
`
`-.
`
`,rlr
`
`.
`
`a1
`
`_
`
`1
`
`‘
`
`To Page ‘ o...—
`
`.
`
`.,
`
`C
`
`Page 54 of 108
`
`

`

`b'm;.--}wa,--»-17*J
`
`Witnessed & Understood by me‘
`.
`,- I
`
`Page 55 of 108
`
`

`

`To Page ‘ 0....—
`
`Page 56 of 108
`
`

`

`5' corded by
`
`Date Md by
`Wimessed & Understood by me,
`f'
`1
`.
`OW
`90
`M U, 9_
`I
`
`"I (I.
`
`‘-
`
`‘l
`
`-
`
`I
`
`..
`
`Page 57 of 108
`
`

`

`Recorded by
`
`Witnessed & Understood by me.
`
`Date
`
`Invented by
`
`To Page No. _
`
`Date
`
`Page 58 of 108
`
`

`

`
`
`Page 59 of 108
`
`

`

`R -I:Irrded by
`
`WWW 332.90 EFflM—gW
`
`_ w
`
`Page 60 of 108
`
`

`

`(corded by
`
`Date M",
`myo
`* -
`)
`
`J-
`
`068:.
`N 2;»
`
`Witnessed 8: Understood by me,
`‘
`,
`-
`‘
`5 444M
`
`-—
`
`’.
`
`Page 61 of 108
`
`

`

`Rec-rded by
`
`ln-erstood by me,
`
`"Itnesse -'
`
`Page 62 of 108
`
`

`

`JIflJ}:¥1"1-"I1 (MAJJj
`
`Witnessed & Understood by me,
`r—
`.-'
`"
`1.
`r
`'
`I
`
`Page 63 of 108
`
`

`

`Witnessed £1 Understood by me.
`
`Page 64 of 108
`
`

`

`v. corded V
`
`1
`‘ “AM
`
`-"
`
`I
`
`-
`
`Witnesned a. Understood by me.
`
`Dale
`
`D 1
`
`f7
`/J‘ 7'2)
`
`Page 65 of 108
`
`

`

`Witnessed & Understood by me.
`
`Page 66 of 108
`
`

`

`Witnessed & Understood by me‘
`
`Page 67 of 108
`
`

`

`Li;3/ 65 .»
`
`' M 1'} u?
`D ' "J; "g" -'m
`
`—- .
`I
`'7
`'
`‘
`
`‘I
`
`' ‘_ “'“
`R . .!.dby
`
`‘
`
`Witnessed & Understood by me,
`_r
`-
`
`Date
`
`.
`
`L O
`
`Page 68 of 108
`
`

`

`/
`
`Date IMO.//.
`0L127
`R
`ordod by
`
`Ill
`
`T!
`
`,
`
`Wnnessed a. Understood by me,
`0 WM WM
`
`A
`
`Page 69 of 108
`
`

`

`9wg%m@fi
`
`Witnessed 8. Understood by me.
`
`Page 70 of 108
`
`

`

`IL
`
`tood b me.
`Y
`
`nness d &
`e
`
`d
`Un ers
`
`a
`/? 90
`
`R _ ”and by
`
`_ 4......
`
`.1
`J. 2'
`
`Page 71 of 108
`
`

`

`i,
`
`W!I'm-Dazalq/
`‘J :-
`.l
`' cordld--y
`
`'r.4-
`
`Witnessod 8. Understood by me.
`K
`V\'
`‘
`M%
`
`Date
`l ’
`? 90
`
`Page 72 of 108
`
`

`

`I
`
`'
`
`‘
`_
`
`TITL
`From Fag: Nn._
`
`Project No.
`Book No.
`.
`
`
`
`
`
`_
`
`.
`
`61
`
`7447667‘ V6.«WE M
`
`:56
`5////9 [ho C(«CMaMSj‘6.'x
`wwmbzflum AMA”
`.0 Coot”
`,MS («.Jflw 1666«.3 Afifm-I 662ina) «,6-,9le w. «2:.
`fl};
`15.14.,«6u141
`(Am 6// [MACH] «,6 AfflIpJ/‘Of/tzfi‘mPWJI-fifiryéj'
`-6116
`53d." «1.1
`«.1: 6466. c.
`it) «5616—:
`{£44,6/«6’...1%.“«6.6(«6.5 ,9m6—4.5;)
`'
`I
`
`‘~.'-
`
`I i | I|
`
`iffl
`
`91.63.17.9457(j_._
`
`Page 73 of 108
`
`Page 73 of 108
`
`

`

`Project No
`Book No.
`
`
`
`
`62
`
`From Page Nag
`
`if.
`
`/r/?0 -// A?“5: flash: LAW/y? ,4. 7/?” "fix/(Z,
`gird;faj+ iii; .
`'1_
`_
`712’: “/r WM. fl??? 2.:
`/5 MG)14%}
`E’jfi 115l/VLCk): EE- jig]
`(67* LACQZ
`("Lo-H $914" [27 Arc!
`
`=37) {fem air firm;
`
`Page 74 of 108
`
`Page 74 of 108
`
`

`

`From Page No.._
`
`5 ”7/?0
`
`7’
`
`t) #3/6’ Cami/IQ!" wig-5w)
`,PV‘sZ
`(“Mfuw Aw]
`
`9/15 ~/V“‘I
`
`gym duh“!
`
`43"“ a saliv-
`
`yw
`
`"
`
`-
`
`{14. Hugh. ”A“ A
`[ma-«LL 37%? 12::
`s) m Wad/f m"I‘ Lat/l. m
`_ (Lia-Lacr!
`be
`7L4!
`’4!" I
`/J
`
`Witneused & Undevitnod by me,
`
`5-“.
`0‘0 M CV7“ édrffivrAt
`{if
`1
`45«/)/’“l
`251-5- 470$
`
`é
`
`2255/4 M'JZ+
`
`7 f/S/Zéz. , @997
`
`Page 75 of 108
`
`Page 75 of 108
`
`

`

`To Fug- Haw
`
`_
`-. _:_::i;/5;q pngm .
`"T.11LM :__‘"§:::;+z;___
`
`'
`
`
`
`Page 76 of 108
`
`Page 76 of 108
`
`

`

`Project No.
`Book No.
`
`/}//’
`
`53:11,,
`i
`£1131
`
`1’5 m‘?~,444;’ -4'
`
`44! get:
`131’;
`{114.4 r
`1551‘}? LE 41'
`(765.
`
`444* 251.4?»
`
`"by.'-_'r"-
`6"“- 455‘:
`hat: Hiring CHI-n.4,.
`#1135 {/M W 2“: {54! 444:}
`:45
`
`1...! a;
`
`9/6 MIN-If 43».
`M9/ ”5‘2 1‘ 54/?!
`_ 4444/“ ‘35 {6,1
`
`{an AJJH/ M4
`
`flaws ,
`cr r.
`.4
`.VFW/lcrvlflmfi. Maw Jf IP46
`4/~‘/
`‘5 4/603:
`
`.444
`
`Page 77 of 108
`
`Page 77 of 108
`
`

`

`m P
`
`roject No.
`
`
`
`
`
` 66 Book No._____ TITLE%’/p% é WJ 91435 flfb‘ VfiLA) 31L
`
`From Page No.
`5
`5/41/27
`
`flux-.1 59m 74!?
`a
`g
`0% )0” “#1/0"
`
`, +13%”
`
`/" [J30
`“1'
`fi-a‘f/V/
`
`Dre.
`éI-Y'C’,
`
`651,4 M) fix”? L/flwfi Qfl é?
`
`m9
`
`farwf.( 47‘“?
`
`~ 44% 3635/
`
`Dan
`Witnessed & Understood by me,
`W "7‘90
`
`I.E:
`
`/._
`
`Page 78 of 108
`
`Page 78 of 108
`
`

`

`
`Project No
`
`“Hm Book No.
`
`67
`
`gym” .7/ zm/
`
`“( LX/tmc/AM links ,4 C
`
`5.J‘_ SWCF 16:2 4
`.....A22 5 #
`
`
`
`Page 79 of 108
`
`Page 79 of 108
`
`

`

`-.+#__a——
`
`; LL! {4:1 was if a? m4 m4:
`
`Project No.
`Book No._______
`
`Page 80 of 108
`
`ragga. 1':
`
`q—~———l——
`
`__ .____—--—
`
`Page 80 of 108
`
`

`

`WW... some.
`
`.
`
`From Page No._
`
`Project No.
`
`
`
`
`_
`
`P
`
`sfz/ 5/75
`/) )fiX’Ty Alexi?
`4.77:6 7.1%..
`517;; <27
`—
`Lag/:377 7/ 7pm.;
`fli" I'M-v.51
`—
`fiflr Arr-1E
`. +-
`iii?7.7;.»
`-
`jam KEV/4rd“ .
`- A; 75mg,
`063 ?‘//
`QQVMZ
`)61 WWW/"/70
`< 7774»
`-
`4.) ,0: «>777
`fizz/4g:
`- M455“;
`.
`7%!{+5 £65777
`val’O‘fl‘;
`‘7 ff“ (07/0 m «as -
`7
`98 AL}CC >fi/o
`)flfw ~ng
`--7'
`/‘§”:4. 411+-
`1’
`.c’ {Pr} ()2[@331
`
`
`
`DIM mm; D}
`Winn-ad I Understood by ma,
`M 5" ? Lb a mu in]
`
`Page 81 of 108
`
`Page 81 of 108
`
`

`

`70
`
`ProlectNo.
`Book No.
`
`a:
`TITLE I SW49. M“
`
`.
`/>
`A ”A b)
`
`
`
`To Page No.__._.-
`
`Page 82 of 108
`
`Page 82 of 108
`
`

`

`
`Project No.
`
`TITLE /43 (“16)
`Book No.
`
`71
`
`From Page No._
`
`‘
`
`-—
`
`,
`
`‘A
`
`.
`
`t
`
`i
`
`r
`
`in“, ,4
`
`,6”) 7.) g/ flC;//.
`
`gym)
`
`I)
`
`[an ”(Q-771x:
`
`b>_
`
`//
`
`35 0/1}; Vé(/2>#/¢/
`
`9/
`
`3/113 M (5) fly
`
`() Wk'77 /A¢E
`7 > £134
`
`Page 83 of 108
`
`Page 83 of 108
`
`

`

`
`
`0/0; 441,24); 0C7»
`
`.
`
`FromPa eNo.__ N13 ///{(,/5/ _-—--3)
`5/39?
`”a
`
`«do: ,, xM
`
`Page 84 of 108
`
`Page 84 of 108
`
`

`

`
`
`Page 85 of 108
`
`Page 85 of 108
`
`

`

`mP
`
`TITLE
`
`0
`_
`-
`.1
`“01““! fl/M/M ,-
`
`W4
`
`74
`
`
`roject No.
`Book No.____..
`
`'W 45”“?
`
`/
`
`mw-JW~-L-m
`
`- LAMA,
`(3/7/1»)
`I 4/4; c/m‘ My“
`I
`S”J{§Iy{10/»€/Pma4rm 4/_
`mafia; Mi; (77/6) #44494 /3m
`(0M5:7¢ ZOM /%
`_
`5) a; /_6 _5A46 4444‘ _
`
`5“ // _'5
`
`#:A
`
`guy)”45$ /764~04m(bvowc[m/>Ouuiu/
`6)‘W 6744
`fax/CW pup/WU.
`(/5154! 2
`
`To Page No.
`
`Witnessed & Understood by me.
`
`Page 86 of 108
`
`Page 86 of 108
`
`

`

`.
`Project No.
`“Tmfl Book No.
`
`M
`
`1151'. Mama/M4111? W] ..
`.RI:£4f/51/L4u21 ALFRm
`
`90. 4/7/5sz w/fib/l/K
`W) 970,7 [Ag
`
`'
`‘
`Mia—1L
`
`'I
`
`.,+__'._.,___+.,
`
`_
`
`.
`
`flag“! it”. (aw
`
`- Egg} a
`
`Mn/
`mt-
`,4
`t
`.
`740£4 02%. M 9.15-.
`
`.
`
`E
`
`1) 3/647 .,41«4./7=.J.«/cz
`z) 7/3” ‘v/flS/(W.
`
`Witneued & Understood by me,
`
`Page 87 of 108
`
`Page 87 of 108
`
`

`

`m P
`
`
`
`
`
`roject No.
`Book No.
`
`76
`
`From Flu. Ho.___
`
`_
`,
`:01??? {466, gm, :flétj'f.xfi¢;
`.
`.C-d-‘Y-‘l ALI! flmiwfi};
`fl:
`
`few 9% my: :12) '
`
`)1 7&9 v.0 WJLOaW M
`/{. Mfflflmlfkr —-
`-
`
`-‘/
`
`
`
`Page 88 of 108
`
`Page 88 of 108
`
`

`

`..+_-.-.___._
`
`‘
`
`.—
`
`.
`
`AV
`
`
`
`TITLE 06AM 0M ~
`
`’
`
`_’
`
`~
`
`,
`
`
`
`ProjectNo.
`
`ff/A (M544
`.
`_
`LI151“ 4/451; Jung}.(It-w!” "
`/.au¢:
`_
`_
`£31135
`.
`'r
`_
`[3*
`#3332439.
`(14419.53 94:41.1“;2’4/Ic (”Jain-Mi
`jaw. 111,4; 1 ._
`9;) 57ka iii-1 fur-Lam.
`.
`I
`.
`.
`.
`.
`
`.
`
`--
`
`upercolled DNA Ladder
`bl
`— 16.21
`— 14.17
`— 12. M
`~10!“
`—— 8.07
`7 7.05
`‘ 6m
`— 5m
`— 3.99
`
`Page 89 of 108
`
`Page 89 of 108
`
`

`

`mP
`
`78
`
`From Plan No,_,
`
`
`
`
`roject No.
`Book No.
`
`L}; wLEJf“55;: ,H a;
`
`Mf/EH'M" $5 (-
`
`Page 90 of 108
`
`Page 90 of 108
`
`

`

`
`
`Project No.
`Book No.
`
`From Page No._
`
`(2/;7/f0
`
`K47” uwf MM .W 9:29: 4‘. 39.3-5
`
`EMA/V "a C55/
`
`/Z:\..¢ .
`
`witnessed & Underslood by me,
`
`dfdtef gnu-“~— (9011,? art-Fr GH££~¢>£1M‘
`vac—11
`7/xjpg
`[84.4
`w/Qc/ My! SM; M// m; H.
`.
`
`Page 91 of 108
`
`Page 91 of 108
`
`

`

`80
`
`Project No. .._.____
`
`Book No.___.___
`
`From Page No._.
`
`4D5 Chimera
`
`affix/9,0
`
`Plasmid
`._p pA9
`
`Expt#
`340
`
`Clone
`2
`
`4D5 light chain chimera
`differs from the original version (dh158) onlyin that the non-
`silent freebie mutations have been removed: V 104L: T 109A
`
`——> pA 10
`
`339
`
`1/4
`
`4DS heavy chain chimera
`differs from the original version (dh160) onlyIn that the non- .
`silent freebie mutation has been removed: QlE
`
`Hu4D5 Heavy Chain
`
`Plasmid
`
`Expt #
`
`Clone
`
`.1pppA1 3
`pA 14
`
`342
`
`1/6
`
`Hu4D5
`Version
`
`c
`d
`
`coming soon (hopefully)
`
`Page 92 of 108
`
`Page 92 of 108
`
`

`

`From Page No.—
`55 7 Nim-
`
`7
`
`7/ / :M Mm m h,“
`14/“ 704/?
`by
`.+
`
`H A-
`
`~09“
`
`lenuud I. Una-armed by me,
`
`'
`.mwM/A I Q.“
`/%/i§;
`”SM? i%~8_;éf a <__.
`.
`.éflmm‘c ; 9244.; .=
`
`Eflp t
`
`. LAW? .
`
`x .2
`
`x
`
`Page 93 of 108
`
`Page 93 of 108
`
`

`

`
`
`Project No.
`
`»
`
`.
`
`.
`
`44441146:
`
`.
`
`/W06
`3C-’47) 1441—01»: {43% [/9034ng
`4 A£,5 t14% Inf 1% CH c/4/5¥/(CfiW-i/4%) C44)
`‘.
`,M[kWMIC/f- 0,63 N M [cw/r Mac-A; Am! a;
`M‘WA‘L
`zéyéf o/m I
`I
`I
`1‘ #3
`719 m Z C/M avg
`.79/ K)
`.
`.'
`‘6 ./;I/rgzwa/ ”my“NW 43/4 c/wn 39>
`Iwué. ,9,Ag.
`W44 SM/Cm As §—Cc//ug c/ag,
`..
`)CMLWWI/I“ 044w. -Muff/8KVie!w: é/‘fiéqflA) it,#5 ‘6 flux/615.00.
`NWJ_ ij/ f/fS— avK.( flJr/S'IC (/
`_
`
`7
`
`3W“ ,pSV/LCAM Z(—7 TAflnJCLIyI/wav;14 {v/fl‘27 CM. /w M14-
`W/rmr :22 .g fife/[’45
`.,M/Jwr-w/ New /Ja1/§ M ..
`f5 Wycw é MJ/bbfifv‘l)
`
`Page 94 of 108
`
`[JV/665’(617(pLil/(:W
`LIQCA\
`0/4147-
`4,,
`(
`3463?ij
`:fE/“is‘T
`£63109)
`
`.
`
`.
`
`To Page NO.
`
`Page 94 of 108
`
`

`

`_
`.
`__
`.
`P ' N.
`"2.11%qu 9.74% 4 ;&__ '31:; N:._.__
`
`From Page No...
`
`9/24”sz L,
`
`‘
`
`4-Way»:
`
`07-» [/Cc /}(c/é
`
`Witnewwby me,
`
`,oww ax
`ran/a £7
`[21w 68/407,.
`fl’-/./; VLC
`8/2} $9 Aaw‘w {22M (9 climax;
`.
`
`ffl//Q fiflfimw J16 MC
`'
`(< 5%)
`T
`(
`J
`6'07
`,
`(fun (a [/GC.
`“W “ M". '
`
`Page 95 of 108
`
`To Page No.
`
`Page 95 of 108
`
`

`

`mP
`
`
`
`
`roject No.
`Book No.
`
`,
`TITLE «5+ ..
`
`‘—
`
`‘
`,w “SM _.
`
`'\
`
`l
`
`. ”I
`
`34
`
`From Page No.
`
`.
`
`A/t‘ 92/3}.Ifii’r‘lh 5W2! "'4'-
`5w gymfwflfs
`W”/1C@fl~/4Ké“+—~—- -
`
`
`
`-—-———np__.
`I? [9de
`
`h
`
`I
`
`I
`
`'
`
`Page 96 of 108
`
`I
`
`I
`
`I
`
`h
`
`I
`
`-
`
`j
`
`I
`
`/32/0?o
`
`1
`mau-
`f?
`
`"'.“y
`
`To Pagt No.__—-
`
`‘7”
`
`.
`
`...___L.‘
`
`Page 96 of 108
`
`

`

`_
`
`‘
`
`TITLE_,W_V/Km 5 M} {’J‘” Mr 5 3&ka
`
`
`,.
`Project No.
`
`
`Book No.
`
`From Page Nu._
`
`.
`
`as
`
`1
`
`r
`
`.
`I
`
`T-h--.-.-.w
`..__u-¢-.
`
`
`
`7/3/6ng _ Gd {Sarim?) TWA o/w... ha-h¢%w.'; My--- .
`'
`——
`ffifl-fl-
`
`'4 UMP //aJ’
`MA JJHL(«M _M -
`(Laid ffklfiT‘S Mg _
`
`To Put Hu.___
`
`'i
`'
`”Mac‘s/””45 (/*4-47Cfm/JAMS).'
`7/5/32}?
`M_“QC/«i;fid ‘v/ 7:,
`(Arc/g far-Cf?/;‘fl.’4&_ _
`fid’fZH-EF"if 4.4M #1182“
`,,
`-
`I
`-—
`V05'? 5W P4>.*fN1MM {LAN} m4
`Imp! fin Sry ~/’ou_g (”2’ (5/4.?!) L/
`CV5“~)‘v1‘ 0f
`’7C‘
`.
`.V
`ZENITH”; W‘LAMVA/‘M.
`.
`..
`,
`/7/L"I.P @M.{ ll)(llln:
`Vi? .CP1Ar’(T',/L[‘9 (AV'l-Jv
`.
`,
`c'
`13-
`-
`-
`-
`.
`.yéék'gj‘ ,
`.501" gifitgl/‘fz
`.
`.
`.
`.
`.
`.
`.
`.
`
`Page 97 of 108
`
`Page 97 of 108
`
`

`

`m P
`
`
`
`roject No.
`Book No._____ TITL
`
`86
`
`/
`
`W 01,5' X/M
`[m( 1 15207;: M”?
`S— SAM/5 7/?”
`f‘./ _
`
`Witnund I Understood by me,
`
`Page 98 of 108
`
`Page 98 of 108
`
`

`

`Project No.
`
`[/141-
`2:4; -
`
`.
`IC/w NM“? (50 it If)
`15‘s) 6/ fi/Vwfiaf‘a/ 5a, (44—?) g 14:)
`
`Witnessod & Understood by me.
`
`To Pay No.
`
`Page 99 of 108
`
`Page 99 of 108
`
`

`

` 1
`
`
`.
`
`Project No.
`Book No.
`
`,
`
`_
`
`_
`
`x
`
`/
`
`88
`
`From Page No._.
`
`//7//¢ 6/411 Q/W’SZ/wgm4 p/ Kf/V/ 64’-
`
`i
`
`.
`
`2
`
`I
`
`ilSJ'fJC/l/UC La/ I;
`
`““2"”?
`
`
`
`- Wf) f,
`
`" CMK
`
`KN“
`
`{3344-1 YTRSHMQ 14M
`
`fSu/589J21’ocf.-%15Vé
`
`L
`
`f.-,L
`
`Dun magi—DI
`Wilma-adIUnderstoodbyme.
`016-/O-Sb
`" M
`W?
`. m
`Ila-co 3 -
`DWW4
`
`
`To Page No.__—
`
`Page 100 of 108
`
`Page 100 of 108
`
`

`

`3;” fliffir
`(1,1161% :41}
`
`.-I
`
`{L é/mM @g‘f‘f nil/IL} %'$f4cg%—
`,
`,A,
`,
`,
`A
`-
`“‘4..—
`
`I
`
`(1;, 7Ya/2/1 5*: 5/ 194mA
`#ng w/Awa/m
`
`
`Prefect No.
`’
`v /
`"
`
`
`mam—-
`
`3001.11,.
`
`89
`
`_
`
`' ézflSJA497M3m
`_
`Qm/w #1 ,1th #1111911;
`,1fl/f 41/21/61. “ LEMM1L 423 4-1.1.
`,
`1.1 59% (W. ,1” Min“
`
`1141—41414 WHneued I: Undoruood W mm
`
`01111110
`
`'
`
`'
`
`1
`
`Page 101 of 108
`
`Page 101 of 108
`
`

`

`m‘
`
`TITLE Q14 fl A!“ 905 61,, 6
`
`,
`
`90
`
`
`
`N .
`
`”210:: N2.
`
`.~
`
`From Page No.,_
`
`6'
`£3:
`
`f/pf/‘fi
`
`,
`
`.
`
`fié/A/ ,MLJM‘
`lgflit ifqg/
`- de/fi‘ )0“ 5/ Fa;
`.f/o/K‘ks«c~>,
`fizzm‘SWJ QH/flé/ZZ‘ ~ >050
`
`. .5/ 4:, m
`
`Page 102 of 108
`
`Page 102 of 108
`
`

`

`l
`
`'
`TITLE ._, dww
`
`From Page No._
`
`~
`
`Project No.
`Book No.
`
`
`
`
`91
`
`61/249;
`
`701‘ m;- 54% #s %ng:.{a.‘
`
`Fifi} (“M V 9‘02; V 04’;
`4%,“ m 4 1961/ of:
`.w $44.5.
`- ”m /
`HA?
`4/ at
`
` Cswrng-lxwfzi #5633 /:}p.(f
`
`l I l r l I r l’
`I
`I
`[
`
`II
`
`[IIIillll[III
`
`1E
`
`Page 103 of 108
`
`To Page No.
`
`
`
`Page 103 of 108
`
`

`

`92
`
`
`Project No.
`Book No.
`
`
`
`
`
`From Page No._
`-
`
`. a ‘
`
`‘
`
`'
`
`(Minx/w W?“ W *’
`A-
`
`«sun
`
`v. xii/W” .3,
`
`“a
`
`
`J
`
`1:}
`
`y
`
`{fl-t;
`
`55;.“ )P'H'E"
`.7
`
`
`
`Witnessed & Understood by me,
`
`
`
`Page 104 of 108
`
`Page 104 of 108
`
`

`

`Vii/:1;
`
`»
`
`ff}: 5/5”};—
`
`
`
`From Pug: Ho.—
`
`
`
`0 h
`
`Page 105 of 108
`
`Page 105 of 108
`
`

`

`a
`
`TITLE
`
`Project No.
`Book No._____
`
`94
`
`Fr m Page‘ No._
`
`
`
`invented by
`
`Recorded by
`
`Witnessed & Understood by me.
`
`Page 106 of 108
`
`Page 106 of 108
`
`

`

`
`
`Project No.
`Book No._____
`
`95
`
`Record-d by
`
`Wilnessed 8. Understood by me;
`
`To Page No.7;
`
`Page 107 of 108
`
`Page 107 of 108
`
`

`

`96
`
`Project No.
`Book No._______
`
`TITLE
`
`
`
`
`
`Page 108 of 108
`
`Page 108 of 108
`
`